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Hubungan Gagal Ginjal Kronik Tingkat 4 Dan 5 Dengan Kejadian Dislipidemia Pada Pasien Gagal Ginjal Kronik Di Rumah Sakit Umum Pusat Fatmawati Periode Tahun 2016 Wibawanto, Dimas Farhan; Paris, Salman; Thadeus, Maria Selvester
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Dyslipidemia is a common complication of chronic kidney disease. Dyslipidemia itself is a common risk for a cardiovascular disease, which is the leading cause of death in chronic kidney disease. This study aims to identify the relationship of chronic kidney disease stage 4 and 5 with the incidence of dyslipidemia at Fatmawati General Hospital in the period of 2016. Design cross-sectional with simple random sampling technique. Data were collected by looking at the patient's medical records. Respondents are 80 people. The study population were all patients diagnosed with chronic kidney disease at Fatmawati Central General Hospital in 2016. The results showed that most chronic kidney disease stage 4 has normal level of low density lipoprotein as many 22 people (73.33%) while at stage 5 most have high level of low density lipoprotein high as many 36 people (72%). High density lipoprotein obtained in patients with chronic kidney disease stage 4 mostly had normal level as many 20 people (66.67%) for stage 5 mostly had low level as many 33 people (66%). Mean lipid values of triglyceride X̄ = 152,36, high density lipoprotein X̄ = 39,36 and low density lipoprotein X̄ = 145,01. Result of bivariate analysis with chi square test showed significant relationship of chronic kidney disease stage 4 and 5 with incidence of dyslipidemia (p = 0,002).

EFEKTIVITAS PEMBERIAN EKSTRAK BIJI KETUMBAR TERHADAP GAMBARAN SEL BUSA ATEROSKLEROSIS AORTA ABDOMINALIS TIKUS HIPERKOLESTEROLEMIA DIABETES Giopratiwi, Kusvandita; Thadeus, Maria Selvester; Yulianti, Retno
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 4, No 2 (2020): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v4i2.8250

Coriander Seed Extract (CSE) is thought to have the potential to repair foam cell formation process which is part of atherosclerotic lesion. The aim of this study is to identify the effects of coriander seed extract on histopathological features of atherosclerotic foam cells abdominal aorta in rats hypercholesterolemia diabetes model. The study was conducted for 63 days. 30 Wistar outbred rats were grouped into five groups, each group consist of 6 rats. Negative control group (standar feed), positive control group (high fat diet and alloxan + glibenclamide 0.045 mg), treatment group 1 (high fat diet and alloxan + CSE 300 mg/kgBB/day), treatment group 2 (high fat diet and alloxan + CSE 500 mg/kgBB/day), treatment group 3 (high fat diet and alloxan + CSE 700 mg/kgBB/day). After the treatment were given to each group, the next procedure were dissection, extraction of the aorta abdominal organ, and histopathological examination of foam cell. Data were analyzed with One Way ANOVA test and Post Hoc Bonferoni test show there are significant difference (P value = 0.049) between positive control group and treatment group 3. In conclusion, CSE 700 mg/kgBB dose can reduce foam cell formation. Keywords: atherosclerosis; coriander seed extract; foam cell; hypercholesterolemia. ABSTRAK Ekstrak biji ketumbar (EBJ) diduga memiliki potensi untuk memperbaiki proses pembentukan sel busa lesi aterosklerosis. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian ekstrak biji ketumbar terhadap gambaran histopatologi sel busa aterosklerosis aorta abdominalis tikus model hiperkolesterolemia diabetes. Penelitian dilakukan selama 63 hari. Sebanyak 30 ekor tikus Galur Wistar outbred dibagi ke dalam 5 kelompok, masing-masing kelompok terdiri dari 6 ekor. Kelompok kontrol negatif (pakan standar), kelompok kontrol positif (pakan tinggi lemak dan aloksan + glibenklamid 0.045 mg), kelompok perlakuan 1 (pakan tinggi lemak dan aloksan + EBJ 300 mg/kgBB/hari), kelompok perlakuan 2 (pakan tinggi lemak dan aloksan + EBJ 500 mg/kgBB/hari), dan kelompok perlakuan 3 (pakan tinggi lemak dan aloksan + EBJ 700 mg/kgBB/hari). Setelah perlakuan, dilakukan pembedahan dan pengambilan organ aorta abdominalis lalu dibuat preparat untuk menilai gambaran sel busa. Analisis statistika dengan Uji One Way ANOVA dan uji Post Hoc Bonferoni menunjukkan ada perbedaan signifikan (P Value=0.049) antara kelompok kontrol positif dengan kelompok perlakuan 3. Kesimpulannya, EBJ dosis 700 mg/kgBB/hari memiliki efektivitas untuk menurunkan pembentukan sel busa dalam proses aterosklerosis.

UJI EFEKTIVITAS EKSTRAK BIJI KETUMBAR (CORIANDRUM SATIVUM L.) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS HIPERKOLESTEROLEMIA DIABETES Nazira, Syarifah; Thadeus, Maria Selvester; Hardini, Niniek
Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Vol 4, No 2 (2020): Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan
Publisher : Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmstkik.v4i2.8249

Diabetes Mellitus (DM) is metabolic disease characterized hyperglicemia caused by abnormalities of insulin secretion, insulin sensitivity, or both of them. Persistent hyperglicemia can trigger the production of oxidative stress. Oxidative stress can cause glomerular hypertrophy. Coriander seed extract has the potential to overcome oxidative stress. This study aims to determine the effect of coriander seed extract to kidney histopathological examination, blood cholesterol, and blood sugar level in hypercholestrolemia diabetic rats. Samples consist of 30 males wistar rats were divided into five treatments i.e: (K1) standard feed and aquades, (K2) high-fat feed, alloxan, and glibenclamid 0,045 mg/day, (K3) high-fat feed, alloxan, and coriander seed extract 300 mg/kgBW/day, (K4) high-fat feed, alloxan, and coriander seed extract 500mg/kgBW/day, (K5) high-fat feed, alloxan, and coriander seed extract 700mg/kgBW/day. Coriander seed extract was given for 28 days. The result of Wilcoxon test showed that coriander seed extract can reduce blood cholesterol level in diabetic hypercholesterolemia, meanwhile the result of paired T-test showed that it can reduce blood sugar level. Measurement of kidney’s histopathological structure as glomerular area was analyzed by Kruskal Wallis test (p=0,001) and continued with Mann-Whitney test. Group K4 can reduce glomerular area significantly compared with group K3 and K5. In conclussion, coriander seed extract can reduce blood cholesterol, blood sugar level and effectively reduce glomerular hypertrophy at dose of 500mg/kgBW/day. Keyword : Coriandrum sativum L.; coriander seed extract; glomerular hypertrophy; blood cholesterol level; blood glucose level ABSTRAK Diabetes Melitus (DM) merupakan suatu penyakit metabolik dengan karakteristik hiperglikemi yang terjadi karena kelainan sekresi insulin, kerja insulin atau kedua-duanya. Hiperglikemi persisten dapat memicu produksi stres oksidatif. Stres oksidatif dapat menyebabkan terjadinya hipertrofi glomerulus. Ekstrak biji ketumbar (Coriandrum sativum L.) berpotensi mengatasi stres oksidatif. Penelitian ini bertujuan untuk mengetahui efek pemberian esktrak biji ketumbar (Coriandrum sativum L.) terhadap gambaran histopatologi ginjal, kadar kolesterol darah, dan kadar gula darah tikus model hiperkolesterolemia diabetes. Sebanyak 30 ekor tikus putih jantan galur wistar, dikelompokkan menjadi lima kelompok dengan perlakuan berbeda yaitu: (K1) pakan standar dan aquades, (K2) pakan tinggi lemak, aloksan, dan glibenklamid 0,045mg/hari, (K3) pakan tinggi lemak, aloksan dan ekstrak biji ketumbar 300mg/kgBB/hari, K4) pakan tinggi lemak, aloksan dan ekstrak biji ketumbar 500mg/kgBB/hari, (K5) pakan tinggi lemak, aloksan, dan ekstrak biji ketumbar 700mg/kgBB/hari. Ekstrak biji ketumbar diberikan selama 28 hari. Hasil uji Wilcoxon menunjukkan ekstrak biji ketumbar dapat menurunkan kadar kolesterol darah, sedangkan hasil uji T berpasangan menunjukkan ekstrak biji ketumbar dapat menurunkan kadar guka darah sewaktu pada tikus model hiperkolesterolemia diabetes. Histopatologi ginjal dianalisis menggunakan uji Kruskal Wallis didapatkan (p=0,001) dan dilanjutkan dengan uji Mann-Whitney. Pada kelompok K4 terdapat penurunan luas glomerulus yang signifikan dibanding kelompok K3 dan K5. Kesimpulannya, esktrak biji ketumbar dapat menurunkan kadar kolesterol darah, kadar gula darah, dan pada dosis 500mg/kgBB/hari paling efektif untuk menurunkan hipertrofi gomerulus.

MANFAAT ASAM FOLAT UNTUK MENCEGAH OROFACIAL CLEFT PADA KOMUNITAS SATU SENYUM Fauziah, Cut; Thadeus, Maria Selvester; Bahar, Meiskha; Sukrisno, Adi; Zulfa, Fajriati
Jurnal Pengabdian Masyarakat AbdiMas Vol 8, No 03 (2022): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v8i03.5185

Kasus bayi lahir dengan bibir sumbing masih banyak terjadi di Indonesia. Bibir sumbing merupakan kelainan berupa celah pada bibir atas. Celah ini bisa terjadi pada bagian langit-langit rongga mulut (cleft palate), bisa juga pada bagian bibir saja (cleft lip). Di beberapa kasus juga bisa terjadi pada kedua bagian. Namun pada umumnya, hampir separuh kasus bibir sumbing melibatkan celah pada bibir atas serta atap rongga mulut. Pemberian asam folat pada ibu hamil bertujuan untuk mencegah terjadinya kelainan kongenital yang terjadi selama masa perkembangan embryo , khususnya di trimester pertama. Kelainan kongenital yang selama ini berhubungan dengan kondisi folat ibu adalah Neural Tube Defect. Penelitian penelitian selanjutnya juga menyatakan bahwa ternyata asam folat juga berpengaruh terhadap kegagalan pembentukan jantung yang sempurna, kejadian celah bibir dan/atau langit. Metode penyuluhan dilakukan dengan metode ceramah secara daring via zoom, menggunakan slide power point tentang manfaat asam folat bagi ibu ibu anggota komunitas yang masih ingin memiliki anak dan tentang mempersiapkan kehamilan yang sehat dan menghadapi seribu hari pertama kehidupan. Keberhasilan dari kegiatan ini adalah terpenuhinya target dari jumlah peserta, serta ketercapaian tujuan dari kegiatan penyuluhan ini juga dapat dikatakan baik dari hasil pretest dan postest dan ketercapaian target materi (100%). Kesimpulan dari kegiatan ini adalah terjadi peningkatan pengetahuan pada ibu ibu anggota komunitas dapat tentang manfaat asam folat untuk pencegahan orofacial cleft pada kehamilan berikutnya. Kata Kunci: Asam folat, orofacial cleft, komunitas

Effects of Leadtree Seed (Leucaena leucocephala) Extract in Inhibiting the Increase of Postprandial Blood Glucose Level in Alloxan-induced Diabetic Rats Ibnu Wadud Pujangga; Dorlina Nainggolan; Maria Selvester Thadeus
Jurnal Gizi dan Pangan Vol. 14 No. 3 (2019)
Publisher : Food and Nutrition Society of Indonesia

This research aimed to add evidence on the effect of white leadtree seed extract (Leucaena leucocephala) on postprandial blood glucose level on white male alloxan induced diabetic rats. This research was an experiment with pretest-posttest control group design. The subjects of this research were 25 white male rats, Wistar strain was divided into 5 groups. Group I was the positive control, which was treated with Acarbose, group II was the negative control, and group III, group IV, and group V were treatment groups and were given white leadtree seed extract of 1.5 g/kg of BW, 3.5 g/kg of BW, and 7.8 g/kg of BW respectively. Blood glucose level was checked before and two hours after treatment. The statistical analysis used one-way ANOVA and Bonferroni post hoc test. The result showed that there were no significant differences between group III, group IV, and group V and the positive control group (p<0.05). The best result of inhibition of the increase in blood glucose level was found in 7.8 g/kg of BW (group V) dosage group with average difference of 186.4 mg/dl. In conclusion, white leadtree seed extract could decrease two hour postprandial blood glucose level in white male alloxan-induced diabetic rats and a dosage of 7.8 g/kg of BW was shown to be the most effective.

