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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 36 Documents

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Search results for , issue "Vol 8, No 1 (2018): Pharmaciana" : 36 Documents clear

The gastroprotective effects of canna edulis ker. tuber starch on peptic ulcer and the histopathological profile of rat stomach Najini, Robby; Bachri, Moch Saiful; Yuliani, Sapto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ganyong rhizome (Canna edulis Ker.) empirically use for treating gastritis (peptic ulcers). Ganyong rhizome contains carbohydrates and flavonoid that can reduce inflammation in the gastric tissues and againsts free radicals that are contributing to the pathogenesis of peptic ulcers. This research aims to know the gastroprotective effect of ganyong rhizome on white female rats, Wistar strain, which were given alcohol (ethanol 96%) by dose 1 ml/200gBB and measuring the total flavonoids content in ganyong rhizome. This research is Post Test Only Control Group Design, using 30 rats, weight 150-200 g, age 6-8 weeks, health condition. It is divided into six groups. Group I (normal) were fed and watered only, Group II (control) were given a CMC-Na 0,5%, Group III-V were given a suspension of ganyong rhizome starch (SGRS) with each doses 250, 500, and 1000 mg/kgBB, then Group VI were given a sucralfate dose 360 mg/kgBB. Rats were given oral treatment for 14 days. An hour after the treatment on 14th day, the whole groups unless the group I were given ethanol 96% 1 ml/200gBB orally. Twenty four hours later the rats were sacrificed, dissected and taken its gastric for further analyzed the number of ulcers as well as the description of histopathology of the gastric. The results showed that ganyong rhizome starch can decrease the index ulcer and increase the protection ratio value to the control group with results of doses SGRS 250, 500, 1000 mg/kgBB sequentially i.e., 12,5; 50; and 75%. The description of histopathology also showed significant improvement of gastric tissue at a dose of 1000 mg/kgBB. In addition, on TLC-Densitometri test also obtained the total flavonoid compound in ganyong rhizome is 112,49 Â± 7,97 ppm. Conclusions of this research are that the ganyong rhizome positive contains flavonoid and it has gastroprotective effect by decreasing the number of index ulcer, increasing the protection ratio value, and improving the histopathology of gastric tissue which had given alcohol.

The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol Parfati, Nani; Rani, Karina Citra
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of Î²-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q30 minutes= 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.

The gel formulation of the aqueous phase of snakehead fish (Channa striata) extract with various combinations of HPMC K4M and Carbopol 934 Taurina, Wintari; Andrie, Mohamad; Anjeli, Lea
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gel is a clear and semi-solid material, translucent and contains active material. The liquid phase of Ekstrak Ikan Gabus contains reactive Albumin benefits to advance the wound-healing process. HPMC and carbopol is the gelling agent uses to form gel material. This research aims to acknowledge the effect of basic combination variety (gelling agent) towards physical and chemical stability of gel material during liquid phase of Ekstrak Ikan Gabus in length of period 28 days.Â Variety of HPMC: Carbopol used, 25:75%, 50:50%, and 75:25%. Physical and chemical test conducted they are, organoleptic test, dispersion test, bonding strength test and pH test. The result is analyzed through one-way ANOVA and continued by LSD test with validity 95%. The whole formula is resulted a stable physical and chemical during 28 days. The higher the consentration of HPMC the the better its physic and chemistry stability. The best and optimum formula was shown by F3 (75:25%), with a stable organoleptic result during 28 days, homogen, the result of the dispere power weight 50 g (Â±14,517 cm2) weight 100 g (Â±16,169 cm2) weight 150 g (Â±16,957 cm2 ) and the average weight is (Â±15,881 cm2), the sticky power (Â±2301,78 second) and pH (Â±6,42) in which can be considered safe for skin.

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability Lestari, Pramulani Mulya; Yati, Kori; Savira, Nanda
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.

The relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 diabetes mellitus at Ulin Regional Public Hospital, Banjarmasin Mulyani, Risya; Hartanto, Dedi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diabetes melitus dapat menimbulkan masalah yang signifikan terhadap kualitas hidup melalui peningkatan risiko terjadinya berbagai komplikasi. Ketidakpuasan terhadap terapi juga ikut berkontribusi terhadap rendahnya efektifitas terapi. Kepuasan terapi memiliki peranan penting dalam pengelolaan DM yaitu untuk mengoptimalkan efektifitas terapi dan diyakini akan memberikan pengaruh terhadap pengambilan keputusan untuk pasien yang berhubungan dengan kesehatannya. Penilaian rutin kepuasan terapi pada pasien DM berguna bagi profesional kesehatan untuk mengidentifikasi masalah potensial yang dialami pasien dengan pengobatan DM yang sedang dijalaninya. Penelitian ini bertujuan untuk mengetahui hubungan kepuasan terapi berbasis insulin dengan efektifitas terapi pada pasien DM tipe 2 di RSUD Ulin Banjarmasin.PenelitianÂ ini merupakan jenis penelitian non eksperimental dengan rancangan penelitian cross sectional. pengambilan data dilakukan secara prospektif dengan melakukan purposive sampling pasien DM tipe 2 di Instalasi Farmasi RSUD Ulin Banjarmasin. Data kepuasan terapi diperoleh dengan kuesioner PSIT dan efektifitas terapi diperoleh melalui pemeriksaaan nilai HbA1c. Kuesioner diisi oleh subyek penelitian sebanyak 56 responden kemudian dianalisis menggunakan analisis bivariat yaitu uji chi-square.Hasil penelitian menunjukkan bahwa tingkat kepuasan cara terapi responden ada pada tingkat kepuasan sedang yaitu 33 orang (58,9%). Selain itu responden dengan efektifitas terapi baik (<6,5%) hanya 3,6% sedangkan yang lain 96,4% dianggap efektifitas terapinya belum terkontrol dengan baik. Terdapat hubungan yang positif dan signifikan antara kepuasan terapi dengan nilai HbA1c (r=0828 ; p<0,05). Ada hubungan yang positif dan signifikan antara kepuasan terapi berbasis insulin dengan efektifitas terapi pada pasien DM tipe 2 di Instalasi Farmasi RSUD Ulin Banjarmasin

Formulation and test activities of hair tonic with a combination of the aqueous extracts of aloe vera ( Aloe vera L.) and licorice (Glycyrrhiza glabra L.) Indriaty, Sulistiorini; Indrawati, Teti; Taurhesia, Shelly
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aloe vera mengandung lignin, asam folat, vitamin A,dan 20 jenis asam amino ( Jatnika, 2009) dan akar manis (Glycyrrhiza glabra L.)mengandung glycyrrhizin, steroid, dan asam beta âglycyrrhetinik yang bermanfaat bagi kesehatan rambut(Dep, 2014). Tujuan dari penelitian ini adalah untuk mendapatkan sediaan hair tonic dengan aktivitas terbaik dari kombinasi ekstrak air lidah buaya dan akar manis. Skrining fitokimia dari ekstrak air akar manis dan Aloe vera dilakukan, selanjutnya sediaan hair tonic dibuat dalam 3 formula dengan zat aktif ekstrak lidah buaya 7,5% dan ekstrak air akar manis 2,5% dengan variasi etanol 96% sebanyak 5%, 10% dan 15% selanjutnya diuji aktivitasnya pada kelinci jantan putih sebanyak 4 ekor selama 28 hari . Evaluasi sediaan hair tonic meliputi uji organoleptik, pH, berat jenis, viskositas dan uji hedonik. Pengujian aktivitasnya dilakukan dengan mengukur laju pertumbuhan rambut, percepatan pertumbuhan rambutÂ dan bobot rambut. Hasil penelitian menunjukkan Sediaan Â hair tonic yang mengandung campuran ekstrak air lidah buaya 7,5% dan ekstrak air akar manis 2,5% dengan etanol 96% sebanyak 5%, 10% dan 15% dapat dibuat sediaan larutan penyubur rambut yang baik, dan yang memiliki aktivitas optimum adalah sediaan Â hair tonic yang menggunakan etanol 96% sebanyak 15 % dengan karakteristik warna coklat, bau khas, homogen, bobot jenis 1,0577 g/ml,viskositas 2,8479 cp terhadap aquades, pH 5,5 dan efektif sebagai penyubur rambut dengan laju pertumbuhan rambut 2,6617 cm dalam 28 hari, percepatan pertumbuhan rambut 0,1635 cm/hari dan bobot rambut 0,1854 gram dalam 28 hari.Kata Kunci : Aloe vera L., Glycyrrhiza glabra L., hair tonic, laju pertumbuhan rambut, bobot rambut.

The formulation of probiotic Lactobacillus acidophilus granule with acacia and sodium alginate as binding agents Widayanti, Ari; Susanah, Lusi; Wahyudi, Priyo
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Probiotics are living microorganisms that can have a positive impact on health when consumed in adequate amounts. This research aimed to determine the effect of different binders on the viability of Lactobacillus acidophilus, a member of Lactic Acid Bacteria (LAB). The probiotic granules were prepared with wet granulation method using mannitol as the filling ingredient. Formulas I-III used acacia as a binder (3%, 4%, and 5%), while Formulas IV-VI used sodium alginate (1%, 1.5%, and 2%). The probiotic granules produced from all formulas were evaluated for flow time, the angle of repose, compressibility, and LAB viability. The LAB viability test results showed that all of the six formulas met the probiotic requirements, i.e., at least 107 CFUs (Colony Forming Units) per gram. The viable LAB in Formulas I-VI were 3.94x107, 4.4x107, 2.7x107, 2.6x107, 3.5x107, and 2.3x107 CFU/g, respectively. The data were analyzed by comparing the average values of the One-Sample T-Test results, followed by Mann-Whitney test. The results revealed that each formula had different capacity in maintaining the viability of Lactobacillus acidophilus with different binders (i.e., acacia and sodium alginate) as a probiotic product. Formula II (4% of acacia) produced probiotic granules that met the requirements of compressibility and the angle of repose. However, its granular flow time exceeded the standard.

