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All Journal Majalah Patologi Indonesia JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Implementa Husada Jurnal Pandu Husada
Des Suryani
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Majalah Patologi Indonesia

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Aplikasi Metode Whole Chromosome Painting untuk Mendeteksi Aberasi Kromosom pada Tumor Padat Ecie Budiyanti; Des Suryani; Jeanne Adiwinata Pawitan
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

In solid tumor, conventional cytogenetic method usualy fails to detect chromosomal aberation due to failure in obtaining good quality metaphases. Therefore, special technique is required to get the karyotype of solid tumors. Whole chromosome painting (WCP) is a method to paint the chromosomes using Fluorescence In Situ Hybridization (FISH) technique. Application of WCP, both using one and multiple colors (mFISH or SKY) or their modifications can be used to identify chromosomal aberrations, which are valuable in helping to attain a diagnosis, to determine the prognosis and management, and to predict the response to therapy. Key words: chromosomal aberation, FISH, solid tumor, whole chromosome painting.
Co-Authors Ecie Budiyanti Eka Febriyanti ELMAN BOY Fadhilla Qudsi Ramadhani Jeanne Adiwinata Pawitan Ratih Yulistika Utami Shinta Damayanti Siregar, Pinta Pudiyanti