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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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FORMULASI DAN EVALUASI SABUN CAIR EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var Rubrum) SERTA UJI AKTIVITASNYA SEBAGAI ANTIKEPUTIHAN Mutmainah Mutmainah; Yuvianti Dwi Franyoto
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Fluor albus is a genital disorder symptoms by women because of infections caused by bacteria, viruses, fungi or parasites. Red ginger (Zingiber officinale var Rubrum) is one of the natural ingredients has been used the potential as antifungal because of the content the active compound for example flavonoids, alkaloids, tannin, saponin and terpenoid. In this research, examines the effects of antifungal C. albicans ethanol extract red ginger after formulated vaginal douche with varying concentrations of 10%, 15% and 20%. vaginal douche is made using by soap base sodium lauryl sulfate, citric acid, sodium chloride, propilenglikol and water. Red ginger extraction methods remaserasi for 5 days using ethanol 96% by the turn of the solvent every 24 hours. Test power using the antifungal C. albicans on PDA medium. Evaluation of vaginal douche red ginger extract consist of organoleptic, homogenity, specific of gravity, pH, and antifungal effect. The results showed that the concentration of ethanol extract red ginger 10%, 15% and 20% have antifungal activity against C. albicans. Power test vaginal douche red ginger activity lower than vaginal douche containing povidone iodine as an active ingredient with the analysis results were significantly different (p <0.05). Keywords: Vaginal douche, Red ginger, C. albicans.

MINYAK NILAM (Patchouli alcohol) SEBAGAI ANTIOKSIDAN DENGAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) Agus Suprijono; Yoel Gunawan; Ariani Hesti Wulan
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAlong with the rapid flow of information and globalization, led to the lifestyle of modern society is also becoming more and more advanced. But this was not accompanied by increased quality of public health. Lifestyle such as this may result in exposure to free radicals degna. Antioxidants are compounds that can inhibit the oxidation of free radicals, so it will form a more stable compound. Oil Patchouli (Patchouli oil) contains patchouli alcohol which have antioxidant activity. The rate is determined by the quality of patchouli oil patchouli alcohol content therein. The purpose of this research is to show the antioxidant activity of patchouli oil and standard determine differences in activity with BHT, as well as to determine the effective concentration expressed in EC50 values by using DPPH method. The examination was conducted by using the test solution at a concentration of 5%, 10%, 15%, 20% and 25%. The process to obtain the patchouli oil is done by means of steam distillation of the dried herb patchouli. Identification test to determine the quality of the oil produced by TLC test and also qualitative test to determine the antioxidant activity. From the research it can be seen that the average value of EC50 for patchouli oil sample is equal to 19.95%, while 11.93% of standard BHT. Based on these results, concluded that the antioxidant activity in patchouli oil, and there are significant differences in antioxidant activity between standard patchouli oil with BHT.Keywords: patchouli oil, patchouli alcohol, anti-oxidant, DPPH.

PEMANFAATAN EKSTRAK BATANG TANAMAN PISANG (Musa paradisiacal) SEBAGAI OBAT ANTIACNE DALAM SEDIAAN GEL ANTIACNE F.X. Sulistiyanto Wibowo; Erna Prasetyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBacterial resistance to antibiotics is a problem that is being faced in both the developing and developed countries. Therefore it takes an effort to diminish these problems by the discovery of new drugs derived from natural ingredients, the banana plant (Musa paradisiaca).The purpose of this study to determine the bactericidal effect of the banana plant stem in antiacne gel dosage forms. The benefity of this study is providing basic information about the benefits of stem extract of banana plants, especially in the health field that is as antiacne.This study found the class of compounds contained in extracts of banana plants include steroids, triterpenoids, alkaloids, plavonoid, tannins and saponins. Results of this study, the pH 4 FI, FII 4, FIII4; Fi viscosity of 204 cps, 216 cps FII, FIII 239 cps; lekatFI power, FII, FIII less than a minute; dispersive power FI> 7cm / 100 grams, FII and FIII> 7cm / 150 grams. Microbiological test FI: 1,337, FII: 1.474 and FIII: 1,529.Keywords: banana stems, antibacterial, antiacne gel, S.aureus

