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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Jurnal Kimia Riset Indonesian Journal of Pure and Applied Chemistry BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS JAMAS: Jurnal Abdi Masyarakat
Notriawan, Doni
Bengkulu University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Aktivitas Antibakteri Membran Nanokomposit Kitosan/Nanopartikel Perak Notriawan, Doni; Nesbah, Nesbah; Ernis, Gustria; Fadhila, Muhammad Adeng; Wibowo, Risky Hadi; Pertiwi, Reza; Ilfanisari, Vinolla
ALCHEMY Vol 9, No 1 (2021): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v9i1.11146

Abstract

The aim of this study was to make and test the antibacterial activity of chitosan/silver nanoparticles nanocomposite membranes. Nanocomposite membranes were synthesized by chitosan with pluronic using acetic acid as a solvent. Silver nanoparticles were synthesized using the green synthesis method and the makasar fruit (Brucea javanica L. Merr) peel extract as a bioreductor. The silver nanoparticles were composited with a chitosan/pluronic mixture and printed on a glass plate. Nanocomposite membranes were characterized using the FTIR spectrophotometer and the scanning electron microscope (SEM). Nanocomposite membrane were tested for antibacterial activity against Escherechia coli. The UV-Vis spectra showed the formation of silver nanoparticles which were indicated by the absorption at 454 nm and the absorbance value of 0.405. Characterization using FTIR showed no new functional groups formed in the composites of chitosan and pluronic. SEM results showed the difference between the chitosan membrane and the nanocomposite membrane. The surface of nanocomposite membrane showed uneven compared to the chitosan membrane. Nanocomposite membranes have antibacterial activity to inhibit E. coli growth.   Keywords: nanocomposite, chitosan/silver nanoparticles, antibacterial Penelitian ini bertujuan untuk membuat dan menguji aktivitas antibakteri membran nanokomposit kitosan/nanopartikel perak. Membran nanokomposit dibuat dengan mensintesis kitosan dengan pluronik menggunakan pelarut asam asetat. Nanopartikel perak disintesis menggunakan metode green synthesis dengan ekstrak kulit buah makasar (Brucea javanica L. Merr) sebagai bioreduktor. Nanopartikel perak dikompositkan dengan campuran kitosan/pluronik dan dicetak di atas plat kaca. Membran nanokomposit dikarakterisasi menggunakan spektrofotometer FTIR dan scanning electron microscope (SEM). Membran nanokomposit dilakukan uji aktivitas antibakteri terhadap Escherechia coli. Spektra UV-Vis menunjukkan terbentuknya nanopartikel perak yang ditandai adanya serapan pada panjang gelombang 454 nm dan absorbansi 0,405. Karakterisasi dengan FTIR menunjukkan tidak adanya gugus fungsi baru yang terbentuk pada komposit dari kitosan dan pluronik. Hasil SEM menunjukkan adanya perbedaan antara membran kitosan dengan membran nanokomposit. Permukaan membran nanokomposit terlihat tidak rata dibandingkan membran kitosan. Membran nanokomposit memiliki aktivitas bakteri sehingga dapat mengambat pertumbuhan bakteri E. coli. Kata kunci: nanokomposit, kitosan/nanopartikel perak, antibakteri
The effect of Raphanus sativus and Pachyrhizus erosus juice combination on the ethanol-induced gastric of mice Reza Pertiwi; Aanisah Hanuun; Noval Kurniawati; Petri Siti Khodijah; Dian Fita Lestari; Dyah Fitriani; Doni Notriawan
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.078 KB) | DOI: 10.12928/pharmaciana.v11i3.20104

