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INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 64 Documents
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Descriptive Study: Level of Communities Knowledge And Perception About Tuberculosis (TB) in Denpasar, Bali Ni Putu Ayu Widiasari; Ida Ayu Jasminarti Dwi Kusumawardani; Ida Bagus Ngurah Rai
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.3

Abstract

Background: Success rate of Indonesia Tuberculosis (TB) treatment did not evenly distribute to every province in 2016, although various program had been carried out by Indonesia Government. Bali’s Case Notification Rate (CNR) and Success Rate (SR) of TB also did not reach target in 2017. Successful control of TB can be influenced by community’s level of knowledge and perception about TB. Our research objective was to know communities level of knowledge and perception about TB in Denpasar, Bali. Method: This was cross-sectional research. Our sample was Denpasar communities who visited Puputan Renon Field Car Free Day (CFD) at 25 March 2018. Sample was chosen by consecutive sampling. Results: Our research result was almost (62%) of respondent had poor knowledge about TB and 67% respondent had right perception about TB. Conclusion: We can conclude that Denpasar communities had poor level of knowledge and good perception about TB.
Two-years Biannual Evaluation of Drug-resistant Tuberculosis Patients Completing Their Treatment at Persahabatan General Hospital Jakarta Murniati Murniati; Diah Handayani; Fathiyah Isbaniah
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.4

Abstract

Background: Drug-resistant tuberculosis (DR-TB) is a worldwide threat, including in Indonesia, which course of treatments are time consuming and are expensive. Recent findings suggest trends in recurrence of DR-TB, while no data is available to summarize the recurrence of DR-TB in Indonesia. Objective: This study aimed to evaluate DR-TB patients which was biannually performed for two-years (e.g. at the 6th, 12th, 18th, and 24th mos) after treatment completion. Methods: This cross-sectional study involved DR-TB patients completing their treatment at Persahabatan General Hospital Jakarta, Indonesia, between April and December 2017. The post-treatment evaluation during the 6th, 12th, 18th, and 24th mos included clinical, chest x-ray (CXR) and sputum culture examination. Results: Sixty patients were observed in this study, 31 (51.7%) were males and 29 (48.3%) were females. The mean age was 42.3+12.5 yo and the mean body mass index was 21.75+4.34. Fourty nine (81.7%) patients showed extensive lesions per CXR and none of the patient showed Mycobacterium tuberculosis growth per sputum culture. Conclusion: There was no recurrence of DR-TB from patients completing their treatment at Persahabatan General Hospital Jakarta, Indonesia during two-years post-treatment evaluation.
Accuration of Circulating Tumor DNA (ctDNA) in Detection of Epidermal Growth Factor Receptor (EGFR) Mutation in Lung Cancer Patient Type Adenocarcinoma in M Djamil Hospital Padang Yandra Darusman; Sabrina Ermayanti; Sari Nikmawati; Afriani Afriani
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.6

Abstract

Background: ctDNA is an alternative test for detecting mutation of EGFR in lung cancer type adenocarcinoma if the tissue speciment can not be carried out. Sensitivity, specificity and accuration of ctDNA test is stil varied. This study is aimed to acknowledge sensitivity, specificity and accuration of ctDNA in detecting EGFR mutation in patient with lung cancer type adenocarcinoma in M Djamil Hospital. Methods: Design this study a diagnostik test comparing ctDNA to tissue speciment in detection EGFR mutation of 42 patients with lung cancer type adenocarcinoma in M Djamil Hospital. Sample was selected through consecutive technique. Results: Incidence of EGFR mutation in patients with lung cancer type adenocarcinoma from tissue speciment was higher than ctDNA ((42,9% vs 28,6%; p=0,031). There was significant diffierence of EGFR mutation detection between sex, smoking status, and TNM staging based on tissue/cytology examination and ctDNA (p=0,031). EGFR mutation in sitologic test and ctDNA was more likely detected in male patient (66.7% and 58.3%), ex-smoker (50% and 41.7%) and stage IV (88.9% and 91.7%). The results of sensitivity, specificity positive prediction value (PPV) and Negative prediction value (NPV) in ctDNA test to detect EGFR mutation were 66,7%, 100%, 100% dan 80% according to sitology test as gold standard. Furthermore, the ctDNA accuration was measured according to AUC score 0.833 (SE 0,072, CI 95%, 0,693-0,974, p=0.0001). Conclusion: ctDNA test have a good accuration with sensitiviy 66.7% and specificity 100% in detecting EGFR mutation in patients with lung cancer type adenocarcinoma.
Lung Function and Respiratory Symptoms of Petrol Station Attendants in Central and North Jakarta and Its Contributing Factors Putri Suci Ramadhany; Faisal Yunus; Agus Dwi Susanto
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.7

