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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

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Articles 8 Documents

Search results for , issue "Vol 9, No 1 (2018): January - June 2018" : 8 Documents clear

HIGH DOSE VITAMIN C ADMINISTRATION EFFECT IN LEYDIG CELLS, SERTOLI CELLS NUMBER, AND SPERM QUALITY ON MALE WISTAR RATS Dwi Juniatiningrum, Ratna; Nasihun, Taufiqurrachman; Isradji, Israhnanto
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Most infertile male are associated with poor spermatogenesis due to oxidative stress, and can be prevented with vitamin C. However, excessive amount of high dose of vitamin C can hindered and lower the sperm quality. Objective: To prove that high dose vitamin C is capable to decrease the number of leydig cells, sertoli cells, and sperm quality on male wistar rats.Methods: This research was using experimental method with Post Test Only Controlled Group Design. Of 24 male Wistar rats, divided randomly to 4 groups. Normal groups (Nor -G), only given 2 ml/day distilled water; vitamin C group (VC18-G, VC36-G, and VC72-G) given 18 mg/day, 36 mg/day and 72 mg/day vitamin C respectively, dissolved in 2 ml of distilled water. Sperm, the number of Leydig cells and Sertoli cells were taken from the epididymis and left right testicle on day 21. Sperm analysis using WHO standard, while the number of Leydig cells and Sertoli cells with HE staining.Results: Mann Whitney analysis indicated that the number of sperm in VC36-G and VC72-G are lower compared to that of Nor-G and VC18-G groups, p <0.05. Post-Hoc LSD analysis showed that the lowest number of Leydig and Sertoli Cell, and the weakest sperm motility and morphology in VC36-G and VC72-G groups, compared to that of Nor-G and VC18-G groups, p <0.05 .Conclusion: Vitamin C 36 and 72 mg/day were capable of reducing Leydig and Sertoli cells number, and worsen sperm quality, characterized by decreased in sperm concentration, motility and morphology in Wistar male- rats.

OBESITY AS A RISK FACTOR FOR SURGICAL SITE INFECTION AFTER TRANSPERITONEAL CESAREAN SECTION Rahayu, Rahayu
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Surgical site infection (SSI) is one of the main complications that can increase morbidity and mortality in obese women after cesarean section. Surgical site infection can be caused by endogenous or exogenous factors. This was a case of a woman, G4P3A0, 32 years, after trans-peritoneal cesarean section for indications of breech presentation; primary uterine inertia; premature rupture + 22 hours with BMI = 30.80 kg/m2. This case report discusses how obesity causes surgical site infection and its management.

Strangulated Femoral Hernia With Perforated Jejunal Pseudodiverticula : a Case Report Ekasaputra, Vito
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Sixty percent of femoral hernias are characterized by incarceration and strangulation. Jejunal pseudo diverticulum are rare and usually asymptomatic. It may cause chronic obstruction of small bowel and can lead to an acute perforation.Case presentation: An 85 – year – old woman presenting with 1 week history of generalized abdominal pain, with episodes of vomiting, fever, and history of 6 months of reponible femoral hernia and 2 weeks strangulated of femoral hernia. An abdominal X-ray displayed multiple dilated loops of the small bowel, coil spring sign and intra peritoneal free air. This patient underwent a laparotomy and hernioraphy, which identified single perforated jejunal pseudo diverticulum 50 cm from ligamentum of treitz orally from strangulated of ileal on femoral hernia site, and associated fecal contamination. The management for this case was perforation repaired with diverticulectomy, simple closure, and extensive washout of intraperitoneal cavity. The non tension femoral hernia repair was performed with monofilament, macroporous MESH.Conclusion: chronic intestinal obstruction caused by femoral hernia in the elderly can lead a performed of intestinal pseudo diverticulum and lead to significant morbidity and mortality. This could be suspected in those presenting with cramping abdominal pain and altered bowel habits.Keywords: hernia, femoral, strangulated, pseudo diverticulum, perforated, management

RELATIONSHIP BETWEEN FAMILY HISTORY, BLOODY STOOL, PALPABLE MASS, ANEMIA, AND MSCT ABDOMEN AND KOLON CARSINOMA Cross-Sectional Study at Dr.Kariadi General Hospital in 2016 Malik, Ricat Hinaywan; Winarto, Winarto; Budijitno, Selamat; Sadhana, Udadi; Prajoko, Yan Wisnu
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Colon cancer, a colorectal cancer, is the third most common epithelial malignancy in the world. Family history, bloody stool, palpable mass, anemia, and abdominal MSCT are symptoms and signs of colon carcinoma.Objective: To determine the relationship between the 5 variables and the incidence of colon carcinoma at Dr. Kariadi Hospital, Semarang in 2016.Methods: a Cross-sectional observational analytical study using medical record (RM) and complementary primary data. The inclusion criteria werethe complete medical record, and clinical diagnosis of suspected colon carcinoma. Data obtained from the department of Anatomy Pathology/PA (11,794PA results) were traced to the medical record section (46 patients with suspected colon carcinoma). The incomplete data were confirmed by: contacting the patient/family, obtaining the archive in the laboratory and radiology resulting in 27 patients meeting the inclusion criteria. Analysis was done using chi-square test, Spearman-Kendall bivariate correlation, and logistic regression.Results: Abdominal MSCT was moderately associated with colon carcinoma (p = 0.003; r = 0.488), while family history, bloody stool, palpable mass, and anemia were not associated with colon cancer. Analysis between predictors of outcome: Bloody stool was moderately associated with anemia (p = 0.006; r = 0.411), and anemia was weakly associated MSCT (p = 0.035; r = 0.351). Abdominal MSCT was the predictive factor for colon carcinoma (p = 0.021).Conclusion: Abdominal MSCT was found to be associated with the incidence of colon carcinoma. Bloody stool was associated with anemia, and anemia was associated with abdominal MSCT. MSCT was the predictive factor for colon cancer.

Results Characteristics of Lipid Profile Examination of Acute Ischemia Stroke Patients at RSUP Dr. Soedono Madiun, East Java Wuryani, Dinik; Darumurti, Rissito Centricia
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Dyslipidemia as reflected in the results of lipid profile examination is among the most common abnormalities found in acute ischemic stroke patients. Studies assessing the characteristic of these results may provide a foundation for an effective plan of treatment and prevention to overcome the burden of the disease.Objective: To study the characteristic of the results of lipid profile examination among acute ischemic stroke patients at Dr. Soedono General Hospital, Madiun, East Java.Methods: This research is a descriptive study with a cross-sectional approach using secondary data taken from the medical records of acute ischemic stroke inpatients at the Stroke Unit of Dr. Soedono General Hospital, Madiun, East Java admitted in January-December 2015. Results of lipid profile examination consisting of total cholesterol, LDL, HDL, and triglycerides were categorized as high, normal, and low based on their respective levels.Results: There were 72 subjects selected using simple random sampling. Level of total cholesterol was high in 52.78%, normal in 36.11%, and low in 11.11% of the subjects. Level of LDL was high in 54.17%, normal in 22.22%, and low in 23.61% of the subjects. Level of HDL was low in 31.94%, normal in 50.00%, and high in 18.06% of the subjects. Level of triglycerides was high in 26.39%, normal in 33.33%, and low in 40.28% of the subjects.Conclusion: Total cholesterol and LDL are generally high, HDL is generally normal, while triglycerides is generally low among acute ischemic stroke patients in Dr. Soedono General Hospital, Madiun, East Java.

Corneal Curvature Measurements Utilizing a New Swept-source Optical Coherence Tomography Tomey OA-2000® and Comparison With IOL Master® 500 in Pterygium Patients Hilmi, Mohd Radzi; Mohd Kamal, Khairidzan; Che Azemin, Mohd Zulfaezal; Ithnin, Mohd Hafidz; Md Mustafa, Md Muziman Syah; Yusof@Alias, Firdaus; Ahmad, Norsham
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Corneal curvature (CC) is an important anterior segment parameter. This study compared CC measurements conducted with two optical devices in pterygium eyes.Methods: Sixty pterygium eyes of 30 patients were enrolled in this study. CC was measured three times with the optical biometer and topography-keratometer Tomey OA-2000 (Tomey Corporation, Nagoya, Japan), then with partial optical coherence interferometry (PCI) IOL Master 500 (Carl Zeiss Meditec, Dublin, CA) and data were statistically analysed.Results: The measurements revealed in a mean CC of 43.86 ± 1.57 D with Tomey OA-2000 and 43.84 ± 1.55 D with IOL Master. Distribution of data is normal, and no significance difference in CC values was detected (P = 0.952) between the two devices. Correlation between CC measurements was highly significant (r = 0. 99; P < 0.0001). The mean difference of CC values between devices was 0.017 D and 95% limit of agreement was -0.088 to 0.12. Duration taken for measurements with the standard biometer IOL Master was longer (55.17 ± 2.24 seconds) than with Tomey OA-2000 (39.88 ± 2.38 seconds) in automatic mode. Duration of manual measurement with Tomey OA-2000 in manual mode was shorter (28.57 ± 2.71 seconds).Conclusion: In pterygium eyes, CC measured with Tomey OA-2000 and IOL Master showed similar values, and high correlation was observed between these two devices. This shows that both devices can be used interchangeably. Tomey OA-2000 is better in terms of faster to operate and has its own topography systems.

The Role of Exercise and Mitochondrial Biogenesis in Aging Process Nasihun, Taufiqurrachman
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Aging can be defined as the progressive accumulation of changes with time associated with increasing vulnerability to disease and death which accompanies advancing age. The time related changes are attributed to the aging process (Harman, 1981). There are growing evidences that a number of the detrimental free radicals reactions are continuously occur throughout the cells of the body constituting the prominent contributor to aging process (Harman, 1981). This theory was extended to mitochondrial theory of aging, suggesting that mitochondria as the main source and target of reactive oxygen species (ROS) produced in association with aging processes and degenerative diseases (Payne and Chinnery, 2015). Mitochondria has a pivotal roles in multiple cellular processes such as oxidative phosphorylation (OXPHOS), apoptosis, b-oxidation of fatty acids, steroid biosynthesis, calcium homeostasis, intermediary metabolism, and cell signaling (Yin and Cadenas, 2015). Recent studies indicated that oxidative damage due to accumulation of ROS result from mitochondria production were associated with multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging (Cedikova et al., 2016).

CORRELATIONS BETWEEN ATTITUDES AND RATIONAL USE OF ANTACID IN SELF MEDICATION (Study on Health Students of Universitas Muhammadiyyah Malang) Husniar, Witri Rochaeni; Pristianty, Liza; Hidayati, Ika Ratna
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): January - June 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v9i1.1060

Intoduction: Self-medication is the selection and use of modern drugs, herbs, and traditional medicines by individuals to overcome diseases or symptoms of disease. One mild disease that can be treated with self-medication is gastritis. The over-the-counter medication which is frequently used in treating gastritis in self- medication is antacid.Objective: To determine the correlation between attitudes and antacid rational use in self-medication among health students at the Universitas Muhammadiyah Malang.Methods: observational analytic method using questionnaire was used for this study. The sample consist of 97 people who met inclusion criteria. Sampling was done by purposive sampling method, then the data were analyzed using Rank Spearman analysis using SPSS. This research was conducted at the campus II, Universitas Muhammadiyah Malang.Results: The results showed that 97 students of health had negative attitudes of 42% (41) and positive attitude of 58 % (56). The rational use of antacid drugs as much as 60% (58), the irrational use of drugs is 40% (39). Results of analysis using Spearman rank correlation test values were rcount 0.680 > rtable 0.202.Conclusion: The results of this study indicated that there is a significant correlation between a positive attitude to the antacid rational use in self-medication on Health Students of Universitas Muhammadiyah Malang

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