EFEK EKSTRAK KULIT UMBI BAWANG PUTIH (Allium sativum L.) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN Rina Wijayanti; Abdur Rosyid
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Bulbs of garlic has been used as a traditional medicine. The use of garlic bulbs waste leaves tuber skin that has not been used optimally. This study aims to determine the content of the active compound and the effects of skin garlic bulbs extract (Allium sativum L) on blood glucose levels in male rats wistar strain induced alloxan. The subject of research in the form of 25 white male rats who were divided into 5 groups, group I are group fed a standard baseline; group II, III, IV and V Alloxan induced a dose of 160 mg/kgBW by intraperitoneal; group III, IV, and V are given skin garlic bulbs extract each with a dose of 200 mg/200gBW, 400 mg/200gBW, and 800 mg/200gBW orally for 14 days. Data obtained from the examination of blood glucose levels and analyzed using Kruskal-Wallis and Mann-Whitney. The results showed that skin garlic bulbs extract contains the active compounds alkaloid, quinones, flavonoids, saponins and polyphenols. Analysis of the data showed that there were significant differences in blood glucose levels between groups I with II, and group II with V. Conclusion, skin garlic bulbs extract (Allium sativum L) has the ability to lower blood glucose levels in mice induced by a decrease alloxan means the dose of 800 mg / 200gBW. Keywords: Skin garlic bulbs extract, Blood GlucosePENDAHULUANDiabetes Mellitus (DM) merupakan penyakit yang

Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015 Fakultas farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015 Fakultas Farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

i Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy Pemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid Hasyim Pemimpin Redaksi Ketua Program Studi Farmasi Fakultas Farmasi Universitas Wahid Hasyim Redaktur Ahli Dr. Sumantri, M.S., Apt Dr. Mimiek Murukmihadi, SU., Apt Redaktur Pelaksana Devi Nisa Hidayati, S.Farm, M.Sc. Staf Redaksi : Ellya Zulfa, S.Farm., M.Sc., Apt. Dewi Andini Kunti, S.Farm., M.Sc. Kiki Damayanti, S.Farm Sekretaris Redaksi Ririn Lispita Wulandari., S.Farm., M.Si.Med., Apt Distributor Rahmad Wahyudi Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680 E-mail : jurnalfarmasiunwahas@gmail.com Terbit 2 kali setahun sejak September 2004 ISSN : 1693-7899 Volume 12 No.2 Desember 2015 ii Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy DAFTAR ISI Pengaruh Variasi Kadar Getah Sagu (Metroxylon sagus Rottb) Sebagai Bahan Pengikat Terhadap Sifat Fisik dan Pelepasan Tablet Dexamethason Sugiyono, Irawan Sukma.………………………………………….................................. 1-6 Perbandingan Kualitas Pelayanan Instalasi Farmasi Pasien BPJS Rawat Jalan Rumah Sakit Pemerintah Dan Swasta Kota Semarang Risha Fillah Fithria, Umi Solikhawati…………….......................................…………… 7-15 Pengembangan Model Hewan Percobaan Tikus Diabetes Mellitus Tipe 2 Karena Resistensi Insulin Yang Diinduksi Dengan Human Insulin Jangka Panjang Yance Anas, Ria Rositasati, Meita Rafika Fitriana, dan Suharjono……..............……… 16-23 Pengaruh Kombinasi Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Dan Simvastatin Terhadap Kadar Kolesterol Total dan Low Density Lipoprotein (LDL) Tikus Yang Diinduksi Pakan Tinggi Lemak Ririn Lispita Wulandari, Sri Susilowati, Murnik Asih………………….......................... Peningkatan Efek Antihipertensi Kaptopril Oleh Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L.) Pada Tikus Hipertensi Yang Diinduksi Monosodium Glutamat Devi Nisa Hidayati, Yance Anas , Siti Nurikha………………….................................... 24-32 33-40 Formulasi Salep Ekstrak Etanolik Daun Binahong (Anrederacordifolia (Ten.) Steenis) Dengan Variasi Basis Salep Elya Zulfa, Tegar Bagus Prasetyo, Mimik Murukmihadi.................................................. Uji Aktivitas Imunomodulator Fermentasi Teh Rosela Jamur Kombucha Terhadap Proliferasi Sel Limfosit Mencit Galur Balb/C Secara In Vitro Maria Ulfah, Dinar Putri Octaviani, Ediati Sasmito......................................................... 41-48 49-56 ISSN : 1693-7899 Volume 12 No.2 Desember 2015

PENGARUH VARIASI KADAR GETAH SAGU (Metroxylon sagus Rottb) SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK DAN PELEPASAN TABLET DEXAMETHASON sugiyono sugiyono; Irawan Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Sago resin is the exudat from the plant sago (Metroxylon sagus Rottb.) from of gels and substances classified as anionic polysaccharides, colloidal nature with consistency and power of adhesive material resembling, it can be used as a binder tablets. This study aims to determine the effect of differences levels of sago resin variation as the ingredient binder dexamethason tablet the physical properties and release. Sago resin comes from the plant of sago then filtered (cleaned of impurities), blended into a fine powder to the next level with mucilago made FI (1%); FII (3%); FIII (5%); FIV (7%) and FV (10%). The sago resin mucilago is used a binder in the manufacture of granule with wet granulation method. The physical properties tested of the granule include flow time, repose of angle and compresibility. Tablets obtained its physical an chemical properties of the tested include uniformity of weight, hardness, friability, disintegration time, disolution and determination of concentration the active substances. The data obtained analyzed by comparing the theoretical approach with the relevant literature and statistically analyzed using corellation regretion alalyzed with a level of 95% The results obtained showed that the granules and tablets of all formulas meet the requirements of physical and chemical properties of a good tablet. The addition concentration of the sago resin as a binder causes the tablet hardness and disintegration time there is a significant difference between the formulas, while the release of the active substance and content uniformity tablets is not influenced by the increase in the concentration of sago resin. Keywords: Sap Sago, Wet Granulation, Dexamethason Tablet

PERBANDINGAN KUALITAS PELAYANAN INSTALASI FARMASI PASIEN BPJS RAWAT JALAN RUMAH SAKIT PEMERINTAH DAN SWASTA KOTA SEMARANG Risha Fillah Fithria; Umi Solikhawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

7 ABSTRACT Currently there are many complaints against service quality of BPJS patients in pharmacy some hospitals. This study aimed to compare the service quality of BPJS outpatient pharmacy installation at government and and public private hospital Semarang in terms of five dimensions of SERVQUAL. This study was an analytic survey research with cross sectional study design. Sample was BPJS outpatient or patient's family who took the drug in one of the government hospital Semarang (Tugurejo Hospital’s pharmacy) and one of the public private hospital Semarang (Sultan Agung Hospital’s pharmacy). The sampling technique used purposive sampling method, and used questionnaires to collect data. Expectations and performance scores had been analized used gap analysis and Mann-Whitney test to compare the service quality of BPJS outpatient pharmacy installation at government and and public private hospital Semarang in terms of five dimensions of SERVQUAL The service quality that terms of five dimensions of SERVQUAL in both of two hospital’s pharmacy installation Semarang could not meet the expectations of BPJS outpatient yet. The biggest gap according to BPJS outpatient in Sultan Agung Hospital’s pharmacy and Tugurejo Hospital’s pharmacy Semarang was the dimension of responsiveness with value respectively -0.73 and -0.63. Dimension that has met the expectations of BPJS outpatients Sultan Agung Hospital’s pharmacy was tangible dimension with value 0.03. There were significant differences between service quality of BPJS outpatient pharmacy installation at government and and public private hospital Semarang above tangible (p. 0,000), and reliability dimension (p. 0,000). Key words : Service quality, Tugurejo Hospital’s pharmacy, Sultan Agung Hospital’s pharmacy, BPJS outpatient, SERVQUAL

