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Sainsmedika
Published by Universitas Islam Sultan Agung
ISSN : 20851545     EISSN : 2339093X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.
Arjuna Subject : -
Articles 184 Documents
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Acute Central Nervous System Infection : a Case Report Masfiyah Masfiyah; Rebriarina Hapsari; Rahayu Rahayu; Maryani Maryani
Sains Medika Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v4i2.377

Abstract

Background : Acute central nervous system infection can be rapidly progressive, causing death or permanent damage in a short period of time. The diagnosis and knowledge of possible etiological agent is critically important. We present a case of a 15-month-old girl with generalized seizures and ecchymosis suspected for meningococcal infection but there was no proof of the agent of infection.Case report : A 15-month-old girl was admitted with fever of 39,4°C, generalized seizures, and petechiae after suffered high fever and cough in previous day. This was her first episode of seizures. She has no past history of growth and developmental disorder. She became rapidly deteriorated after few hours being hospitalized in Kariadi. Brain CT-scan was not done due to her conditions. She had anemia, normal white blood count, monocytosis, thrombocytopenia (4000/mm3), low CD4 count (99 cell/mm3), hipoalbuminemia (1.4 g/dl), increased lactate (2.5 mmol/L) and procalcitonin (>200.00 ng/ml). Cerebrospinal fluid analysis revealed normal cells count and glucose but increased protein level (375.2 mg/dL). Meningococcal infection was suspected due to clinical appearance, and ceftriaxone was given. Bacteriological and fungal culture of CSF and blood showed no growth. Despite of cardiorespiratory support given, she died after 4 days of admission.Discussion : Features of seizure and general ecchymosis do not belong exclusively to meningococcal infection. There are other possible etiological agent such as Haemophylus influenza, Streptococcal infection and viral infection. Shortage of available diagnostic tools such as Polymerase Chain Reaction (PCR) made it difficult to confirm the etiological agent (Sains Medika, 4(2):204-209).Question Remarks : What agent which you think cause the infection?
Lip Reconstruction Using Radial Forearm Freeflap After Radical Excision of Squamous Cell Carcinoma: A Case Report Eko Setiawan; Erythrina Permata Sari
Sains Medika Vol 10, No 2 (2019): July-December 2019
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v10i2.1661

Abstract

INTRODUCTION: The main treatment modality for squamous cell carcinoma of the head and neck is by surgical wide excision. Post-excision reconstructive surgery is essential for restoring aesthetics and function. Fasciocutaneous free-flap is an acceptable method for reconstructing a wide lession of the face since the technique does not cause significant morbidity.CASE REPORT: A 41 year-old female was diagnosed with squamous cell carcinoma (T3N0M0) of the inferior lip after achieving tumor-free margin radical excision. Reconstruction of the defect was made with radial forearm freelap followed by a three-phase refinement flap. The patient was left with a aesthetically acceptable lip without other facial morbidity.DISCUSSION: Reconstructive surgery following a widely excised tumor of the lips requires special attention because of its important physical and aesthetical role. Radial forearm freeflap causes minimal facial morbidity since the technique does not require donor tissue from the face. Other benefits include adequate tissue thickness, minimal contracture and unaltering skin color. Further refinement flaps is needed to complete the reconstruction process.CONCLUSION: Radial forearm free flap is a good choice for reconstruction a wide lession following a wide excision of lip tumor.
The Correlation between Mothers’ Knowledge and Attitude following Posyandu and Weight Gain in Children Aged 2-3 Years in Sawah Besar Village, Gayamsari District of Semarang Anis Fitriyani; Nuke Devi Indrawati
Sains Medika Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v5i1.361

Abstract

Minister of health decree No. 1457/ MENKES/ SK/ 2003 states that the minimum service standard in health sector for growth monitoring activitiesat integrated service post (Posyandu) in the office of Semarang Municipality targeted 80.17% children gain wight. But the gaining weight infants in the District Gayamsari were 72.09%.The study seeks to know the corelation between the level of knowledge and atittude of mothers following Posyandu and weight gain in children aged 2-3 years in the Sawah Besar Village Gayamsari District of Semarang. This study was a cross-sectional study a using a questionner. A sample were 87 mothers who had children aged 2-3 years in the Village and following the Sawah Besar Posyandu from total population 690 children were selected using a proportionate random stratified sampling method. The finding indicates that 46 % mothers had enough knowledge 48.3% mothers showed ‘not good’ attitute. Most of the children (59.8%) did not gain weight. There was a correlation between the mothers’ level of knowledge and attitute and the weight gain in children aged 2-3 years.
Comparison of Serum Interleukin-6 (Il-6) Levels Between Patients With HELLP Syndrome Versus Normotensive Pregnant Eugenius Phyowai Ganap; Sulchan Sofoewan; Risanto Siswosudarmo
Sains Medika Vol 9, No 2 (2018): July-December 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v9i2.3630

Abstract

Background: Interleukin-6 (IL-6) has been known associated with oxidative stress and endothelial dysfunction, and also has important roles in pathogenesis of preeclampsia. Several studies have demonstrated that there was a significant increase of serum IL-6 levels in preeclamptic compared to normotensive pregnant women. However, study to evaluate serum IL-6 level in pregnant women with HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome is not well documented yet. This study aims to evaluate serum IL-6 levels between women with HELLP syndrome compared to normotensive pregnant.Methods: The research design was observational cross-sectional study. Samples were recruited consecutively using inclusion and exclusion criteria from emergency department and inpatient wards at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Serum IL-6 were collected from venous blood sample and measured by enzyme-linked immunoassay (ELISA) method. Independent-samples t-test or Mann-Whitney test was used to compare serum IL-6 values between women with HELLP syndrome and normotensive pregrnancy. A statistical measurement conducted using SPSS IBM Statistics 19® and considered significance when p<0,05.Results: There were 46 subjects, consisted of 23 women with HELLP syndrome and 23 women with normotensive pregnancy. Serum IL-6 level was a mean of 0,11±0,08 pg/mL and 0,15±0,20 pg/mL in women with HELLP syndrome compared to normotensive pregnancy respectively. There was no significant statistical difference between both groups (p=0,17).Conclusion:.The result of this study has shown that no significant difference of serum IL-6 level in HELLP syndrome women compared to normotensive pregnant women. 
Overview of The Incidence and Risk Factors for Nosocomial Infections Using a Geographic Information System Maps Rochady Setianto; Lutfan Lazuardi; Andaru Dahesihdewi
Sains Medika Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v5i2.345

Abstract

Hospitalized patients have a high risk of getting nosocomial infections due to various reasons. They tend to be more susceptible to infection because oftheir underlying disease condition, and they have higher when patients undergo invasive procedures. If the patient’s immune system is impaired, thenon-pathogenic microorganism are capable of causing disease. Map is a method of illustrating an epidemiologic effectively . Maps can be used to showplace of incidence. Mapping the incidence of nosocomial infections in Sultan Agung Hospital is a method developed for the surveillance of nosocomialinfections. This type of research is a quantitative study with a cross sectional design. This study illustrates the risk factors of nosocomial infection withincidence of nosocomial infections that occur based on time point. Risk factors are extrinsic and intrinsic factors. Based on the spatial image on the map,in extrinsic incidence of nosocomial infections is Plebitis. Genesis Plebitis incidence correlates with the placement of hand washing points handrub. Whilethe intrinsic factor in the Plebitis image and ILO most inpatient distribution in patients aged 50 years with impaired skin integrity due to infusion andphysically due to decreased immunity associated with a variety of underlying diseases. Incidence of nosocomial infections in the inpatient unit is theprimary predisposing factors such as age and clinical issues related predisposing underlying disease can weaken the immune system of the patient, so thatthe procedures and even the most basic medical treatment could potentially cause nosocomial infection.
Development of Anti Acne Cream (w/o/w Multiple Emulsion) Containing Green Tea Leaf Waste Naniek Widyaningrum
Sains Medika Vol 8, No 2 (2017): July-December 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v8i2.2030

Abstract

Background: To date, green tea leaf waste is not well utilized, the waste is remain considered as a waste. Previous studies found that green tea leaf waste still have a fairly high EGCG content. EGCG has benefits as an antibacterial. Utilization of green tea leaf waste started from formulation until the diversification of multiple emulsion w/o/w products has not been reported.Objective: To develop anti acne cream (W/O/W) multiple emulsion containing green tea leaf waste and evaluate its antibacterial activity against acne-inducing bacteria of Propionibacterium acnes (P.acnes).Methods: Phase one of this research was green tea leaves was extracted by infundation and fractionation method using ethyl acetate and prepared in different concentration (1% to 6%). The second stage was ethyl acetate fraction of green tea leaf extract was tested for its antibacterial activity against P.acnes. Third stage was tested physical properties of formulation with w/o/w multiple emulsion.Results: The optimal antibacterial activity of ethyl acetate fraction of green tea leaf extract against P.acne was at the concentration of 6%, with inhibition zone of 32.6 mm ±0.57. The formula of w/o/w multiple emulsion loaded with green tea leaves waste of 6% active substance demonstrated a good physical properties which can spread 90.4 cm2 ± 0.03, pH 5.00 ± 0.02 and microscopic analysis showed multiple emulsion w/o/w.Conclusion: The concentration of 6% green tea leaf waste formulated in multiple emulsion had a good physical and antibacterial activity for a referred standard. It is necessary to test the stability of multiple emulsion formula.
Uji Efikasi Obat Nyamuk Bakar dengan D-Allethrin 0,2% terhadap Vektor Malaria di Desa Gembong, Kecamatan Kandangserang, Kabupaten Pekalongan
Sains Medika Vol 1, No 1 (2009)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v1i1.1678

Abstract

Mixed Lung Cancer in 46 Years Old, Male Smoker, Untreated Patient Susilorini Susilorini; Dik Puspasari; Siti Amarwati; Bambang Endro
Sains Medika Vol 7, No 2 (2016): July-December 2016
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v7i2.1178

Abstract

Lung cancer is a large heterogeneous family of malignancies, with tumors containing more than one subtype are very common. Over 50 different histologi­cal variants are recognized within the WHO typing system. Small Cell Lung Cancer comprises approximately 20% of all lung cancers and exhibits a neuroendocrine phenotype while Non Small Cell Lung Carsinoma (NSCLC) lacks these features and makes up the remaining 80% of cases. This case was reported in view of the rarity of this combination of morphologic patterns. The incidence of c- SCLC (Combined- Small Cell Lung Carsinoma) has been reported ranging from less than 1% to 14.6% of all SCLC. Mixed lung cancer in untreated patients suggests a common endodermal origin for c-SCLC which contains small-cell and non-small-cell pulmonary tumors. Quoix et al found that presentation as a solitary pulmonary nodule (SPN) is particularly indicative of a c-SCLC. Combined- Small Cell Lung Carsinoma contains a squamous cell and/or adenocarcinoma component. It’s becoming more important for pathologists to correctly subclassify NSCLC’s as distinct tumor entities, or as components of c-SCLC cause it’s more agrresive. A 46-year-old smoker man was referred because of rapid growth of a solitary nodule mass revealed by chest radiography with brain and limfonodes metastases. There was mixed histological feature including adenocarsinoma, squamous cell carsinoma and large cell carsinoma. The patient is dead after a few weeks later. It was revealed a panel immunohistochemistry stain (CK-7, CK-20, TTF-1, P63 and Chromoganin). It was concluded as c- SCLC.
Flavonoids and Aging Taufiqurrachman Nasihun
Sains Medika Vol 7, No 1 (2016): January - June 2016
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v7i1.998

Abstract

Aging is inevitable process, however human comes into aging is in difference way and difference rates. Some of them undergo aging earlier due to degenerative diseases, unable to reach the maximum lifespan and are thus denominated secondary aging (Huebschmann AG, 2011). Some of others undergo aging latter, looked younger than their truely chronological age, have no suffer degenerative disease, able to achieve maximum lifespan and so called primary aging (De la Fuente, 2009; Huebschmann AG, 2011). Maximum lifespan or often called longevity of the species is defined as maximum time that a species belonging to determine how long the species can live, for example maximum lifespan in human beings is 122 years, whereas the lifespan in rats and mouse strains is only 3 and 4 years respectively (De lafuente, 2009). It must be distinguished this longevity from mean or averages longevity. Average longevity can be defined as the average of time that member of population that have been born on the same date live (De la Fuente, 2009). The maximum lifespan is fixed in each species, meanwhile the lifespan of individual subject in the population, even when their genotype are the same and grow in a common environment condition, such as protected from external hazard show marked variability (Kirkwood, 2005).
The Effect of Honey Administration on Gastrohistopathological Image Study In Male White Wistar Rat Induced With Indomethacin Agus Suprijono; Setyo Trisnadi; Henri Perwira Negara
Sains Medika Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26532/sainsmed.v3i1.407

Abstract

Background: Gastric disorder often generates clinical symptoms such as gastritis or peptic ulcer. Bee honey has high nutrient has been shown to have a protective effect against drugs destroying stomach. The purpose of this study was the difference effect of honey in various concentrations on the gastrohistopathological image in male white Wistar rat induced with indomethacin. Design and Methods: This was an experimental research using control group post test design. 24 male white rats Wistar were randomly divided into 6 groups of 4 mice each. Group I served as the control group (standar and aquades), group II: 3.78 mg of indometachin, group III: 3.78 indomethacin and 3.6 ml honey (25%,) group IV: 3.78 indomethacin 3.6 ml honey (50%,) group V: 3.78 mg indomethacin 3.78 mg and 3.6 ml (75%(), group VI: 3.78 indomethacin 3,78 mg and honey 3.6 ml 100%. Treatment given by sonde once a day for 15 days. the gastrohistopathological image was evaluated for degree of gastritis and degree of peptic ulcer. The data were tested with test Kruskal-Wallis followed by Mann-Whitney test. Results: Kruskal-Wallis test showed at least significant differences in the degree of gastritis and peptic ulcer between between the two groups (p <0.05). Mann-Whitney test howed that not all groups compared to control showed a significant different in the degrees of gastritis and peptic ulcer. Conclusion: The study suggested that honey have effect on the gastrohistopathological image of indomethacin-induced stomach (Sains Medika, 3(1):41-47).

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