Improvement of family caregiversâ knowledge of polypharmacy in the elderly after health education Mustaming, Mustaming; Loriana, Rina; Azhari, Azhari; Badar, Badar
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The different health problems in elderly patients require complex management. However, if the use of medicines is uncontrolled, it will lead to polypharmacy. This study aimed to analyze the effect of health education on family caregiversâ knowledge of polypharmacy particularly to prevent drug therapy problem in elderly patients. This quasi-experimental study used one-group pre-test post-test design. The population was family caregivers who had elderly members in their care and lived within the working area of Bengkuring Public Health Center. The population members were selected according to the inclusion criteria until a minimum sample size was reached. Having met the criteria, the respondents were asked to fill in a pre-test questionnaire before they partook in the health education for polypharmacy and a post-test questionnaire after their participation. The pre-test and post-test information were then analyzed using a paired t-test. This study revealed that the family caregiversâ knowledge of polypharmacy improved by 32.5% with a probability value (p= 0.000< 0.001) less than the level of significance (5%). The contribution of the health education to the family caregiversâ knowledge of polypharmacy was 74.3%. There was an improvement in the family caregiversâ knowledge of polypharmacy after participating in the health education.

Antibacterial activity of two isolated endophytic extracts assosiated with Indonesian mangrove plant Rhizophora mucronata Fareza, Muhamad Salman; Choironi, Nur Amalia; Harwoko, Harwoko; Sunarto, Sunarto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Endophytic fungi are microorganisms reside in the living tissues of the host plant. This fungi can contribute to provide protection to the host from the infection caused by another microorganism. The one reasonable strategy to discover a new antibacterial agent from endophytic fungi are from the plant which lived in special condition such Rhizophora mucronata. The aim of this research is to determine antibacterial activity of the endophytic fungi extracts assosiated with Rhizophora mucronata from Sagara anakan. The isolated endophytic fungi was identified as Neopestalotiopsis sp. and Peniophora lycii using molecular analysis method. The antibacterial activity was carried out by using microdillution method. The antibacterial properties from mycelium extracts showed moderate to low antibacterial activity with Minimum Inhibitory Consentration (MIC) values of 125-500 Âµg mL-1 against Eshcerichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 bacteria. The n-hexane extract of both endophytic fungi shows the strongest antibacterial activity against Escherichia coli with MIC values of 125 Âµg mL-1

Curcumin encapsulation using dendrimer PAMAM G4 conjugated with polyethylene glycol to improve the properties of gel dossage form Al Rasyied, Faisal Dharojat; Elfiyani, Rahmah; Srifiana, Yudi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcumin had a low bioavailability, to improve it than curcumin was encapsulated in the PAMAM dendrimer conjugated PEG. To facilitate topical use, curcumin dendrimer was combined with a carbomer 940 that can produce hydration conditions in the stratum corneum so as to increase the bioavailability of curcumin. This study aimed to obtain the ratio between curcumin with dendrimer of PAMAM G4: PEG in the formation of curcumin dendrimer combined in the base of carbomer 940 to produce the optimal of physical characteristics of dendrimer and physical stability of gel. The study was conducted by conjugating PAMAM G4 with PEG with a ratio of 1:5, and then encapsulated curcumin in dendrimer with a ratio of 1:0.2 (F1); 1:0.02 (F2) and 1:0.002 (F3). Further dendrimers that have encapsulated curcumin were formulated in a gel with a carbopol base 940. The physical characteristics of the gel tested were polydispersity index, zeta potential and particle size, organoleptic, flow properties, and pH at weeks 0, 2, 4 and 6. The results shows that F1 has zeta potential highest and the lowest viscosity of the other formula, while F3 has the lowest potential zeta and highest viscosity of other formulas. In addition, the polydispersity index, particle size, organoleptic, flow properties and pH; there are not a significant difference in each formula, but the particle size, zeta potential, and viscosity of gel can decrease with longer storage time. Conclusion of this study that the ratio between curcumin and dendrimer PAMAM G4:PEG of 1: 0.2 shows the optimal of physical characteristics of dendrimer and physical stability of gel.

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Muhammad Syahrir

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Home Page

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Editorial Team

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Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA