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Hubungan antara Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Karakteristik Klinikopatologik Karsinoma Payudara Duktal Invasif Huratio Nelson; Heni Maulani; Aida Farida; Irsan Saleh
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Breast cancer is the most common malignancy and related death of female worldwide. The angiogenesis has an important role in the invasive ductal mammary carcinoma carcinogenesis, and vascular endothelial growth factor (VEGF)is a primary angiogenic factor. The aim of this study is to determine the relationship between the VEGF expression and clinicopatologic characteristics of the invasive ductal mammary carcinoma. Methods It was a cross-sectional study. Fifty-five parafin block samples of mastectomy tissue diagnosed as invasive mammary ductal carcinoma were obtained from the archieves of the Anatomical Pathology Department of RSMH, was stained by immunohistochemical method with anti-VEGF antibody. The result was analyzed in relation to age, tumor size, lymph node status, and histological grade. Results The positivity of VEGF expression was more common in the ≤49 years age of group, in the tumor of ≥9,6 cm size group, in the positive lymph node status, and in the high histological grade. There was a significant correlation between the VEGF expression and the category of lymph node status (p=0.047), as well as histological grade (p=0.020). There was unsignificant correlation between VEGF expression and the age category (p=0.781), as well as tumor size category (p=0.700). Conclusion There was correlation between VEGF expression and lymph node status and histological grade in invasive ductal mammary carcinoma. Key words: clinicopathologic characteristics, invasive ductal mammary carcinoma, VEGF.
Kepadatan CD8 di Lingkungan Mikrotumor pada Subtipe Diffuse Large B Cell Lymphoma Indah Yunalda; Krisna Murt; Aida Farida; Ika Kartika; Erial Bahar
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.239 KB) | DOI: 10.55816/mpi.v30i2.466

Abstract

BackgroundDiffuse Large B Cell Lymphomas (DLBCL) is divided into two subtypes, GCB and non-GCB, which are determined based on Hans'salgorithm. The GCB subtype has a better prognosis than non-GCB. Some studies indicate that the tumor progression wasinfluenced by tumor microenvironment, including CD8+ TILs located both surrounding tumor cells and peripheral. This study aims todetermine the density of CD8+ TILs in the tumor microenvironment of DLBCL subtypes.MethodsA Cross sectional study of 40 samples of DLBCL registered to Department of Anatomical Pathology Faculty of Medicine UniversitasSriwijaya/Dr. Mohammad Hoesin Palembang Hospital from 1st October 2017 to 31st December 2018. All samples were stained usinganti-CD8 antibody, afterward, lymphocytes express CD8 were assessed both in surrounding tumor cells and peripheral. The densityof CD8 in each DLBCL subtype was analyzed statistically using Mann Whitney U Test.ResultsIn this study, non-GCB subtype was found higher in comparison to GCB subtype (72.5%) and the samples was dominated by youngages (75%). Significantly, peripheral CD8 density was higher than that of surrounding tumor cells, both in the GCB (p=0.003) andnon-GCB subtypes (p=0.000).ConclusionIn both subtypes, CD8 density is higher in peripheral than surrounding tumor cells and a high density in surrounding tumor cells willbe followed by an increase in peripheral CD8 density.
Financial and non-financial factors are important indicators to evaluate performance of corporation.  The main objective of this study is to build a model for improving performance of estate and plant by using balance scorecard.  The study uses balance scorecard, and fuzzy analytical hierarchy process to model the criteria of performance measurement for both estate and plant.  Results generated from the model of estate performance criteria measurements are seed, fertilizing, cost management, har Aida Farida; Irawadi Jamaran; A. Aziz Darwis; Khaswar Syamsu; Yandra Arkeman
Forum Pasca Sarjana Vol. 34 No. 3 (2011): Forum Pascasarjana
Publisher : Forum Pasca Sarjana

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Abstract

Financial and non-financial factors are important indicators to evaluate performance of corporation.  The main objective of this study is to build a model for improving performance of estate and plant by using balance scorecard.  The study uses balance scorecard, and fuzzy analytical hierarchy process to model the criteria of performance measurement for both estate and plant.  Results generated from the model of estate performance criteria measurements are seed, fertilizing, cost management, harvest, plant maintenance, production, and employee development.  Results generated from the model of plant performance criteria measurements are production rate, cost management, losses, plant utilization, CPO quality, employee development, and environmental friendly production process.  Estate and plant scoring board model are used to measure the performance of estate and plant based on set targets.  Results generated from estate scoring board model are low performance in cost management, production, and employed development.  Results generated from plant scoring board model are low performance in cost management, losses, and environmental friendly production process.  Performance improvement model for estate and plant are conducted by using expert management.  The result generated from this study is a software of decision support system by using expert management, and it is called In-KK v1.00.   Keywords: oil palm agroindustry, key performance indicator, scoring board
Perbedaan Ekspresi Epidermal Growth Factor Receptor pada Karsinoma Tiroid Papilari dan Folikular Syaugi Syaugi; Henny Sulastri; Aida Farida; Ya'kub Rahadiyanto
JURNAL KEDOKTERAN DAN KESEHATAN Vol 1, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Karsinoma tiroid merupakan kanker endokrin terbanyak yang berasal dari sel-sel folikel tiroid. Secara umum terbagi menjadi karsinoma tiroid papilari, folikular, anaplastik dan medulari. Karsinoma tiroid papilari dan folikular selanjutnya digolongkan kedalam karsinoma tiroid berdifernsiasi. Karsinoma tiroid berdiferensiasi mempunyai prognosis yang baik, walaupun  masih dijumpai 20-40% rekurensi atau metastasis.Beberapa penelitian menyatakan bahwa epidermal growth factor receptor berperan didalam karsinogenesis karsinoma tiroid. Ekspresi EGFR masih menjadi kontroversi pada karsinoma tiroid papilari dan folikular Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan ekspresi EGFR pada karsinoma tiroid papilari dan folikular dengan menggunakan pemeriksaan imunohistokimia. Penelitian ini merupakan penelitian observasional dengan pendekatan potong lintang . Pengambilan sampel menggunakan tehnik acak sederhana. Sebanyak 55 slaid kasus karsinoma tiroid papilari dan folikular diambil dari arsip patologi anatomi RSUP dr. Mohammad Hoesin Palembang dari Januari 2011 sampai Desember 2013. Dilakukan pulasan menggunakan antibodi EGFR dan diteliti perbedaan ekspresi EGFR antara karsinoma tiroid papilari dan folikular. Pada kedua subtipe karsinoma tiroid, jenis kelamin perempuan (78,2%) lebih banyak dibanding laki-laki (21,8%) dengan perbandingan 4:1. Umur termuda dijumpai pada usia 16 tahun, tertua usia 72 tahun dengan rata-rata usia 44 tahun. Sebanyak 65,5% karsinoma tiroid papilari dan 16,4% karsinoma tiroid folikular menunjukkan ekspresi positif EGFR. Tidak terdapat perbedaan ekspresi EGFR antara karsinoma tiroid papilari dan folikular (p = 0,649). Kesimpulan dari penelitian ini adalah tidak terdapat perbedaan ekspresi EGFR antara karsinoma tiroid papilari dan folikular   Kata kunci: Karsinoma tiroid papilari, karsinoma tiroid folikular, EGFR
Studi Deskriptif Membandingkan Karakteristik Klinis Pasien Mioma Uteri dan Adenomiosis Eko Roharto; Aida farida; Irawan Sastradinata
Majalah Kedokteran Sriwijaya Vol 49, No 3 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i3.8514

