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All Journal Majalah Patologi Indonesia JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Jurnal Implementa Husada Jurnal Pandu Husada
Des Suryani
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia

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Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol Fadhilla Qudsi Ramadhani; Des Suryani
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.127

Abstract

ABSTRACT Background: Paracetamol is used for analgesics and antipyretics, its use can damage the liver. Herbs that prevent liver disorders are curcuma. Black cumin can increase antioxidants. Objective: This study aims to compare the effectiveness of black cumin extract and curcuma against the liver function of paracetamol-induced rats. Methods: A laboratory experimental study posttest only with control group design. A total of 4 groups were treated for 7 days. SGOT and SGPT levels were tested. Data analysis using one-way ANOVA post hoc Games-Howell.Results: K- and K+ groups in this study showed an increase in SGOT SGPT levels. There is an effect of giving a dose of paracetamol 500 mg/kgBB on liver damage, there is no differences and significant effect in the administration of black cumin extract and curcuma dose 500 mg/kgBB to the liver of rats that have been induced by paracetamol (p>0.05). Conclusion: Giving paracetamol has an influence on rat liver damage. And there was no difference in the effects of hepatoprotector in groups given black cumin extract and curcuma in paracetamol-induced rats. Keywords: black cumin, curcuma, paracetamol, SGOT, SGPT
Co-Authors Ecie Budiyanti Eka Febriyanti ELMAN BOY Fadhilla Qudsi Ramadhani Jeanne Adiwinata Pawitan Ratih Yulistika Utami Shinta Damayanti Siregar, Pinta Pudiyanti