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PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)

COMORBID
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Published by Transpublika Publisher

ISSN : - EISSN : 28099745 DOI : https://doi.org/10.55047/comorbid

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Neuroscience Nursing

About the Journal PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) is an international, modern, general medical publication that publishes research on all aspects of medicine, from fundamental research to significant clinical trials and cost-effectiveness analyses. We generally publish human research that contribute to our understanding of medical epidemiology, etiology, and physiology; the development of prognostic and diagnostic technologies; clinical trials that evaluate the efficacy of particular therapies and comparative trials; and systematic reviews. We want to encourage the conversion of fundamental research into clinical trials and clinical evidence into therapeutic practice. When studies in animal models produce remarkable research findings that are extremely clinically relevant, we publish them on occasion. The international medical community, as well as educators, policymakers, patient advocacy groups, and other interested parties, are among our target audiences. The online edition of COMORBID is updated on a regular basis. Medical Informatics, Basic Science, Clinical Science, Case Report, Brief Communication, Public Health, Public Policy, and Review Articles from all branches of medicine and associated subjects are published in PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 37 Documents

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RECURRENT PREGNANCY LOSS Muhamad Nofa Cholili; Arsana Wiyasa
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

Miscarriage occurs when the fetus is unable to survive outside the womb and the results of conception are expelled. Although the issue of RPL is still controversial, current information about the suggested treatment offers effective treatment to improve reproductive quality and can provide appropriate therapy in a woman with RPL based on the etiology. The time restriction until the fetus is pronounced viable or capable of surviving outside the womb varies by country. According to the World Health Organization, over 21.6 million abortions occurred worldwide in 2008, with almost all of these cases occur in developing countries. The risk of miscarriage increases most significantly at the age of 35 years. Women aged 35 years have twice the risk of miscarriage compared to women aged < 35 years. Antiphospholipid syndrome is a risk factor for recurrent miscarriage, which occurs in about 15% of patients. The reason of recurrent miscarriage can be linked to both fetal and maternal factors. Diagnostic examinations are not recommended in patients with recurrent miscarriage unless certain criteria are met. However, screening can be used to identify risk factors. The management of recurrent miscarriage should be addressed toward the underlying cause with a treatable etiology or pathophysiology.

CLEAN AND HEALTHY LIVING BEHAVIOR IN THE FAMILY ENVIRONMENT AS A PREVENTION OF COVID-19 IN SERANG CITY Stevany Afrizal; Inez Athallaisya Adinda
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

The rapid spread of the COVID-19 virus throughout the world has come as a complete shock, and it is causing serious concerns. The COVID-19 virus can be prevented with the help of a simple yet highly successful method called "clean and healthy living behavior" (PHBS). The health of family members is expected to improve as a result of the implementation of clean and healthy living behavior (PHBS) in the family environment, which includes adhering to health protocols, staying at home for those who do not have to leave the house, and allowing workers or employees to work from home (Work From Home/WFH). Family participation in PHBS is essential in order to prevent COVID-19 from spreading, as demonstrated by the emergence of COVID-19. The objective of this paper is to educate the community and families about PHBS, as well as to ensure that it is properly implemented. Descriptive qualitative interviews and scientific references are employed to perform the research. The researcher chose this title because he wants to break the chain of the COVID-19 virus's transmission in order to establish a family environment that is mindful of health and enhancing a healthy and clean family environment, so that people do not get sick as easily as before. A healthy family environment can increase productivity, so that family members will get used to implementing PHBS and children can grow up healthy and have adequate nutrition.

HEADACHE PROFILE AND ASSOCIATED SYMPTOMS IN INTRACRANIAL TUMORS Adhitya Riski Apriady; Yusuf Wibisono; Asep Nugraha Hermawan
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

Intracranial tumors are rare in headache sufferers, although headache is common in intracranial tumor patients. This limits the utility of headache symptoms to make a diagnosis, and it's crucial to know whether people with intracranial tumors have specific headache criteria. Other investigations do not support the classic criteria for headache in intracranial tumors, such as progressive, worse in the morning, and exacerbated by Valsalva maneuvers. Clinical studies found that headache as the sole symptom was rare, and only occurred in 2% of patients, hence this study also investigated the prevalence of nausea/vomiting, seizures, loss of consciousness, and motor deficits. This study uses resumes of medical records of patients diagnosed with intracranial tumors and hospitalized in the Department of Neurology, dr. Hasan Sadikin Central General Hospital West Java, Indonesia. While the sampling method in this study was total sampling, by taking all medical record resumes of patients with intracranial tumors from January to December 2018. Headache was a prevalent symptom of intracranial tumors in this study, occurring in 75,3 % of the subjects and was usually accompanied by other symptoms, especially motor deficits (64,5%), loss of consciousness (60,2%), nausea and vomiting (31) 2%), and seizures (23,7%). Patients were most likely to have bilateral headaches (62,5%), and 63,6% of patients who had unilateral headaches had a unilateral intracranial tumor on the same side of the headache. Patients who experienced progressive headaches were 93,5% of patients. While, the most common headache onset in patients with intracranial tumors before hospital admission were; 3-30 days (40,4%) and > 30 days - 6 months (38,5%).

CATECHOL-O-METHYLTRANSFERASE (COMT) ENZYME LEVELS IN PATIENTS WITH PREOPERATIVE ANXIETY Akhyar Hamongan Nasution; Aznan Lelo
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

The preoperative anxiety’s incidence is very high and mostly preoperative patients have anxiety. It was found that low COMT levels indicate a tendency to develop anxiety. Hence, this study aims to investigate COMT enzyme levels in patients with preoperative anxiety. This research is a purely experimental research with a pretest-posttest control group design and double-blind. Measurement of COMT enzyme levels was executed by utilizing ELISA technique. Blood samples were taken from preoperative anxiety patients who were assessed with the Amsterdam Preoperative Anxiety Information Scale (APAIS). The research was carried out at Haji Adam Malik General Hospital and Regional General Hospital dr. Pirngadi Medan, and Integrated Laboratory of the Faculty of Medicine, University of North Sumatra. The were 64 samples involved in this research that fit the inclusion and exclusion criteria. The findings show that COMT levels in the anxiety and control groups had differences with p values = 0.014. In addition, COMT levels in the preoperative anxiety group were lower when compared to those without the preoperative anxiety group, where in the anxiety group had COMT enzyme levels of 0,14 ± 0,08 ng/dl, while in the control group had higher COMT levels 0,96 ± 1,11 ng/dl. The results showed that patients with preoperative anxiety had lower levels of the COMT enzyme compared to patients without preoperative anxiety. Researchers suspect there is a role for the COMT enzyme in causing preoperative anxiety.

OPTIMIZATION OF JAMBLANG (Syzygium Cumini (L.) Skeels) FRUIT EXTRACT LEVELS IN YOGHURT FORMULATION AS ANTIOXIDANT Tri Yanuarto; Nurkhasanah; Laela Hayu Nurani
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

The reactivity of oxidant compounds that exceed the limits of antioxidant protection ability can cause chain reactions which cause interference with the system. Prevention is needed to neutralize the oxidants, so that exogenous antioxidants are needed. One example is the jamblang fruit (Syzygium cumini (L)) which has high antioxidant activity due to its natural anthocyanin. The purpose of this study was to determine the optimal form of yogurt with the addition of jamblang fruit extract with a concentration of 0%, 5%, 7.5% and 10% and the quality of SNI. Tests carried out include physical, chemical and microbiological tests, namely sensory, acid content, total protein, fat content, and a number of bacterial starters, as well as safety tests with storage at 4° C then 0, to 7, 14th, 21st and 28th day. Data analysis using MANOVA. The results of the effect of the product showed that the fruit of yogurt with 10% extract level provided good stability during storage. Decreased antioxidant levels on day 7 to day 28. Antioxidant activity is more stable than antioxidant jamblang fruit extract. The antioxidant activity of yogurt with 5% jamblang fruit extract; 7.5% and 10% on day 0% % inhibition value of 57.48%; 62.06%; and 73.01%.

