Pediatric Sciences Journal
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
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<![CDATA[The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients ]]>
<![CDATA[Ery Olivianto]]>;
<![CDATA[Ade Habibi]]>;
<![CDATA[Muchammad Fahrul Udin]]>;
<![CDATA[HMS Chandra Kusuma]]>
<![CDATA[ Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020) ]]>
Publisher : <![CDATA[Medical Faculty of Brawijaya University, Indonesia ]]>
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DOI: 10.51559/pedscij.v1i1.1
<![CDATA[Background: Asthma is a heterogenouse disease with chronic inflammation which is characterized by hyperreactivity and obstruction of respiratory tract. Many hypothesis of asthma were related with nutrition, such as vitamin D status. Vitamin D is a precursor of steroid hormone that has immunomodulator effect but the relationship of asthma and vitamin D still controversial. This study aims to find the relationship of vitamin D (25-(OH)D) with level of IgE, Eosinophils, and asthma control test (ACT) in mild to moderate pediatric asthmatic patient. Method: An observational analytic study with cross-sectional approach has been conducted among 40 pediatric asthmatic patients by consecutive sampling technique. Data regarding gender, age, vitamin D status, the levels of 25-(OH)D, IgE, Eosinophil, and ACT score were assessed in this study. Correlation analysis test was used as statistical analysis using SPSS version 20 for Windows.Result: Most of respondents were male (70.0%), 5-7 years of age range (52.5%), and insufficient of vitamin D (20-30 ng/ml) (45.0%). The recent study suggests a significant negative relationship between serum 25 (OH) D levels with total immunolobulin E levels (p=0.002; r=-0.476) and eosinophils (p = 0.002; r=-0.479). However, the 25-(OH)D level did not show a significant relationship with the ACT score (p = 0.195; r=0.209).Conclusion: Negative relationship was found between total serum 25(OH)D, total immunoglobulin E, and eosinophils in children with asthma. Moreover, 25(OH)D was not related to ACT score in children with asthma.]]>
<![CDATA[The levels of Human Beta Defensin-2 (HBD-2) in premature neonates’ feces at Saiful Anwar Hospital, Malang, Indonesia ]]>
<![CDATA[Eko Sulistijono]]>;
<![CDATA[Putri Primawardani]]>;
<![CDATA[Krisni Subandiyah]]>;
<![CDATA[Anik Puryatni]]>
<![CDATA[ Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020) ]]>
Publisher : <![CDATA[Medical Faculty of Brawijaya University, Indonesia ]]>
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DOI: 10.51559/pedscij.v1i1.2
<![CDATA[Background: Clinical evidence shows that the etiology of neonatal sepsis is translocation of the digestive tract of premature neonates. Human ß-defensor 2 has a protective effect during inflammation and apoptosis. This study aimed to determine the levels of fecal human ß-defensus-2 (HBD-2) as an inflammatory biomarker in premature neonates related to nutrition consumption. Methods: A cohort study design used in thirty-nine premature neonates according to inclusion criteria were collected in January to March 2019 in the neonatology room of RSUD Dr. Saiful Anwar Malang. The levels of premature neonatal feces HBD-2 were taken from all three sample groups on the seventh and fourteenth days and measured by the ELISA method. Data were analyzed using SPSS version 20 for Windows. Results: The mean levels of HBD-2 premature neonatal feces consuming formula milk alone were higher than other groups (349.16 + 67.66 vs 330.24 + 44.08 vs 215.65 + 51.34). There is a relationship between levels of HBD-2 premature neonatal feces with only breastfeeding (p=0,005; r=0.731), breast milk (p=0,005; r=0,727) and, formula milk only (p=0,003; r=0,761). Conclusion: The levels of HBD-2 in premature neonatal stools who consuming formula milk alone were significantly higher than levels of human HBD-2 premature neonatal stools that consumed only breast milk.]]>
<![CDATA[The low level of vitamin D3 among Type 1 Diabetes Mellitus (T1DM) children at Saiful Anwar General Hospital, Malang, Indonesia ]]>
<![CDATA[Harjoedi Adji Tjahjono]]>;
<![CDATA[Wisnu Barlianto]]>;
<![CDATA[Dian Handayani]]>;
<![CDATA[Handono Kalim]]>
<![CDATA[ Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020) ]]>
Publisher : <![CDATA[Medical Faculty of Brawijaya University, Indonesia ]]>
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DOI: 10.51559/pedscij.v1i1.3
<![CDATA[Background: The Type 1 Diabetes Melitus (T1DM) is a disease which is occurred because of autoimmune destruction in pancreas islet (insulin-producing ß cells). A Failure mechanism of immunoregulator causes inflammatory process in the islets and continue to damage the pancreatic β cell. Vitamin D deficiency may increase the risk of autoimmune diseases including type 1 diabetes mellitus. The aim of this study was to know the level of vitamin D in type 1 diabetes mellitus. Methods: An observational analytic cross-sectional design was conducted among 40 T1DM subjects and 40 healthy controls aged between 10-18-year-old. They were not having local or systemic infection, nor liver and kidney disorders. Vitamin D levels were measured by the ELISA method (ng/ ml). Subjects’ data were collected and processed by 2007 Microsoft Excel software, then analyzed with SPSS version 16.0 for Windows. Results: Most of respondents in T1DM group were female (57.5%) and 15.94±1.00 years old for average age but not statistically significant compared with control group (p>0.05). There was a significant different of the mean level of vitamin D3 in the T1DM group (10.41 + 2,20 ng/ml) compared with control group (18.41 + 1.41 ng/ml) (p<0,05). Conclusion: The level of vitamin D (25 (OH) D3) in the T1 DM group were significantly lower compared to the control group]]>
<![CDATA[The effect of vitamin 25-(OH)-D3 on Glucocorticoid Receptor-β (GRβ) and 25-(OH)-D receptors in idiopathic nephrotic syndrome patients ]]>
<![CDATA[Krisni Subandiyah]]>;
<![CDATA[Harinda Khanifa Khusna]]>
<![CDATA[ Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020) ]]>
Publisher : <![CDATA[Medical Faculty of Brawijaya University, Indonesia ]]>
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DOI: 10.51559/pedscij.v1i1.4
<![CDATA[Backgound: Idiopathic Nephrotic Syndrome (INS) is the most chronic glomerular disease in children. Glucocorticoid is the main therapy acts by binding to glucocorticoid receptor α (GRα), whereas it is reported that glucocorticoid receptor β (GRβ) is a main inhibitor of GRα. The interaction between glucocorticoid receptors and vitamin D can increase anti-inflammation at glucocorticoid receptors, thereby decreasing GRβ levels. This study was aimed to investigate the effect ssupplementation of vitamin D3 on GRβ and 25-(OH)-D level in children with INS and the correlation between both of parameters. Method: A randomized clinical trial, double blind, pre and post-test control group was conducted among 30 subjects with newly diagnosed as INS. Subjects were divided into 2 groups, group 1 (G1) were treated with prednisone and vitamin D3 whereas group 2 (G2) were only treated with prednisone. The level of GRβ and 25-(OH)-D level was measured by ELISA method. Data were analyzed using SPSS version 17 for Windows. Result: There was significant elevation of 25-(OH)-D plasma between G1 (31.46 ± 9.69 ng/mL) and G2 (13.43±17.25 ng/mL) (p<0.001), and significant decrease of GRβ levels between G1 (-13.71 ± 8.06 ng/mL) and G2 (-0.917 ± 3.76 ng/mL) (p<0.000). Pearson testing first group showed that vitamin D level was positively correlated with GRβ levels (r=0.458; p= 0.01). Conclusion: The effect supplementation of vitamin D3 can increase 25-(OH)-D level and decrease of GRβ levels significantly in children with idiopathic nephrotic syndrome who receive glucocorticoid therapy.]]>
<![CDATA[The effect of centella asiatica extract in Zebrafish (Danio rerio) larvae as a Chronic Constant Hypoxia (CCH) model ]]>
<![CDATA[Ariani]]>;
<![CDATA[Teni Widiyastuti]]>
<![CDATA[ Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020) ]]>
Publisher : <![CDATA[Medical Faculty of Brawijaya University, Indonesia ]]>
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DOI: 10.51559/pedscij.v1i1.5
<![CDATA[Backgound: Chronic Constan Hypoxia (CCH) are able to occur in cyanotic congenital heart disease and bronchopulmonary dysplasia (BPD). Centella asiatica has antioxidant and neuroprotective effects in experimental animals.This study aims to observe the effect of Centella asiatica ethanol extract on Zebrafish in chronic hypoxic conditions Method: A laboratory experimental study with a randomized post-test controlled group design was conducted among 20 Zebrafish (Danio rerio) 3-8 day post fertilization (dpf) as samples per tube. The total group treatment was five with inclusion and exclusion criterias. Variables assessed in this study included Average body length, locomotor activity, and the relationship between average body length and locomotor activity. Data were analyzed using SPSS version 18 for Windows. Result: There was a moderate significant correlation between Centella asiatica concentration of 1.25 µg/ml, 2.5 µg/ml, 5 µg/ml with an enhancement of body length (r=0.431) and locomotor activity (r=0.262) in zebrafish larvae CCH model (p<0.05). Conclusion: It can be concluded that chronic constan hypoxia (CCH) inhibit the growth of body length and decrease locomotor activity in Zebrafish larvae. Centella asiatica treatment can avoid the CCH by using various concentration.]]>
