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Profile of photic driving in electroencephalography records at Mohammad Hoesin Hospital Palembang Sri Handayani; Erial Bahar; Olivia Amanda
JURNAL KEDOKTERAN DAN KESEHATAN Vol 6, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V6I3.9437

Abstract

Photic driving (PD) is a normal electroencephalography phenomenon in the parietooccipital region  during intermittent photic stimulation (IPS). The PD response is an indicator that is sensitive to age, brain maturity, certain abnormalities, changes in brain signal and brain complexity. Currently, there is not much  data about the PD response based on individual characteristics. Methods: It is a cross-sectional study with secondary data from EEG and medical records,  from January to December 2017. Result: Of 536 records, only 444 EEG records fulfilled the research criteria. PD response was more common in women (61.4%) and age group between 20-60 years (78.6%). Normal EEG result was 71.4%. PD responses were most commonly diagnosed with epilepsy etiology (33.8%). Only 28.6% of PD responses were found in abnormal EEG results. Conclusion: Distribution showed that the response of PD decreased in older age. The PD response is more common in patients with normal EEG results.  The more abnormal results of EEG, PD response rarely arise.
Hubungan Ekspresi Top 2A dengan Karakteristik Histopatologi dan Status Reseptor Hormon pada Karsinoma Payudara Her-2 Positif Agustine Tinambunan; Henny Sulastri; Fifie Julianita; Erial Bahar
Majalah Patologi Indonesia Vol 22 No 2 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.52 KB)

Abstract

ABSTRAK Latar belakang Top 2A adalah enzim inti yang berperan penting pada replikasi DNA dan merupakan terapi target banyak agen kemoterapi. Pada karsinoma payudara ekspresinya berhubungan dengan proliferasi sel dan ekspresi berlebih protein HER-2, namun hubungan ekspresi keduanya dengan karakteristik histopatologi dan status reseptor hormon masih kontroversial. Penelitian ini bertujuan menganalisis hubungan antara ekspresi Top 2A dengan karakteristik histopatologi yang merupakan faktor prognosis dan status reseptor hormon pada karsinoma payudara primer HER-2 positif. Metode Penelitian ini adalah penelitian retrospektif cross sectional. Tiga puluh sampel preparat karsinoma payudara HER-2 positif hasil biopsi, lumpektomi dan mastektomi diambil dari arsip di bagian Patologi Anatomik RSMH, dilakukan pulasan dengan antibodi Top 2A, diteliti hubungannya dengan derajat keganasan, invasi limfovaskular dan status reseptor hormon serta sebaran ekspresinya berdasarkan usia dan morfologi tumor. Enam belas sampel preparat hasil mastektomi diteliti untuk menilai hubungan antara ekspresi Top 2A dengan status kelenjar limfe dan ukuran tumor. Hasil Ekspresi Top 2A positif dijumpai 14 kasus (46,7%) seluruhnya dengan massa tumor berukuran lebih dari 2 cm, derajat keganasan tinggi (71,4%), invasi limfovaskuler (71,4%), status kelenjar limfe sebagian besar negatif (71,4%) dan hanya 50% dengan status reseptor hormon positif. Karsinoma payudara HER-2 positif dengan ekspresi berlebih Top 2A sebagian besar dengan morfologi karsinoma duktal invasif (71,4%) dan pada kategori usia 41-50 tahun (71,4%). Analisis hubungan ekspresi Top 2A dengan ukuran tumor, status kelenjar limfe, invasi limfovaskuler, derajat keganasan dan status reseptor hormon secara statistik tidak bermakna (p>0,05). Rasio Odds dengan status reseptor sebesar 0,26. Terdapat hubungan bermakna antara ekspresi berlebih Top 2A dengan karakteristik usia kurang dari 50 tahun (p 2cm, and mostly with high degree of malignancy (71.4%), and with positive hormone receptor status (50%). Most of breast cancer with positive Top 2A are invasive ductal carcinoma (71.4%) and have age category 41-50 years old in 10 (71.4 %) cases. There are no significant correlation between Top 2A expression with tumour size, tumour grade, lympho-vascular invasion, lymph nodes status and hormone receptor status in HER-2 positif breast cancer. However, over-expression of Top 2A have a signifiant correlation with age category
CORRELATION OF Hba1c LEVELS WITH PUPILLARY RESPONSE TO APRACLONIDINE 0,5% EYE DROPS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Devi Azri Wahyuni; Nafila Mahida Sukmono; Erial Bahar
Majalah Kedokteran Sriwijaya Vol 52, No 3 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i3.12503

