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Krisni Subandyah
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Departemen Ilmu Kesehatan Anak FKUB (Department of Pediatrics, Faculty of Medicine, Universitas Brawijaya). Jl. Jaksa Agung Suprapto No. 2 Malang, Provinsi Jawa Timur, Indonesia
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Pediatric Sciences Journal
Published by Universitas Brawijaya
ISSN : 27220427     EISSN : 27221474     DOI : https://doi.org/10.51559/pedscij
Core Subject : Health,
Health Professions Public Health
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 40 Documents
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The correlation of 25-Hydroxyvitamin D (25-(OH)D) to IgE level, eosinophil, and Asthma Control Test (ACT) score in asthma patients Ery Olivianto; Ade Habibi; Muchammad Fahrul Udin; HMS Chandra Kusuma
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.817 KB) | DOI: 10.51559/pedscij.v1i1.1

Abstract

Background: Asthma is a heterogenouse disease with chronic inflammation which is characterized by hyperreactivity and obstruction of respiratory tract. Many hypothesis of asthma were related with nutrition, such as vitamin D status. Vitamin D is a precursor of steroid hormone that has immunomodulator effect but the relationship of asthma and vitamin D still controversial. This study aims to find the relationship of vitamin D (25-(OH)D) with level of IgE, Eosinophils, and asthma control test (ACT) in mild to moderate pediatric asthmatic patient. Method: An observational analytic study with cross-sectional approach has been conducted among 40 pediatric asthmatic patients by consecutive sampling technique. Data regarding gender, age, vitamin D status, the levels of 25-(OH)D, IgE, Eosinophil, and ACT score were assessed in this study. Correlation analysis test was used as statistical analysis using SPSS version 20 for Windows.Result: Most of respondents were male (70.0%), 5-7 years of age range (52.5%), and insufficient of vitamin D (20-30 ng/ml) (45.0%). The recent study suggests a significant negative relationship between serum 25 (OH) D levels with total immunolobulin E levels (p=0.002; r=-0.476) and eosinophils (p = 0.002; r=-0.479). However, the 25-(OH)D level did not show a significant relationship with the ACT score (p = 0.195; r=0.209).Conclusion: Negative relationship was found between total serum 25(OH)D, total immunoglobulin E, and eosinophils in children with asthma. Moreover, 25(OH)D was not related to ACT score in children with asthma.
The levels of Human Beta Defensin-2 (HBD-2) in premature neonates’ feces at Saiful Anwar Hospital, Malang, Indonesia Eko Sulistijono; Putri Primawardani; Krisni Subandiyah; Anik Puryatni
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.505 KB) | DOI: 10.51559/pedscij.v1i1.2

Abstract

Background: Clinical evidence shows that the etiology of neonatal sepsis is translocation of the digestive tract of premature neonates. Human ß-defensor 2 has a protective effect during inflammation and apoptosis. This study aimed to determine the levels of fecal human ß-defensus-2 (HBD-2) as an inflammatory biomarker in premature neonates related to nutrition consumption. Methods: A cohort study design used in thirty-nine premature neonates according to inclusion criteria were collected in January to March 2019 in the neonatology room of RSUD Dr. Saiful Anwar Malang. The levels of premature neonatal feces HBD-2 were taken from all three sample groups on the seventh and fourteenth days and measured by the ELISA method. Data were analyzed using SPSS version 20 for Windows. Results: The mean levels of HBD-2 premature neonatal feces consuming formula milk alone were higher than other groups (349.16 + 67.66 vs 330.24 + 44.08 vs 215.65 + 51.34). There is a relationship between levels of HBD-2 premature neonatal feces with only breastfeeding (p=0,005; r=0.731), breast milk (p=0,005; r=0,727) and, formula milk only (p=0,003; r=0,761). Conclusion: The levels of HBD-2 in premature neonatal stools who consuming formula milk alone were significantly higher than levels of human HBD-2 premature neonatal stools that consumed only breast milk.
The low level of vitamin D3 among Type 1 Diabetes Mellitus (T1DM) children at Saiful Anwar General Hospital, Malang, Indonesia Harjoedi Adji Tjahjono; Wisnu Barlianto; Dian Handayani; Handono Kalim
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.478 KB) | DOI: 10.51559/pedscij.v1i1.3

Abstract

Background: The Type 1 Diabetes Melitus (T1DM) is a disease which is occurred because of autoimmune destruction in pancreas islet (insulin-producing ß cells). A Failure mechanism of immunoregulator causes inflammatory process in the islets and continue to damage the pancreatic β cell. Vitamin D deficiency may increase the risk of autoimmune diseases including type 1 diabetes mellitus. The aim of this study was to know the level of vitamin D in type 1 diabetes mellitus. Methods: An observational analytic cross-sectional design was conducted among 40 T1DM subjects and 40 healthy controls aged between 10-18-year-old. They were not having local or systemic infection, nor liver and kidney disorders. Vitamin D levels were measured by the ELISA method (ng/ ml). Subjects’ data were collected and processed by 2007 Microsoft Excel software, then analyzed with SPSS version 16.0 for Windows. Results: Most of respondents in T1DM group were female (57.5%) and 15.94±1.00 years old for average age but not statistically significant compared with control group (p>0.05). There was a significant different of the mean level of vitamin D3 in the T1DM group (10.41 + 2,20 ng/ml) compared with control group (18.41 + 1.41 ng/ml) (p<0,05). Conclusion: The level of vitamin D (25 (OH) D3) in the T1 DM group were significantly lower compared to the control group
The effect of vitamin 25-(OH)-D3 on Glucocorticoid Receptor-β (GRβ) and 25-(OH)-D receptors in idiopathic nephrotic syndrome patients Krisni Subandiyah; Harinda Khanifa Khusna
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.994 KB) | DOI: 10.51559/pedscij.v1i1.4

Abstract

Backgound: Idiopathic Nephrotic Syndrome (INS) is the most chronic glomerular disease in children. Glucocorticoid is the main therapy acts by binding to glucocorticoid receptor α (GRα), whereas it is reported that glucocorticoid receptor β (GRβ) is a main inhibitor of GRα. The interaction between glucocorticoid receptors and vitamin D can increase anti-inflammation at glucocorticoid receptors, thereby decreasing GRβ levels. This study was aimed to investigate the effect ssupplementation of vitamin D3 on GRβ and 25-(OH)-D level in children with INS and the correlation between both of parameters. Method: A randomized clinical trial, double blind, pre and post-test control group was conducted among 30 subjects with newly diagnosed as INS. Subjects were divided into 2 groups, group 1 (G1) were treated with prednisone and vitamin D3 whereas group 2 (G2) were only treated with prednisone. The level of GRβ and 25-(OH)-D level was measured by ELISA method. Data were analyzed using SPSS version 17 for Windows. Result: There was significant elevation of 25-(OH)-D plasma between G1 (31.46 ± 9.69 ng/mL) and G2 (13.43±17.25 ng/mL) (p<0.001), and significant decrease of GRβ levels between G1 (-13.71 ± 8.06 ng/mL) and G2 (-0.917 ± 3.76 ng/mL) (p<0.000). Pearson testing first group showed that vitamin D level was positively correlated with GRβ levels (r=0.458; p= 0.01). Conclusion: The effect supplementation of vitamin D3 can increase 25-(OH)-D level and decrease of GRβ levels significantly in children with idiopathic nephrotic syndrome who receive glucocorticoid therapy.
The effect of centella asiatica extract in Zebrafish (Danio rerio) larvae as a Chronic Constant Hypoxia (CCH) model Ariani; Teni Widiyastuti
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.256 KB) | DOI: 10.51559/pedscij.v1i1.5

Abstract

Backgound: Chronic Constan Hypoxia (CCH) are able to occur in cyanotic congenital heart disease and bronchopulmonary dysplasia (BPD). Centella asiatica has antioxidant and neuroprotective effects in experimental animals.This study aims to observe the effect of Centella asiatica ethanol extract on Zebrafish in chronic hypoxic conditions Method: A laboratory experimental study with a randomized post-test controlled group design was conducted among 20 Zebrafish (Danio rerio) 3-8 day post fertilization (dpf) as samples per tube. The total group treatment was five with inclusion and exclusion criterias. Variables assessed in this study included Average body length, locomotor activity, and the relationship between average body length and locomotor activity. Data were analyzed using SPSS version 18 for Windows. Result: There was a moderate significant correlation between Centella asiatica concentration of 1.25 µg/ml, 2.5 µg/ml, 5 µg/ml with an enhancement of body length (r=0.431) and locomotor activity (r=0.262) in zebrafish larvae CCH model (p<0.05). Conclusion: It can be concluded that chronic constan hypoxia (CCH) inhibit the growth of body length and decrease locomotor activity in Zebrafish larvae. Centella asiatica treatment can avoid the CCH by using various concentration.
Clinical features and neonatal outcomes of neonatus with mother suspected COVID-19 in Malang, Indonesia: a serial-cases, single-centre Brigitta Ida Resita Vebrianti Corebima; Eko Sulistijono; Setya Mithra Hartiastuti; Atiek Wulandari; Vanisia Hayu Firdayanti; Nisak Humairoh; Setya Trista Kusumawahyuni
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Supplementary)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (703.521 KB) | DOI: 10.51559/pedscij.v1i1.6

Abstract

Background: The COVID-19 pandemic has affected every facet of life, beginning with the first hours and days after birth, some have argued that the prudent course is to isolate infants from mothers with suspected or confirmed COVID-19. This serial-cases showed the neonate’s outcome with mother suspected COVID-19. Cases: Four neonates were born from mother with suspected or confirmed with COVID-19. The neonates were born with 7-9 APGAR score and within normal limit. All of the patients were discharged from the hospital after two days of isolation in the hospital with negative Nucleic Acid Test of SARS-CoV-2 results. Conclusion: The clinical characteristics of neonates and neonatal outcome appear very good, and these outcomes are achieved with intensive, active management, which might be the best practice in resuscitation, stabilization, bathing the baby before going to the isolation ward, and management the patient in the isolation ward
The rationalization of personal protective equipment usage and the solution of its limitation during COVID-19 era Irene Ratridewi; Saptadi Yuliarto
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Supplementary)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.124 KB) | DOI: 10.51559/pedscij.v1i1.8

Abstract

Covid-19 pandemic is a global burden health problem caused by Coronavirus. The disease can be transmitted swiftly by droplets after sneezing, coughing, or holding stuff (droplet contaminated). The contagion is eased by bad habit like does not wash hand after touching others or stuff. To date, data says that The Covid-19 morbidity rate is still highest in a densely populated place. Even though several mechanisms in the community have been done to prevent the spreading of this disease, but the spread is still relatively high and needs medical treatment intervention in the health care system especially in the hospital.1 Moreover, the daily hospital treatment of Covid-19 patients’ needs appropriate personal protective equipment (PPE) to protect and to minimalize the risk of infection to health workers.
The Strategy to Encounter Limited Capacity of Critical Care for COVID-19 Children Saptadi Yuliarto
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Supplementary)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.399 KB) | DOI: 10.51559/pedscij.v1i1.9

Abstract

Coronavirus disease (COVID) – 19 morbidity rates in Indonesia have exponentially increased since its first case in March 2020. To date, 15,438 (0.004%) Indonesian population have been confirmed with Covid-19. Although it is only 0.004% from all of Indonesian, the patient's enhancement is high, also, the patients who recover just only 21.3%, It would endanger the healthcare capacity in Indonesia.1 Recent data from the Indonesian Health Ministry revealed 1,065 (6.9%) confirmed COVID-19 are at young ages. Considering confirmed to suspected/ probable case ratio was 1:2.1, it is estimated that 2,236 children in Indonesia require treatment with COVID-19 protocols. According to the China data’s, the prevalence of moderate to critical illness in children was 44.5%.2 If applied in Indonesia, to date, about 995 children need intensive care treatment, which it will rise around 10-40 patients in each day
The difficulty of establishing the diagnosis of pediatric COVID-19 in Indonesia Kurniawan Taufiq Kadafi
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Supplementary)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.413 KB) | DOI: 10.51559/pedscij.v1i1.10

Abstract

The Covid-19 pandemic has not shown any signs of ending soon. Until May 1, 2020, the latest data recorded that Covid-19 cases in the world have reached 3,336,680 cases, with 235,245 people died and 1,054,786 people recovered. Of  the number of still-active cases, 98% are mild cases, while the remaining 2% are severe. Since it was first identified (December 2019) until it was announced as a pandemic on March 11, 2020), cases of children have not escaped the effects of infection.
Cytogenetic and clinical features of down syndrome in malang, east java, indonesia Ariani
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.888 KB) | DOI: 10.51559/pedscij.v1i2.12

Abstract

Introduction: Down syndrome (DS) is the most common chromosomal disorder. DS characterized by multiple congenital anomaly caused by trisomy 21This study was designed to evaluate the karyotype pattern, clinical features and risk factors of patients with Down syndrome. Method: Data were obtained from a retrospective analysis of a questionnaire from Down syndrome patients. Result: A total of 34 patients were studied, with 67,6% of males. Out of 34 patients, there were 25 children (73,5%) with no cytogenetic test, 4 children (11,7%) with lost cytogenetic test, 3 children (8,82%) with free trisomy (non-disjunction), 1 (2,9%) with translocation, and 1 (2,9%) with mosaics. Maternal age categories showed one mother less than 20 years, two mothers between 21-25 years, four mothers were between 25 and 30 years, 12 mothers were between 31 and 35 years, ten mothers were between 31 and 40 years, and five mothers were over 41 years of age. The most common clinical features in this study are Congenital Heart Disease (CHD), which was recognized in 9 (26,4%) patients with five patients had Atrial Septal Defect (ASD), two patients had ASD and Ventricular Septal Defect (VSD), two patients had Patent Ductus Arteriosus (PDA). All of them followed by dental problems in 8 (23,5%) patients, ophthalmology problems in 6 (17,6%) patients, digestive problems in 4 (11,7%) patients, seizure in 1 (2,9%) patient, hormonal problems in 1 (2,9%) patient, and hearing problem in 1 (2,9%) patient. There is no significant difference in CHD prevalence between each maternal age group (p = 0776, p>0.05). Conclusion: Down syndrome has a higher prevalence in males and is frequently seen among mothers between 31 -35 years of age, yet maternal age did not seem to influence CHD prevalence significantly. Early diagnosis and proper screening should be undertaken among these patients.

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