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International Journal of Integrated Health Sciences
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
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Articles 136 Documents
Chronic Rhinosinusitis Patient with Nasal Polyp Characteristics at Otorhinolaryngology-Head and Neck Surgery Outpatient Clinic, Dr. Hasan Sadikin General Hospital, Bandung Dina Riana; Arif Dermawan; Wijana Wijana; Ongka Muhammad Saifuddin
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate chronic rhinosinusitis (CRS) with nasal polyp (NP) characteristics in patients with routine visits to the Otolaryngology-Head and Neck Surgery outpatient clinic of Dr. Hasan Sadikin General Hospital, Bandung.Methods: This descriptive retrospective cross-sectional study was conducted at the Rhinology-Allergy Outpatient Clinic, Departement of Otolaryngology-Head and Neck Surgery, Dr. Hasan Sadikin General Hospital, Bandung, in the period of January 2014 to December 2014. Data were obtained from medical records and the sampling method used was total sampling. A total of 100 CRS with NP patients were evaluated. Nasal endoscopy examinations were performed. Patients were classified based on age into 10–20 years, 21–31 years, 32–42 years, 43–53 years, and >54 years groups. Results: Chronic rhinosinusitis with NP incidences were mostly found in male patients compared to females. There were several CRS cases with NP risk factors, including smoking and allergy. Conclusions: In the study, CRS with NP patients may possibly have one or more risk factors. Smoking is the major risk factor from CRS with NP after allergy. Keywords: Nasal polyp, nasal endoscopy, rhinosinusitis, risk factor DOI: 10.15850/ijihs.v4n2.834
Multimodal Analgesic Effect on Proinflammatory and Anti-inflammatory Cytokines Serum Muhammad Ramli Ahmad; Tatang Bisri
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To investigate the effect of combination epidural bupivacaine and intravenous parecoxib analgesia on  immune response in patients who underwent open reduction and internal fixation of the lower limb under epidural anesthesia.  Methods: This research was conducted using the randomized, placebo-controlled double blind trial method on 52 patients who were randomly divided into 2 groups: the Parecoxib group which received 40 mg intravenous parecoxib for 30 minutes before incision and the control group which received an equal volume of 0.9% normal saline. Both groups received epidural anesthesia and postoperative epidural 0.125% bupivacaine analgesia continously. Venous blood samples were obtained before parecoxib administration, 2 and 24 hours after the surgery. The data were analyzed using Mann Whitney U and Independent t tests (p<0.05).     Results: There was a significant difference between the two groups (p<0.05) in IL-1β, IL-6, IL-10 levels and proinflammatory to anti-inflammatory ratio, 2 hours after surgery.    Conclusions: Multimodal analgesic combination of 40 mg IV parecoxib and 0.125% bupivacaine epidural analgesia have the effect to alter and stabilize the  systemic immune response.    Keywords: Cytokines, epidural analgesia, interleukins, immune response, parecoxib, tissue damage DOI: 10.15850/ijihs.v2n1.272
Relationship between Periodontal Disease Index and Low Birth Weight Babies in Pregnant Women with Periodontitis Ira Komara; Soertini E Lambri; Ina Hendiani
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To identify the relationship between periodontitis in pregnant women through the periodontal disease index (PDI) and low birth weight babies.Methods: A case-control study was conducted to determine the relationship between periodontitis in pregnant women through the periodontal disease index (PDI) and the low birth weight babies (LBW). The participants were mothers with periodontitis and non-periodontitis mothers aged 20–35 years who gave birth in the Department of Obstetrics and Gynecology-Dr. Hasan Sadikin General Hospital, Bandung in the period of December to January 2005. Results: Based on the chisquare test results a highly significant relationship between periodontitis and low birth weight (p=0.002) was found. The Odd’s ratio showed that the risk of low birth weight in pregnant women with periodontitis was 15.58 times higher compared to those who did not suffer from periodontitis. The periodontal disease index has an accuracy of 88.6% in predicting the incidence of LBW. It strongly influenced the incidence of LBW with a high Odd’s ratio of 28.0. Pregnant women who suffer from periodontitis with a PDI > 3.25, have 19.2 times higher risk for delivering babies with LBW compared to the non-periodontitis mothers. Conclusions: The loss of attachment affects the possibility of delivering LBW babies.Keywords: Periodontitis, periodontal disease index, low birth weight DOI: 10.15850/ijihs.v4n1.681 
Strategy for the Use of Erythropoetin Alpha to Maintain Hemoglobin Level in Breast Cancer Patient Treated with Anthracycline-base of Adjuvant Chemotherapy Dimyati Achmad; Yusuf Hariady Hariady; Benny Isakh; Maman Abdurrahman; Ahmad Faried
