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FAKULTAS FARMASI UNIVERSETAS JENDERAL ACHMAD YANI Jl. Terusan Jenderal Sudirman PO BOX 148, Cimahi, Jawa Barat, 40531, Indonesia
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Kartika : Jurnal Ilmiah Farmasi
Published by Universitas Jenderal Achmad Yani
ISSN : 23546565     EISSN : 25023438     DOI : https://doi.org/10.26874/kjif.v6i1.135
Core Subject : Health, Science, Social,
Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences
Kartika: Jurnal Ilmiah Farmasi (KJIF) merupakan media publikasi ilmiah dalam bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Jenderal Achmad Yani, bekerjasama dengan Ikatan Apoteker Indonesia (PD IAI Jawa Barat). Ruang lingkup artikel yang diterbitkan adalah: Farmasetika, Kimia Farmasi, Kimia Analisa, Farmasi Fisika, Farmakognosi dan Etnobotani, Natural Produk, Farmakologi dan Toksikologi, Praktik Kefarmasian dan Farmasi Rumah Sakit, Farmakogenomik, Farmakoekonomi, Studi Kasus dan Uji Klinis.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
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Search results for , issue "Vol 7 No 1 (2019)" : 8 Documents clear
Minimum Inhibitory Concentration Determination of Bambusa vulgaris Leaves Extract Against Skin and Digestive Diseases Bacteria Kelly Zhiang; Rafika Sari; Pratiwi Apridamayanti
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.158

Abstract

Infections that are commonly happened in developing countries such as Indonesia are skin infection that caused by Staphylococcus aureus and Staphylococcus epidermidis, and digestive infection that caused by Bacillus subtilis and Bacillus cereus. The ethanol extract of Bambusa vulgaris leaves contained metabolite compounds that potential to have antibacterial activity. This study aimed to determine MIC (Minimum Inhibitory Concentration) value of ethanol extract of Bambusa vulgaris leaves against those four bacteria. The research was conducted by Kirby-Bauer disc diffusion method using ethanol extract of Bambusa vulgaris leaves with concentration variations of 80 mg/mL, 40 mg/mL, 20 mg/mL, 10 mg/mL, 5 mg/mL, 2.5 mg/mL, and 1.25 mg/mL. The results showed that ethanol extract of Bambusa vulgaris leaves can inhibit the growth of all four bacteria with MIC value against Staphylococcus aureus and Bacillus subtilis is 20 mg/mL, with inhibition zone diameter of 7,33 ± 0,416 mm and 6,32 ± 0,057 mm respectively. While the MIC value against Staphylococcus epidermidis and Bacillus cereus is 10 mg/mL, with inhibitory zone diameter obtained respectively 7,33 ± 0,416 mm and 6,07 ± 0,029 mm. The conclusion of this research was that ethanol extract of Bambusa vulgaris leaves had inhibition zone with MIC value 20 mg/mL against Staphylococcus aureus and Bacillus subtilis, and 10 mg/mL against Staphylococcus epidermidis and Bacillus cereus.Keywords: Ethanol extract of Bambusa vulgaris leaves, antibacterial, disc diffusion, MIC (Minimum Inhibitory Concentration)
Efek ekstrak daun sirih (Piper betle L.) pada pengobatan scabies hewan ternak kambing kacang (Capra hircus) Nur Sriani Rezki; Abdul Wahid Jamaluddin; Muhammad Fadhlullah Mursalim
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.170

Abstract

Salah satu penyakit infeksi parasit yang sering dijumpai mengganggu ternak kambing adalah scabies disebabkan oleh Sarcoptes scabiei. Penelitian ini bertujuan untuk menguji efek ekstrak daun sirih (Piper betle L.) pada kambing kacang (Capra hircus) yang terinfeksi scabies. Hewan uji dikelompokkan menjadi 5 perlakuan, yaitu kontrol positif, kontrol negatif, ekstrak daun sirih  10, 20 dan 30%. Parameter yang diamati adalah adanya alopecia, penebalan dan keropeng pada permukaan luka. Hasil pengamatan menunjukkan ekstrak daun sirih 10, 20 dan 30% memberikan aktivitas yang baik terhadap penyembuhan scabies pada kambing kacang, dimana efek terbaik diberikan oleh ekstrak daun sirih 30%. Kata Kunci:  ekstrak daun sirih, kambing Kacang, scabies Effects of betel leaf extract (Piper betle L.) on the treatment of scabies for sheep goats (Capra hircus) Abstract One of the parasitic infectious diseases that are often found to interfere with goat livestock is scabies caused by Sarcoptes scabiei. This study aimed to examine the effect of betel leaf extract (Piper betle L.) on scabies-infected goat (Capra hircus) goats. Test animals were grouped into 5 treatments, namely positive control, negative control, betel leaf extract 10, 20 and 30%. The parameters observed were the presence of alopecia, thickening and scab on the wound surface. Observation results showed that betel leaf extracts of 10, 20 and 30% gave a good activity to cure scabies in goat nuts, where the best effect was given by 30% betel leaf extract. Keywords: extract betel leaf, Indonesian native Kacang goat, scabies
SURVEY TENTANG KEMAMPUAN BEKERJA SAMA APOTEKER DI BALI Desak Ketut Ernawati; Ketut Agus Adrianta
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.171

Abstract

Abstrak Tenaga kesehatan diharapkan mampu bekerja sama dengan profesi lain pada pelayanan kesehatan sehingga kurangnya kemampuan bekerja sama dapat menghambat pelayanan kesehatan yang efektif. Penelitian ini dilakukan untuk mengetahui pemahaman apoteker dalam bekerja sama dengan profesi lain. Penelitian merupakan penelitian potong selintang dengan menggunakan survey kolaborasi yang terdiri dari 13 pernyataan tentang pemahaman kemampuan bekerja sama yang diberikan skala dari tidak ada sampai sangat baik (1-5). Faktor yang diteliti adalah pengetahuan dan ketrampilan bekerja sama. Survey menggali hal-hal yang dibutuhkan oleh apoteker dalam bekerja sama dengan profesi kesehatan lain dan hambatan apoteker dalam bekerja sama dengan profesi lain. Survey diberikan kepada seluruh apoteker yang menghadiri Konferensi Daerah di Bali pada pertengahan Tahun 2018. Data dianalisa dengan menggunakan SPSS versi 22. Total responden yang mengikuti survey adalah 274, 52,8% responden bekerja di apotek, 24,7% bekerja di dan 5% bekerja di klinik. Analisis Anova menunjukkan terdapat perbedaan bermakna dalam pengetahuan (p=0,001) dan ketrampilan dalam bekerja sama (p=0,03) berdasarkan tempat bekerja. Hasil kualitatif diperoleh hasil bahwa hal yang dianggap penting oleh apoteker dalam berkolaborasi antara lain kemampuan berkomunikasi, adanya wadah untuk berkomunikasi serta pemahaman tentang peranan tugas dan tanggungjawab profesi lain sehingga kurangnya hal l tersebut merupakan faktor penghambat kemampuan bekerja sama dengan profesi lain. Disarankan dimasa depan diperlukan kegiatan yang dapat meningkatkan kemampuan bekerja sama antar profesi kesehatan.   Kata kunci: Apoteker, ketrampilan, pengetahuan bekerja sama A survey of collaborative competencies amongst pharmacist in Bali  Abstract Healthcare professional are expected to be able to work together with other professions in the health service. So that the lack of ability to work together can hamper effective health services. This research was conducted to determine the understanding of pharmacists in collaboration with other professions. The research is a cross-sectional study using a collaborative survey consisting of 13 statements about understanding the ability to work together given a scale from none to very good (1-5). The factors studied are the knowledge and skills to work together. The survey explores the things needed by pharmacists in working with other health professions and the obstacles of pharmacists in working with other professions. The survey was given to all pharmacists who attended the Regional Conference in Bali in mid-2018. Data were analysed using SPSS version 22. Total respondents who took the survey were 274, 52.8% of respondents worked in pharmacies, 24.7% worked in and 5% work in the clinic. Anova analysis showed that there were significant differences in knowledge (p = 0.001) and skills in working together (p = 0.03) based on the place of work. Qualitative results obtained result that what is considered important by pharmacists in collaboration include the ability to communicate, the existence of a place to communicate and an understanding of the role of duties and responsibilities of other professions so that this lack of l is an obstacle to the ability to cooperate with other professions. It is suggested that in the future activities are needed that can improve the ability to work together between healthcare professional. Keywords: Knowledge in collaboration; skills in collaboration; pharmacist
UJI AKTIVITAS ANTIOKSIDAN DAN ANTIKANKER EKSTRAK BATANG MURBEI (MORUS ALBA L.) TERHADAP SEL KANKER WIDR SECARA IN VITRO Asril Burhan; Andi Nur Aisyah; Akbar Awaluddin; Zulham Zulham; Burhanuddin Taebe; Abdul Gafur
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.173

