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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 14 Documents
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Search results for , issue "JKKI, Vol 12, No 3, (2021)" : 14 Documents clear
Agreement test between Ziehl Neelsen staining and GenXpert in adult pulmonary tuberculosis diagnosis Kemas Ya'kub Rahadiyanto; Muhammad Syahrul Ramadhan; Ella Amalia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art4

Abstract

Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). Most of healthcare facilities in Indonesia still use Ziehl Neelsen (ZN) staining to diagnose pulmonary tuberculosis (TB) rather than GeneXpert MTB/RIF. However, the agreement between both methods is not well established.Objective: This study aims to observe levels of agreement between ZN staining and GeneXpert MTB/RIF in diagnosing adult pulmonary TB at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang.Methods: This study was a retrospective comparative analytical study using an agreement test. Its samples were patient specimens for a period of January 2016 - March 2017 which were examined by ZN staining and GeneXpert MTB/RIF to diagnose pulmonary TB at the Clinical Pathology and Microbiology Installation of RSMH Palembang. Its data were obtained from laboratory results of ZN staining and GeneXpert MTB/RIF. Then, Cohen’s Kappa was used to measure the levels of agreement between both the assays.Results: Of 150 specimens, 69.3% were from male patients and 30.7% were from female patients with mean age of 46.71±14.57. Both ZN staining and GeneXpert positivity were 57.3%. 0.05% of positive GeneXpert MTB/RIF were negative ZN smear, while 0.06% of negative GeneXpert were positive ZN smear. The Cohen’s Kappa coefficient was 0.893 indicating a very good agreement.Conclusion: This study found that there was a very good agreement between ZN staining and GeneXpert MTB/RIF in diagnosing adult pulmonary TB at the RSMH Palembang. 
Supplementation and fortification program in eradicating micronutrient deficiencies in Indonesia Lestari Octavia; Johan Harlan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art11

Abstract

Micronutrients play a significant role in metabolism reaction although this only needs a few micronutrients such as iron (Fe) and folic acid as folate substitutes. Fortification and supplementation program aims to meet the requirement of micronutrients by providing synthetic formula. The Indonesian government has applied iron-folic acid fortification (IFA) in flour. Moreover, the IFA supplementation program was given to vulnerable groups, pregnant mothers and women at reproductive age, including adolescent girls. The program has been applied for almost five decades, but the micronutrients deficiencies remain high. This study aims to review effects of the supplementation and fortification to vulnerable groups in Indonesia. This is necessary to  to determine their effectiveness within a specified period since the program has been applied for decades and to assess whether an additional program is needed or not. The data of this study were collected from verified international journal articles in the National Centre for Biotechnology Information (NCBI)/PubMed and Cochrane Library website. 11 articles related to the program were obtained. The program has been conducted for an extended period, yet its effectiveness should be reinforced to diminish the micronutrient deficiencies. It is mandatory to reformulate an additional program to strengthen the program. Nutrition education program, campaign for a healthy and balanced diet, protein consumption based local resources can be designated to assist the eradication of micronutrient deficiencies.
Correlation between transduction signal route with serum dehy-drogenase lactate level in non-Hodgkin’s lymphoma Hary Gustian
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art5

Abstract

Background: PPI3K/pAKT/pMTOR expression is important in NHL patients. The cascade of biomarker signals regulates translational events, cell survival, cytoskeleton organisation, and ion transport. pPI3K/pAKT/pMTOR enhance gene transcription increasing lactate dehydrogenase (LDH). LDH is one of the important markers in plasma people with non-Hodgkin’s lymphoma (NHL).Objective: This study aims to determine the correlation between the expression of kPI3K, pAKT, and pMTOR and serum LDH levels in NHL patients.Methods: This study was used an observational approach with a cross-sectional design. The expression score of pPI3K, pAKT, and pMTOR was obtained from medical records and expressed in histoscore obtained from multiplication between intensity (1=weak, 2=medium, 3=strong) with an express area (1=<20%, 2=20-50%, 3=50-80%, 4=>80%). The correlation between the histoscore of pPI3K, pAKT, and pMTOR expressions with LDH levels was statistically analysed using Pearson correlation tests. Results: The mean of pPI3K, pAKT, and pMTOR expression respectively were 5.29 + 2.95; 4.71 + 2.26 and 7.62 + 1.86. There was a weak correlation between pPI3K expression and serum LDH levels in NHL patients (r=0.293). A very weak correlation occurred between pAKT (r=-0.064) and pMTOR (r=-0.172) with serum LDH in NHL patients.Conclusion: There is a weak correlation between pPI3K expression and serum LDH levels in NHL patients. There is a very weak correlation between pAKT and pMTOR with serum LDH in NHL patients.
The potency of red onion skin flavonoids in acetaminophen-induced liver injury management: A biomolecular review Radya Kusuma Ardianto; Lucky Dimas Abimanyu; Afif Wafiq Waliyuddin; Abi Noerwahjono; Dian Yuliartha Lestari; Fathiyah Safithri
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art12

Abstract

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common and responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It was understood that glutathione (GSH) depletion causes a deposit of acetaminophen metabolites which are toxic to liver cells. N-acetylcysteine (NAC), used as acetaminophen intoxication therapy, has been reported to cause side effects such as nausea, vomiting, and anaphylactic reaction. This narrative review aimed to discuss other potential candidates in AILI management. The biomolecular approach was used to investigate onion skin in-depth and holistic discussion. According to the results, onion peel extract is rich in flavonoids (quercetin and kaempferol) and potentially be a candidate in the management of AILI through proposed mechanisms such as restoration of reduced glutathione (GSH), inhibition of cytochrome P450 (CYP) enzymes, upregulation of uridine 5'-diphospho-glucuronosyltransferase (UGT) enzyme, and inhibition of TLR4 activity. 
Sleep quality and attention of senior high school students Christine Kurniawan; Meiyanti Meiyanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art3

Abstract

Background: A successful learning process can be influenced by an individual’s attention level that can affect his/her concentration level and memory capacity. Some psychological and neurological aspects contribute to the attention level. If an individual experiences attention disorder, he/she can be difficult to learn and work efficiently. One of factors that may affect the individual’s attention is sleeping quality. A sufficient sleeping quality plays an important role in an individual’s development and daily activities.Objective: This study aims to analyse relationships between the sleeping quality and the attention of students to improve their learning performances.Methods: This study was an observational analysis study with a cross-sectional design that involved 87 senior high school students. The inclusion criteria of this study were male/female students between 14 to 19 years old who were willing to be respondents by signing informed consent form. Its exclusion criteria were male/female students who were experiencing brain-related injuries and who were on medical treatment causing drowsiness such as influenza drugs, cough syrups and sleeping pills. This study was conducted for four months. The data were collected by interviews and questionnaires including identity data, educational level, Pittsburgh Sleep Quality Index valuation and digit span tests. The samples were collected with a consecutive non-random sampling method. Its data analysis was conducted by applying SPSS V.21 through Chi-Square statistical test with a significance level of 0.05.Results: Of the 87 respondents, 50.6% were females and 35.6% were 15 years old. The majority of them were at class X (10th grade). Also, 52.9% of them had low sleeping quality and 74% of them suffered bad attention. Based on the Chi-Square test, the relationship between the sleeping quality and the attention level was not significant with p value of 0.938. Conclusion: There was no a significant relationship between the sleeping quality and the attention levels on the senior high school students.
The time administration and cost burden of intravenous immunoglobulin (IVIG) therapy in a 4-year-old girl with Kawasaki disease: A case report Nenden Nursyamsi Agustina; Fitranto Arjadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art13

Abstract

Kawasaki disease (KD) is an acute systemic vasculitis frequently affecting children under five years old. KD can cause severe complications. It can lead to coronary aneurysms in 15-25% of untreated cases. Intravenous immunoglobulin (IVIG) treatment within ten days of initial onset can reduce the rate of coronary artery aneurysms. However, IVIG administration in Indonesia is currently limited due to its high cost. The case reported a 4-year-old girl with a chief complaint of fever. She complained about a high fever seven days before hospitalization. She also complained about vomiting, cough, joint pain, diarrhea, skin peeling, and rash on her body, palms, and soles. On examination, she looked irritable and sluggish. The temperature was 39.9o C. There were red eyes without discharge, strawberry tongue, oral thrush, and red, dry, cracked lips, swollen neck lymph nodes, and skin rash on her body, palms, and soles. Laboratory testing showed microcytic hypochromic anemia with Hb 7.9 g/dL and leukocytosis 24.230/mm3. Chest X-ray showed perihilar and paracardial infiltrates. Electrocardiogram revealed sinus tachycardia. An echocardiogram showed left ventricle dilatation with trivial mitral regurgitation and no coronary abnormalities were found. She was diagnosed with Kawasaki Disease. She was treated by IVIG 30 gr single dose during 12 hours on day 7 of initial onset, methylprednisolone injection 10 mg/8 hours, paracetamol 150 mg/8 hours, and aspirin 400 mg/8 hours orally and discharged from the hospital with improvement. There weren’t any coronary artery abnormalities found. IVIG administration within ten days of initial onset in KD patients can reduce the risk of coronary artery complications. IVIG administration after day 10 of initial onset can achieve resolution of inflammation but can be insufficient for preventing coronary artery lesions (CALs).
PENGARUH PEMBERIAN PROPOLIS TERHADAP EKSPRESI BDNF DI HIPPOCAMPUS TIKUS YANG DIINDUKSI STRES Kuswati Kuswati; Zainuri Sabta Nugraha; Ety Sari Handayani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art8

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin secreted by dendrite, which plays a role in differentiation, maturation, neuroplasticity, learning, and memory, which the expression decreases under stress conditions. Propolis contains chrysin which has antioxidant and neuroprotectant effects.Objective: This study aimed to examine the effect of propolis on BDNF expression in the hippocampus of stress-induced rats.Methods: Experimental study using posttest only control group design. The subjects were 25 male Spraque-Dawley rats (Rattus norvegicus), four months old, weighing 200-300 grams. Rats were randomly divided into five groups: group N, did not receive any treatment; group K, received stress treatment; groups P1, P2, and P3, received stress treatment and followed by administered propolis at doses of 100, 150, and 200 mg/kg/day. Social isolation stress was carried out by putting one rat in one cage. Oral propolis administration used oral gavage. In the end, the rats were terminated and brain tissue was collected. Immunohistochemical staining using anti-BDNF antibodies was performed to make histological slides. Observations were made with a light microscope with 1000x magnification in the CA1 area of the hippocampus.Results: There is a significant difference in BDNF expression in the CA1 area of the hippocampus in all groups (p=0.000). The highest BDNF expression was in the P3 group and the lowest in group K.Conclusion: There is an effect of propolis on BDNF expression in the hippocampus of the stress-induced rat. Propolis dose of 100 mg/kgBW/day has increased BDNF expression.
Target protein prediction of Indonesian jamu kunyit asam (Curcumin-tamarind) for dysmenorrhea pain reliever: A network analysis approach Galuh Wening Permatasari; Mochammad Fitri Atho'illah; Wira Eka Putra
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art7

Abstract

Background: Dysmenorrhea is a monthly problem for reproductive-age women before or during menstruation. Dynamic changes of prostaglandins (PGs) and progesterone in the late reproduction cycle regulating signal pathways of PGE2 and PGF2 can contribute to menstrual cramps and other dysmenorrhea symptoms. Curcuma longa and Tamarindus indica (CT) are traditional medicines more preferred by Indonesian women to overcome menstrual pain than painkiller drugs.Objective: This study aims to observe potentially active compounds and detailed mechanism of Curcuma longa and Tamarindus indica (CT) as a pain reliever.Methods: Bioactive compounds in the CT were collected from two databases and then screened by bioavailability and drug-likeness parameter by utilizing SwissADME software. The target proteins and genes associated with dysmenorrhea were retrieved from HitPick and GeneCard database. The possibility of how CT healed dysmenorrhea was predicted by protein-protein interaction (PPI) using STRING Webserver and was visualized by Cytoscape v.3.7.0 and REVIGO.Results: Totally, 147 active compounds were obtained from C. longa and 212 active compounds from T. indica. Respectively, 36 and 66 compounds were obtained from C. longa and T. indica by the ADME screening. Finally, 20 and 22 target proteins were identified in both herbs. Then, an overlap analysis of this study showed that four target proteins had strong interaction with pain-related dysmenorrheaConclusion: This study found possible target proteins of the CT to relieve dysmenorrhea. The target proteins included HSD17B1, ALOX5, GSTM1, and ESR2 genes. Further, these findings are needed to be validated by using in vitro and in vivo approaches.
Massive pleural effusion due to heart failure in an undetected diabetic hypertensive patient: A case report Citra Ayu Aprilia; Rizka Dwi Aulia; Arif Eko Wibowo; Evy Novita Permatasari; Samsul Bakhri; Abdurrahman Abdurrahman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art14

Abstract

Pleural effusion is pathological accummulation of pleural fluid. The most common causes of pleural effusion are cancer, pneumonia, pulmonary embolism and heart failure. Diabetes mellitus and hypertension are two risk factors of heart failure. A 74-year-old male patient came to the emergency room feeling fatigued all over the body since seven days before, dyspneu and notable reduced appetite and weight loss. Initial vital examination revealed an increase in heart rate and blood pressure (BP=140/80 mmHg, 120 bpm). Oxygen saturation was normal and deteriorate from time to time (92.5%). Chest physical examination showed pleural effusion on the right lungs. Laboratory findings noted an elevated blood glucose and mild hypokalemia in patients. ECG result showed old myocardial infact (OMI) anteroseptal and infrequent premature ventricular contraction (PVC). Chest X-Ray revealed a massive pleural effusion on the right lugs, a mediastinal shift and cardiomegaly. The patient were given IVFD RL, gliquidone, Lantus Bisoprolol, B-Complex, and also thoracentesis for the pleural effusion. The underlying pathology largely determines the clinical symptoms of pleural effusion. In this case, the most probable underlying cause is heart failure. The risk factors of heart failure, in this case, are undetected diabetes melitus, hypertension, OMI and arrythmia. Increasing prevention and early detection of chronic illness such as diabetes melitus and hypertension is a very necessary step.
THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Abstract

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.

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