Abstract

Mioma adalah tumor jinak uterus yang berasal dari miometrium sedangkan adenomiosis adalah kondisi jinak uterus ditandai dengan adanya kelenjar ektopik endometrium di miometrium. Kedua penyakit ini dipengaruhi oleh kadar estrogen yang tinggi dan sering ditemukan pada wanita usia reproduktif. Mioma dan adenomosis memiliki keluhan yang mirip, seperti dismenorhe, menorhagia dan pembesaran uterus sehingga secara klinis sulit dibedakan. Oleh karena itu penelitian ini dilakukan untuk mengetahui karakteristik klinis mioma dan adenomiosis di RSUP Mohammad Hoesin.Penelitian ini menggunakan data sekunder di Instalasi Rekam Medis RSUP Mohammad Hoesin periode Januari 2015 sampai Desember 2015 dengan jumlah 131 sampel yang terdiri dari mioma 79 kasus dan adenomiosis 52 kasus.Mioma paling banyak ditemukan pada kelompok usia 35-49 tahun (68,4%), paritas terbanyak adalah nullipara (49,4%), menggunakan kontrasepsi hormonal (72,5%), IMT terbanyak adalah kategori obesitas (51,9%) dan keluhan terbanyak adalah benjolan di perut bawah (29,1%) sedangkan adenomiosis, paling banyak ditemukan pada kelompok usia 35-49 tahun (69,2%), paritas terbanyak adalah multipara (42,3%), memiliki riwayat operasi uterus (53,8%), IMT terbanyak adalah kategori normal (65,4%) dan keluhan terbanyak adalah dismenorhe (34,6%). Mioma paling banyak ditemukan pada pasien usia 35-49 tahun, nullipara, menggunakan kontrasepsi hormonal, obesitas dengan keluhan benjolan di perut bawah sedangkan adenomiosis paling banyak ditemukan pada pasien usia 35-49 tahun, multipara, memiliki riwayat operasi uterus dengan keluhan dismenorhe.
Urgensi Perkembangan Motorik Kasar Pada Perkembangan Anak Usia Dini Aida Farida
JURNAL RAUDHAH Vol 4, No 2 (2016): RAUDHAH
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.562 KB) | DOI: 10.30829/raudhah.v4i2.52

Abstract

Growth and development is a whole matching in dyeing rate of child development day after day, month after month and year after year. We realize that both are important to a child's development in particular the physical development of the child. pemehaman will be harsh on the motor development of children will give you an idea on us about motor development of children's motor characteristic rough, rough children as well as the urgency of the development motor rough kids. At least the motor on rough urgency through appropriate actions in memaksimalkannya will have an impact on the incidence of self-confidence and emotional stability in children.
Penggunaan biostimulan Orgamin untuk efisiensi pemupukan dan peningkatan produktivitas kelapa sawit di dataran tinggi Application of Orgamin biostimulan to enhance fertilizer efficiency and productivity of oil palm grown in highland Happy WIDIASTUTI; Djoko SANTOSO; Soekarno Mismana PUTRA; Memed WIRAMIHARDJA; Aida FARIDA; B. MARAHIMIN MARAHIMIN; K. PANJAITAN PANJAITAN; Jisman SINAGA
E-Journal Menara Perkebunan Vol 81, No 2: Desember 2013
Publisher : INDONESIAN RESEARCH INSTITUTE FOR BIOTECHNOLOGY AND BIOINDUSTRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.286 KB) | DOI: 10.22302/iribb.jur.mp.v81i2.37

Abstract

AbstractThe extension of oil palm area has been expanded tomarginal land such as the highland regions. However, theproductivity of the oil palm became the main demand for theplanters. Increasing of oil palm productivity can be done byapplication of growth regulators. Growth regulators aresmall molecules in a relatively very small amount that affectthe growth and development of plant. This study wasconducted to asses the efectiveness of plant growth regu-lators (Orgamin and Orgamin plus) in improving fertilizerefficiency and productivity of mature oil palm (TM 7). Theexperiments were conducted at Marjandi oil palm plantationat an altitude of 700 m above sea level in a total area of 16 ha. Six treatments tested were 1). 100% inorganicfertilizer (control), 2). 50% inorganic fertilizer + Orgamin(50K+O), 3). 75% inorganic fertilizer + Orgamin (75K+O),4). 50% inorganic fertilizer + Orgamin plus (50K+OP), 5).75% inorganic fertilizer + Orgamin plus (75K+OP), and 6).100% inorganic fertilizer + Orgamin plus (100K+OP)arranged in a randomized block design (RBD) with threereplications. Orgamin (O) and Orgamin plus (OP) wereapplied in the hole around the oil palm along with inorganicfertilizers. The results showed that application of O and OPimproved the efficiency of inorganic fertilizers by 50% basedon vegetative variables and increased the concentration ofN, P, and K of leaf and soil compared to those of 100%inorganic fertilizer. In addition to the height and leaf numberof plant parameters, the leaf of the plant treated with O andOP showed more greenish compared to those of control.There is an indication that the O application increased thepercentage of female flowers. In addition the application ofOrgamin also produced the highest oil content in oil palmfruit particularly in the treatment of 75% of inorganicfertilizer + orgamin harvested in October compared to thosein March. Moreover, application of OP increased both thetotal weight and weight per bunch of FFB.AbstrakPengembangan kelapa sawit mengharuskan pengguna-an lahan suboptimal seperti daerah dataran tinggi. Produk-tivitas kelapa sawit menjadi tuntutan utama bagi pekebun.Peningkatan produktivitas kelapa sawit di dataran tinggididuga dapat dilakukan dengan aplikasi zat pengatur tumbuh.Zat pengatur tumbuh merupakan molekul “kecil” (small molecules) yang dalam jumlah relatif sangat sedikit mem-pengaruhi pertumbuhan/perkembangan tanaman. Penelitiandilakukan untuk menguji formula zat pengatur tumbuh(Orgamin dan Orgamin plus) dalam meningkatkan efisiensipemupukan dan produktivitas kelapa sawit TM 7. Percobaandilakukan di kebun Marjandi dengan ketinggian 700 dpl padaareal seluas 16 ha. Enam perlakuan yang diuji adalah 1).pupuk anorganik 100% (100K), 2). pupuk anorganik 50% +Orgamin (50K+O), 3). pupuk anorganik 75% + Orgamin(75K+O), 4). pupuk anorganik 50% + Orgamin plus (50K+OP), 5). pupuk anorganik 75% + Orgamin plus (75K+OP),dan 6). pupuk anorganik 100% + Orgamin plus (100K+OP)yang disusun dalam rancangan acak kelompok (RAK)dengan tiga ulangan. Orgamin (O) dan Orgamin plus (OP)diberikan dalam lubang di piringan pokok bersamaan denganpupuk anorganik. Hasil pengamatan menunjukkan bahwapemberian O dan OP dapat meningkatkan efisiensi pemupuk-an anorganik hingga 50% dilihat dari beberapa peubahvegetatif dan menghasilkan kadar N, P, dan K daun dantanah lebih tinggi dibandingkan dengan pemberian pupukanorganik 100%. Selain pada parameter tinggi tanaman danjumlah daun, peningkatan juga terlihat pada tingkatkehijauan daun. Terdapat indikasi bahwa pemberian Orgaminmeningkatkan persentase jumlah bunga betina. PemberianOrgamin juga menghasilkan kadar minyak tertinggi khusus-nya pada pemberian Orgamin + pupuk anorganik 75% padabuah yang dipanen bulan Oktober dibandingkan dengan buahyang dipanen bulan Maret. Baik data bobot per tandanmaupun bobot TBS menunjukkan bahwa pemberian OPdapat meningkatkan kedua peubah tersebut. 
Urgensi Perkembangan Motorik Kasar Pada Perkembangan Anak Usia Dini Aida Farida
JURNAL RAUDHAH Vol 4, No 2 (2016): RAUDHAH
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (532.562 KB) | DOI: 10.30829/raudhah.v4i2.52

Abstract

Growth and development is a whole matching in dyeing rate of child development day after day, month after month and year after year. We realize that both are important to a child's development in particular the physical development of the child. pemehaman will be harsh on the motor development of children will give you an idea on us about motor development of children's motor characteristic rough, rough children as well as the urgency of the development motor rough kids. At least the motor on rough urgency through appropriate actions in memaksimalkannya will have an impact on the incidence of self-confidence and emotional stability in children.
Penggunaan biostimulan Orgamin untuk efisiensi pemupukan dan peningkatan produktivitas kelapa sawit di dataran tinggi Application of Orgamin biostimulan to enhance fertilizer efficiency and productivity of oil palm grown in highland Happy WIDIASTUTI; Djoko SANTOSO; Soekarno Mismana PUTRA; Memed WIRAMIHARDJA; Aida FARIDA; B. MARAHIMIN MARAHIMIN; K. PANJAITAN PANJAITAN; Jisman SINAGA
Menara Perkebunan Vol. 81 No. 2: Desember 2013
Publisher : INDONESIAN OIL PALM RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22302/iribb.jur.mp.v81i2.37