PENGEMBANGAN MODEL HEWAN PERCOBAAN TIKUS DIABETES MELLITUS TIPE 2 KARENA RESISTENSI INSULIN YANG DIINDUKSI DENGAN HUMAN INSULIN JANGKA PANJANG Yance Anas; Ria Rositasati; Meita Rafika Fitriani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Hyperinsulinemia may precede insulin resistance in patients with Type 2 diabetes. In this study, we tried to reveal an influence of long-term treatment of human insulin to hyperglycemic and insulin resistance in male Wistar rats. Before the experiment, blood-glucose levels measured two hours after 2 g/Kg glucose imposition. Rats receive human insulin (0.45-1.80) IU/KgBW/day subcutaneously every day for 14 days. Furthermore, human insulin 1.8 IU/KgBW/day also provide a period of7,14and 21days. At theend of the experiment,we mademeasurements ofblood-glucoselevelstwo hoursafterthe imposition glucose.There are, the influence oflong-termtreatment of human insulin determined bycomparing the blood-glucoselevelsbeforeandafter insulin treatment. Insulin resistance isdeterminedby comparing thehypoglycemiceffect of glibenclamide 10 mg/Kg BW to the control group. The results concluded that the humaninsulin1.80 IU/KgBW/day treatment for 14dayscan improveblood-glucoselevel'sWistarmale ratsup to126.369mg/dL(p<0.05)withpatternsdoes notdepend onthe length of timeof administration.The averageof % hypoglycemiceffect of glibenclamide10mg/kgBW in ratswhoreceived treatment with human insulin 1.80IU/kg BW/dayswereat 18,31%,smaller thancontrols (62.20%) (p<0.05). Decrease in hypoglycemic effects of glibenclamide 10 mg/kg BW caused by mice has insulin resistance might be due to a result of long-term insulin administration. Keywords : Human insulin, insulin resistance, Type 2 diabetes animal models

PENGARUH KOMBINASI EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) DAN SIMVASTATIN TERHADAP KADAR KOLESTEROL TOTAL DAN LOW DENSITY LIPOPROTEIN (LDL) TIKUS YANG DIINDUKSI PAKAN TINGGI LEMAK Ririn Lispita Wulandari; Sri Susilowati; Murnik Asih
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Soursop leaves can be used as a drug hypercholesterolemia. Simvastatin is one of the drugs that can be used to lower total cholesterol and LDL. This study aims to determine the effectiveness of combination therapy EEDS and simvastatin in inhibiting elevated levels of total cholesterol and LDL induced rats a high-fat feed when compared with simvastatin alone or single EEDS. This study is experimental with post-test only control group design. Using the test animals were 30 male rats Wistar strain were divided into 6 groups. Test animals fed a high-fat twice daily for 14 days except for the normal control group, the test preparation administration once a day for 5 days. Measurement of total cholesterol using the reagent kit CHOD-PAP and LDL measurement method Direct Enzymatic Colorimetric Test with a spectrophotometer UV-Visibel. Data were statistically analyzed by One Way Anova followed by Tukey test. The results showed that administration of EEDS can inhibit LDL levels induced rats a high-fat feed. eeds combination and simvastatin can inhibit the increase in total and LDL cholesterol levels did not differ significan (p> 0.05), which means it has the same ability in lowering total cholesterol and LDL induced rats a high-fat feed simvastatin compared with administration of single and single EEDS. Keywords: Hypercholesterolemia, Soursop Leaf Extract Ethanol, Total Cholesterol, LDL.

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