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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
Arjuna Subject : -
Articles 200 Documents
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Comparison of Ahmed Versus Baerveldt Implant Outcomes in Malayan Glaucoma Patients Artini, Widya; Mustafa, Syukri; Octariana, Virna D; Suryono, Astrianda
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Ahmed and Baerveldt implants have already have been established for treating refractory glaucoma, but, to date, their outcome in Malayan eyes has not yet been reported. This study aimed to evaluate a comparison of the success rate between Ahmed and Baerveldt implants surgical intervention in Malayan patients with glaucoma. Methods: A descriptive retrospective study was conducted at Cipto Mangunkusumo Hospital, Indonesia, from January 2013 to December 2015. All glaucoma patients who underwent Ahmed and Baerveldt implants and intraocular pressure (IOP), and presented for follow-up evaluation one year post implant, were enrolled in this study. Visual acuity and complications were also recorded. A comparison between the two groups was then analysed. Results: The study cohort included a total of 117 eyes, of which 64 and 53 received the Ahmed and Baerveldt implants, respectively. The pre-operation IOP between the two groups was found to be significantly different (p = 0.01), but no significant difference (p = 0.24) was observed after surgery, although both groups showed a declining IOP. Complete success was achieved in 75% of Ahmed and 60.38% of Baerveldt implant patients. Overall, 9 patients developed complications. Conclusions: Both the Ahmed and Baerveldt implant groups demonstrated similar success in reducing IOP.
Evaluation of Bioactive Compounds on Different Extracts of Linum Usitatissimum and Its Antimicrobial Properties against Selected Oral Pathogens Fadzir, Ummu A; Mokhtar, Khairani I; Mustafa, Basma E; Darnis, Deny S
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Antibacterial agents from natural sources have been suggested as alternatives for treating infectious diseases due to their low side effects. Flaxseed (Linum usitatissimum) exhibits some antibacterial properties, but its effects against oral pathogens are poorly understood. This study investigated flaxseed extracts' antibacterial effects against such pathogens. Methods: Non-polar and polar extracts of flaxseed, with n-hexane, dichloromethane (DCM) and methanol (MeOH), were prepared by sequential Soxhlet extraction. All extracts were qualitatively screened through gas chromatography-mass spectrometry to detect bioactive compounds. Antibacterial activities of flaxseed extracts with different volumes per disc (Oxoid, Badhoevedorp, Netherlands) (5, 7, 10, 12 and 15 µL/disc) were evaluated against four different oral pathogens: Streptococcus pyogenes, Streptococcus mutans, Lactobacillus casei and Enterococcus faecalis, using the disc diffusion method. Flaxseed extracts' inhibitory activities against the tested oral pathogens were examined by measuring the inhibition zone diameter. Results: Polar extract (methanolic extract) demonstrated significant antibacterial activity (p<0.01) against all tested oral pathogens, with inhibition zones comparable to those for penicillin. In contrast, n-hexane and DCM extracts demonstrated variable antibacterial activities. Conclusions: This study suggests that Linum usitatissimum methanolic extract exhibited the best inhibitory activity on all tested strains compared to the other extracts.
Effects of Physical Exercise on Indicators of Inflammation Risk of the Gaster in a Male Wistar Rat Aging Model Created with D-galactose Induction Murwaningsih, Dian; Meliala, Andreanyta; Sofro, Zaenal M
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Physical exercise is a non-pharmacological treatment for various diseases. Aging is associated with deteriorating physiological function, and elderly individuals generally have inflammation or infection in the digestive tract. This study aimed to examine the effects of mild and moderate physical exercise intensities on the indicators of inflammation risk of the gaster in a male Wistar rat aging model created with D-galactose induction. Methods: This experimental research study had a post-test-only group design. The study included 24 3-month-old male Wistar rats weighing 200-300 g. The rats were equally divided into four groups (saline,+light-intensity physical exercise, and D-galactose+moderate-intensity physical exercise)D-galactose, D-galactose. D-galactose was continuously administered at 300 mg/ml/kg body weight. The study period was four weeks. The number of fibrocytes, mucosal thickness, and the number and size of mucosal glands were analyzed. Results: D-galactose induction triggered aging. Physical exercise had an effect on weight gain and decreased the number of fibrocytes. However, there were no effects on mucosal thickness and the number and size of mucosal glands. Conclusions: Physical exercise of mild/moderate intensity had an effect on the number of fibrocytes but did not have impact on the mucosal thickness or the number and size of mucosal glands.
Oral Antidiabetic Utilization and Various Factors as an Indicator for HbA1c Control Among Patients with Type 2 Diabetes Liberty, Iche A; Roflin, Eddy; Aziz, Muhammad; Pariyana, Pariyana; Tjekyan, Suryadi
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Diabetes mellitus requires aggressive long-term therapy to decrease morbidity and mortality. Non-adherence to oral antidiabetic therapy represents a barrier to treatment that could lead to the deterioration of patient health. This study aimed to develop an indicator for predicting glycemic control among patients with type 2 diabetes. Methods: This unmatched case-control study recruited 110 patients from the Primary Health Care center in Palembang City. The chi-square test was used for certain variables, and multivariate analysis was performed using unconditional logistic regression to assess the effects of different variables after considering certain sociodemographic and economic characteristics as potential confounding variables. Results: The results revealed no statistically significant association of sociodemographic and economic variables (sex, age, education, and employment) with glycemic control. Family history of diabetes, duration of diabetes, body mass index, adherence, monitoring, therapy, and comorbidity were associated with glycemic control. Conclusions: Continuous education of primary care physicians is one way of improving skills for managing hyperglycemic patients. However, the challenge in treating patients with type 2 diabetes is to shift the main criterion from a disease-oriented to patient-centered approach in the context of patients' circumstances. Additionally, our developed indicator can be used as a screening test for assessing glycemic.
A Systematic Review of the Association Between Intrapersonal Factors and Smoking Cessation in Adolescents in the United States Hana, Amanita K; Cho, Sung-il; Cheon, Eunsil; Kwon, Suhyun; Thishani, Rajapakshe
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Abstract

Background: Premature death in developed countries, and smoking by adolescents is a serious health issue in the US. There are several aspects that influence smoking cessation in adolescents, one of which comprises intrapersonal factors. The aim of this systematic review was therefore to identify and categorize specific intrapersonal factors that affect the smoking cessation of adolescents in the United States. Methods: Through a search on PubMed, identified quantitative research studies on the intrapersonal factors affecting the smoking cessation of adolescents in the US. The search results imported into Endnote X9. The intrapersonal factors examined into 4 classifications: nicotine dependence, stress, related beliefs, and other emotional factors. Each study's bias was assessed using RoBAN and RevMan 5. Results: The sample sizes ranged from 66 to 975 participants, with an age range of 12-21 years. 7 studies were classified as covering nicotine dependence, 2 studies as covering other emotional factors, 1 study was classified as covering related beliefs, and 1 study was classified as covering stress. Conclusions: Nicotine dependency was found to have the highest incidence among all the contributing factors. Stress and other emotional factors were found to stem from depression and low emotional control.
Molecular Detection for Japanese Encephalitis and Chikungunya Virus as Etiology Agent for Dengue-Like Fever Symptoms Ariani, Rizka; Sudiro, Tjahjani M; Dewi, Beti E
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Acute fever with dengue-like fever symptoms with headache, rash, arthritis, perifer bleeding like ptechie and rinhorrhea are symptoms that often complained by patient and it may be caused by arboviruses infection. Arboviruses are very endemic in Indonesia, especially Dengue Virus (DENV), Japanese Encephalisitis Virus (JEV), and Chikungunya Virus (CHIKV) that causing similar symptoms. Molecular detection is very important to confirm the etiology for adequate management. Methods: This study investigated the etiological agent using one step real time RT reverse transcription polymerase chain reaction (RT PCR) method and SYBR Green I as fluorescent binding dye reporter. The viruses that were investigated were JEV and CHIKV. Primer design was using online software NCBI. Those primers fulfill the good primer requirements and can be used as material in RT PCR reaction. Results: The optimum temperature for all primers were at 60 °C. The limit detection of JEV primer was 4355 copy DNA every reaction. Cross reactivity between all primers with DENV serotype 2 RNA and false positive result using healthy person sample were not found. Conclusions: This study has optimized condition RT PCR protocol that can be used as diagnostic tools for patient with dengue-like fever symptoms.
Health Financing Policies in Jordan: The Allocation of Public Expenditures in Global Context Rawabdeh, Ali A; Khassawneh, Anis S
Makara Journal of Health Research Vol. 22, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: This article aimed to clarify the adequacy of government financial resources toward furnishing the provision of efficient healthcare for fulfilling the health challenges in the light of worse economic scenario in Jordan. Methods: This analytical and prognostic study of healthcare spending in Jordan focuses on the public sectors that finance healthcare. Hence, all the available studies and posted materials in the nearby and global levels were used to analyze the government abilities to proceed with presenting healthcare within the current constraints. Results: Our results revealed that, in any case, the Jordanian government is not organized to proceed or prepared to continue providing health services at the present trend: fast increase in demand over publicly funded services in the absence of efficiency gains. Conclusions: For the healthcare system to be significantly efficient and equitable, the cash burden of contributions ought to be progressive toward preserving long-term sustainability. There is a progressive impact of the reform on healthcare provision and finance systems once the contributor's expenses are used to construct it; however, these findings do not seem to be conclusive.
Measurement of Contrast Sensitivity Using the M&S Smart System II Compared with the Standard Pelli–Robson Chart in Patients with Primary Pterygium Hilmi, Mohd R; Khairidzan, Mohd K; Azemin, Zulfaezal C; Azami, Muhammad H; Ariffin, Azrin E
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Background: Contrast sensitivity (CS) is widely used as a measure of visual function in research and clinical settings. CS is regarded as an important visual parameter, detecting subtle reductions in vision prior to significant reduction in visual acuity. Methods: We examined the agreement between the gold-standard Pelli-Robson chart and a computerized test termed the M&S Smart System II (MSSS-II) in patients with primary pterygium. Ninety-three patients (93 primary pterygium eyes) who visited an ophthalmology clinic were selected. The patients were randomly assessed for CS using the MSSS-II or Pelli-Robson chart. The primary outcome was agreement in log units between these two tests in the assessment of CS in patients with primary pterygium. Results: The mean and standard deviation of CS measurement in the two tests were comparable (1.22 ± 0.56 vs. 1.21 ± 0.57 log units, respectively, p = 0.083). The Bland-Altman plot revealed that the mean difference between the two charts was 0.0016 log units (standard deviation: 0.009 log units) with narrow limits of agreement of -0.0186 to 0.0186. Conclusions: MSSS-II provides an alternative for the clinical assessment of CS using a computerized method that describes the status of visual function in patients with primary pterygium.
Stressors and Their Association with Symptoms of Depression, Anxiety and Stress in Dental Students Radeef, Ali S; Faisal, Ghasak G
Makara Journal of Health Research
Publisher : UI Scholars Hub

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Background: Dental students are exposed to varying levels of stress that may affect their mental and physical health, academic performance and quality of life. This study aim was to determine the prevalence and severity of depression, anxiety and stress (DAS), and the relationships between DAS symptoms and stressors. Methods: This cross-sectional study included 257 dental students at the International Islamic University Malaysia. The prevalence and severity of DAS symptoms was measured by the Depression, Anxiety, Stress Scale (DASS-21). The stressors were self-reported by students from a list, and the relationships with the DAS symptoms were assessed. Results: The overall prevalence of DAS symptoms for depression, anxiety, and stress were 47.5%, 67.3% and 42.8%, respectively. Clinically significant depression was experienced by 9.3% of the students, anxiety by 28.8% and stress by 10.1%. Anxiety was significantly more frequent in women than in men, and anxiety scores were significantly increased in young students. The top five stressors were time management problems, fear of failing, examination and low grades; feeling of incompetence and study pressure. Conclusions: DAS symptoms occurred in dental students. Academic and personal factors produced stress that precipitated psychological distress.
Quality of Life in Pre- and Post-Treatment among Head and Neck Cancer Survivors at A Tertiary Centre, Malaysia Ludin, Salizar M; Abdullah, Che-Azunie C; Abdullah, Kahairi
Makara Journal of Health Research Vol. 22, No. 2
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Background: Treatment for head and neck cancer (HNC) may result in a variety of long term consequences that impair their health and quality of life (QoL). HNC patients often are prone to have a poor health related QoL due to significant changes in vital functions. Despite researches being done in the area cancer survivors' QoL internationally, those done locally were relatively scares and not clear. The study aim to determine and compares the pre and post treatments QoL in HNC patients. Methods: A cohort study was carried out to recruit 81 newly diagnosed HNC patients purposively; pre and six months post treatment using QoL Cancer Survivor and Questionnaire-Head &Neck 35 questionnaires. .Data was analyzed for descriptive and inferential analysis. Results: A total of 40 (50%) patients participated and the result shows that QoL of HNC patients were at medium level (6.22 ± 1.8) pre-treatment, and however reduced (4.84 ± 1.16) at 6 months post treatment), despite the symptoms or problems that occur reduced post treatment compared (1.58 ± 1.25). The Pearson coefficient correlation test result shows that QoL of HNC patients pre and post treatment were strong but negatively correlated (r = -0.447, p = 0.002). Conclusion: Understanding of QoL and affecting factors in HNC patients' QoL is very crucial as it may potentially assist in designing interventions that lessen the adverse impact of this disease process and more accurately support those in active treatment, survivors, and caregivers.

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