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All Journal Jurnal Ilmiah Dinamika Teknik Jurnal Kedokteran Syiah Kuala Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Teknika Dentika Dental Journal Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Mechanova Jurnal Informatika Proceeding International Conference on Information Technology and Business Jurnal Pendidikan Matematika Universitas Lampung Jurnal Mudarrisuna: Media Kajian Pendidikan Agama Islam Jurnal SIMADA (Sistem Informasi dan Manajemen Basis Data) JURNAL TEKNIK INFORMATIKA DAN SISTEM INFORMASI JUSPI (Jurnal Sejarah Peradaban Islam) Petir Jurnal Peurawi : Media Kajian Komunikasi Islam Jurnal Penelitian IPTEKS Techno Xplore : Jurnal Ilmu Komputer dan Teknologi Informasi Jurnal Pengabdian Masyarakat IPTEKS Jurnal Teknologi dan Riset Terapan (JATRA) PELS (Procedia of Engineering and Life Science) Jurnal Isu Teknologi Suara Teknik : Jurnal Ilmiah
Hendra Kurniawan
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Journal : Jurnal Kedokteran Syiah Kuala

 1 
The Effect of Administration of Lycopene on Interleukin 8 Levels and Hospitalization Time of Patients with Chronic Obstructive Pulmonary Disease Exacerbations Yusup Subagio Sutanto; Diana Kurniasari Sagita; Suradi Suradi; Hendra Kurniawan
Jurnal Kedokteran Syiah Kuala Vol 19, No 1 (2019): Volume 19 Nomor 1 April 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i1.17404

Abstract

Background: Exacerbated chronic obstructive pulmonary disease is an acute condition, characterized by persistent air flow limitations, related to the excessive chronic inflammatory response in the airways and lung parenchyma caused by exposure to harmful gases or particles. Increased airway inflammation during exacerbations leads to increased levels of IL-8 and the risk of hospitalization. Lycopene is a carotenoid which has a positive effect on the respiratory system. The purpose of this study was to determine the effect of administration  lycopene to IL-8 levels and hospitalization time of patients with COPD disease exacerbations.Methods: The  experimental test with pretest and posttest  design for 30 patients with COPD exacerbations in Dr. Moewardi Surakarta Hospital and Dr. Soehadi Prijonegoro Sragen Hospital was conducted from February to March 2018. Samples were taken by consecutive sampling divided into two groups including the treatment group receiving standard therapy and lycopene 1x10 mg / day during treatment and the control group only receiving standard therapy. IL-8 levels  and hospitalization time of patients with COPD disease exacerbations  were measured.Results: There were significant differences between the treatment group compared to the control group for a decrease in IL-8 (p = 0.029) and a decrease in hospitalization time (p = 0,000).Conclusion: The administration of lycopene 1x10 mg / day significantly reduce IL-8 levels and hospitalization time of patient with COPD exacerbations. 
Co-Authors - Nurjoko Ali Hamdan Arnelis Djalil Budi Nuryono Diana Kurniasari Sagita Didik Wahjudi Eko Julianto Eko Sarwono Fitria - Fitria Fitria Fuazen Fuazen H. Harapan Harijanto Wijaya Ihwan Nurdin Irah Damayanti Libasut Taqwa M Ariza Eka Y Martaleli Bettiza Mohammad Bellal Hossain Mohd. Andalas Neni Purwati Nerfita Nikentari Nola Ritha Nurfiana Nurfiana Pentatito Gunowibowo Roche Alimin Ruki Rizal Sabar Rudiarto Sri Karnila SRI LESTARI Suaib H. Muhammad Suradi Suradi Suryo Adi Sahfutra Syarifah Feramuhawan Tekad Matulatan Tri Erri Astoeti Umi O. Retnaningsih Widijanto Sudhana Widiyanto, Eka Puji Yusup Subagio Sutanto