Abstract

Abstrak Murbei merupakan salah satu obat yang penting didalam pengobatan tradisional Cina. Murbei mengandung berbagai macam senyawa diantaranya fenol dan flavanoid yang umunya berfungsi sebagai antioksidan alami dan juga memiliki fungsi antikanker. Penelitian ini bertujuan untuk mengetahui kadar fenolik, aktivitas antioksidan dan antikanker ekstrak batang murbei (Morus alba L.). Pembuatan ekstrak dilakukan dengan cara maserasi menggunakan pelarut etanol. Penetapan kadar fenolik menggunakan reagen Folin-Ciocalteu, pengujian aktivitas antioksidan menggunakan metode ABTS dan pengujian aktivitas antikanker menggunakan metode MTT terhadap sel kanker WIDR dan sel vero. Hasil pengujian menunjukkan kadar total fenolik ekstrak batang murbei sebesar 35,9%. Nilai aktivitas antioksidan ekstrak batang murbei adalah  83,18 µg/mL. Aktivitas antikanker pada sel WIDR menunjukkan nilai IC50 71,24 µg/ml dan pada sel vero memiliki nilai IC50 154,241 µg/ml. Dapat disimpulkan bahwa ekstrak etanol batang murbei (Morus alba L.) memilki aktivitas antioksidan yang kuat dan berpotensi sebagai antikanker alami yang bekerja selektif terhadap sel kanker. Kata kunci : Murbei (Morus alba L.), batang, IC50, antioksidan, antikanker Antioxydant and anticancer effect of murberry (Morus alba L.) stem extract in vitro Abstract Mulberry is one of the important medicines in traditional Chinese medicine. Mulberry contains a variety of compounds including phenols and flavonoids which generally function as natural antioxidants and also have anticancer functions. This study aims to determine phenolic levels, antioxidant activity and anticancer of mulberry stem extract (Morus alba L.). Extracts were made by maceration using ethanol as a solvent. Determination of phenolic levels using the Folin-Ciocalteu reagent, testing of antioxidant activity using the ABTS method and testing of anticancer activity using the MTT method against WIDR cancer cells and vero cells. The test results showed total phenolic levels of mulberry stem extract amounted to 35.9%. The antioxidant activity value of mulberry stem extract was 83.18 µg / mL. Anticancer activity in WIDR cells showed IC50 values 71.24 µg / ml and vero cells had IC50 values 154.224 µg / ml. It can be concluded that the ethanol extract of mulberry stem (Morus alba L.) has a strong antioxidant activity and has the potential as a natural anticancer that works selectively against cancer cells. Keywords: Mulberry (Morus alba L.), stem extract, IC50, antioxidant, anticancer
Aktivitas antihiperurisemia teh asam daun tin (Ficus carica) terhadap tikus putih (Rattus norvegicus) Sierra Aprilia Junaidah Az-Zahro; Siti Humaira Umami; Uswatun Hasanah; Ernanin Dyah Wijayanti
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.176