THE COMPARISON OF THE EFFICACY OF CEFTRIAXONE AND COMBINATION OF AMPICILLIN-CHLORAMPHENICOL OF CHILDREN WITH PNEUMONIA OF PKU MUHAMMADIYAH HOSPITAL IN BANTUL Nur Astuti Wulandari; Endang Darmawan; Nurcholid Umam Kurniawan
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

Pneumonia is an infectious disease that occurs in the lungs caused by various microorganisms. Patients of children with pneumonia in Indonesia experienced an increase in 2013. Antibiotics therapy is the main therapy for patients with pneumonia. This study aims to compare of the efficacy of ceftriaxone and combination of ampicillin-chloramphenicol of children with pneumonia of PKU Muhammadiyah hospital in Bantul. The study design was a randomized controlled trial with prospective Open trial do in March 2018 to June 2018. The outcomes used were tightness, cough, retraction, temperature, respiration rate, and length of stay. Research data were analyzed using Chi Square test, Fisher test, independent t test and Mann Whitney test. The results of the study of ceftriaxone (n=26) and ampicillin chloramphenicol groups (n=26) showed that the percentage of patients who had not experienced tightness was 82.7%, not cough 7.7%, and there was no retraction of 76.9% with p<0.05. The mean ±SD temperature of the ceftriaxone group was 36.5±0.12 and the ampicillin chloramphenicol group was 36.57±0.09 with a p<0.05. The mea n±SD respiration rate of the ceftriaxone group was 27.9±3.22 and the ampicillin chloramphenicol group was 27.92±2.62 with a p <0.05. The mean ±SD length of stay in the ceftriaxone group was 4.5±0.81 and the ampicillin chloramphenicol group was 4.26±0.66 with a p<0.05. Conclusions showed that there was no significant difference between the effectiveness of ceftriaxone and ampicillin chloramphenicol on fever, spasms, cough, retraction, temperature, respiration rate and length of stay.

EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL Amalia Agamasi; Endang Darmawan; Akrom
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT

RATIONALITY OF ANTIBIOTICS USE WITH QUANTITATIVE AND QUALITATIVE METHODS AT HOSPITAL IN INDONESIA Fadhila Diah Suminar
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

Infection is one of the biggest causes of death in Indonesia which can be influenced by the appropriate use of antibiotics. Irrational use of antibiotics can cause bacteria to become resistant to antibiotics so that the effectiveness of the drug decreases or even disappears. This study aims to evaluate the use of antibiotics given to inpatients at a private hospital in Indonesia both quantitatively and qualitatively in the period July to December 2021. This study is an observational study with retrospective data collection where qualitative analysis using the Gyssens Method and quantitative analysis uses the DDD method. The results of the qualitative analysis showed that from 30 cases observed, there were 9 cases (30%) irrational prescriptions, namely 1 case in category V, 4 cases in category IVA, 2 cases in category IIIB and 2 cases in category IIA. The results of the quantitative analysis showed that the antibiotics with the highest DDD/100 patient days in the period July to December 2021 were Ceftriaxone with a successive value of 39.15; 39.81; 36.22; 55.65; 41,48 and 49, 42 while antibiotics with the lowest DDD/100 patient-days values in the period July to December obtained different results. Based on research results, there are irrational antibiotic prescriptions and Ceftriaxone became the most commonly prescribed antibiotic.