Abstract

Gastric ulcers can be caused by active inflammation due to impaired mucosal integrity, which causes local or widespread lesions. Gastric ulcers can occur due to the use of ethanol, which has a local effect on the gastric. Therefore, the continuous consumption of ethanol can damage gastric cells. Raphanus sativus and Pachyrhizus erosus contain flavonoids, which are well-known to reduce stomach acid as a curative agent.  The objective of this study is to see the effect of Raphanus sativus and Pachyrhizus erosus juice as a preventive agent on alcohol-induced gastric ulcers in mice (Mus musculus). A combination of Raphanus sativus and Pachyrhizus erosus was given at a dose of 100, 300, and 600 mg/kgBW. Specifically, Raphanus sativus was given at a dose of 300 mg/kgBW, Pachyrhizus erosus at a dose of 300 mg/kgBW, and positive control was included using sucralfate. The treatment was carried out for 12 days, and 1 hour after the last day of treatment, 20 ml/kgBW of ethanol induction was given 24 hours after the animals were dissected. The results showed that the index value of gastric ulcers in the normal group, negative control, and the combination of Raphanus sativus and Pachyrhizus erosus juice given orally at a dose of 100, 300, and 600 mg/kgBW (Raphanus sativus at a dose of 300 mg/kgBW, Pachyrhizus erosus at a dose of 300 mg/kgBW, and sucralfate as positive control) were 0; 4.00; 1.00; 1.33; 2.33; 2.67; 0 and 2.00. The results of the histopathological analysis also showed improvement in the gastric of mice fed with Pachyrhizus erosus juice. Therefore, it is inferred that treatment using Raphanus sativus and Pachyrhizus erosus juice can reduce the number of ulcers, increase ratio protection, and repair the cells in gastric histopathology. Additionally, giving a single dose of Pachyrhizus erosus juice results in a more significant gastric improvement. 
Penentuan Status Mutu Air Tanah Dangkal di Sekitar Tempat Pembuangan Akhir Sampah (TPA) Air Sebakul Kota Bengkulu menggunakan Metode STORET: A Cross-Sectional Study Deni Agus Triawan; Doni Notriawan; Gustria Ernis
Jurnal Kimia Riset Vol. 5 No. 1 (2020): Juni
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v5i1.17053

Abstract

Ground Water quality has a special significance for drinking, hygiene sanitation and domestic water supply. The study aims to understand the distribution of ground water quality in solid waste landfill of Bengkulu City. The following objectives of the study are to determine ground water quality parameters such as pH, total dissolved solid, electrical conductivity, hardness, iron, manganese, nitrate and nitrite. Sampling was carried out at a radius of 0 - 250 meters from the location of the landfill. The results of the pH at 10 sampling points show the values that are quite varied between 6,45 – 7,59; conductivity between 56 µS – 492 µS; TDS between 28 mg/L – 246 mg/L; salinity 32 mg/L – 284 mg/L; Iron (Fe) 0,040 mg/L – 0,323 mg/L; Manganese (Mn) 0,089 mg/L – 0,295 mg/L; Nitrate (NO3-) 0,2 mg/L – 0,8 mg/L and Nitrite (NO2-) 0,006 mg/L – 0,033 mg/L. Based on an assessment with the STORET system, water quality in the study area is classified as good (score =-4) by parameters such as temperature, pH, total dissolved solid, electrical conductivity, hardness, iron, manganese, nitrate and nitrite. By the total sampling sites, all sample site had good-quality water for hygiene sanitation based on STORET method.
Aktivitas Antibakteri Nanopartikel Perak Hasil Green Synthesis Menggunakan Ektrak Kulit Buah Kemuning (Murraya Paniculata (L) Jack) Doni Notriawan; Gustria Ernis; Risky Hadi Wibowo; Reza Pertiwi; Tessa Rianti Malau
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 3 No 2 (2020): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.997 KB) | DOI: 10.31539/bioedusains.v3i2.1850

Abstract

Antibacterial activity using silver nanoparticles synthesized using Murraya Paniculata (L) rinds extract has been carried out. This study aims to determine the antibacterial activity of green synthesized silver nanoparticles using Murraya Paniculata (L) rinds extract. Silver nanoparticles were synthesized by reacting AgNO3 with water extract of the Murraya Paniculata (L) rinds. Green synthesized silver nanoparticles were tested for antibacterial activity using Escherichia coli ATCC 8739. Silver nanoparticles synthesized using Murraya Paniculata (L) rinds extract were characterized using a UV-Vis spectrophotometer to confirm the formation of silver nanoparticles. The UV-Vis spectrophotometer results showed the formation of silver nanoparticles which was indicated by an absorption around 400-450 nm. The antibacterial activity test results of silver nanoparticles showed a strong inhibitory activity. Keywords: Green Synthesis, Silver Nanoparticles, Antibacterial, Echerichia Coli
Uji In Vitro Aktivitas Imunomodulator Minyak Atsiri Serai Dapur (Cymbopogon citratus) terhadap Proliferasi Sel Limfosit Mencit Gustria Ernis; Doni Notriawan; Dyah Fitriani; Elvira Yunita; Inta Cantika
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.527 KB) | DOI: 10.31539/bioedusains.v4i2.2524