Abstract

AbstractThe extension of oil palm area has been expanded tomarginal land such as the highland regions. However, theproductivity of the oil palm became the main demand for theplanters. Increasing of oil palm productivity can be done byapplication of growth regulators. Growth regulators aresmall molecules in a relatively very small amount that affectthe growth and development of plant. This study wasconducted to asses the efectiveness of plant growth regu-lators (Orgamin and Orgamin plus) in improving fertilizerefficiency and productivity of mature oil palm (TM 7). Theexperiments were conducted at Marjandi oil palm plantationat an altitude of 700 m above sea level in a total area of 16 ha. Six treatments tested were 1). 100% inorganicfertilizer (control), 2). 50% inorganic fertilizer + Orgamin(50K+O), 3). 75% inorganic fertilizer + Orgamin (75K+O),4). 50% inorganic fertilizer + Orgamin plus (50K+OP), 5).75% inorganic fertilizer + Orgamin plus (75K+OP), and 6).100% inorganic fertilizer + Orgamin plus (100K+OP)arranged in a randomized block design (RBD) with threereplications. Orgamin (O) and Orgamin plus (OP) wereapplied in the hole around the oil palm along with inorganicfertilizers. The results showed that application of O and OPimproved the efficiency of inorganic fertilizers by 50% basedon vegetative variables and increased the concentration ofN, P, and K of leaf and soil compared to those of 100%inorganic fertilizer. In addition to the height and leaf numberof plant parameters, the leaf of the plant treated with O andOP showed more greenish compared to those of control.There is an indication that the O application increased thepercentage of female flowers. In addition the application ofOrgamin also produced the highest oil content in oil palmfruit particularly in the treatment of 75% of inorganicfertilizer + orgamin harvested in October compared to thosein March. Moreover, application of OP increased both thetotal weight and weight per bunch of FFB.AbstrakPengembangan kelapa sawit mengharuskan pengguna-an lahan suboptimal seperti daerah dataran tinggi. Produk-tivitas kelapa sawit menjadi tuntutan utama bagi pekebun.Peningkatan produktivitas kelapa sawit di dataran tinggididuga dapat dilakukan dengan aplikasi zat pengatur tumbuh.Zat pengatur tumbuh merupakan molekul “kecil” (small molecules) yang dalam jumlah relatif sangat sedikit mem-pengaruhi pertumbuhan/perkembangan tanaman. Penelitiandilakukan untuk menguji formula zat pengatur tumbuh(Orgamin dan Orgamin plus) dalam meningkatkan efisiensipemupukan dan produktivitas kelapa sawit TM 7. Percobaandilakukan di kebun Marjandi dengan ketinggian 700 dpl padaareal seluas 16 ha. Enam perlakuan yang diuji adalah 1).pupuk anorganik 100% (100K), 2). pupuk anorganik 50% +Orgamin (50K+O), 3). pupuk anorganik 75% + Orgamin(75K+O), 4). pupuk anorganik 50% + Orgamin plus (50K+OP), 5). pupuk anorganik 75% + Orgamin plus (75K+OP),dan 6). pupuk anorganik 100% + Orgamin plus (100K+OP)yang disusun dalam rancangan acak kelompok (RAK)dengan tiga ulangan. Orgamin (O) dan Orgamin plus (OP)diberikan dalam lubang di piringan pokok bersamaan denganpupuk anorganik. Hasil pengamatan menunjukkan bahwapemberian O dan OP dapat meningkatkan efisiensi pemupuk-an anorganik hingga 50% dilihat dari beberapa peubahvegetatif dan menghasilkan kadar N, P, dan K daun dantanah lebih tinggi dibandingkan dengan pemberian pupukanorganik 100%. Selain pada parameter tinggi tanaman danjumlah daun, peningkatan juga terlihat pada tingkatkehijauan daun. Terdapat indikasi bahwa pemberian Orgaminmeningkatkan persentase jumlah bunga betina. PemberianOrgamin juga menghasilkan kadar minyak tertinggi khusus-nya pada pemberian Orgamin + pupuk anorganik 75% padabuah yang dipanen bulan Oktober dibandingkan dengan buahyang dipanen bulan Maret. Baik data bobot per tandanmaupun bobot TBS menunjukkan bahwa pemberian OPdapat meningkatkan kedua peubah tersebut.