Abstract

Pupillary reflex abnormalities can result from disorders of the innervation or iris structure of the eye. In people with diabetes mellitus, the pupil size becomes smaller than normal due to neuropathy in innocent sympathetic innervation of the pupil. This neuropathy is associated as a manifestation of uncontrolled diabetes complications. Pupillary response is associated as a general indication of autonomic neuropathy disorders in diabetes mellitus patients. Apraclonidine as an ophthalmic sympathomimetic agent can cause mydriasis, which is likely to identify pupillary sympathetic denervation in type 2 diabetes mellitus patients. This study aimed to find out the correlation between HbA1c levels and pupillary response to 0.5% Apraclonidine eye drops in diabetes mellitus type 2 patients at Mohammad Hoesin Hospital Palembang. Observational research with a correlation test design to investigate the correlation of HbA1c levels with pupillary response to apraclonidine 0.5% eye drops in patients with type 2 diabetes mellitus has been conducted from March to May 2019. The study sample met the inclusion and exclusion criteria of 31 diabetics mellitus type 2 with HbA1c level> 6.5% in the Eye clinic at the Mohammad Hoesin Palembang hospital. In this study 31 patients with type 2 diabetes mellitus with HbA1c levels >6.5 mg% were obtained. The average HbA1c level was 9.5 ± 1.4 mg%, which ranged from 7.6 - 12.6 mg%. The glycemic status of the patients in this study were all (100.0%) in an uncontrolled condition (HbA1c> 7.5 mg%). The estimated duration of diabetes mellitus is 2.7 ± 1.8 years, with a minimum value of 1 year and the largest being 8 years. The average change in pupillary diameter before - after dropping 0.5% apraclonidine was 1.16 ± 1.06 mm, ranging from 0 - 4 mm. There were 9 (29.0%) eyes that did not show any changes. Significant enlargement of pupillary size after dropping 0.5% apraclonidine (p = 0,000). This change in pupil size correlated with the estimated duration of diabetes mellitus (r = 0.436, p = 0.014) and HbA1c levels (r = 0.492, p = 0.005). Pupil size after using 0.5% apraclonidine has a distribution value of 4 (3-6) mm can be interpreted that there are subjects who have no change, but there are patients who have pupils dilated to 6 mm.
Hubungan antara Ekspresi VEGF dan Karakteristik Kliniko-patologis pada Karsinoma Sel Skuamosa Serviks Linda Fatrisia; Jusuf Fantoni; Ika Kartika; Erial Bahar
Majalah Patologi Indonesia Vol 22 No 3 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.879 KB)