Akurasi Diagnostik FNAB Dalam Mendiagnosis Karsinoma Tiroid Pada Pasien Dengan Nodul Tiroid Adrian Dharmawan; Niniek Hardini; Maria Selvester Thadeus
Jurnal Kedokteran Syiah Kuala Vol 21, No 3 (2021): Volume 21 Nomor 3 Desember 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i3.22193

Nodul tiroid merupakan temuan klinis yang umum ditemui dimana nodul yang dapat teraba pada pemeriksaan klinis ditemukan pada sekitar 4-7% dari populasi di seluruh dunia. Karsinoma tiroid ditemukan pada sekitar 3-16,6% nodul yang diperiksa. Salah satu uji diagnostik yang sering digunakan dalam menegakkan karsinoma tiroid adalah fine-needle aspiration biopsy (FNAB). Tujuan dari penelitian ini adalah diharapkan dapat mengidentifikasi akurasi diagnostik FNAB dalam mendiagnosis karsinoma tiroid berdasarkan sensitivitas dan spesifisitasnya. Metode penelitian ini berupa systematic review yang dilakukan berdasarkan the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) 2015. Database yang digunakan adalah PubMed dan ScienceDirect. Tiga puluh lima studi memenuhi kriteria inklusi. Hasil penelitian memberikan sensitivitas gabungan 0,68 (95% CI, 0,650-0,703) dan spesifisitas gabungan 0,97 (95% CI, 0,961-0,976). Kesimpulan penelitian ini adalah FNAB merupakan uji diagnostik yang baik karena memberikan sedikit false positive namun tidak cocok dijadikan sebagai uji skrining karena jumlah false negative yang cukup tinggi.

Hubungan antara Tingkat Keparahan Obstructive Sleep Apnea dan Fungsi Kognitif pada Pasien Rumah Sakit Angkatan Laut Dr. Mintohardjo Eko Satrio Bahari; Nurfitri - Bustamam; Maria Selvester Thadeus
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I1.11073

Hubungan antara Tingkat Keparahan Obstructive Sleep Apnea dan Fungsi Kognitif pada Pasien Rumah Sakit Angkatan Laut Dr. Mintohardjo. Prevalensi obstructive sleep apnea (OSA) pada populasi dewasa diperkirakan berkisar antara 5-14%. Sebagian besar pasien OSA di Rumah Sakit Angkatan Laut (Rumkital) Dr. Mintohardjo, Jakarta diukur tingkat keparahannya menggunakan polisomnografi. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat keparahan OSA dan fungsi kognitif. Penelitian menggunakan desain cross sectional dan teknik consecutive sampling. Data diambil dari 60 pasien OSA Rumkital Dr. Mintoharjo pada bulan April-Mei 2018. Data tingkat keparahan OSA diambil dari rekam medis, sedangkan data fungsi kognitif diukur menggunakan kuesioner Montreal Cognitive Assessment Indonesia version (MoCA-Ina). Subjek penelitian sebagian besar adalah pasien OSA laki-laki dengan usia rata-rata 43 tahun, berpendidikan tinggi, dan bekerja sebagai pegawai swasta. Berdasarkan data apnea-hypopnea index didapatkan 25 pasien OSA berat, 23 pasien OSA sedang, dan 12 pasien OSA ringan. Pada penelitian didapatkan pula sebanyak 45 pasien dengan fungsi kognitif terganggu dan 15 pasien dengan fungsi kognitif normal. Hasil uji Chi-square menunjukkan hubungan antara tingkat keparahan OSA dan fungsi kognitif (p = 0,000). Perlu diberikan edukasi kepada pasien OSA agar patuh mengikuti tatalaksana yang dianjurkan dokter, sehingga penurunan fungsi kognitif lebih lanjut dapat dicegah.

Analisis Faktor Tingkat Kepatuhan Minum Obat Pasien Diabetes Melitus di Puskesmas Pancoran Mas Periode Maret – April 2019 Nadira Safa Jasmine; Sri Wahyuningsih; Maria Selvester Thadeus
Jurnal Manajemen Kesehatan Indonesia Vol 8, No 1 (2020): April 2020
Publisher : Magister Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmki.8.1.2020.61-66

The prevalence of diabetes mellitus (DM) will continue to increase throughout the years. A way to achieve normal blood sugar levels is through adherence to medications. Nonadherence to medications in DM patients can result in high blood sugar levels and increase the risk of complications. This study was conducted to determine factors affecting medication adherence among DM patients in Puskesmas Pancoran Mas Depok in March – April 2019. This was an observational analytic study using a cross-sectional method. MMAS-8, DKQ-24 and family support questionnaires were used to collect the data along with the demographic data. Chi-square was used to analyze the data. The factors affecting medical adherence included patients’ education level (OR=2.325; 95%CI=1.034-5.224), gender (OR=4.200 95%CI=1.699-10.380), diabetes duration (OR = 2.426 95%CI=1.019-5.775), number of drugs taken (OR=3.680 95%CI=1.604-8.445), dosing frequency (OR=3.350 95%CI=1.283-8.749), and patient’s knowledge (OR=2.668 95%CI=1.135-6.276). Logistic regression analyzes showed that gender is the most powerful factors in affecting medication adherence.

Hubungan Gagal Ginjal Kronik Tingkat 4 Dan 5 Dengan Kejadian Dislipidemia Pada Pasien Gagal Ginjal Kronik Di Rumah Sakit Umum Pusat Fatmawati Periode Tahun 2016 Dimas Farhan Wibawanto; Salman Paris; Maria Selvester Thadeus
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v12i2.296

Dyslipidemia is a common complication of chronic kidney disease. Dyslipidemia itself is a common risk for a cardiovascular disease, which is the leading cause of death in chronic kidney disease. This study aims to identify the relationship of chronic kidney disease stage 4 and 5 with the incidence of dyslipidemia at Fatmawati General Hospital in the period of 2016. Design cross-sectional with simple random sampling technique. Data were collected by looking at the patient's medical records. Respondents are 80 people. The study population were all patients diagnosed with chronic kidney disease at Fatmawati Central General Hospital in 2016. The results showed that most chronic kidney disease stage 4 has normal level of low density lipoprotein as many 22 people (73.33%) while at stage 5 most have high level of low density lipoprotein high as many 36 people (72%). High density lipoprotein obtained in patients with chronic kidney disease stage 4 mostly had normal level as many 20 people (66.67%) for stage 5 mostly had low level as many 33 people (66%). Mean lipid values of triglyceride X̄ = 152,36, high density lipoprotein X̄ = 39,36 and low density lipoprotein X̄ = 145,01. Result of bivariate analysis with chi square test showed significant relationship of chronic kidney disease stage 4 and 5 with incidence of dyslipidemia (p = 0,002).

Potential of Flavonoids on Aortic Histopathological Improvement of ApoE-/- Mice With High-Fat Diet: A Systematic Literature Review Hilmi Adyatma; Niniek Hardini; Maria Selvester Thadeus
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.6358

Non-communicable diseases account for more than 36 million deathsevery year (63% of all deaths). Globally, non-communicable diseases (NCDs) thatcause the most deaths each year are cardiovascular diseases. One of thecardiovascular diseases is coronary heart disease. The cause of coronary heartdisease is acute coronary syndrome. More than 90% of acute coronary syndromes(ACS) are the result of atherosclerotic disorders. Therefore, research on thepotential of flavonoids to improve histopathology of atherosclerosis needs to becarried out in order to provide information about alternative drugs that can beused by patients. The purpose of this research using a systematic literature reviewresearch methodology is to identify the potential of flavonoids to improve aortichistopathology in ApoE-/- mice with a high-fat diet. Systematic literature reviewby conducting a literature search using PubMed and Google Scholar. Literaturethat discusses flavonoids, ApoE-/- mice, high-fat diet, aorta, and atherosclerosis.There were 8 studies which concluded that flavonoids could inhibit or reduce theenlargement or further formation of aortic atherosclerotic plaques in ApoE-/- miceon a high-fat diet. Flavonoids have the potential to inhibit or reduce theenlargement or further formation of aortic atherosclerotic plaques in ApoE-/- miceon a high-fat diet.

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