THE INCREASED RISK OF RANDOM BLOOD GLUCOSE, BODY MASS INDEX AND ABDOMINAL CIRCUMFERENCE IN THE SCHIZOPHRENIC PATIENTS USING CLOZAPINE AND QUETIAPINE Lailatul Hidayah; Endang Darmawan; Santi Yuliani
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 1 (2022): JANUARY 2022
Publisher : Transpublika Publisher

The use of atypical antipsychotics often causes an increase in blood glucose levels, body mass index (BMI) and abdominal circumference. This study aims to identify the increased risk of random blood glucose, BMI and abdominal circumference in the schizophrenic patients using clozapine and quetiapine. This cohort study involved 35 schizophrenic patients (19 patients used clozapine and 16 patients used quetiapine). The measurement of random blood glucose BMI and abdominal circumference was done in the zero month, the first month and the second month. The average of random blood glucose, BMI and abdominal circumference were analyzed using Wilcoxon and Chi-square. In the use of clozapine, there is a significant increase in the average of random blood glucose between the first month and the second month (p=0.1) with the difference of 6.37 mg/dl, there is an increase average in BMI between the first month and the second month (p=0.03) with the difference of 0.18 kg/m² and an average increase in abdominal circumference between the zero month and the first month (p=0.04) with the difference of 1.47 cm, between the first month and the second month (p=0.02) with the difference of 1.94 cm. In the use of quetiapine, a significant increase in abdominal circumference between the first month and the second month (p=0.02) with the difference 1.38 cm. The use of clozapine has more risk in increasing random blood glucose (OR 2.00: CI 95% 0.41-9.76), BMI (OR 2.78: CI 95% 0.69-11.10) and abdominal circumference (OR 3.61: CI 95% 0.89-14.64) compared to the use of quetiapine. The use of clozapine has more risk in increasing blood glucose, BMI and abdominal circumference compared to the use of quetiapine.

THE EFFECT OF ATTITUDE, LEVEL OF EDUCATION AND SUPPORT OF HEALTH PERSONNEL ON THE ABILITY OF REGULATING DIET PATTERNS IN DIABETES MELLITUS PATIENTS USING A SELF-CARE THEORY APPROACH Dian Anggraeni; Riza Fikriana; Wiwit Dwi Nurbadriyah
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Vol. 1 No. 2 (2022): APRIL 2022
Publisher : Transpublika Publisher

Diabetes mellitus is a chronic disease of metabolic disorders and hyperglycemia caused by impaired insulin secretion which is characterized by an increase in blood glucose levels exceeding normal limits (70-140 mg/dL). Diabetes mellitus can be caused by several factors, one of which is a poor diet. The purpose of this study was to analyze the effect of attitudes, education level and support of health workers on the ability to manage dietary patterns in diabetes mellitus sufferers using the Self-Care theory approach in Banjarejo Village, Pakis District. The research design used Analytical Observational with Cross-Sectional method. The sample used is 80 respondents using Non Probability Sampling with purposive sampling technique. The variables used are attitude, level of education, support of health workers and ability to manage diet patterns. The process of collecting data using a questionnaire in accordance with the inclusion and exclusion criteria, then data processing is carried out and followed by a statistical test of logistic regression using the help of a computer program. The results of the Logistic Regression Test showed that the variable that had the most influence on the ability to manage dietary patterns was the support of health workers variable with a significance value (p-value) of 0,044 < 0,05. As a result, it can be seen that health worker support is one of the factors that can affect a person's ability to manage diet patterns, and thus that there is a need for positive health worker support for diabetes mellitus patients in order to increase their ability to manage diet patterns and avoid uncontrolled increases in blood sugar levels or complications.

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Home Page

OAI Link

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Contact Name Veri Hardinansyah Dja'far

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Editorial Address Jl. Kolonel Sugiono IIIC/438 RT 10/RW 04 Mergosono, , Malang, Provinsi Jawa Timur, 65134

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Abstract

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Abstract

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Abstract

Contact Name
Veri Hardinansyah Dja'far

Contact Email
admin@transpublika.co.id

Phone
+6281234560500

Journal Mail Official
admin@transpublika.co.id

Editorial Address
Jl. Kolonel Sugiono IIIC/438 RT 10/RW 04 Mergosono, , Malang, Provinsi Jawa Timur, 65134

Location
Kota malang,

Jawa timur

INDONESIA