Abstract

This study aims to determine the immunomodulatory activity of lemongrass essential oil on the proliferation of mouse lymphocyte cells in vitro. The method used is steam distillation to obtain citronella essential oil. Isolation of lymphocyte cells was obtained from the spleen organ of Swiss-Webster strain mice which was carried out aseptically. The lymphocyte cell proliferation test was carried out using the MTT Assay method and the absorbance was measured using an ELISA reader at 550 nm. The results showed that the lemongrass essential oil contained positive alkaloids, flavonoids, saponins, and steroids/triterpenoids with an essential oil yield of 0.043%. The higher the volatile oil concentration, the higher the Optical Density (OD) value obtained, but the OD increase at a 50 to 100 g/mL concentration was not significantly different. In conclusion, lemongrass essential oil has immunomodulatory activity against lymphocyte cell proliferation in mice tested in vitro. Keywords: Immunomodulator, Essential Oil, Lemongrass (Cymbopogon citratus), Immune System
Pengaruh Pemberian Perasan Lobak Putih (Raphanus sativus L.) dan Bengkuang (Pachyrhizus erosus L.) terhadap Kadar Glukosa Darah pada Mencit Model Diabetes Reza Pertiwi; Petri Siti Khodijah; Mifta Violina Aniza; Noval Kurniawati; Eni Kurniati; Dian Handayani; Dian Fita Lestari; Doni Notriawan
Jurnal Farmasi Sains dan Terapan Vol 9, No 1 (2022): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i1.3027

Abstract

Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.
Pemanfaatan Tanaman Obat Keluarga (TOGA) Meningkatkan Imunitas Tubuh sebagai Pencegahan COVID-19 Reza Pertiwi; Doni Notriawan; Risky Hadi Wibowo
DHARMA RAFLESIA Vol 18, No 2 (2020): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v18i2.12665

Abstract

Pada bulan Desember, 2019, serangkaian kasus pneumonia yang penyebabnya tidak diketahui muncul di Wuhan, Hubei, Cina, dengan gambaran klinis sangat menyerupai virus pneumonia. Setelah dilakukan uji laboratorium menunjukkan adanya virus baru, yang diberi nama COVID-19. Jumlah kasus terus tumbuh secara eksponensial menyebabkan WHO mengingatkan semua negara untuk melakukan kegiatan pencegahan dan pengendalian yang kuat agar dapat menghentikan penyebaran virus ini. Sejauh ini, belum ditemukannya obat spesifik untuk penyembuhan infeksi COVID-19. Terapi yang digunakan hanyalah menghilangkan gejala yang muncul dengan meningkatkan imunitas penderita. Potensi peningkatan imunitas dari jamu dapat diperoleh dari tanaman obat keluarga (TOGA). Tanaman obat dapat meningkatkan kekebalan tubuh, karena bersifat pencegahan (preventif) dan promotif melalui kandungan metabolit sekunder contohnya seperti gingiro pada jahe dan santoriso pada temulawak yang mampu meningkatkan sistem kekebalan tubuh. Berdasarkan observasi mahasiswa UNIB dan masyarakat di Kelurahan Pematang Gubernur, Kecamatan Muara Bangkahulu RT. 22, masih membutuhkan jamu sebagai pencegahan terhadap penyebaran virus COVID-19
BIOSINTESIS DAN KARAKTERISASI PARTIKEL PERAK EKSTRAK TANAMAN DAUN PORANG (Amorphophallus muelleri Blume) SEBAGAI PENDETEKSI ION LOGAM MERKURI Doni Notriawan; Febrika Laila; Eka Angasa; Gustria Ernis; Teja Dwi Sutanto; Reza Pertiwi; Ida Ayu Suci
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 1 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i1.63771