Abstract

Background: To satisfy growing needs of petrol consumption in big city many new petrol stations has been built. Petrol station attendant is considered to have high risk exposure to dangerous pollutant from motor vehicle emission and petrol fumes, especially while filling up petrol tanks. Combination of those exhaust and petrol fumes is suspected to cause the reduction of lung function. Methods: This research is a cross sectional study in petrol station in Central Jakarta and North Jakarta region between August 2017 and February 2018. A total of 97 petrol station attendants were taken in this research using consecutive sampling technique. The subjects were interviewed with questionnaires, spirometry and chest radiograph. Measurements of sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), ozone (O3), particulate matter 2,5 (PM 2,5) and steam gasoline (benzene) concentrations were performed at the study sites. Results: In this study, 56.7% normal spirometry results, 42.3% abnormalities in the form of restriction, 1% obstruction and none of which experienced mixed disorders of restriction and obstruction. Most subjects (84.6%) did not experience respiratory complaints, 10.3% had a dry cough and 5.1% complained of cough with phlegm. There was a statistically significant association between peak expiratory flow and duration of work (p=0.011), but no significant association with other parameters such as forced vital capacity (FVC), %FVC, forced expiratory volume in the first second (FEV1), %FEV1 and the ratio of FEV1/FVC. Conclusion: Prevalence of lung function abnormalities of petrol station attendant is 43,3% and respiratory symptoms at 15,4% subject.
The Effect of Two-Mile Jogging Training on Lung Function Values in TNI Soldier Kodam I/Bukit Barisan Rifda Hayati; Nuryunita Nainggolan; Amira Permatasari Tarigan; Putri Chairani Eyanoer
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.8

Abstract

Background: Military soldiers are army personnel who are required to have good physical endurance and optimal fitness, include. So, it's needed physical exercise, include to be able to improve lung function. One parameter that can reflect physical fitness are lung function and m VO2max. This study aims to determine whether there is a relationship between physical exercise in the form of 2-mile jogging with increased lung function and VO2max of military soldiers Kodam 1 Bukit Barisan Methods: This research is an experimental study carried out in February-April 2019 against the TNI soldiers of the Bukit Barisan Military District 1. The research subjects were divided into two groups, group 1 who underwent regular 2-mile jogging exercises 3-5 times a week with a duration of 25 minutes for 2 months, and group 2 who underwent non-routine jogging exercises (less than 3 times a week). Lung function was assessed by spirometry. Results: As many as 68 military soldiers were involved in this study which were divided into two groups, 38 people in the group 1 who routinely trained and 30 people in group 2 that did not routinely practice. Group 1 VEP1 values were higher than group 2 (p=0.03). No significant differences in terms of KVP, MVV and VO2max in both groups. Lung function of smokers were lower than non-smokers, but not statistically significant. Conclusion: There were significant differences in VEP1 values between military soldiers who routinely and did not routinely undergo 2-mile jogging exercises.
Concordance Rate Between Examination of EGFR Mutation Blood Plasma Sample (ctDNA) With Citological/Histopathological Sample in Adenocarcinoma Lung Cancer Dian Utami Wulaningrum; Ana Rima Setijadi; Suradi Suradi
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.9

Abstract

Background: Most adenocarcinoma lung cancer which is found at an advanced stage with cytology / histopathological samples is hardly available. Examination of EGFR mutations in ctDNA blood plasma sampling is simpler and easier, which also can be used as predictive and prognostic markers in non-small cell carcinoma lung cancer patients. The purpose of this study is to determine and analyse the degree of compatibility between examination of EGFR mutations by blood plasma (ctDNA) samples with the examination of cytology / histopathological EGFR mutations in adenocarcinoma lung cancer. Methods: Diagnostic test research, by taking medical records of patients with adenocarcinoma lung cancer from January to September 2019 at Dr. Moewardi Surakarta, who was examined by EGFR mutations in cytology / histopathology and ctDNA samples. Result: The Subjects of this study were 73 patients with adenocarcinoma lung cancer. The level of compatibility of ctDNA with EGFR mutations in cytology / histopathology samples was categorized as moderate and statistically significant (Kappa = 0.459; p = 0.000). Conclusion: The level of concordance between the examination of EGFR mutations with blood plasma samples (ctDNA) with the examination of EGFR mutations in cytology / histopathology samples was moderate and statistically significant.
Proportion of Pneumoconiosis in Limestone Mining Workers In Citatah Village, West Bandung District Widhy Yudistira Nalapraya; Agus Dwi Susanto; Mukhtar Ikhsan; Muchtarrudin Mansyur; Caecilia Marliana
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.10

Abstract

Background: Silica, asbestos and coal dust are associated with pneumoconiosis in mining workers. The International Labor Organization (ILO) reports that 30-50% of workers in developing countries are diagnosed with pneumoconiosis. This study aims to identify pneumoconiosis in limestone mining workers in Indonesia. Method: This cross-sectional study involved 73 subjects of limestone mining workers in Citatah Village, West Bandung Regency, Indonesia. Two conclusions were similar from three AIR-Pneumo certified photo readers by blind reading and using the ILO guidelines. Result: Pneumoconiosis was found in 11/73 (15.1%). The median age of the pneumoconiosis group was older than the non-pneumoconiosis group (51 [33-63] vs. 37.5 [18-85] age in years, p = 0.013). All subjects in the pneukoniosis group worked> 6 years (p = 0.001). The highest dust concentration was in the pneumoconiosis group compared to the non-pneumoconisosis group (61.41 ± 103.98 vs. 14.92 ± 55.17 mg / m3, p = 0.030). This study showed that the length of work and the level of dust in the mine were risk factors for pneumoconiosis, although not significant (OR = 14.6, p = 0.999 and OR = 7,171, p = 0.998). Conclusion: The proportion of pneumoconiosis in lime mining workers in this study was 15.1%. Length of work and dust levels in the mine are risk factors for pneumoconiosis; but not meaningful in this study.
Analysis of Vitamin D Levels on Bronchiectasis Severity Yacob Arawamin Batkunde; Muhammad Ilyas; Irawaty Djaharuddin; Nur Ahmad Tabri; Harun Iskandar; Arif Santoso
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.11