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate the value of erythropoietin alpha (epoetin) administration, as an alternative treatment of anemia in the operable breast cancer patients.Methods: This is a multicenter phase III randomized clinical trial to evaluate the value of epoetin administration among anemic breast cancer patients who are undergoing anthracyclin-based adjuvant chemotherapy. Sixty four patients were incuded in this trial with initial hemoglobin (Hb) level of 10–12 g/dL. The patients were randomly distributed into two groups: one group received aministration of 40,000 IU epoetin/week for six times a week after operation and the other did not.  In the third week after the operation, both groups were started on a 6 cycles of adjuvant chemotherapy with three weeks intervals. Hb levels were evaluated during every chemotherapy cycle. Results: The Hb levels in the epoetin group were always above 10 g/dL up until the end of the sixth chemotherapy cycle or until the twenty first week post operation without blood transfusion. Conclusions: The administration of epoetin 3 weeks prior and 3 weeks after the first cycles of chemotherapy, maintains a sufficient/normal Hb level in breast cancer patients receiving anthracycline-based chemotherapy.Keywords: Anthracyclin-based chemotherapy, breast cancer, erythropoietin alpha DOI: 10.15850/ijihs.v1n1.102
Effect of Quadriceps Muscle Strengthening Exercise on Quadriceps and Hamstring Muscle Strength Ratio in Patients with Osteoarthritis Grade 2 and 3 Thomas Sintong Pratama Purba; Marina Annette Moeliono; Sunaryo Barki Sastradimadja
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate the effect of quadriceps muscle strengthening exercise on quadriceps and hamstring strength ratio in knee osteoarthritis (OA). Methods: This was a quantitative study with quasi-experimental design. The subjects in the study were 16 female patients with knee OA grade 2 and 3. Quadriceps muscle strengthening exercise was given to the subjects 3 times a week during 8 weeks. The study was conducted at the Department of Physical Medicine and Rehabilitation of the Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital in August–September 2015. Results: It was revealed that the quadriceps muscles improved significantly. However, the hamstring muscles did not show significant improvement based on the comparison between before and after performing the exercise. The average right quadriceps muscle strength before exercise was 12.46 and after exercise was 18. The average left quadriceps muscle strength before and after exercise were 11.59 and 17.7, respectively. The average right hamstring muscle strength before and after exercise were 7.29 and 7.94, respectively. Conclusions: There are quadriceps muscle strength improvements after practicing quadriceps muscle strengthening exercise. However, no significant hamstring muscle strength improvement is seen after practicing quadriceps muscle strengthening exercise. An improvement in quadriceps and hamstring muscle ratio is observed. Keywords: Osteoarthritis, quadriceps and hamstring muscle strength ratio, quadriceps muscle strengthening exercise DOI: 10.15850/ijihs.v5n2.1041 
Comparison of VO2 Max Prediction Value, Physiological Response, and Borg Scale between 12-Minute and 3200-Meter Run Fitness Tests among Indonesian Army Soldiers Maulidi Abdillah; Tertianto Prabowo; Marietta Shanti Prananta
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To compare the VO2 max and physiological responses between 12-minute and 3200-meter run fitness tests.Methods: The subjects were 40 soldiers aged 18–21 years old of the Infantry Battalion 303/SSM of Cikajang, Garut, West Java, Indonesia. The 12-minute and 3200-meter run fitness tests were conducted with one week resting period. The measurement of the VO2 max prediction was based on each of the formulations and the measurement of physiological response included blood pressure, heart rate, respiratory rate, Borg scale and oxygen saturation before and after the tests. This study used a cross-sectional method while the data were analyzed statistically using t-test (p=0.05). Results: The results showed that the VO2 max prediction in 12-minute run fitness test was 52.046±2.980 mL/KgBB/min and the 3200-meter run test was 55.323±3.238 mL/KgBB/min. The value was statistically significant (p=0.008). There was no significant difference in the physiological response in both tests, except the SpO2 parameter after the tests (p=0.021). Conclusions: There is a significant difference in VO2 max prediction between 12 minutes and 3200 meter run test. No significant difference was found in the physiological response in both tests, except the SpO2 parameter. Keywords: 12-minute run fitness test, 3200-meter run fitness test, physiological response, soldiers, VO2 max DOI: 10.15850/ijihs.v4n2.836
Cardiovascular Disorders in Adolescents with Chest Pain Sri Endah Rahayuningsih; Rahmat Budi; Herry Garna
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To detect cardiovascular abnormalities in adolescents with chest pain.     Methods: In this cross sectional study, the subjects were 25 adolescents with chest pain who came to the Cardiac Center of Dr. Hasan Sadikin General Hospital, Bandung during the period of January 2008 to January 2011. The presence of established cardiovascular disorders were based on history, physical examination, electrocardiography and echocardiography    Results: It was found that 13/25 adolescents with chest pain had cardiovascular abnormalities. Of the 25 teens that came with chest pain, most of which showed normal electrocardiographic results, only 9/25 of those with dysrhythmias experienced sinus tachycardia and 8 had a first degree AV block. Echocardiography examination showed only four patients with abnormal cardiac anatomy.  No correlation between nutritional status and chest pain, and cardiovascular abnormalities and chest pain (p = 0.206 and p = 0.632, respectively). There was a positive correlation between sex and cardiovascular abnormalities in adolescents with chest pain (p = 0.007).Chest pain is a prevalent problem that is usually benign and that it frequently signals underlying cardiac disease.Conclusions: Cardiovascular abnormalities in adolescents with symptoms of chest pain are found in some cases. There is no correlation between female and male adolescents with chest pain  and  cardiovascular abnormalities.Keywords: Adolescents, cardiovascular, chest painDOI: 10.15850/ijihs.v2n1.287
Fetus inside Brain - Mature Cystic Teratoma in Posterior Fossa Farid Yudoyono; Mirna Sobarna; Agung Budi Sutiono; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To describe a rare case of posterior fossa cystic teratoma in central nervous system. Methods: A 2-year old boy was admitted with a chief complaint of decreased consciousness with tonic clonic seizure. Non-Contrast Head Computed Tomography (NCCT) scan showed acute hydrocephalus and a well-defined extra-axial cystic lesion mass, 3.4x3.9x4.2 cm in size, in the posterior fossa.Results: Patient underwent a total resection of the tumor. No systemic complication was found in ten days following the surgery. There was no evidence of tumor recurrence one year after the surgery. The histopathologycal diagnosis of the tumor was cystic teratoma.Conclusions: Mature cyst teratoma located in the posterior fossa is a rare case. Total resection and long-term follow up is the treatment of choice for mature teratoma.Keywords: Hydrocephalus, posterior fossa, teratoma DOI: 10.15850/ijihs.v4n1.687
Chlamydial Infection Prevalence in Human Immunodeficiency Virus Patients Feilicia Henrica Teja; Rasmia Rowawi Rowawi; Asmaja Soedarwoto; Diah Puspitosari; Rini Rasianti; Rahmatdinata Rahmatdinata; Tony Djadjakusumah
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To determine the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients based on PCR assay in Teratai Clinic, Dr. Hasan Sadikin General Hospital Bandung. Methods: A cross sectional observational study with consecutive sampling method, which was conducted in Teratai Clinic during the month of July 2012. All participants underwent history taking, physical examination, and PCR assay for C. trachomatis. Swab samples were obtained from male urethra and female endocervix. Results: Eighty one HIV-positive patients, consisted of 48 males and 33 females were included in this study. The PCR examination for C. trachomatis was positive in 14 of 81 subjects (17.3%), with 10 (20.8%) urethral chlamydial infection in 48 males and four (12.1%) cervical chlamydial infection in 33 females. Conclusions: The study concluded that the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients were 20.8% and 12.1%, respectively. Identifying chlamydial infection based on PCR testing should be considered for routine screening test in HIV-positive patients.    Keywords: Chlamydia trachomatis, HIV, prevalence, PCR DOI: 10.15850/ijihs.v1n1.107
The Use of Superoxide Dismutase in Accelerating Symptom Relief in Asthmatic and House Dust Mite Allergic Children Receiving House Dust Mite Immunotherapy: Double Blind Randomized Controlled Clinical Trial Endaryanto, Anang; Hikmah, Zahrah; Harsono, Ariyanto
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate the efficacy of superoxide dismutase (SOD) in lung function (FEV1 reversibility) and respiratory symptoms (drug scores, symptoms scores) in asthmatic and house dust mite allergic children receiving house dust mites immunotherapy.Methods: Forty subjects aged 6–17 years old with asthma and tested positive for house dust mite allergy on skin prick test, and received immunotherapy were enrolled in this study. All subjects completed clinical based assessments and diary-based assessments for drug and symptom scores. Following a four-week baseline assessment, all subjects were randomized to receive SOD or placebo. Respiratory symptoms (drug and symptoms score) and FEV1 were evaluated at the end of the 1st, 2nd, 3rd, and 4th weeks after randomization. Drug score, symptoms score and FEV1 reversibility test results were analyzed using a Paired t test and repeated measure of ANOVA. Results: There was a significant difference in drug scores, symptoms score and FEV1 reversibility test outcomes between SOD and placebo. SOD group showed a significant decrease in all outcome measures compared to those in placebo group. Conclusions: The use of SOD as antioxidants is effective in accelerating symptom relief for children with asthma and house dust mite allergy receiving house dust mite immunotherapy. Keywords: Allergic asthma, antioxidant, drug score, immunotherapy, symptoms score DOI: 10.15850/ijihs.v3n2.587

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