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Yolanda Handayani
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INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 64 Documents
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The Role of miRNA in Non-Small Cell Lung Carcinoma Ahmad Arfan; Sita Laksmi Andarini
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.39

Abstract

Micro Ribonucleic Acids, or miRNAs, are short non-coding RNAs. Their length, on average, is 22 nucleotides, and they function in post-transcriptional regulation of gene expression. MiRNAs have their own nomenclature, and the same miRNAs can be found across different species. MiRNAs play important roles in many physiological and pathological processes in the human body. Regarding cancer, miRNAs are involved in carcinogenesis. MiRNAs work by binding completely or incompletely with messenger RNAs (mRNAs). Complete binding with mRNA produces mRNA degradation, while incomplete binding produces translational inhibition. Eventually, miRNAs decreased gene expression. In cancer, miRNAs show unique and different expression profiles. Based on their role in activating or deactivating intracellular signaling pathways, miRNAs can be classified as oncomiR or tumor suppressor miRNA. In non-small cell lung cancer (NSCLC), miRNAs are associated with gene mutation status, and they have important roles as diagnostic, prognostic, and predictive biomarkers.  
The Associations Between Severity Of Symptoms, D-Dimer and Incidence of ARDS In COVID-19 Herani Mutia Riandini; Fajrinur Syaran; Syamsul Bihar; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.40

Abstract

Background: Severe acute respiratory injury caused by COVID-19 (ARDS) is a serious emerging complication. ARDS results from a cytokine storm that occurs in the second week of the disease course and acute-onset hypoxemia can be seen with bilateral infiltrates on chest radiograph. This study aimed to relate the severity of symptoms and D-dimer level to the incidence of ARDS in COVID-19 at H. Adam Malik Hospital as the referral center for COVID-19 in North Sumatra. Method: This was a descriptive study with a retrospective cohort design. The sample of this study was secondary data from medical records of positive RT-PCR COVID-19 patients from November 2020 to April 2021. The inclusion criteria were patients with moderate to critical COVID-19 cases with D-dimer examination taken from the first day of admission. Subjects were then followed up until discharge from the hospital to assess for ARDS episodes which were confirmed by the results of PaO2/FiO2 in arterial blood gases and bilateral infiltrations in chest X-Ray. The exclusion criteria were incomplete medical records. Results: The association between the severity of symptoms and the incidence of ARDS, 1 of which was found to be moderate, 19 cases were severe and 20 were critical. However, there was a statistically significant correlation between the severity of symptoms and the incidence of ARDS (P=0.0001). Conclusion: There was a significant correlation between the severity of symptoms and the D-dimer value on the incidence of ARDS.
One Year Survival of Wild-Type Adenocarcinoma Lung Cancer Patients Receiving Chemotherapy at dr. Saiful Anwar Hospital, Malang Ungky Agus Setyawan; Hendy Setyo Yudhanto; Aura Madarina
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.47

Abstract

Background: Lung cancer is one of the most common malignancies that leads to mortality. In Indonesia, lung cancer ranks first in men and third in women. The most common histological type of lung cancer is adenocarcinoma. Adenocarcinoma lung cancer is divided into 2 types, namely EGFR mutations and no mutations (wild-type). Chemotherapy is the treatment of choice for advanced wild-type adenocarcinoma lung cancer. This study aimed to assess the one-year survival of wild-type adenocarcinoma lung cancer patients receiving chemotherapy. Method: This study used a cross-sectional study design.Data were taken from the medical records of cancer patients at Dr. Saiful Anwar Hospital Malang in 2018-2019. Data were processed and analyzed by chi-square test. Results: Of the 54 subjects, 24 patients received carboplatin/ pemetrexed (44.4%), 15 patients received carboplatin/paclitaxel (27.8%), 9 patients received carboplatin/gemcitabine (16.7%), 2 patients received pemetrexed (3.7%), and 4 patients received gemcitabine (7.4%). The chemotherapy drug regimen had no correlation with one-year survival (P=0.899). Conclusion: There wasno significant difference between one-year survival andchemotherapy drug regimens. This study required a larger sample to minimize bias.
Preoperative Assessment Prior to Lung Resection: How to Eliminate the Risk Dian Megawati; Menaldi Rasmin; Budhi Antariksa; Faisal Yunus
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.48

Abstract

Lung resection is part of the treatment of various lung diseases, both malignancy and infection. Although it has great benefits, lung resection can result in a variety of functional disorders that can affect the whole cardiopulmonary system. The mortality of these procedures is 2-4% in segmentectomy and 6-8% in lobectomy, while the mortality of pneumonectomy in the world is 11%. Good preoperative assessment of patients has been reported to have reduced mortality and morbidity after lung resection. Things that need to be considered to assess preoperative eligibility include age, lung function, cardiovascular fitness, nutrition, and performance status. The preoperative pulmonary tolerance assessment is divided into three stages: the first stage is the assessment of lung function and blood gas analysis, the second stage is to assess postoperative prediction of pulmonary function, and the third stage is to assess the maximum oxygen consumption per minute by doing a cardiopulmonary exercise test. Patients who have a good tolerance for lung resection are patients who have predictive postoperative force expiration volume one second (ppoFEV1) values more than 40%, predictive postoperative diffusion capacity of the lung for carbon monoxide (ppoDLCO) more than 50%, and maximum oxygen consumption (VO2 max) more than 15ml/kg/min.
Calculation of Pleural Fluid Estimation Using Ultrasonography Adityo Wibowo; Mia Elhidsi; Agus Dwi Susanto
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.51

Abstract

Pleural effusion is an abnormal accumulation of fluid in the pleural space due to an imbalance in increased pleural fluid production and decreased absorption. An ultrasound device can be used to guide the procedure to evacuate the pleural effusion fluid, increasing the procedure's accuracy and lowering the risk of complications. Several calculation methods can be used to calculate the volume of fluid in both an upright sitting position and a supine position. Ultrasound is nearly 100% more accurate than chest X-ray in detecting pleural fluid.
Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera Dyana Destylya; Bintang YM Sinaga; Parluhutan Siagian; Putri Chairani Eyanoer
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.53

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The increase in the number of COVID-19 cases was happening quite quickly and has spread between countries so that COVID-19 has become a pandemic in the world. This study aimed to determine the characteristics of COVID-19 patients at Haji Adam Malik General Hospital Medan. Method: This was a descriptive study. Data were taken from the medical records of 110 hospitalized patients with positive RT-PCR results for COVID-19 from December 2020 to April 2021. The inclusion criteria for the case samples were patients diagnosed with COVID-19 based on RT-PCR and the exclusion criteria were incomplete medical records. Characteristic analysis was carried out using the Kruskal Wallis test. Results: The most common comorbidities found in patients with severe COVID-19 were diabetes mellitus and HIV. The most common comorbidity found in moderate-level COVID-19 patients was pregnant women. The most common chest X-rays finding in severe and critical levels was bilateral infiltrates. Recovered patients were mostly obtained at moderate level, while deceased patients were mostly observed at critical levels. Conclusion: Characteristics of COVID-19 patients at Haji Adam Malik General Hospital were classified based on the degree of disease by age, lymphocyte value, N/L ratio, levels of CRP, D-dimer, procalcitonin, fibrinogen, ferritin, and comorbidities as well as the appearance of infiltrates in both lung fields.
Factors Related to Complaints of Lung Function Disorders In UPN Veteran Jakarta Employees Prasetyo Risky Alamsyah; Fajaria Nurcandra; Cahya Arbitera; Fathinah Ranggauni Hardy
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.36

Abstract

Background: One characteristic of lung dysfunction is obstruction of airflow in the respiratory tract. The prevalence of COPD as lung function disorder among men in Indonesia is 3.7% and 2.7% in DKI Jakarta. One of the causes of decreased lung function is smoking. A large portion of UPN Veteran Jakarta employees is smoker. This research was aimed to determine risk factors of lung dysfunction among employees in UPN Veteran Jakarta. Method: A cross sectional study was conducted from April to May 2019 in UPN Veteran Jakarta. Total 102 samples of employees who work at UPN includes staff, lecturers, cooperative officers, office boys, and security guards were selected using purposive sampling. Measuring instruments used in this study were questionnaires, scales, microtoise and spirometer. Spirometer was used to measure lung function. Questionnaires to obtain data on gender, age, body mass index (BMI), employment status, education, allergies, history of lung disease, family history, Brinkman index, physical activity, vehicle emissions exposure and smoking environment. The data was analysed using the chi square test and logistic regression test Results: The results of the logistic regression test showed risk factors of lung dysfunction were BMI (POR: 4.718; 95% CI 1.673-13.305), history of lung disease (POR: 3,424; 95% CI 0.836-14.028) and smoking environment (POR: 2.956; 95% CI 0.953-9.168). Conclusion: The most influencing factors for lung dysfunction were BMI, history of lung disease, and smoking environment.
Early Diagnosis of Interstitial Lung Disease Anita Masniari Pulungan; Fanny Fachrucha
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.43