Abstract

AbstrakTin (Ficus carica) merupakan tanaman yang memiliki aktivitas antioksidan sehingga dapat digunakan sebagai alternatif pengobatan penyakit degeneratif salah satunya yaitu hiperurisemia. Aktivitas antioksidan tersebut dapat ditingkatkan melalui proses fermentasi. Hasil dari proses fermentasi tersebut berupa teh asam. Tujuan penelitian ini adalah untuk mengetahui aktivitas antihiperurisemia teh asam daun tin pada tikus putih (Rattus norvegicus). Pengujian dilakukan terhadap 5 kelompok kontrol negatif (Pakan tinggi purin 10,8 ml/kgBB), kontrol positif (Allopurinol 9 ml/kgBB), teh asam daun tin dosis 20, 25 dan 30 ml/kgBB. Pemberian sediaan uji setiap hari selama 8 hari. Pengukuran kadar asam urat dengan menggunakan metode fotometrik enzimatis. Pengambilan sampel darah melalui vena jantung pada hari ke 22. Hasil pengukuran kadar asam urat dengan pemberian teh asam daun tin dengan dosis 30 ml/kgBB menunjukkan kadar asam urat paling rendah dibandingkan dengan kontrol positif. Dapat disimpulkan bahwa teh asam daun tin dengan dosis 30 mL/kgBB memiliki aktivitas antihiperurisemia terhadap hewan uji. Kata Kunci: antihiperurisemia, fermentasi kombucha, teh asam daun tin.Antihyperuricemic activity of fig (Ficus carica) sour tea on male rat (Rattus norvegicus) AbstractFig (Ficus carica) are known to have antioxidant activity, thus it can be used as an alternative treatment of degenerative diseases, such as hyperuricemia. The antioxidant activity of Fig can be increased by the fermentation process. The result of the fermentation process is sour tea. This study aimed to investigate the antihyperuricemic activity of Fig (Ficus carica) sour tea on male rat (Rattus norvegicus). This research was a True experiment study with the design of Post Test Control Group. Research samples were divided into 5 groups, in which there were 3 rat in each group. Group 1 was the positive control (Allopurinol 1,8 ml/200grBW), and Group II was the negative control (High purin diet 2,16 ml/grBW). In addition, the Group III, IV, and V were the experimental group with different dose of sour tea of Fig; 4ml/200grBW/day, 5ml/200grBW/day, and 6ml/200grBW/day for 8 days. Identification of uric acid levels was performed using enzymatic photometric method. Meanwhile, the serum samples were taken from the heart vein on the 22nd day of experiment. The results the best dose of sour tea of Fig in lowering the level of uric acid in male rat (Rattus norvegicus) was 6 ml/200grBW/day (3,87 mg/dl) compared to the positive controls which had the average level of 4,2 mg/dl. In addition, the result of One Way ANOVA demonstrated the significant difference in the probability value of 0,05. Therefore, it can be concluded that sour tea of Fig (Ficus carica) can effectively lower the uric acid level of male (Rattus norvegicus). Keywords: antihyperuricemic, kombucha fermentation, sour tea of Fig leaves.
Studi etnomedicine pengobatan luka terbuka dan sakit kulit pada beberapa etnis di Provinsi Kalimantan Timur Rohmat Mujahid; Slamet Wahyono; Wahyu Joko Priyambodo; Dyah Subositi
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.178

Abstract

Abstrak Pemetaan penggunaan tumbuhan sebagai obat dan jamu di Kalimantan Timur telah dilakukan dalam bentuk riset tanaman obat dan jamu (RISTOJA) 2015. Eksplorasi dilakukan terhadap 5 etnis yaitu Bahau, Berau, Apokayan, Kutai dan Bentian. Data dikumpulkan dari 5 orang pengobat dan penyehat tradisional (hattra) pada masing-masing etnis yang dipilih secara purposive untuk memperoleh data terkait penggunaan tumbuhan dalam pengobatan. Sejumlah 520 ramuan dikelompokkan dalam 70 jenis keluhan/penyakit. Diperoleh 47 ramuan yang dapat digunakan untuk pengobatan luka terbuka dan sakit kulit, dengan 25 ramuan untuk pengobatan luka terbuka dan 22 ramuan utnuk pengobatan sakit kulit. Hasil identifikasi tumbuhan yang digunakan pada ramuan menunjukkan ada 27 tumbuhan yang digunakan pada ramuan luka terbuka dan 26 tumbuhan yang digunakan pada ramuan sakit kulit. Identifikasi tumbuhan menunjukkan adanya 39 jenis tumbuhan dimana 14 jenis diantaranya memiliki lebih dari 1.000 publikasi terkait penggunaan secara medis dan penggunaan sebagai anti bakteri dan hanya 7 jenis diantaranya yang memiliki publikasi kurang dari 100. Kata kunci : Riset Tanaman Obat dan Jamu, RISTOJA 2015, luka terbuka, sakit kulit, etnis Ethnomedicine studies on treatment of open wounds and skin aches in several ethnicities in the province of East Kalimantan Abstract Mapping the use of plants as medicine and herbal medicine in East Kalimantan has been carried out in the form of research on medicinal plants and herbs (RISTOJA) 2015. Exploration is carried out on 5 ethnic groups namely Bahau, Berau, Apokayan, Kutai and Bentian. Data were collected from 5 traditional healers (hattra) in each ethnic who were selected purposively to obtain data related to the use of plants in medicine. A total of 520 herbs are grouped into 70 types of complaints / diseases. Obtained 47 ingredients that can be used for the treatment of open wounds and skin ailments, with 25 herbs for the treatment of open wounds and 22 herbs for the treatment of skin ailments. The results of the identification of plants used in the concoction showed that there were 27 plants used in the open wound herb and 26 plants used in the skin ache mixture. Plant identification shows that there are 39 species of plants where 14 of them have more than 1,000 publications related to medical use and anti-bacterial use and only 7 of them have less than 100 publications. Keywords : Riset tumbuhan obat dan jamu, wounds, skin aches, ethnic
Aktivitas ektrak etanol Lansau, ramuan tradisional suku etnis Muna, terhadap perbaikan fungsi ginjal Ruslin Ruslin; Henny Kasmawati; Munarsi Munarsi; Sundar Ihsan; Suryani Suryani
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.200