Abstract

Background: Bronchiectasis is a chronic disease caused by repeated infection and inflammation of the bronchial walls. Vitamin D plays a role secretion of antimicrobial peptide and inhibits release of pro-inflammatory cytokines in the lungs. Vitamin D deficiency is associated with exacerbations, severity and decreased lung function in bronchiectasis. Several studies have found an association between vitamin D levels and bronchiectasis severity. Methods: This study used cross-sectional study design with consecutive sampling method on bronchiectasis patients who enrolled outpatient and inpatient at Wahidin Sudirohusodo hospital in February - May 2020. All research procedures obtained the approval of the Health Research Ethics Commission, Medicine faculty, Hasanuddin University Makassar. Bronchiectasis severity was assessed based on the FACED score (FEV1, Aged, chronic Colonization by Pseudomonas aeuroginosa, radiological Extension of the disease, Dyspnea). Levels of vitamin D serum {25 (OH) D} were checked using the ELISA method. Results: The study subjects were 44 patients, consisting of 61.4% male and 38.6% female. Most of the bronchiectasis patients in this study were mild (77.3%) based on the FACED score, 15.9% moderate and 6.8% severe. As many as 77.3% of patients had vitamin D deficiency and insufficiency as much as 9.1%. All patients with moderate-severe FACED scores had vitamin D deficiency. The correlation between vitamin D levels and FACED scores showed a positive significant with p-value 0.04. Conclusion: Low vitamin D levels are a risk factor for aggravating bronchiectasis severity and have a positive significant correlation between the two.
The Effect of Soluble CD14 Subtype (sCD14ST)/ Presepsin and Lactate Clearance on Mortality Status In Pneumonia Patients With Sepsis Zikanovelia Zikanovelia; Ngakan Putu Parsama Putra; Yani Jane Sugiri; Harun Al Rasyid
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.12

Abstract

Background: Severe pneumonia accompanied with sepsis could increase death ratio by 7.6%. Lactate clearance is used in assessing the success of early resuscitation in treating sepsis. Presepsin is a biomarker that is sensitive and specific to the bacterial infection that causes sepsis. The purpose of this study was to analyze the effect of presepsin levels and lactate clearance on mortality in pneumonic patients accompanied with sepsis after fourteen day of observation. Methods: Prospective cohort study was done on 42 patients who were admitted to intensive care unit of dr. Saiful Anwar Public Hospital, from March 2019 until May 2019. Blood samples were collected on the first, second, and third day of treatment to measure lactate clearance and presepsin levels. Mortality was observed on the 14th day after admittance. Results: Out of 42 patients, 25 patients lived (59.5%), and 17 patients died (40.5%). Logistic regression analysis performed on the presepsin levels on the third day with a cut-off 957 ng/L had a significant effect on mortality after 14th day (p=0.034). However, presepsin levels on the first day with a cut-off 957 ng/L had no significant effect on mortality (p=0.24). Likewise, the lactate clearance with cut-off 10% did not significantly influence the mortality status (p=0.136). Conclusion: There is a significant effect between presepsin level on the third day in patient mortality, however lactate clearance and presepsin level assessed on the first day had no significant effect on the mortality after fourteen day of observation.
New GOLD COPD Guideline 2019: How We Deal with It? (Inhaled Corticosteroid Use and Blood Eosinophil Count) Ari Julian Saputra; Kiki Widyastuti; Yusup Subagio Sutanto
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.13

Abstract

Background: Blood eosinophils may predict response to inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), where ICS is recommended in patients at high risk of exacerbations by the Global Initiative for COPD (GOLD) strategy. It can help clinicians to estimate the likelihood of beneficial preventive responses to the addition ICS to regular bronchodilator treatment, and thus can be used as a biomarker in conjunction with clinical assessment when making decisions regarding ICS use. This study aims to compare therapeutic data with blood eosinophil count in COPD patients. Methods: Data were collected from consecutive COPD outpatients in Bukit Asam Medika Hospital starting from March 1st, 2019 until June 30th, 2019 and dr. H. Mohamad Rabain Hospital starting from Oct 1st, 2019 until Dec 27th, 2019. We collected demographics, anthropometrics, smoking history, therapy, dynamic lung volumes, the Medical Research Council scale (MRC), CAT score, and blood eosinophil count. Results: From 57 data collected, 24 (42,1%) patients were having blood eosinophil count ≥300. Patients who have more exacerbation in COPD Group C were 33,3% and 63,2% in COPD Group D. The proportions of ICS-treated COPD Group D patients and blood eosinophil count of <300 and ≥300 was 63,9% and 36,1%, respectively. Conclusion: This study may provide information and characteristic of COPD patient in Indonesia rural area and showed who may have benefit to ICS therapy based on recommendation GOLD COPD 2019. Blood eosinophils counts is a low-cost biomarker and may help clinicians to made decision therapy.

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