Abstract

Interstitial Lung Disease (ILD) includes more than 200 diseases that involve the interstitial lung. The diagnosis of ILD depends on the onset of symptoms, causes, and clinical manifestations. An anamnesis comprehensive and physical examination are essential in diagnosing ILD. In addition, laboratory tests are carried out in certain clinical conditions. The analysis of biomarkers in ILD is helpful for diagnosis, disease monitoring, and prediction of prognosis. Pulmonary function studies support the diagnosis of ILD and as a predictor of prognosis. High-resolution Computed Tomography (HRCT) is the main diagnostic procedure in ILD patients. In certain conditions, a lung biopsy may be considered. Multidisciplinary discussion (MDD) enhances accurate diagnosis. An accurate early diagnosis of ILD is necessary to ensure that patients receive optimal management, reduce the risk of developing pulmonary fibrosis and reduce the risk of death. Early diagnosis of ILD define as early identification of symptoms, laboratory and radiological findings at the early stage of the disease
Effect of Chemotherapy on Quality of Life of Lung Cancer Patients: Scoping Review Novita Andayani; Suryawati suryawati; Nadya Salsabila; Desi Salwani; Hendra Kurniawan
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.45

Abstract

Background: Lung cancer is a tumor originating from the lung parenchyma or in the bronchi. Lung cancer is the second most frequently diagnosed cancer. The treatment often used is chemotherapy as most lung cancers are diagnosed late. Chemotherapy can provide many benefits but also has side effects because it works by killing healthy replicating cells. Symptoms of cancer that appear as well as side effects of therapy have an impact on the patient's quality of life. Quality of life is a person's perception of his position in life in the context of values ​​and culture. Quality of life can determine a person's general well-being and well-being is the main goal of treatment. This study aims to determine the effect of chemotherapy on the quality of life of lung cancer patients. Method: This Scoping Review was compiled by conducting a literature search on the PubMed, ScienceDirect, SpringerLink databases, and manual searches on Google Scholar with the keywords “Lung Cancer” AND “Chemotherapy” AND “Quality of Life” from 2016 to 2021 publication period. Scoping This review is guided by the PRISMA-ScR checklist. Results: As much as 30 journals were obtained based on inclusion and exclusion criteria from this process. We found that most of the literature states that chemotherapy has a positive effect in improving the quality of life of lung cancer patients, which are dominated by advanced NSCLC cancer types. Conclusion: Aspects that can affect the quality of life of lung cancer patients undergoing chemotherapy are the available health facilities, the choice of chemotherapy regimen, the timing of the quality-of-life assessment, and the patient's socio-cultural background.
The Effect of Ginseng Extract Supplementation on Procalcitonin Level, Neutrophil, and Length of Stay In Patients With Community Acquired Pneumonia Anita Ramlie; Reviono Reviono; Jatu Aphridasari
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.49

Abstract

Background: Pneumonia is an acute inflammation of the lung parenchyma caused by microorganisms (bacteria, viruses, fungi, parasites) and causes of high morbidity and mortality. Ginsenoside in ginseng have anti-inflammatory effects, potentially as adjunctive therapy in community-acquired pneumonia (CAP) patients. As much as 43% of patients at dr. Moewardi Hospital in 2016 were hospitalized have passed away. The aim of this study was to determine the effect of ginseng extract on levels of procalcitonin, neutrophils, and length of stay of community-acquired pneumonia patients. Method: The quasi-experimental clinical trial with the pretest posttest design approach was conducted on 26 community acquired pneumonia patients who were hospitalized in Dr. Moewardi Hospital Surakarta from October until November 2019 using consecutive sampling. The control group (n=13) received standard antibiotics while the treatment group (n=13) received additional ginseng extract 2x100 mg/day for 14 days. Procalcitonin was measured at admission, third and fourteenth day; neutrophils are measured at admission and third day; length of stay is based on the number of days of treatment in hospital. Results: There was a significant difference (P=0.001) towards decreased of serum procalcitonin levels between treatment group    (-0.63±0.06) compared to control group (-0.38±0.07). There was a significant difference (P<0.001) towards decreased of neutrophil levels between treatment group (-6.68±1.34) compared to control group (-3.51±0.88). There was a significant difference (P=0.001) towards decreased of length of stay between treatment group (5.69±0.95) compared to control group (7.15±0.99). Conclusion: Ginseng extract containing ginsenoside as its main ingredient, can act as an anti-inflammatory which can be used as adjunctive therapy in community-acquired pneumonia patients who are hospitalized to accelerate clinical improvement and shorten the length of stay.

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