Abstract

ABSTRAK Latar belakang Kanker serviks masih menjadi masalah yang signifikan di seluruh dunia. Angiogenesis sangat berperan dalam hal progresivitas, invasi dan metastasis.Vascular endothelial growth factor (VEGF) sebagai faktor angiogenik primer merupakan salah satu faktor prognostik karsinoma sel skuamosa serviks bila ekspresinya meningkat. Penelitian ini bertujuan untuk mengetahui hubungan antara ekspresi VEGF dan karakteristik klinikopatologis pada karsinoma sel skuamosa serviks. Metode Penelitian ini adalah penelitian cross sectional. Lima puluh tiga sampel terdiri atas 40 jaringan hasil biopsi dan 13 histerektomi diambil dari arsip di bagian Patologi Anatomi RSMH, dilakukan pulasan dengan antibodi VEGF, diidentifikasi dan dianalisis hubungannya dengan stadium klinis, derajat keganasan histologi, invasi limfovaskular, status limfonodus, kedalaman invasi dan keterlibatan parametrium. Hasil Ekspresi VEGF positif pada karsinoma sel skuamosa serviks lebih banyak dijumpai pada kelompok usia >50 tahun, stadium IIIB dan IVA, derajat keganasan semakin buruk, invasi limfovaskular dan status limfonodus positif serta kedalaman invasi stroma hingga 2/3 bagian luar dan tanpa keterlibatan parametrium. Terdapat hubungan yang bermakna antara ekspresi VEGF dengan kategori usia (p=0,038) dan korelasi yang kuat antara persentase positif ekspresi VEGF dengan usia (r=0,709) dan derajat keganasan (r=0,897). Namun, tidak ada hubungan yang bermakna antara ekspresi VEGF dengan karakteristik klinikopatologis (p>0,05). Kesimpulan VEGF belum dapat digunakan sebagai faktor prediktor progresivitas pada karsinoma sel skuamosa serviks Kata kunci : Karsinoma sel skuamosa serviks, VEGF, karakteristik klinikopatologis. ABSTRACT Background Cervical cancer remains a significant problem worldwide. The angiogenesis has an important role in the progression, invasion and metastasis. VEGF is a primary angiogenic factor that is one of the prognostic factor of cervical squamous cell carcinoma if the expression of VEGF increases. This study aimed to determine the relationship between the expression of VEGF and clinicopatological characteristics of the cervical squamous cell carcinoma. Methods It was a cross-sectional study. Fifty-three samples of biopsy and hysterectomy tissue were from the archives of the Anatomical Pathology Department of RSMH, stained with VEGF antibody, identified and analyzed the relation to clinical stage, histological grade, lymphovascular invasion, lymph node status, depth of invasion and parametrial involvement. Results The positive expression of VEGF in cervical squamous cell carcinoma was more common in the age group > 50 years, stage IIIB and IVA, the worse histological grade, the positive invasion lymphovascular and lymph nodes status, deep of stromal invasion up to the outside 2/3 and without parametrial involvement. There was a significant correlation between the expression of VEGF and the age category (p=0.038) and a strong correlation between the percentage of positive expression of VEGF andthe age range (r=0.709) and the histological grade (r=0.897). There was no significant correlation between the expression of VEGF and clinicopatologic characteristics (p>0.05). Conclusion VEGF can not be used as a progression predictor factorof thesquamous cell carcinoma. Key words : cervical squamous cell carcinoma, VEGF, clinicopathologic characteristics
Kepadatan CD8 di Lingkungan Mikrotumor pada Subtipe Diffuse Large B Cell Lymphoma Indah Yunalda; Krisna Murt; Aida Farida; Ika Kartika; Erial Bahar
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.239 KB) | DOI: 10.55816/mpi.v30i2.466

Abstract

BackgroundDiffuse Large B Cell Lymphomas (DLBCL) is divided into two subtypes, GCB and non-GCB, which are determined based on Hans'salgorithm. The GCB subtype has a better prognosis than non-GCB. Some studies indicate that the tumor progression wasinfluenced by tumor microenvironment, including CD8+ TILs located both surrounding tumor cells and peripheral. This study aims todetermine the density of CD8+ TILs in the tumor microenvironment of DLBCL subtypes.MethodsA Cross sectional study of 40 samples of DLBCL registered to Department of Anatomical Pathology Faculty of Medicine UniversitasSriwijaya/Dr. Mohammad Hoesin Palembang Hospital from 1st October 2017 to 31st December 2018. All samples were stained usinganti-CD8 antibody, afterward, lymphocytes express CD8 were assessed both in surrounding tumor cells and peripheral. The densityof CD8 in each DLBCL subtype was analyzed statistically using Mann Whitney U Test.ResultsIn this study, non-GCB subtype was found higher in comparison to GCB subtype (72.5%) and the samples was dominated by youngages (75%). Significantly, peripheral CD8 density was higher than that of surrounding tumor cells, both in the GCB (p=0.003) andnon-GCB subtypes (p=0.000).ConclusionIn both subtypes, CD8 density is higher in peripheral than surrounding tumor cells and a high density in surrounding tumor cells willbe followed by an increase in peripheral CD8 density.
CORRELATION BETWEEN CHRONIC PAIN WITH DEPRESSION AND ANXIETY DISORDERS IN PATIENTS AT RSUP DR MOHAMMAD HOESIN PALEMBANG Henry Sugiharto; Hasnawi Haddani; Yusril Yusril; Nia Elisa Ginting; Erial Bahar
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11970

Abstract

The International Association for the Study of Pain defines pain as an unpleasant sensory and emotional experience related to the actual or potential damage to a tissue. Recent research reports 30% - 60% of the incidence of pain in depression and anxiety. Both of these conditions affect the quality and function of life of patients with chronic pain. This study was observational analytic research with a cross-sectional study. The subject of this study was the patien with chronic pain treated at Dr. Moh. Hoesin Palembang. Determination of pain level was assessed by Numeric Pain Rating Scale (NPRS) and Functional Pain Scale (FPS). Determination of depression is valued by Beck Depression Inventory II (BDI II) and determination of anxiety with the Beck Anxiety Inventory (BAI). Statistical analysis using a correlation test, is a method to find relationships between variables with a confidence level of 95%, significant if p <0.05. In this study there were 78 patients with chronic pain where the correlation between NPRS scores and depression disorders with a correlation of 35.3% and a p-value of 0.002 showed significant. The correlation between NPRS scores and anxiety disorders with a correlation was 43.5% with and p-value 0,000 which showed a significant correlation. Correlation between FPS score and depression disorders was 33.1% and p-value of 0.003 which showed a significant correlation. Correlation between FPS score and anxiety disorders was 20.8% with a p-value of 0.068 showed not significant correlation. There was a significant correlation between chronic pain with depression and anxiety disorders.
Perbandingan Ekspresi PD-L1 dan TILS pada Karsinoma Payudara Triple Negative dan HER2 Enriched Muhammad Asprianto; Krisna Murti; Citra Dewi; Erial Bahar
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.729 KB) | DOI: 10.55816/mpi.v30i3.480

Abstract

BackgroundTriple negative and positive HER 2 subtype breast carcinoma are aggressive subtype that have worst prognosis among othersubtype. High level of tumor infiltrating lymphocytes (TILs) is associated with longer disease free survival and overall survival.Breast cancer is also influenced by the presence of ligation between PD-1 and PD-L1, expressed by activated CD8+ T cells andtumor cells, consecutively. To analysed the comparison of PD-L1 expression levels in triple negative breast cancer and HER2enriched subtype.MethodsA cross sectional study was conducted with 35 samples, which were immunostained with an anti-PD-L1 antibody. TILs weremeasured on HE slides, and together with PD-L1 expression were calculated using image J. Clinicopathological data were obtainedfrom medical record. All data were analysed by SPSS V25.0ResultsA significant difference was observed between PD-L1 expression in HER2 enriched and triple negative samples, where the HER2enriched subtype had a possibility to express PD-L1 3.3 times higher than those of triple negative (p = 0.021; OR = 3.3). There wereno significant differences in clinopathological characteristics or TILs density in both subtypes. Likewise, no significant differenceswas found among PD-L1 expression, and intratumoral and stromal TILs expression.ConclusionMajority patient of both subtypes are mostly older than 40 years old, with positive LVI and higher histological grading. The HER2expression showed a higher level of PD-L1 than triple negative. There was no significant difference of TILs expression betweenthese two subtypes of breast cancer.
Hubungan Siklus Bioritme dengan Nilai Computer Based Test (CBT) pada Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Nurul Salmah Alia Dita; Erial Bahar; Eddy Roflin
Biomedical Journal of Indonesia Vol. 5 No. 2 (2019): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

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Abstract

Tubuh manusia memiliki banyak irama, salah satunya bioritme. Bioritme terdiri dari tiga siklus yaitu, siklus fisik,emosi dan intelektual. Masing-masing siklus memiliki fase positif, negatif dan kritis. Saat mengikuti ujian seseorangmemerlukan keadaan fisik, mental, dan intelektual yang baik. Dengan menggunakan siklus bioritme, seseorangdapat melihat keadaan-keadaan tersebut agar dapat mempersiapkan diri ketika ujian. Penelitian ini adalahpenelitian analitik observasional dengan desain cross sectional. Sampel terdiri dari 386 mahasiswa Program StudiPendidikan Dokter Universitas Sriwijaya angkatan 2014 dan 2015 secara total sampling yang memenuhi kriteriainklusi. Data yang diambil berupa data sekunder yang terdiri dari nilai CBT, tanggal ujian, dan jalur masuk yangdiperoleh dari bagian akademik Fakultas Kedokteran Universitas Sriwijaya, sedangkan data tanggal lahir, IMT dannilai IQ diambil dari kuesioner. Data siklus bioritme diambil menggunakan biorhythm software. Pengolahan datadilakukan dengan menggunakan analisis uji Kruskal Wallis dan Regresi Linier. Dari hasil analisis bivariat dengan ujiKruskall Wallis didapatkan nilai IQ memiliki hubungan dengan nilai CBT (p=0,010), jalur masuk universitas memilikihubungan dengan nilai CBT (p=0,000), dan siklus fisik bioritme berhungan dengan nilai CBT (p=0,011), Namun,pada analisis multivariat (Regresi Linier) siklus fisik bioritme tidak memiliki hubungan dengan nilai CBT. Tidakterdapat hubungan siklus bioritme dengan nilai CBT pada mahasiswa Program Studi Pendidikan Dokter FakultasKedokteran Universitas Sriwijaya.
Benefits of domperidone in ambulatory acute diarrhea with severe vomiting Irene A. O.; Achirul Bakri; Erial Bahar; Rusdi Ismail
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.164 KB) | DOI: 10.14238/pi47.5.2007.207-10

Abstract

Background Recently, most patients with diarrheal disease (DD)cases are hospitalized not due to severe dehydration, but due tosevere vomiting which interferes with fluid and food intake. Useof anti-vomiting medicines is not recommended because of its“central” side effects. Domperidone has prokinetic and antiemeticeffects with only minimal extrapyramidal side effects.Objective To evaluate domperidone in preventing hospitalizationof DD patients in outpatient setting.Methods This randomized double blind, placebo-controlledclinical trial, was conducted from February to August 2005 atMohammad Hoesin Hospital, Palembang. We included patientsaged 6 to 59 months old with acute diarrhea who had vomited atleast 4 times in the last 24 hours, not in need of hospitalization,and agreed to participate. We excluded patients who had takenanti-vomiting drug, or those who had severe diseases, includingsevere malnutrition. The dose of domperidone was 1.25 mg per 5kg body weight.Results There were 183 subjects randomized, consisted of 91 whotook domperidone (treatment group) and 92 who took placebo(control group). The duration and decrease of vomiting frequencywere significantly different in favor of domperidone. Domperidoneprevented hospitalization significantly (P=0.001, OR=4.1, ARR= 20%, RRR=71%, NNT=5). No overt acute clinical side effectswere found.Conclusion Domperidone significantly shortened the duration anddecreased the frequency of vomiting in DD cases.
PERBEDAAN INDEKS TROMBOSIT ANTARA PASIEN KANKER KOLOREKTAL NONMETASTASIS DAN METASTASIS DI RSMH PALEMBANG Eva Syahriana; Mediarty Mediarty; Erial Bahar; Subandrate Subandrate
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I2.13432

Abstract

Kanker kolorektal masih menjadi permasalahan kesehatan di dunia. Hal ini karena progresivitas kanker berkaitan dengan prognosis dan angka kematian. Salah satu faktor yang berhubungan dengan progresivitas dan metastasis pada kanker kolorektal adalah indeks trombosit. Penelitian ini bertujuan untuk mengetahui perbedaan indeks trombosit antara pasien kanker kolorektal nonmetastasis dan metastasis. Penelitian ini adalah penelitian analitik komparatif dengan pendekatan case-control. Subyek penelitian adalah pasien kanker kolorektal di Poliklinik Hematologi dan Onkologi Medik Penyakit Dalam dan di bangsal rawat inap Penyakit Dalam RSMH Palembang mulai Januari – Juli 2020. Sampel berupa darah yang diambil dari vena mediana cubiti. Indeks trombosit (jumlah trombosit, MPV dan PDW) diperiksa menggunakan automated hematology analyzer di Laboratorium Patologi Klinik RSMH Palembang. Data dianalisis menggunakan uji T tidak berpasangan. Hasil penelitian menunjukkan kadar trombosit (484,1±185,1/µL) lebih tinggi pada kelompok kanker kolorektal dengan metastasis dibandingkan kelompok nonmetastasis (361,9±97,9/µL) dengan nilai p=0,000. Kadar MPV (8,9±0,7 fl) dan PDW (9,1±1,4%) lebih rendah pada kelompok kanker kolorektal dengan metastasis dibandingkan kelompok nonmetastasis (masing-masing 9,5±0,8 fl dan 10,6±2,2%) dengan nilai p=0,000.  Pada penelitian ini, ada perbedaan indeks trombosit antara pasien kanker kolorektal dengan metastasis dan kanker kolorektal nonmetastasis.