Abstract

Abstrak Lansau adalah ramuan tradisional masyarakat Suku Muna Sulawesi Tenggara yang terdiri dari 44 jenis tanaman yang dipercaya oleh masyarakat setempat berkhasiat untuk mengobati berbagai macam penyakit. Lansau telah digunakan selama ratusan tahun secara turun temurun. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol ramuan lansau terhadap histopatologi organ ginjal pada model hewan yang mengalami kerusakan fungsi ginjal dengan induksi kombinasi injeksi gentamisin 3,6 mg/kgbb dan suspensi oral piroksikam 100 mg/kgbb. Hewan uji tikus dikelompokkan menjadi 6 kelompok, yaitu normal, kontrol negatif, kontrol positif, ekstrak etanol lansau dosis 6,90; 13,81 dan 27,62 mg/kg bb. Pemberian bahan uji dilakukan secara oral setiap hari selama 4 minggu. Pada minggu kelima hewan dikorbankan, dilakukan pembedahan dan diamati histopatologi organ ginjal meliputi tubulus normal, degenerasi sel tubulus, nekrosis sel tubulus, penyempitan lumen tubulus, adhesi dan atrofi glomerulus. Hasil pengamatan menunjukkan ektrak etanol lansau dosis 6,90; 13,81 dan 27,62 mg/kgbb memiliki kemampuan dalam menghambat kerusakan fungsi ginjal.  Berdasarkan histopatologi organ ginjal pemberian ekstrak etanol lansau dosis 13,81 mg/kgbb lebih efektif dalam menghambat kerusakan organ ginjal dengan tidak ditemukannya sel yang mengalami degenerasi dan nekrosis.  Kesimpulan dari penelitian ini adalah ektrak etanol lansau mempunyak aktivitas untuk perbaikan fungsi ginjal. Kata kunci: Lansau, suku Muna, histopatologi, perbaikan fungsi ginjal.  The ethanol extract activity of Lansau, a traditional Muna ethnic concoction, on improving kidney function AbstractLansau is a traditional concoction of the Southeast Sulawesi Muna Tribe community which consists of 44 types of plants that are believed by local people to be efficacious for treating various diseases. Lansau has been used for hundreds of generations. The aim of this study was to determine the activity of ethanol extract of elderly herbs against the histopathology of kidney organs in animal models that have impaired kidney function by induction of a combination of gentamicin injection of 3.6 mg / kgbb and oral suspension of piroxicam 100 mg / kgbb. Rat test animals were grouped into 6 groups, namely normal, negative control, positive control, ethanol extract, or 6.90; 13.81 and 27.62 mg / kg bw. Provision of test material is carried out orally every day for 4 weeks. In the fifth week the animals were sacrificed, performed surgery and observed histopathology of kidney organs including normal tubules, tubular cell degeneration, tubular cell necrosis, tubular lumen constriction, adhesion and glomerular atrophy. The observation results showed an ethanol extract of a dose of 6.90; 13.81 and 27.62 mg / kg have the ability to inhibit damage to kidney function. Based on histopathology of kidney organs, the administration of ethanol extract at a dose of 13.81 mg / kg is more effective in inhibiting kidney organ damage with the absence of degenerated and necrotic cells. The conclusion of this study is the ethanol extract of the elderly has activity to improve kidney function.  Keywords: Lansau, Muna ethnic, histopathology, improvement of kidney function.
Formulasi Dan Evaluasi Transdermal Patch Kalium Diklofenak Nira Purnamasari; Fikri Alatas; Dolih Gozali
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 1 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i1.209

Abstract

Abstrak Kalium diklofenak adalah salah satu obat golongan anti-inflamasi non steroid (AINS) yang memberikan efek samping iritasi pada saluran pencernaan. Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan dengan rute alternatif lain penggunaan kalium diklofenak melalui transdermal patch. Patch dibuat dengan metode penguapan pelarut. Polivinil pirolidon (PVP) digunakan sebagai polimer untuk pembentukan patch transdermal kalium diklofenak dengan dibutil ftalat (DBP) sebagai plasticizer dan mentol sebagai peningkat penetrasi. Uji in vitro dilakukan dengan alat difusi modifikasi Franz dan ditentukan dengan spektroskopi UV-sinar tampak. Kadar zat aktif, berat, ketebalan dan organoleptis dari patch juga ditentukan. Hasil penelitian menunjukan bahwa rata-rata uji laju difusi sediaan patch 1,3884 mg/cm2 dengan persen permeasi sebesar 8,9 % selama 180 menit.           Kata Kunci : Transdermal; Patch; kalium diklofenak; mentol. Formulation and Evaluation Patch Transdermal Diclofenac Potassium Abstract Diclofenac potassium is one of the non-steroidal anti-inflammatory drugs (NSAIDs) that provides irritating side effects to the digestive tract. The purpose of this study is to formulate and evaluate preparations with alternative routes of using potassium diclofenac through the transdermal patch. Preparation of the matrix patches used the solvent casting method. Polyvinyl pyrrolidone (PVP) was used as a matrix for the formation of transdermal diclofenac potassium patches, dibutyl phthalate (DBP) as the plasticizer and menthol as the permeation enhancer. The in vitro assay was carried out in a modified Franz diffusion cell and the rates of diffusion were determined by UV spectroscopy. The average drug content, thickness, organoleptic, weight uniformity of the matrix patches was also determined. The results showed that the average dosage rate of diffusion test Patch is 1,3884 mg/cm2 with permeation percentage 8,9 % for 180 minutes.  Keywords: Transdermal; Patch; diclofenac potassium; menthol

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