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All Journal Jurnal Ilmu Lingkungan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biota Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia Science and Technology Indonesia IJEMS (Indonesian Journal of Environmental Management and Sustainability) Jurnal Akademika Baiturrahim Jambi Seminar Nasional Lahan Suboptimal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Vokasi Bioscientia Medicina : Journal of Biomedicine and Translational Research
Arum Setiawan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PENGARUH PEMBERIAN HIDROKUINON TERHADAP PERKEMBANGAN FETUS MENCIT (MUS MUSCULUS L.) SWISS WEBSTER Rubiyati Rubiyati; Arum Setiawan
Jurnal Akademika Baiturrahim Jambi Vol 5, No 1 (2016): Maret
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v5i1.44

Abstract

Background : Hydroquinone is natural substance chemistry that were using by cosmetics as bleachers skin. The creams contains of more than >2% hydroquinone could cause irritation in the skin. In long usage will caused skin bluish black and ochronosis. The aims of this study is to find the effect of hydroquinone to the fetus development. Method : The research about the influence of hydroquinone to the mouse fetal development has been done on February – April 2014 at The Research Center (LPPT) Gadjah Mada University Yogyakarta. This research used randomized complite design 5 treatment and 5 replicated. The datas were analyzed with one way Anova and then with Duncan’s test. Hydroquinone administrated intraperitoneal injection at a dosage 10 mg/kgbw, 20 mg/kgbw, 30 mg/kgbw in 6 days of gestation. The remaining animals were used as an untreated control, and placebo were given by aquades. at 18th days of gestations, twenty five pregnant mice were sacrificed and caesarian sectioned to remove the fetuses and then check fetus body wight, life fetus, dead fetus and morfology fetus. The results showed that administration of hydroquinone to pregnant mice decreased the average number of fetuses, fetal weight, and implantation. The congenital malformation that caused by administration of hydroquinone were neural tube defects, anotia, microtia, Intra Uterine Fetal Defects, limb defects, tail defects.It was concluded that hydroquinone administrated to the pregnant mice inhibits the fetal growth, decreased the number of fetal and increased malformation of fetal.Keywords : Hydroquinone, Mice, Fetal, Malformation, NTDs
Papaya (Carica Papaya L.) Seed Extract as Male Contraception via Decreasing The Quality of Rat's (Rattus Norvegicus) Sperm Sri Nita; Arum Setiawan; Rara Inggarsih; Uci Tantri; Meryska Hardiana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 4 No. 1 (2020): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v4i1.110

Abstract

Background. Population growth needs to be controlled so as not to cause new and serious problems. Pregnancy and birth control is a solution to control this sizable population growth. Contraception is a way to prevent pregnancy, by inhibiting the process of ovulation, fertilization and implantation. Nevertheless, most of contraceptive regiments were aimed to woman. Male contraception nowadays is very rare. Papaya seed is one of the male contraceptive candidates which has the potential to be developed as male contraception. Previous studies have shown the potential of papaya seed extract could reduce the weight of reproductive organs of male white rats, where it was believed that there was a decrease in spermatogenesis activity. Methods. This research was an in-vivo experimental research post-test only with control group. The study used 32 male and healthy rats (Rattus norvegicus) Wistar strain with 8-10 weeks of age. Rats were grouped into 1 control group and 4 treatment groups that were randomly selected. The four treatment groups were group 1: control administered 1% 2ml CMC orally one time per day every morning, group 2: were given N-hexane papaya seed fraction, group 3: were given ethyl acetate papaya seed fraction and group 4: were given ethanol-water papaya seed fraction. The three fractions were given to rats orally at a dose of 100 mg / KgBB / day for 24 days. After that, rat's testes and epidydimis were evacuated to observe reproductive organs and sperm quality. Results. Anatomically, Group 2 and 3 were statistically significant in reducing testicular's and epidydimis' weight compared to the control group, but the n-hexane group was more effective in reducing testicular weight than other treatment groups. Furthermore, groups 2, 3 and 4 were statistically significant in reducing sperm quality (motility, viability, amount of sperm cells and normal sperm cell morphology) compared to the control group, but the n-hexane group was more effective in reducing sperm quality than other treatment groups. Conclusion. Papaya seed n-hexane fraction has potential as a male contraceptive by reducing spermatogenesis activity and decreasing sperm quality in white rats. Keyword : papaya seed, male contraception, rat's sperm
Co-Authors Ali Djamhuri Amin Ali Mubarok Andes Syahputra Anita Desiani Arsi Arsi Azhar Kholiq Affandi Elfita Elfita Erise Anggraini Erwin Nofyan Fikri Adriansyah Harman Hamidson hasbi hasbi Indra Yustian Irmeilyana Istriyati Istriyati Jamhari Jamhari Khodijah Khodijah Laila Hanum Mammed Sagi Marieska Verawaty Meryska Hardiana Mimma Gustianingtyas Muhammad Iqbal Ngudiantoro . Nurlaily Agustini Rara Inggarsih Rubiyati Rubiyati Ryan Hidayat Salni Salni SITI HERLINDA Sri Nita Sri Nita suparman suparman Suwandi Suwandi Uci Tantri Widya Asmara Yuanita Windusari Yulia Hariani