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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 18 Documents

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Search results for , issue "Vol 1, No 2 (2011): Pharmaciana" : 18 Documents clear

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Bachri, Moch Saiful
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

MeOH extract of Zingiber officinale Roscoe (ZO) were investigated forhepatoprotective effect at the doses (p.o) of 100 and 200 mg/kg body weight using CCl4induction method. Male Swiss mouse (25Â±1,5 g) were treated with ZO doses 100 and200 mg/kg bw and Sillymarin (100 mg/kg bw) for two week before treatment with asingle dose of CCl4, 0.5 ml/kg bw, intraperitoneally. The mouse were sacrifactivity ofSGPT-SGOT. The study showed the activity of SGPT of MeOH extract of ZO doses 100mg/kg bw and 200 mg/kg bw, Sillymarin, control and normal groups are (34,51Â±5,34)(27,38Â±4,28) (27,26Â±1,06) (36,61Â±1,87) dan (25,37Â±2,01I) U/L. respectively. Whilethe activity of SGOT of MeOH extract of ZO doses 100 mg/kg bw and 200 mg/kg bw,Sillymarin, control and normal groups are (88,88Â±0,94) (83,88Â±3,91) (83,99Â±7,24)(92,97Â±8,16) (82,99Â±3,97) U/L.respectively. MeOH extract of ZO dose 200 mg/kg BWand Sillymarinsignificantly (p < 0,05) decrease the activities two enzymes (SGPT andSGOT). The results showed MeOH extract Zingiber officinale Roscoe hashepatoprotective effect.

ANALISIS COST-EFFECTIVENESS PENGGUNAAN SEFTRIAKSON DAN SEFOTAKSIM PADA TERAPI PROFILAKSIS APENDEKTOMI DI RS PKU MUHAMMADIYAH YOGYAKARTA TAHUN 2006-2007 Muhartati, Sri Aisyah; Muhlis, Muh; Supadmi, Woro
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cost-effectiveness analysis of ceftriaxone and cefotaxim prophylactic antibioticsof appendectomy in PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007 has been studied. This study was aimed to explore the direct medicalcost, cost-effectiveness ratio, and determine whether drugs of ceftriaxone or cefotaximwhose had more effective cost. This study was carried out by descriptive retrospectivedesign. The population was all inpatients of appendectomy getting prophylaxisantibiotics with either ceftriaxon or cefotaxim therapy in PKU MuhammadiyahHospital Yogyakarta. The population target were the appendectomy patients in thethird class of PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007. The result indicated that direct medical cost of the patients gettingceftriaxone therapy was Rp 422.257, whereas the cost of the patients getting cefotaximtherapy was Rp 487.680. Cost-effectiveness ratio of whom getting ceftriaxone therapywas Rp 105.564/day, whereas the ratio of whom getting cefotaxim therapy was Rp162.560. Finally, it have not been able to determine which drug is more cost-effective.

ANALISIS SGPT-SGOT EKSTRAK ETANOL DAGING BUAH PARE (Momordica charantia L.) PADA TIKUS JANTAN PUTIH GALUR WISTAR Nugrahani, Dwi Ari; Sofia, Vivi
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The traditional medicine in Indonesia which is the cultural heritage and hasbecome an integral part of the life of the nation Indonesia, want to be employed in theformal health care system. As the circulation of drugs in general terms, traditionalmedicine should fulfill the requirements of quality, safe, and efficacious. This studyaims to analyze the levels of SGPT, SGOT of suspension of the ethanol extract of bittermelon fruit (Momordica charantia L.) by orally. The study was conducted using a whitemale Wistar rats amounted to 36 animals, divided into 6 groups. Each group consistedof 6 male white rats. Group I (control) were given 0.5% CMC solution of 2.5 ml/200 gBW. Group II was given a suspension dosage doses of bitter melon fruit extract ethanol0.5 g/kg, then consecutive group III with the test preparation doses of 1 g/kg, the testpreparation group IV were given a dose of 2 g/kg, group V was given dosage test doseof 4 g/kg, and group VI were given the highest dose of the test preparation 8 g/kg. Theresults of acute toxicity tests on white male Wistar rats showed that administration ofethanol extract of peroral dosage suspension pare (Momordica charantia L.) singledose on white male Wistar rats from the dose of 0.5 g/kg until a dose of 8 g/kg did notsignificantly influence the value of SGPT, SGOT.

ISOLASI DAN IDENTIFIKASI ZAT AKTIF EKSTRAK METANOL RIMPANG KUNYIT PUTIH (Curcuma mangga Val) FRAKSI ETIL ASETAT kusmiyati, Kusmiyati; Aznam, Nurfina; Handayani, Sri
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma mangga contains a lot of variety of active compound which use as traditional medicines. This research aimed to isolated and determinated the active compound of methanol extract Curcuma mangga rhizomes of ethyl acetate fraction and its rendemen. Amount of 1000 g Curcuma mangga rhizomes was macerated with methanol solvent at room temperature for 24 hours. Remaceration was done seventh times. Methanol extract was fractionated with ethyl acetate. About 39,05 g of concentrated ethyl acetate fraction was then separated by Column Chromatography. According to the similarity of UV-Vis spectra and GC-MS, active compound in methanol extract Curcuma mangga rhizomes ethyl acetate fraction is predicted as Labda-8(17),12-dien-15,16-dial with rendemen amount of 0,00149 %.

AKTIVITAS ANTIFUNGI EKSTRAK ETANOL BATANG BINAHONG (Anredera cordifolia (Tenore) Steen.) TERHADAP Candida albicans SERTA SKRINING FITOKIMIA Kumalasari, Eka; Sulistyani, Nanik
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Anredera cordifolia is a plantused as antifungal empirically. This study aims tofind out the antifungal activity of ethanol extract of A. cordifolia stem against C.albicans and to identify the chemical subtance groups of the ethanol extract of A.cordifolia. The A. cordifolia stem was extracted by maceration method using ethanol 70% as solvent. The antifungal assay was done using liquid dilution method with variousconcentrations of (85; 86; 87; 88; 89; 90% w/v). The mixtures of extract and suspensionof C. albicans in CYG (Casein Yeast Glucose) medium and the media were incubated at37ÂºC for 18-24 hours to determine Minimum Inhibitor Conceration (MIC).Theculturewas streaked on SDA (Sabouraud Dextrose Agar) medium to determineMinimum Fungicidal Conceration (MFC). Chromatographic test and tube test weredone to identify the chemical substances of A. cordifolia extract. The result showed thatthe MIC could not be determined because the extract was brownish and turbid while theMFC of A. cordifolia stem ethanolic extract was 86% w/v. The result of thephytochemical screening with tube test and the thin layer chromatography test showedthat the extract of A. cordifolia stem contained flavonoids, polyphenols, and saponin.

UJI SITOTOKSISITAS DAN ANTIPROLIFERATIF FRAKSI ETIL ASETAT EKSTRAK ETANOL BIJI JINTEN HITAM (Nigella sativa, Lour) TERHADAP SEL MIELOMA Nurani, Laela Hayu
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cancer is the formation of new tissue which is abnormal and malignant. A groupof cells suddenly become disorganized and reduplicate themselves rigorously(hyperproliferation). Nigella sativa L. is one of the herbs which have an anticancereffect. This research aims to assess the cytotoxic and antiproliferative effect of Nigellasativa L. ethanol extract of Myeloma cells. Ethanolic extract was produced fromNigella sativa L. powder with maseration method. The cytotoxicity test was done byincubating Myeloma cells with the treatment concentration group of N. sativa L. ethylacetic fraction of ethanolic extract 2000; 1000; 500; 250; and 62,5 Âµg/ml, respectively.The test was done with an MTT method and then with a calculation of its deathpercentage. The LC50 is calculated using a probit analysis method. The test was thencontinued with the antiproliferative test to assess the doubling time at treatmentconcentration 125; 62,5 Âµg/ml and cellular control at hours 24, 48, and 72. The resultsshowed that Nigella sativa L. ethanolic extract had cytotoxic activity towards theMieloma cells with an LC50 value 177,01 Âµg/ml. The antiproliferative test showed thatthere was a growth inhibition, even cell death at the extract treatments. The doublingtime was 253 hours at 62,5 Âµg/ml concentration, 298,4 hours at 125 ug/ml, while thecell control had 54,52 hours.

OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Sugihartini, Nining
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Octyl methoxycinnamate is an active ingredient in sunscreen that will bedegradated after exposure by sunlight. On the other hand, antioxidants have potentialcapability as photoprotector which in this study is used the ethanol fraction of leaf ofPlantago major, L to support activity of OMS. In addition, rice flour is added toobecause it has the ability to reflect sunlight. The aim of this study is to obtain theoptimum composition of them, based on the effectivity of OMS. This study used threeformulas based on the simplex lattice design method with a comparison of octylmethoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%:50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the valueof % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed toget the optimum composition which has the highest of response. The results showed that100% rice flour was the optimum addition to support activity of OMS as sunscreen withdecreasing of % erythema transmission and pigmentation was 200%, 75%,respectively.

EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH Maysara, Risha; Yuliani, Sapto
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Liver is one of the most important organ for drug metabolism in the body. Thedamage to the liver can be marked by increased activity of the enzyme alanineaminotransferase (ALT) in the blood. Lycopene is an antioxidant that has the ability toeliminate free radicals and detoxifies electrophilic compounds that damage can beprevented. The purpose of this research is to know whether lycopene can inhibit theincrease alanine aminotransferase activity of SD (Sprague Dawley) rats induced byparasetamol. This experiment using 20 male rats Sprague Dawley. They were dividedinto 4 groups. Group I is a healthy control (baseline) was only given aquadest, group IIwere given paracetamol as pain control, group III and IV are treatment group wereeach given lycopene with a dosage 15 Âµg/kg BW and 30 Âµg/kg BW for 21 days. On 19thday group II, as well as all treatment groups induced paracetamol. The blood samplingwas performed on orbital sinus on 19th day (before induced by paracetamol) and on 21thday or two days after induced paracetamol to know the difference alanineaminotransferase activity. The data were analyzed using non-parametric statisticalmethods with Kruskal-Wallis test followed by Mann-Whitney test with 95% confidencelevel. The result has showed that the lycopene doses 15 Âµg/kgBW had alanineaminotransferase activity of 130.10 Â± 11.83 U/I and lycopene doses 30 Âµg/kgBW hadalanine aminotransferase activity of 106.46 Â± 2.36 U/I. If compared with paracetamolcontrol had alanine aminotransferase activity of 92.53 Â± 2.57 U/I, should take asummary that the lycopene doses 15 Ã¬g/kg BW and 30 Ã¬g/kg BW couldnât decreasealanine aminotransferase activity on SD (Sprague Dawley) male rats.

EVALUASI IMPLEMENTASI PELAYANAN INFORMASI OBAT PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT YOGYAKARTA Baroroh, Farida
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

To support high quality health service in hospital, Pharmacy Installation ofYogyakarta Hospital needs to evaluate implementation of drug information service foroutpatient. This study is aimed to identify the realization of drug information service ofoutpatient implementation of Pharmacy Installation of Yogyakarta Hospital comparedto the specified target. This study was carried out by descriptive design using secondarydata of Pharmacy Installation programs, interview with a pharmacist was assignedoutpatients serving as research subjects, as well as direct observation of druginformation service for outpatient. Gap analysis was used to identify the comparisonbetween the realization and specified target. The result of this study of evaluation indrug information service implementation of outpatient showed negative gaps as muchas -0.67%. The component information presented included the efficacy of drugs, how touse, the rules of use, duration of drug use, drug side effects, however the components ofdrug information that is unallowed in Pharmacy Installation of Yogyakarta Hospitalhow shcedule of drug use and signs toxicity.

ANALISIS COST-EFFECTIVENESS PENGGUNAAN SEFTRIAKSON DAN SEFOTAKSIM PADA TERAPI PROFILAKSIS APENDEKTOMI DI RS PKU MUHAMMADIYAH YOGYAKARTA TAHUN 2006-2007 Sri Aisyah Muhartati; Muh Muhlis; Woro Supadmi
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA