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Dental Journal (Majalah Kedokteran Gigi)

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Published by Universitas Airlangga

ISSN : 19783728 EISSN : 24429740 DOI : -

Core Subject : Health,

Dentistry

The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.

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Articles 838 Documents

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The inhibition of malignant epithelial cells in mucosal injury in the oral cavity of strains by pomegranate fruit extract (Punica granatum linn) through Bcl-2 expression Sri Hernawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 46 No. 1 (2013): March 2013
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Squamous cell carcinoma of oral cavity is a malignant neoplasms derived from epithelia. The malignant neoplasms are cells that have changed their structure and function, and their number becomes increasing abnormally, invasive, and metastatic. Carcinoma can be caused by the resistance of malignant cell apoptosis. Bcl-2 is a proto-oncogene of Bcl family that inhibits the process of cell apoptosis and suppresses Bax protein (pro-apoptotic). The management efforts of cancer diseases, however, still have many obstacles. Thus, the researcher was triggered to explore more herbal plants, namely pomegranate. Pomegranate as a medicinal plant is accessible and cheap. Ellagic acid (EA) is a single active compound derived from whole pomegranate fruit extract (PGL), which has anti-cancer activity as in vitro, but EA is low concentration in plasma, low water solubility, and insoluble in intestinal. These facts prompted the researcher to compare between pomegranate extract, which consists of several active compounds, and that, which only consists of ellagic acid. Thus, this research is expected to know how some active compounds can work synergistically in the PGL, so the effect can be more potent. Purpose: The purpose of this research, therefore, was to compare EA with PGL in reducing the expression of Bcl-2. Methods: This laboratory experimental research was used 32 male mice (Balb/c) in the age of 5 months. They were randomly divided into 4 groups: 2 control groups (K0: which was not exposed with benzopirene and also untreated and K1: which was exposed with benzopirene and also untreated), 2 treatment groups (P1: which was exposed with benzopirene and also treated with EA and P2: which was exposed with benzopirene and also treated with the PGL). Next, an examination was conducted by using immunohistochemical techniques. results: The results then showed that the provision of the PGL could decrease the expression of Bcl-2 significantly higher than that of EA in the malignant epithelial cells of the oral mucosa of those mice. Conclusion: It may be concluded that the provision of the PGL can kill malignant cells in the oral cavity of mice by increasing apoptosis through decreasing Bcl-2 expression that was higher than the provision of EA.latar belakang: Karsinoma sel skuamosa rongga mulut adalah istilah yang digunakan menyebut neoplasma ganas berasal dari epitel. Neoplasma ganas adalah sel yang telah berubah struktur dan fungsi, sehingga mengalami peningkatan jumlah secara abnormal,invasif dan metastasis. Terjadinya karsinoma salah satu disebabkan oleh karena hambatan apoptosis terhadap sel ganas. Bcl-2 adalah protoonkogen keluarga Bcl yang berperan menghambat proses apoptosis sel dan bekerja menekan protein Bax (pro apoptosis). Berbagai upaya penatalaksanaan penyakit kanker masih banyak menemui kendala,sehingga peneliti menggali tanaman obat yaitu buah delima. Buah delima sebagai tanaman obat, mudah didapat dan harganya murah. Ellagic acid (EA) senyawa tunggal bahan aktif dari ekstrak buah delima yang memiliki aktivitas sebagai anti kanker secara in-vitro tetapi EA aktivitas dan konsentrasinya dalam plasma rendah, kelarutan dalam air rendah, metabolisme (EA) tidak larut dalam intestinal. Fakta ini mendorong peneliti untuk membandingkan dengan whole ekstrak delima (PGL) yang terdiri dari beberapa senyawa bahan aktif, tidak hanya ellagic acid, memungkinkan beberapa senyawa bahan aktif pada PGL bisa bekerja sinergis, sehingga efeknya lebih poten. tujuan: Tujuan penelitian ini membandingkan antara EA, dengan whole ekstrak buah delima (PGL) dalam menurunkan ekspresi Bcl-2. Metode: Metode penelitian yang digunakan adalah eksperimental laboratories, 32 ekor mencit (Balb/c), jantan, umur 5 bulan dibagi secara random menjadi 4 kelompok, 2 kelompok kontrol (K0: tidak dipapar benzopirene dan tidak diberi perlakuan, K1: dipapar benzopirene dan tidak diberi perlakuan), 2 kelompok perlakuan (P1: dipapar benzopirene dan diberi EA, P2: dipapar benzopirene dan diberi PGL). Pemeriksaan dengan menggunakan teknik imunohistokimia. hasil: Hasil penelitian menunjukkan bahwa pemberian PGL dapat menurunkan ekspresi Bcl-2 lebih tinggi dibandingkan EA pada sel epitel ganas mukosa rongga mulut mencit. Kesimpulan: Kesimpulan penelitian ini adalah pemberian PGL dapat membunuh sel ganas pada rongga mulut mencit dengan jalan meningkatkan apoptosis melalui penurunan ekspresi Bcl-2 lebih tinggi dibandingkan pemberian EA.

The comparison of minocycline oral-rinse and gel on pocket depth Eka Fitria Augustina
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Infection disease is still considered as a prominent disease in many developing countries, like Indonesia. The most oral infection disease is periodontitis. Despite scaling and root planning as the main therapy, minocycline as adjunct therapy has already been used for periodontitis. There are a lot of media used, such as oral rinse and gel. Many researches even have also shown that the use of minocycline as adjunct therapy can decrease inflammation in periodontitis. Like tetracycline, minocycline as an anti inflammatory and anticollagenase is also considered to be very effective for the treatment of periodontitis. Media of minocycline that are available are gel, fiber, and oral rinse, as the newest one. Purpose: The purpose of this research is to examine the comparison of 0.2% oral rinse minocycline and 2% minocycline gel to reduce the pocket depth. Method: The samples were divided into two groups, the first group using oral rinse and the second one using gel after scaling. Result: There was no statistically significant difference between the group with minocycline gel and oral rinse. Conclusion: The application of 2% minocycline gel or 0.2% minocycline mouth wash after scaling and root planning has the same effect in reducing pocket depth.Latar belakang: Penyakit infeksi masih merupakan kasus yang menonjol di banyak negara berkembang, seperti Indonesia. Infeksi rongga mulut yang banyak terjadi adalah periodontitis. Selain terapi utama yaitu skeling dan root planning, menggunakan minosiklin sebagai terapi tambahan telah banyak digunakan, seperti obat kumur dan gel. Banyak penelitian menunjukkan bahwa penggunaan minosiklin sebagai terapi tambahan dapat menurunkan keradangan pada pasien periodontitis. Seperti tetrasiklin, minosiklin sebagai anti keradangan dan anti kolagenase, sangat efektif sebagai perawatan periodontitis. Media minosiklin yang banyak digunakan di antaranya yaitu gel, fiber, dan obat kumur yang terbaru. Tujuan: Tujuan penelitian adalah mengetahui perbandingan antara penggunaan 0,2% obat kumur minosiklin dan 2% minosiklin gel untuk mengurangi kedalaman poketperiodontal. Metode: Sampel dibagi menjadi dua grup, grup pertama menggunakan obat kumur, dan kelompok kedua menggunakan gel, setelah terapi skeling. Hasil: Tidak ada perbedaan yang signifikan antara kelompok minosiklin obat kumur dan gel. Kesimpulan: Minosiklin gel dan obat kumur sama-sama efektif dalam mengurangi kedalaman poket.

Henoch-Schönlein purpura in children: its relation to oral and to oral and oral and dental health Arlette Suzy Puspa Pertiwi
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 3 (2012): September 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

> Background: Henoch-Schönlein purpura (HSP) is a rare systemic small vessel vasculitis, which commonly occur in childrenbetween 2 and 10 years of age. The course of the disease is often self-limiting, although may manifest long-term renal morbidity. Theseverity of renal involvement decides about the prognosis of this disease. Many factors can trigger the disease attack, which is the mostcommon is bacterial invasion. Since the oral cavity is often refer as infectious foci to other part of the body, it seemed rationally tobe part that contribute the course of disease, thus management of these infectious foci, if possible, gives rise to an astoundingly goodprognosis. Purpose: This paper will describe a review on HSP and the possible association with oral and dental health since it mightbe related to the prognosis of HSP. reviews: Rashes in children are common; they may develop a rash after prescription of antibiotics.Nevertheless there are some childhood diseases that may manifest a rash presentation, such as HSP. It is important for pediatric dentistto have knowledge about HSP and consider the possibility of dental treatment or disease as potential triggers. Conclusion: Oral anddental condition may be the trigger cause of HSP attack. Therefore, it is important for pediatric dental practitioner to be aware of thecourse of the disease in order to limit the expanding complications.> latar belakang: Henoch-Schönlein purpura (HSP) merupakan vaskulitis pembuluh darah kecil sistemik yang jarang terjadi danbiasanya menyerang anak usia 2 hingga 10 tahun. Penyakit tersebut seringkali dapat sembuh sendiri, tetapi pada jangka panjangdapat bermanifestasi dengan morbiditas ginjal. Keparahan keterlibatan ginjal menentukan prognosis penyakit. Banyak faktor yangdapat memicu serangan penyakit, tersering adalah invasi bakteri. Karena rongga mulut sering kali merupakan fokus infeksi terhadapbagian lain dari tubuh, maka mempunyai peluang sebagai faktor pemicu timbulnya penyakit, sehingga penatalaksanaan fokus infeksidalam rongga mulut, jika ada, dapat memberikan prognosis yang baik pada pasien. tujuan: Makalah ini akan menggambarkantinjauan mengenai HSP dan hubungannya dengan kesehatan gigi dan mulut berkaitan pengaruhnya terhadap prognosis HSP. tinjauanPustaka: Ruam sering terjadi pada anak; pasien anak dapat memperlihatkan gejala ruam setelah pemberian antibiotika. Selain itu,beberapa penyakit dapat bermanifestasi sebagai ruam, misalnya HSP. Merupakan hal yang penting bagi dokter gigi anak untuk memilikipengetahuan mengenai HSP dan mempertimbangkan perawatan atau penyakit gigi sebagai pemicu potensial. Kesimpulan: Keadaangigi dan mulut dapat merupakan pencetus serangan HSP, oleh karena itu penting bagi dokter gigi anak untuk memahami perjalananpenyakit sehingga dapat membatasi komplikasi yang terjadi.

The increasing of enamel calcium level after casein phosphopeptideamorphous calcium phosphate covering Widyasri Prananingrum; Puguh Bayu Prabowo
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 2 (2012): June 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Caries process is characterized by the presence of demineralization. Demineralization is caused by organic acids as a result of carbohydrate substrate fermentation. Remineralization is a natural repair process for non-cavitated lesions. Remineralization occurs if there are Ca2+ and PO43- ions in sufficient quantities. Casein-amorphous calcium phosphate phosphopeptide (CPP-ACP) is a paste material containing milk protein (casein), that actually contains minerals, such as calcium and phosphate. The casein ability to stabilize calcium phosphate and enhance mineral solubility and bioavailability confers upon CPP potential to be biological delivery vehicles for calcium and phosphate. Purpose: The aim of this study was to determine the calcium levels in tooth enamel after being covered with CPP-ACP 2 times a day for 3, 14 and 28 days. Methods: Sample were bovine incisors of 3 year old cows divided into 4 groups, namely group I as control group, group II, III and IV as treatment groups covered with CPP-ACP 2 times a day. All of those teeth were then immersed in artificial saliva. Group II was immersed for 3 days, while group III was immersed for 14 days, and group IV was immersed for 28 days. One drop of CPP-ACP was used to cover the entire labial surface of teeth. The measurement of the calcium levels was then conducted by using titration method. All data were analyzed by One- Way ANOVA test with 5% degree of confidence. Results: The results showed significant difference of the calcium levels in tooth enamel of those groups after covered with CPP-ACP 2 times a day for 3, 14 and 28 days (p = 0.001). There is also significant difference of the calcium levels in tooth enamel of those treatment groups and the control group (p = 0.001). Conclusion: The calcium levels of tooth enamel are increased after covered with CPP-ACP 2 times a day for 3, 14 and 28 days.Latar belakang: Proses terjadinya karies gigi ditandai oleh adanya demineralisasi. Demineralisasi terjadi oleh asam organik sebagai hasil fermentasi substrat karbohidrat oleh bakteri. Remineralisasi adalah proses perbaikan alami untuk lesi non cavitated. Remineralisasi terjadi jika terdapat ion Ca2+ dan PO43- dalam jumlah cukup. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) adalah bahan berbentuk pasta berisi suatu protein susu (kasein). Pada kasein terkandung mineral kalsium dan fosfat. Kemampuan kasein untuk menstabilkan kalsium fosfat dan meningkatkan kelarutan dan bioavailabilitas sehingga CPP memiliki potensi menghantarkan kalsium dan fosfat. Tujuan: Tujuan penelitian ini untuk mengetahui kadar kalsium enamel setelah pengulasan CPP-ACP pada permukaan enamel 2 kali sehari selama 3,14 dan 28 hari. Metode: Sampel adalah gigi insisif sapi, usia 3 tahun. Pada penelitian ini sampel (n = 24) dibagi menjadi 4 kelompok yaitu kelompok I sebagai kelompok kontrol, dan kelompok II, III, IV sebagai kelompok perlakuan dengan pengulasan CPP-ACP 2 kali sehari. Semua kelompok direndam dalam saliva buatan. Kelompok II direndam 3 hari, kelompok III direndam 14 hari, kelompok IV direndam 28 hari. Pengulasan CPP-ACP sejumlah 1 tetes diratakan pada seluruh permukaan labial gigi. Pengukuran kadar kalsium dilakukan dengan metode titrasi. Semua data dianalisa dengan uji One-Way ANOVA dengan taraf kemaknaan 5%. Hasil: Hasil penelitian menunjukkan perbedaan yang signifikan kadar kalsium enamel gigi di antara kelompok (p = 0,001). Hasil penelitian menunjukkan perbedaan yang signifikan kadar kalsium gigi pada kelompok kontrol dan perlakuan antara lama waktu pengulasan 3, 14, dan 28 hari (p = 0,001). Kesimpulan: Pengulasan CPP-ACP selama 3, 14 dan 28 hari mampu meningkatkan kadar kalsium pada enamel.

Microleakage of conventional, resin-modified, and nano-ionomer glass ionomer cement as primary teeth filling material Dita Madyarani; Prawati Nuraini; Irmawati Irmawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 4 (2014): December 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Glass ionomer cements are one of many dental materials that widely used in pediatric dentistry due to their advantage of fluoride release and chemical bond to tooth structure. Adherence of the filling material to the cavity walls is one of the most important characteristic that need to be examined its effect on microleakage. Purpose: This study was conducted to examine the microleakage of nano-ionomer glass ionomer cement compared with the conventional and resin-modified glass ionomer cements. Methods: Standard class V cavities sized 3 mm x 2 mm x 2 mm were made on a total of 21 extracted maxillary primary canine teeth and restored with the conventional, resin-modified, dan nano-ionomer glass ionomer cements. All the teeth were immersed in a 2% methylene blue dye for 4 hours. The depth of dye penetration was assessed using digital microscope after sectioning the teeth labio-palatally. The results were statistically analyzed using Kruskal-Wallis test. Results: All type of glass ionomer material showed microleakage. Conventional glass ionomer cement demonstrated the least microleakage with mean score 1.29. the resin-modified glass ionomer cements (mean score 1.57) and nano-ionomer glass ionomer cement (mean score 2.57). Conclusion: The conventional glassionomer, resin modified glassionomer, and nano-ionomer glassionomer showed micro leakage as filling material in primary teeth cavity. The micro leakage among three types was not significant difference. All three material were comparable in performance and can be used for filling material but still needs a coating material to fill the microleakage.Latar belakang: Semen ionomer kaca adalah salah satu dari banyak bahan gigi yang banyak digunakan dalam praktek kedokteran gigi anak karena bahan tersebut merilis fluoride dan berikatan kimia dengan struktur gigi. Perlekatan bahan tumpatan pada dinding kavitas adalah salah satu karakteristik paling penting yang perlu diteliti efeknya terhadap kebocoran mikro. Tujuan: Penelitian ini dilakukan untuk meneliti kebocoran mikro nano-ionomer glass ionomer dibandingkan dengan glass ionomer konvensional dan resin-modified. Metode: Standard kelas V kavitas berukuran 3 mm x 2 mm x 2 mm dibuat pada total 21 gigi kaninus sulung rahang atas hasil pencabutan dan ditumpat dengan glass ionomer tipe konvensional, resin-modified, dan nano-ionomer. Kemudian semua gigi direndam dalam 2% metilen biru selama 4 jam. Setelah gigi dibelah labio-palatal kedalaman penetrasi pewarna dinilai menggunakan mikroskop digital. Hasil dianalisis secara statistik menggunakan uji Kruskal-Wallis. Hasil: Semua jenis bahan glass ionomer menunjukkan kebocoran mikro. Glass ionomer tipe konvensional menunjukkan kebocoran mikro terendah dengan rata-rata skor 1,29; glass ionomer tipe resin-modified (rata-rata 1,57) dan glass ionomer tipe nano-ionomer (rata-rata skor 2.57). Hasil uji statistik menunjukkan kebocoran pada tepi ketiga bahan tersebut tidak berbeda secara signifikan. Simpulan: Bahan tumpatan glass ionomer tipe konvensional, resin-modified, dan nano-ionomer, ketiganya menunjukkan kebocoran tepi tumpatan yang tidak berbeda signifikan. Ketiga bahan yang sebanding dalam performance dan dapat digunakan untuk bahan tumpatan tapi masih membutuhkan bahan pelapis untuk mengisi kebocoran mikro yang terjadi.

Relationship between salivary fluor concentration and caries index in 12–15 years old children Vidyana Pratiwi; Dudi Aripin; Ame Suciati Setiawan
Dental Journal (Majalah Kedokteran Gigi) Vol. 45 No. 1 (2012): March 2012
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Dental caries is a bacterial infection leading to dissolution and localized damage of hard tissues. The assessment of caries risk is based on several caries indicators including clinical conditions (DMF-T index), environment (fluor), and general health. Purpose: The objective of this study was to assess the relationship between salivary fluor concentration and caries index in children aging 12–15 years old at SMP Negeri 2 PTPN VIII Pangalengan. Methods: This study is an observational analytical study using crosssectional approach and is conducted in a field trial manner. The study sample consists of 80 students in the age of 12 to 15 years old at SMP Negeri 2 PTPN VIII selected through Probability Sampling manner using simple random sampling method. Results: The result of this study shows a DMF-T index of 4.32 and salivary fluor concentration mean of 0.018. Pearson Product Moment correlation test shows that there is a weak correlation between salivary fluor concentration and DMF-T index. Conclusion: It is concluded that the salivary fluor concentration has an insignificant correlation with the DMF-T index since the fluor concentration in saliva is very low.Latar belakang: Karies gigi adalah penyakit infeksi bakteri yang berakibat pada disolusi dan kerusakan terlokalisasi jaringan keras. Penilaian risiko karies berdasarkan atas beberapa indikator karies yaitu kondisi klinis (indeks DMF-T), lingkungan (fluor), dan kesehatan umum. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan konsentrasi fluor yang terdapat dalam saliva dengan indeks karies pada anak usia 12-15 tahun di SMP Negeri 2 PTPN VIII Pangalengan. Metode: Jenis penelitian ini adalah penelitian analitik observasional dengan pendekatan cross sectional yang dilakukan di lapangan. Sampel penelitian sebanyak 80 orang siswasiswi usia 12–15 tahun di SMP Negeri 2 PTPN VIII Pangalengan yang dipilih secara Probability Sampling dengan metode simple random sampling. Hasil: Hasil penelitian menunjukkan indeks DMF-T 4,32 dan rerata konsentrasi fluor dalam saliva sebesar 0,018. Tes korelasi Pearson Product Moment menunjukkan hubungan yang tidak kuat antara konsentrasi fluor dalam saliva dengan indeks DMF-T. Kesimpulan: Dapat disimpulkan konsentrasi fluor dalam saliva mempunyai hubungan dengan indeks DMF-T tetapi tidak signifikan dikarenakan nilai konsentrasi fluor dalam saliva yang sangat rendah.

Characterization of lactoferrin in gingival crevicular fluid of chronic periodontitis patient Sisca Meida Wati; Istiati Istiati; Pratiwi Soesilawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 3 (2014): September 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Human periodontal diseases are inflammatory disorders as the result of complex interactions between periodontopathogens and the host’s immune response. Periodontitis results in tooth loss and can even lead to systemic diseases if not treated. Gingival crevicular fluid (GCF) reflects the condition of the gingiva and contains proteins transuded from serum or cells at inflamated sites. Polymorphonuclear leukocyte (PMNs) infiltration can be seen in each stage of periodontitis. Lactoferrin is one of the PMN specific granules and could be a useful marker of PMN activity. Purpose: The aim of this study was to determine the band intensity of lactoferrin used as periodontitis biomarker. Methods: Gingival crevicular fluid (GCF) samples were collected using paper point no.30 from 40 subjects, 30 periodontitis patients that devide according to the severity (10 mild periodontitis, 10 moderate periodontitis, and 10 severe periodontitis) and 10 healthy controls, ranging in ages from 20 to 35 years. GCF lactoferrin was analyzed by Western blot and measured the band intensity by quantity one software (bio-rad). Results: The periodontitis sites exhibited significantly greater band intensity of lactoferrin than healthy sites. The band intensity of lactoferrin was positively correlated with the severity of periodontitis (α = 0.05). Conclusion: The study showed that the intensity of the lactoferrin protein bands could be used as biomarkers of periodontitis.Latar belakang: Penyakit periodontal adalah gangguan inflamasi yang merupakan hasil dari interaksi yang kompleks antara periodontopathogens dan respon imun host. Periodontitis mengakibatkan hilangnya gigi dan bahkan dapat menyebabkan penyakit sistemik jika tidak diobati. Cairan sulkus gingiva (GCF) mencerminkan kondisi gingiva dan mengandung protein yang tertransudasi dari serum atau sel pada lokasi radang. Infiltrasi polymorphonuclear leukosit (PMN) dapat dilihat pada setiap tahap periodontitis. Laktoferin adalah salah satu granula spesifik PMN dan bisa menjadi indicator aktivitas PMN. Tujuan: Tujuan penelitian ini adalah untuk meneliti intensitas band laktoferin dapat sebagai biomarker periodontitis. Metode: Cairan sulkus gingiva (GCF) dari tiap sampel dikumpulkan menggunakan paper pint no. 30 dari 40 subjek, 30 pasien dengan periodontitis yang dibagi sesuai dengan tingkat keparahan (10 periodontitis ringan, 10 periodontitis moderat, dan 10 periodontitis parah) dan 10 kontrol, mulai usia 20-35 tahun. GCF lactoferrin dianalisis dengan Western blot dan diukur intensitas bandnya dengan quantity one software (bio-rad). Hasil: Pada jaringan yang mengalami periodontitis menunjukkan intensitas band yang secara signifikan lebih besar dari laktoferin daripada periodontal yang sehat. Intensitas band laktoferin berkorelasi positif dengan tingkat keparahan periodontitis (α = 0,05) Simpulan: Hasil penelitian ini menyimpulkan bahwa intensitas band protein laktoferin dapat digunakan sebagai biomarker periodontitis.

The role of probiotic on alveolar bone resorption Desi Sandra Sari; Zahara Meilawaty; M. Nurul Amin
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 3 (2011): September 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Probiotics are microbes derived from the group of lactic acid bacteria that work to maintain the health of hosts. Probiotics can also be used to improve oral health. Periodontal disease is usually marked with gingival inflammation and alveolar bone resorption. Gram negative anaerobic bacteria that play important role in human periodontal disease are Porphyromonas gingivalis. (P. gingivalis). P. gingivalis is a virulent bacteria in vivo or in vitro, and mostly found in subgingival plaque of periodontitis patients. Purpose: This study is aimed to know the role of probiotics to inhibit the resorption of alveolar bone induced with P. gingivalis. Methods: This study used male wistar rats divided into 4 groups. Group I was control group (without treatment); group II was induced with P. gingivalis ATCC 33277 for 5 days; group III was induced with P. gingivalis ATCC 33277 and also injected with probiotics (Lactobacillus casei ATCC 4224) for 5 days simultaneously; and group IV was induced with P. gingivalis ATCC 33277 for 5 days and also injected by probiotics (Lactobacillus casei ATCC 4224) in the next 5 days. After that, the samples were decapitated, taken their alveolar bone, and then were examined by immunohistochemistry to observe osteoclast activity in alveolar bone resorption by using tartrate-resistant acid phosphatase (TRAP) expression. All data were then analyzed statistically. Results: It is known that there were significant differences of TRAP expression among all those treatment groups (p < 0.05). Conclusion: It then can be concluded that probiotics can decrease osteoclast activity in periodontal tissue of wistar rats, so it can inhibit alveolar bone resorption.Latar belakang: Probiotik adalah mikroba dari golongan bakteri asam laktat yang bekerja mempertahankan kesehatan host dan probiotik dapat digunakan untuk meningkatkan kesehatan rongga mulut. Penyakit periodontal ditandai dengan adanya keradangan pada gingiva dan resobsi tulang alveolar. Bakteri Gram negatif anaerob yang sangat berperan dengan penyakit periodontal pada manusia adalah Porphyromonas gingivalis (P. gingivalis). P. gingivalis merupakan bakteri yang virulen, baik diuji secara in vivo maupun in vitro, dan banyak ditemukan pada plak subgingiva penderita periodontitis. Tujuan: Penelitian ini bertujuan untuk mengetahui peran probiotik dalam menghambat resorbsi tulang alveolar yang diinduksi P.gingivalis. Metode: Penelitian ini memakai tikus jenis wistar jantan sebagai sampel dan dibagi menjadi 4 kelompok: Kelompok I yaitu kontrol tanpa perlakuan; kelompok II di induksi P.gingivalis ATCC 33277 selama 5 hari; Kelompok III di induksi P.gingivalis ATCC 33277 ditambah suntikan probiotik (Lactobacillus casei ATCC 4224) selama 5 hari secara bersamaan; dan Kelompok IV di induksi P.gingivalis ATCC 33277 selama 5 hari ditambah suntikan probiotik (Lactobacillus casei ATCC 4224) 5 hari selanjutnya. Setelah itu sampel didekaputasi, diambil tulang alveolar dilakukan pemeriksaan imunohistokimia untuk melihat aktivitas osteoklas dalam resopsi tulang alveolar dengan mendeteksi tartrate-resistant acid phosphatase (TRAP). Data yang dikumpulkan dianalisis secara statistik. Hasil: Terdapat perbedaan yang bermakna antar kelompok untuk ekspresi TRAP (p < 0.05). Kesimpulan: Dapat disimpulkan bahwa probiotik dapat menurunkan aktivitas osteoklas pada wistar tikus yang mengalami periodontitis sehingga dapat mencegah resorbsi tulang alveol.

Topical applications effect of casein phospho peptide-amorphous calcium phosphate and sodium fluoride on salivary Mutans Streptococci in children Fajriani Fajriani; Aini Dwi Handini
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 2 (2014): June 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Dental caries is one of the major human diseases caused by Mutans Streptococci (MS). Topical application casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) dan Sodium fluoride are often use in children and play a role in the caries prevention. Purpose: The aim of study was to determine the effect of casein phosphopeptide–amorphous calcium phosphate (CPP-ACP) and Sodium fluoride topical applications to the number of salivary MS colonies in children. Methods: This study using cross-over design with quase experiment time-series. The subjects were 30 children in range of age 6-12 years old that obtained with simple random sampling. The saliva samples of subjects were collected 3 times. First, saliva samples were taken before the treatment; second, after CPP-ACP topical application; third, after sodium fluoride topical application. Between the CPP-ACP and sodium fluoride treatments there was a one week wash-out period. After each treatment, saliva samples were taken twice, 15 and 30 minutes after topical applications respectively. After cultivation on specific agar, the colony number of salivary MS was determined by colony counting (Colony Forming Units-CFU). Results: There was no significant difference between topical application casein phosphopeptide – amorphous calcium phosphate (CPP-ACP) and Sodium fluoride in reducing the number of Streptococcus mutans. But topical application of Sodium fluoride tended to show more reduction than CPP-ACP. Conclusion: The topical application of CPP-ACP and Sodium fluoride could reduce the number of salivary MS in children. The effect of Sodium Fluoride was somewhat greater than CPP-ACP.Latar belakang: Karies gigi merupakan salah satu penyakit manusia utama yang disebabkan oleh Streptococcus Mutans (MS). Topikal aplikasi kasein phosphopeptide - amorf kalsium fosfat (CPP-ACP) dan sodium fluoride sering digunakan pada anak-anak dan berperan dalam pencegahan karies. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi kasein phosphopeptide - amorf kalsium fosfat (CPP-ACP) dan Sodium fluoride secara topikal terhadap jumlah koloni MS pada saliva anak. Metode: Penelitian ini menggunakan desain cross-over dengan percobaan Quase time-series. Subjek penelitian ini adalah 30 anak dalam rentang usia 6-12 tahun yang diperoleh dengan simple random sampling. Sampel saliva subjek dikumpulkan 3 kali. Pertama, sampel saliva diambil sebelum perlakuan; kedua, setelah aplikasi topikal CPP-ACP; ketiga, setelah aplikasi topikal sodium fluoride. Antara aplikasi CPPACP dan sodium fluoride ada periode wash-out satu minggu. Setelah perlakuan, sampel saliva yang diambil dua kali, 15 dan 30 menit setelah masing-masing aplikasi topikal. Setelah ditumbuhkan pada media agar yang spesifik, jumlah koloni MS ditentukan dengan cara hitung koloni (Colony Forming Unit-CFU). Hasil: Tidak ada perbedaan yang signifikan antara topikal aplikasi kasein phosphopeptideamorf kalsium fosfat (CPP-ACP) dan sodium fluoride dalam mengurangi jumlah Streptococcus mutans. Tetapi aplikasi topikal Sodium fluoride cenderung menunjukkan penurunan lebih banyak dari CPP-ACP. Simpulan: Aplikasi topikal dari CPP-ACP dan Sodium fluoride dapat mengurangi jumlah MS pada saliva anak. Pengaruh Sodium Fluoride sedikit lebih besar dari CPP-ACP.

Relieving idiopathic dental pain without drugs Haryono Utomo; M. Rulianto
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 2 (2011): June 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Teeth are commonly obvious source of orofacial pain. Sometimes the pain source is undetectable, thus called as idiopathic dental pain. Since dentist wants to alleviate or eliminate the pains with every effort in their mind, a lot of drugs could be prescribed. Moreover, it is make sense that endodontic treatment or even tooth extraction will be done. Unfortunately, endodontic treatment may also initiate neuropathic tooth pain that is caused by nerve extirpation, thus worsen the pain. Therefore, another cause of dental pain such as referred pain, periodontal disease, or stress which related to psychoneuroimmunology should be considered. In order to prevent from unnecessary drugs or invasive treatment such as root canal treatment and extraction, correct diagnosis and preliminary non-invasive therapies should be done. Purpose: This review elucidates several therapies that could be done by dentists for relieving idiopathic dental pain which includes massage, the “assisted drainage” therapy, modulation of psychoneuroimmunologic status and dietary omega-3. Reviews: Understanding the basic pathogenesis of pain may help in elucidating the effects of non-drug pain therapy such as muscle massage, the “assisted drainage” therapy, omega-3 and psychological stress relieving. These measures are accounted for eliminating referred pain, reducing proinflammatory mediators and relieving unwanted stress reactions consecutively. Psychological stress increases proinflammatory cytokines and thus lowered pain threshold. Conclusion: As an individual treatment, this non-drug therapy is useful in relieving idiopathic dental pain; nevertheless, if they work together the result could be more superior.Latar belakang: Gigi adalah suatu penyebab umum dari nyeri orofasial. Kadang kala penyebab nyeri tidak dapat ditemukan, sehingga disebut sebagai nyeri gigi idiopatik. Karena dokter gigi berupaya untuk mengurangi atau menghilangkan nyeri dengan segala cara maka banyak obat akan diresepkan ke pasien. Bila gagal maka sangat mungkin dilakukan perawatan saraf gigi bahkan pencabutan gigi. Akan tetapi, perawatan endodontik juga dapat menimbulkan nyeri neuropatik yang disebabkan oleh ekstirpasi saraf gigi, sehingga nyeri makin parah. Sebab itu, penyebab lain nyeri gigi seperti nyeri yang dialihkan (referred pain), penyakit periodontal atau stres yang berhubungan dengan psikoneuroimunologi perlu dipertimbangkan.Untuk mencegah kejadian konsumsi obat yang tidak perlu ataupun perawatan endodontik dan pencabutan gigi maka diagnosis yang tepat dan terapi non-invasif harus dilakukan terlebih dahulu. Tujuan: Studi pustaka ini menerangkan beberapa terapi yang dapat dilakukan dokter gigi untuk mengurangi nyeri gigi idiopatik yaitu masase, terapi assisted drainage,modulasi status psikoneuroimunologi dan diet omega-3. Tinjauan Pustaka: Pengetahuan mengenai patogenesa nyeri dapat menerangkan efek terapi nyeri non-medikamentosa seperti masase otot, terapi assisted drainage, diet omega-3 dan mengurangi stres psikologis. Berbagai terapi ini dapat mengurangi nyeri alihan, mediator proinflamasi dan mengurangi stres. Stres psikologis akan mengingkatkan sitokin proinflamasi yang menurunkan ambang nyeri. Kesimpulan: Sebagai terapi individual, terapi non-medikamentosa ini berguna untuk mengurangi nyeri gigi idioaptik, akan tetapi bila bekerja sama dapat lebih baik lagi.

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Home Page

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Contact Name Saka Winias

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Phone -

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Contact Name
Saka Winias

Contact Email
saka.winias@gmail.com

Phone
-

Journal Mail Official
dental_journal@yahoo.com

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA