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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 14 Documents
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Search results for , issue "Vol 7 No 2 (2021)" : 14 Documents clear
SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES CONTAIN CURCUMIN AS AN EARLY CANDIDATE FOR ANTICANCER DRUG Ersalina Nidianti; Devyana Dyah Wulandari; Fadlilah Nur Aini; Herliani Rahmania Sari
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3458

Abstract

Cancer treatment can be done with tumor surgery, radiotherapy, immunotherapy, and chemotherapy. These treatments effectively kill cancer cells but have side effects and are resistant to patients. Based on this, further research is needed related to cancer drugs based on herbal plants, one of which is by using curcumin from Curcuma longa or turmeric in the form of nanoparticles to increase bioavailability and solubility. Especially silver nanoparticles with a mixture of curcumin. The aim of this study was to determine the characterization and screening of candidate activities to be used as anticancer drugs from curcumin extract and silver nanoparticles (AgNO3) containing curcumin carried out solubility test, thin layer chromatography (TLC) analysis, UV-Vis spectrophotometer analysis, and morphological analysis with XRD. The results obtained in this study were curcumin extract insoluble in water while silver nanoparticles could dissolve in water. TLC analysis on chloroform mixture: ethanol Rf = 0,92 and Rf = 0,94; chloroform: hexane obtained Rf = 0,36; Rf = 0,36: Rf 0,38; Rf = 0,3. While chloroform: benzene: methanol eluent has no Rf value. UV-Vis spectra obtained a maximum absorbance of 4,267 at a wavelength of 290 nm. The morphological analysis of XRD silver nanoparticles containing curcumin was 17,45 nm. In conclusion, curcumin extract and silver curcumin nanoparticles have the potential as initial candidates for anticancer drugs.
EFFECTIVENESS OF BAKUNG EXTRACT (CRINUM ASIATICUM L) AS AN ANALGESIC IN ACETIC ACID-INDUCED MICE Teodhora Simangunsong; Elzius Fransiscus Lumban Gaol; Sister Sianturi
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3806

Abstract

Crinum asiaticum L. leaves is a plant that has a pharmacological effect, which is to relieve pain. The purpose of this study was to determine the effect of the ethanol extract of daffodils as an analgesic effect on male mice DDY. The extract was obtained through the maceration extraction method and was administered by oral administration with three dose variations, namely 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW. Ibuprofen 52 mg/kgBW was used as a positive control and Na-CMC 0,5% as a negative control. 30 minutes after induced with 1% acetic acid the amount of stretching was observed every 5 minutes to 60 minutes. The results showed the best analgesic effect at dose III 800 mg/kg BW with the percentage of analgesic protection of 80,66%. The results of effectiveness at dose III 800 mg/kg BW of 99,37% which is almost the same as the effectiveness of Ibuprofen at a dose of 52 mg/kgBW of 100%
RELATIONSHIP OF PB LEVELS WITH BLOOD PRESSURE IN TIRE REPAIRMAN ON PANTURA HIGHWAY, PEKALONGAN CITY Tri Minarsih
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.3960

Abstract

Lead (Pb) is a type of metal that has an acute effect on blood pressure and causes hypertension if it accumulates in the blood for a long time. Many types of work are at risk to cause accumulation of Pb in the blood. One of the work sectors that is estimated to be potentially contaminated by Pb is the tire repairman that exists along the highway, which comes from paint, dust (residual fuel) engines and others. The purpose of this study was to determine the relationship between Pb levels and blood pressure in tire repairman on Pantura Highway, Pekalongan City. This type of research is Analytic Observational. The sample used in this study was the tire repairman on Pantura Highway, Pekalongan City, who were willing to be a respondent of 13 people. The research data were taken from blood samples of tire repairman to measure their Pb levels, measure blood pressure and questionnaires. The results of this study are the Pb levels in the blood of tire repairman on Pekalongan City's Pantura Highway, all exceeding normal with the lowest value of 19,76 (µg / dL) and the highest of 32,55 (µg / dL). The average systolic blood pressure obtained at the tire repairman was 149.61mm Hg, while the diastolic blood pressure was an average of 92,46 mm Hg In conclusion, the value of R obtained was 0,09995 for the correlation of Pb content with systole and 0,1551 for the correlation of Pb levels with diastole. This shows a correlation that is not so strong 9,99% (the contribution of Pb levels to the system) and 15,51% (the contribution of Pb levels to diastole).
THE EFFECT OF VARIATIONS IN ROASTING TEMPERATURE ON YIELD AND PERCENTAGE OF INHIBITION OF DPPH RADICAL REDUCTION IN CANDLENUT OIL THE UV-Vis SPECTROPHOTOMETRIC METHOD Aldi Budi Riyanta; Maulani Fitrie Nabila; Akhmad Aniq Barlian
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4131

Abstract

Antioxidant compounds are able to dampen free radicals by donating electrons to pair with free radicals and become harmless to the body. One of the plants that can be used as an antioxidant is candlenut. Candlenut (Aleurites moluccana (L.) Willd.) Candlenut is a plant that has many benefits. Chemical content contained in candlenut seeds is such as flavonoids have the ability as antioxidants. This research aims to determine the roasting temperature of yield and inhibition percentage of DPPH radical reduction (1,1-diphenyl-2-picylhydrazyl) contained in candlenut oil using the UV-Vis spectrophotometric method. The variations in roasting temperature used were 30, 70, 75, 80, 85, and 90˚C. The yield obtained from the extraction was 42,12 %, 38,47 %, 36,44%, 32,58 %, 31,06 %, and 25,38 % which indicated that the higher the roasting temperature the lower the yield obtained. While the percentage of DPPH radical reduction showed a value of 24,689±0,23%; 27,399±0,02%; 38,464±0,01%; 44,562±0,04%; 37,222±0,03% and 22,657±0,03% which shows that 80°C is the best temperature to produce the biggest DPPH radical scavenging.
ANALYSIS OF TOTAL FLAVONOID LEVEL AND ANTIOXIDANT ACTIVITY TEST PURPLE CABBAGE (BRASSICA OLERACEA L. VAR. CAPITATA F. RUBRA) AND WHITE CABBAGE (BRASSICA OLERACEA L. VAR. CAPITATA F. ALBA) ETHANOL EXTRACT USING DPPH METHOD (1,1-DIFENIL-2-PIKRILHIDRAZIL) Any Guntarti; Ratna Yuningtyas; Hari Susanti; Zainab Zainab
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4369

Abstract

Antioxidants are compounds that are needed by the body to protect the body from free radical attacks that can trigger the emergence of degenerative diseases. One of the compounds that has free radical scavenger activity by inhibiting Reactive Oxygen Species (ROS) is flavonoids found in purple cabbage and white cabbage. This study aims to determine the total levels of flavonoids expressed as quercetin equivalent (EK) and antioxidant activity using the DPPH method (1,1-diphenyl-2- picrylhydrazyl). Identification of flavonoid compounds by Willstater test and determination of total flavonoid levels using spectrophotometry, AlCl3 reagent. Flavonoid levels were calculated using linear regression equations. Qualitative test for the presence of antioxidant activity using TLC and antioxidant activity test using the DPPH method with the parameter value of ES50. The qualitative test results showed that the ethanol extract of purple cabbage and white cabbage contained flavonoids. The total flavonoid content of ethanol extract of purple cabbage was 5.17% w/w (EK) and ethanol extract of white cabbage was 3.84% w/w (EK). Qualitative test with TLC showed antioxidant activity. The standard antioxidant activity values ​​of quercetin, ethanol extract of purple cabbage and white cabbage were 2.138±0.064 µg/mL; 154.445±0,999 µg/mL and 373.546±1.336 µg/mL. The antioxidant activity of purple cabbage is weak and white cabbage is very weak.
ANTI INFLAMMATORY ACTIVITY OF SUNGKAI LEAVES (Peronema canescens JACK) ETHANOL EXTRACT IN CARRAGEENAN INDUCED MICE Madyawati Latief; Anggun Tri Fisesa; Putri Maya Sari; Indra Lasmana Tarigan
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4532

Abstract

Anti-inflammatory compounds play a role by inhibiting the formation of prostaglandin mediators, inhibiting the migration of leukocytes to the area of ​​inflammation, and inhibiting the release of prostaglandins from the cells where they are located. Several plant-derived compounds that can act as anti-inflammatory candidates are flavonoids, saponins, alkaloids, and phenols. This study aims to determine the anti-inflammatory activity of the ethanol extract of Sungkai leaves and to determine the effect of the concentration given on the level of anti-inflammatory activity. The method used was the formation of granuloma pockets and edema on the mice's backs by inducing subcutaneous carrageenan using ethanol extract of Sungkai leaves with various concentrations of 5%, 10%, and 15%, respectively. The results of anti-inflammatory activity showed that the ethanol extract of Sungkai leaves had a significant effect on the average exudate volume and the percentage of inflammation inhibition. At a concentration of 15%, the extract was able to reduce the volume of exudate by 46,67 ± 5,506 µl and inhibition of inflammation by 87.78%. In addition, the ethanol extract of Sungkai leaves significantly affected lymphocytes, stem neutrophils, and segment neutrophils, but did not significantly affect the number of monocyte cells. At a concentration of 15%, the ethanol extract of Sungkai leaves showed the smallest number of leukocyte cell types, namely 50.11 ± 2.389 lymphocyte cells; stem neutrophil cells 10,44 ± 0,475; segmented neutrophil cells were 19.78 ± 0.596 and monocyte cells 2,0 ± 0,236. It can be concluded that the ethanol extract of Sungkai leaves has anti-inflammatory activity but has not approached the effect of anti-inflammatory drugs in general.
ANTI-FUNGAL ACTIVITY TEST OF PLETEKAN LEAVES LIQUID SOAP (Ruellia tuberosa L.) ON CANDIDA ALBICANS Ahmad Fuad Masduqi; Mighfar Syukur
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4563

Abstract

The fungus Candida albicans is a pathogenic species that causes candidiasis. Pletekan plant has potential as a medicinal plant. This plant is proven to have one of the effects as an antimicrobial. The purpose of this study was to determine whether the pletekan leaf extract liquid soap could inhibit the growth of Candida albicans and whether there were differences in the antifungal activity of the liquid soap pletekan leaf extract at a concentration of 20%, 40%, and 60%. This study used maceration extraction methods, screening for secondary metabolites and continued with TLC tests. Liquid soap formulations from extracts with different concentrations. Furthermore, the research was carried out to test the antifungal activity by using the good method on liquid soap for the pletekan leaf extract against the growth of Candida albicans. Screening and TLC results showed that the pletekan leaf extract contained flavonoids, steroids, triterpenoids, and alkaloids. Liquid soap preparations including organoleptic, pH, homogeneity, and viscosity are included in the criteria for the Indonesian National Standard. The results showed that pletekan leaf extract in a liquid soap preparation could inhibit the growth of Candida albicans. The results of statistical tests show that the data are normally distributed and homogeneous. There were differences in the antifungal activity of the liquid soap for pletekan leaf extract with a concentration of 20%, 40%, and 60% which resulted in a succession of 8,456mm; 12,186mm; and 14,293mm. The antifungal activity showed that the extract concentration was directly proportional to the resulting inhibition zone
COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR Anita Puspa Widiyana
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4827

Abstract

The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted by computer programs and online servers. Substituents are added at positions 2 and 3 to the quinazoline-4(3H)-on ring, such as -H, -NO2, -OCH3, -N(CH3)2, -SO2NH2, -OH, and –OCH3. QSAR as COX-2 inhibitor analysis was performed by SPSS Ver. 21 software. Lipinski’s rule of five for determining bioavailability is performed by an online server at http://ilab.acdlabs.com. The best QSAR equation used to predict the COX-2 inhibitors from these compounds is RS-pred = 0.372 Log P + 0.014 MR + 0.979 Etot – 4.859, with n= 12, R = 0.998; SE = 0.356, F = 805.252 and sig = 0.001. Six compounds were predicted to have good oral bioavailability, such as 3-(benzylideneamino)-2-(2,4-dichlorophenyl)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-methoxybenzilidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-methoxybenzylidene)amino)quinazolin-4(3H)-one, and 2-(((2-(2,4-dichlorophenyl)-4-oxoquinazolin-3(4H)-yl)imino)methyl)- benzenesulfonamide. This research can be used as an in vitro and in vivo study for BDCQ derivatives as anticancer drugs.
ANTIBACTERIAL ACTIVITY OF FENNEL LEAVES ETHANOL EXTRACT (FOENICULUM VULGARE MILL) AGAINST PSEUDOMONAS AERUGINOSA Ahwan Abdul; Fadilah Qonitah; Partonowati _
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4873

Abstract

Fennel leaf (Foeniculum vulgare Mill) is an herbal plant that is used for treatment. Flavonoid compounds and essential oils contained in fennel leaves have an antibacterial effect. The purpose of this study was to determine the activity of fennel leaf extract against Pseudomonas aeruginosa bacteria. Testing of antibacterial activity using a pure experimental method with a randomized design with a unidirectional pattern using the extraction method, namely maceration and bacterial activity testing with the diffusion method. The parameter measured is the diameter of the inhibition formed in the paper disc area. The data were measured using the Anova statistical approach. Fennel leaf extract has an inhibitory effect on the growth of Pseudomonas aeruginosa bacteria, namely at concentrations of 15% (11.04 ± 1.59 mm), 25% (13.68 ± 3.54 mm), 50% (18.14 ± 2.04 mm), 75% (20.53 ± 0.88 mm) and 100% (22.82 ± 0.32 mm) compared with 1% Dimethyl Sulfoxide (DMSO) negative control (00.00 ± 0.00 mm), while the test with positive control Gentamicin 1% (22.82 ± 0.32 mm) with a strong category (10 - 20 mm), namely at concentrations of 15%, 25% and 50%, very strong category (>20mm), namely at concentrations of 75% and 100%, the statistical significance value of ANOVA was p<0.05. It can be concluded that the ethanol extract of fennel leaf (Foenicullum vulgare Mill) has antibacterial activity against Pseudomonas aeruginosa. The value of the minimum inhibitory concentration (MIC) of ethanol extract of fennel leaf (Foenicullum vulgare Mill) against Pseudomonas aeruginosa bacteria was 15% w/v.
EVALUATION OF DRUG MANAGEMENT IN SALAMAN 1 PRIMARY HEALTH CENTER MAGELANG DURING THE COVID 19 PANDEMIC Endaryanti Wulandari; Aris Widayati
Jurnal Farmasi Sains dan Praktis Vol 7 No 2 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i2.4960

Abstract

The scope of drug management in Primary Health Center (PHC) includes planning/selection, procurement, storage, distribution, control of use, and documentation and reporting. During the COVID-19 pandemic, there were many changes in regulation and management in Primary Health Center. Such a situation certainly has an impact on the drug management of Primary Health Center. The purpose of this study is to evaluate drug management in Salaman 1 Primary Health Center in Magelang District, Central Java Province, during the COVID-19 pandemic in 2020. This research is an evaluative study using a descriptive design with a qualitative approach. The data was obtained by three methods, i.e., direct observation, interview, and secondary data. Direct observation was applied to observe the medicines' storage space. Interviews were conducted with five informants selected purposively according to the research's purpose. The assessments of secondary data were performed from the available and relevant data documentations. Data were analyzed by triangulation approach of the three types of data produced, namely observation data, interview data, and secondary data assessment. The results show several problems regarding drug management in Salaman 1 PHC during the COVID-19 pandemic. The drug selection is not precisely suitable for the needs, while drug procurement cannot always be arranged according to the planning. Furthermore, drug distribution is relatively impeded. Control of use found the number of expired and almost expired drugs increases. Drug storage and documentation are the two steps in the drug management cycle conducted appropriately in Salaman 1 PHC during the COVID-19 pandemic. This evaluative study concludes that the COVID-19 pandemic affected the drug management cycle in Salaman 1 PHC in Magelang District in 2020. Therefore, coordination among stakeholders must be improved to anticipate unforeseen circumstances, especially during the pandemic situation. The impacts of new policy implementations must be anticipated by testing, monitoring, and evaluating.

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