Abstract

This study aims to synthesize and characterize silver particles using Porang leaf extract (Amorphophallus muelleri Blume) and determine the selectivity of silver particles as mercury metal ion detectors. The study employed Porang leaf extract as a bioreductor and stabilizer, 0.01M AgNO3 solution as a precursor, and HgCl2 salt solution and PbCl2 salt solution as standard salt solutions to be tested for selectivity. The 2 g of Porang leaves used were cleaned, cut into pieces, allowed to stand at room temperature for three days, and mashed. Porang leaf powder was added with 50 mL of demineralized water and then heated for 15 minutes at a solution temperature of 80°C. The reaction of silver particle formation was carried out by adding Porang leaf extract and AgNO3 0.01M in variations of 1:3, 1:4, 1:5, 1:6, and 1:7, then irradiating under indirect sunlight for 15 minutes. The reaction results of a mixture of colloidal extract and AgNO3 solution showed a change in color to brownish-yellow. The color change indicated the formation of silver particles. The silver particles were then characterized with a UV-Vis spectrophotometer after 15 minutes of heating, 1 hour, and 5 hours at room temperature. The results obtained with colloidal silver particles can be synthesized with a bioreductor of Porang leaf extract (Amorphophallus muelleri Blume) with optimum variations of 1:3 and 1:4. The PSa results obtained in the mixture of silver particles formed were micro-nano-sized silver particles. The results of silver particles tested against metal ions showed that silver particles selectively detect Hg (II) metal ions in HgCl2 solutions compared to Pb (II) metal ions in PbCl2 solutions.
PENINGKATAN KETERAMPILAN SISWA/I SMKS AGRO MARITIM KOTA BENGKULU MELALUI PELATIHAN PEMBUATAN VIRGIN COCONUT OIL (VCO): Improving the Skills of Students of SMKS Agro Maritime Bengkulu City through Training in Making Virgin Coconut Oil (VCO) Doni Notriawan; Reza Pertiwi; Aprillia Devi Wibowo; Mustika Dewi Lestari; Zavira Nurjali
JAMAS : Jurnal Abdi Masyarakat Vol. 1 No. 3 (2023)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

SMKS Agro Maritim Laboratorium Pertanian Universitas Muhamadiyah Kota Bengkulu merupakan sekolah yang baru saja didirikan pada tahun 2018. SMKS Agro Maritim memiliki dua kelas kejuruan yaitu Agro (Agribisnis) dan Maritim ( Kelautan). Kurikulum SMKS Agro Maritim berbasis mengolah sumber daya alam sektor pertanian dan kelautan. Kegiatan belajar mengajar di SMKS lebih terfokus pada praktikum untuk mengolah sumber daya alam menjadi produk. VCO atau lebih dikenal dengan minyak kelapa murni karena pada proses pembuatannya dilakukan secara alami (fermentasi), yaitu proses pembuatan yang dilakukan tanpa mengalami proses secara kimia maupun fisika. VCO yaitu minyak yang dibuat dengan menggunakan metode fermentasi memiliki komponen asam lemak laurat yang tinggi, yaitu 46,70%. Asam lemak yang terkandung memiliki peranan yang sangat penting bagi kesehatan. Kegiatan pengabdian masyarakat berbasis pembinaan ini dilaksanakan dengan menggunakan metode penyuluhan dan praktek tentang pembuatan VCO. Setelah kegiatan pendampingan pembuatan VCO, siswa/I SMKS Agro Maritim sudah mengetahui mengenai VCO, sehingga tujuan kegiatan untuk memberikan keterampilan kepada siswa/i sehingga nantinya dapat menjadi produk unggulan dari SMKS Agro Maritim telah terpenuhi.
Co-Authors Aanisah Hanuun Aprillia Devi Wibowo Dian Fita Lestari Dian Fita Lestari Dian Handayani Dyah Fitriani Dyah Fitriani Eka Angasa Elvira Yunita Eni Kurniati Ernis, Gustria Fadhila, Muhammad Adeng Febrika Laila Gustria Ernis Gustria Ernis Ida Ayu Suci Ilfanisari, Vinolla Inta Cantika Mifta Violina Aniza Mustika Dewi Lestari Nesbah, Nesbah Noval Kurniawati Noval Kurniawati Petri Siti Khodijah Petri Siti Khodijah Reza Pertiwi Reza Pertiwi Reza Pertiwi Reza Pertiwi Reza Pertiwi Risky Hadi Wibowo Teja Dwi Sutanto Tessa Rianti Malau Triawan, Deni Agus Wibowo, Risky Hadi Zavira Nurjali