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INDONESIA
Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 12, No 1 (2022): Pharmaciana" : 14 Documents clear
Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery Dewa Ayu Arimurni; Made Dwi Pradipta Wahyudi S; Erika Yuda Colatama
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.828 KB) | DOI: 10.12928/pharmaciana.v12i1.22285

Abstract

A long-term oral administration of NSAID and DMARD on rheumatoid arthritis (RA) treatment may cause gastritis, kidney, and cardiovascular disorder. One of the alternative therapies that have been investigated is by using herbal medicine such as Curcuma longa Linn. which contains curcumin and essential oils. Even though both compounds are quite effective in treating RA, poor aqueous solubility and low intestinal absorption limit their oral bioavailability. To overcome these drawbacks, transdermal delivery was chosen as an alternative route of administration. This study was aimed to formulate the Curcuma longa Linn. oleoresin into a transdermal non-aqueous gel system using Carbopol 934 and low substituted hydroxypropyl cellulose (4.25:0.75 %) as the gelling agent. In this study, multiple solvents (PEG 400, PG, glycerin, ethanol, and tween 20) were used in the system. The solvents were chosen based on their ability to dissolve the gelling agents. Optimization was done using a simplex lattice design based on the physical characteristics (viscosity, pH, spreadability, and adhesivity) of the prepared gel. The system with the optimum concentration of PEG 400 and PG was then observed for its stability and in vitro transport through snakeskin membrane using Franz diffusion cell with PBS pH 7.4 as acceptor medium. The optimal formula was comprised of 75% PEG and 25% PG which has a viscosity of 6.34+0.19 dPa.s, adhesivity of 6.05+0.11 seconds, pH of 5.16+0.09, spreadability of 6.94+0.06 cm, and quite stable after freeze-thaw cycling test, whilst around 26.85% curcumin was diffused through the membrane (flux = 0.084 mg.cm-2) after 2 hours. It can be concluded that the Curcuma longa Linn. oleoresin can be formulated into a non-aqueous gel system, which showed a fair gel physical characteristic with good stability and ability to permeate across the skin membrane, and is promising to be further developed as an alternative for RA treatment.
Models for predicting the quality of life domains on the general population through the orange data mining approach Bustanul Arifin; Dyah Aryani Perwitasari; Zulkarnain Zulkarnain; M Rifqi Rokhman
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (741.688 KB) | DOI: 10.12928/pharmaciana.v12i1.20827

Abstract

The incidence of type 2 diabetes mellitus (DM) has been predicted to increase until 2045 in the world. Furthermore, long-term treatment and lifestyle factors affect the quality of life. This study aims to determine the models that can be used to predict the quality-of-life domains in prediabetes patients by using Artificial Intelligent (AI) devices. This is a cross-sectional design in which the inclusion criteria were individuals of age above 18 years and has never been diagnosed with diabetes mellitus (both type 1 DM and type 2 DM), fasted for at least 8 hours, and are willing to sign an informed consent after having received an explanation. Participants were asked to fill out two questionnaires, namely the Indonesian version of the Finnish Diabetes Risk Score (FINDRISC) and the EuroQoL-5 Dimensions-5 Level (EQ-5D-5L). The AI application uses Orange® machine learning with three models used in predictive analysis, such as Logistic Regression, Neural Network, and SVM. In addition, the model was evaluated using the sensitivity, precision, and accuracy of the AU-ROC parameters. The results showed that the neural network model based on the AUC value, precision, accuracy, and also the ROC analysis, was the best for predicting the utility index of domains in the EQ-5D-5L questionnaire, based on demographic data and the FINDRISC questionnaire.
In vitro study of antioxidant and antibacterial properties of Phyllanthaceae and Rubiaceae plant families from Simeuleu Island, Aceh, Indonesia Marlin Megalestin Raunsai; Ahmad Fathoni; Andria Agusta
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.653 KB) | DOI: 10.12928/pharmaciana.v12i1.21572

Abstract

Plants are still the preferred solution to solve several of the main problems the world is facing today, such as antibiotic resistance and free radicals. The plant chemical compounds have the potential as antibacterial and antioxidant agents. Therefore, four plants representing Phyllantaceae family (Glochidion varians Miq., Glochidion zeylanicum (Gaertn.) A.Juss) and two plants from Rubiaceae family (Uncaria lanosa var. glabrata, and Uncaria cordata (Lour.) Merr.)  were collected from Simeulue island, Aceh. We obtained 32 extracts from several plants with various solvents, such as hexane, dichloromethane, ethyl acetate, and methanol. The methods applied to investigate antibacterial activities were Thin Layer Chromatography (TLC) and Minimum Inhibitory Concentration (MIC). Meanwhile, TLC and Microdilution Assay were utilized to analyze antioxidant capacity against 1,1-diphenyl-2-picrylhydrazyl (DPPH). The result of antibacterial activity shows 32 extracts displayed very strong to weak activity against Staphylococcus aureus and Escherichia coli. Among all extracts, methanol extracts of G. varians (stem and leaf), methanol extracts of G. zeylanicum (stem and leaf), methanol and ethyl acetate extracts of U. cordata (leaf), and ethyl acetate extract of G. varians (leaf) indicate potent antioxidant activity with the range of antioxidant activity index (AAI) values of 2.16 -11.73. Furthermore, all extracts exhibit moderate to weak antibacterial evaluation. The methanol extract of G. varians stem has the highest MIC value of 128 µg/ml against S. aureus. The methanol extracts of G. varians stem and leaf and methanol extract of G. zeylanicum leaf against E. coli have MIC value of 256 µg/ml, whereas other extracts have >256 µg/ml MIC value. To sum up, four plants from Phylantaceae and Rubiaceae families have the potential to be expanded as antioxidant agents rather than antibacterial agents.
Description of antibiotic therapy of hospitalized-community-acquired pneumonia in PKU Muhammadiyah Gamping hospital Joko Sudibyo; Akrom Akrom
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.635 KB) | DOI: 10.12928/pharmaciana.v12i1.17034

Abstract

Long-term administration of IV antibiotics risks increasing treatment costs and patient morbidity, but until now, intravenous (IV) antibiotics are still the most comprehensive choice in treating community pneumonia inpatients in hospitals. The purpose of this study was to describe the use of antibiotics and duration of AB replacement from IV administration to oral administration (P.O) in community-acquired pneumonia (CAP) patients at PKU Muhammadiyah Gamping Hospital (PMGH). This study used a cross-sectional design. Data were collected prospectively by purposive sampling. Inclusion criteria were hospitalized patients with CAP who received AB IV therapy for 24-72 hours. Patients with lung cancer or sepsis were excluded. Data were collected from medical records, laboratory examination records, and drug administration. Data were analyzed univariately. The number of 38 patients according to the criteria with a mean age of 59.8 ± 12.7 years; most were male (55.3%) and comorbid with heart failure (13.2%). The mean length of hospitalization was 4.9 ± 1.6 days. Most of the patients received Cephalosporins antibiotic group, either given IV (89.5%) or P.O. (78.1%); the rest received the quinolone group. The mean time of changing AB from IV to oral administration was 134.25 ± 15.98 hours. Most inpatient CAP patients at PMGH received a cephalosporins group, either IV or orally.

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