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All Journal Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Vokasi Keperawatan (JVK)
Adek Zamrud Adnan
Fakultas Farmasi Universitas Andalas
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Jurnal Sains dan Teknologi Farmasi

 1 
Penetapan Kadar Kumarin dari Kulit Manis (Cinnamomum burmanii Bl.) dengan Metoda Kromatografi Gas Yulianis, Yulianis; Adnan, Adek Zamrud; Putra, Deddi Prima
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

The qualitative and quantitative analysis of coumarin in cinnamon (Cinnamomum burmanii Bl.) which are qualified in to AA, KA and KB has been done by gas chromatography and gas chromatography-mass spectrometry. Extraction of quality KB coumarin was carried out by soxchletation in hexane, dichloromethane and methanol. Meanwhile, quality AA and KA coumarins are soxchletated in methanol. The qualitative analysis using gas chromatography-mass spectrometry with column BP-5 showed that hexane, dichloromethane and methanol extracts of qualified KB coumarin, as well as methanol extracts of qualified AA and KB only contain coumarin compounds, no other coumarin groups were found. From coumarin quantitative analysis by gas chromatography using BP-624 column and FID detector of methanol extracts obtained 1855.51 ppm (0.186%), 1915.75 ppm (0.192%), 9177.36 ppm (0,918%), for qualified KB, AA, and KA respectively.
Uji Praklinis Efek Anti Inflamasi dan Toksisitas Fraksi Aktif Spilanthes Paniculata Wall & Dc Djamain, Armi; Almahdy, Almahdy; Adnan, Adek Zamrud
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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The aim of this study was to evaluate an antiinflamation effect of S.paniculata and Siabadicencis extracts at the dose of 300 mg/200 g BW by induction of rats paw edema. Edema condition was induced by administration of 0,2 ml aqueous solution of 0,1 % carrageenan. This was followed by the assay of antiinflamatory effect of fractionated S. paniculata extract with hexane, DCM, ethyl acetate and butanol respectively. A decrease in rats paw edema volume was measured after treatments. Results showed that percent inhibition of inflammation after administration of Siabadicencis, S. paniculata extracts and positive control were 35;48 and 63 % respectively, while that of the hexane, DCM, ethyl acetate and butanol fraction was 69, 27, 53, and 43 % respectively. The antiinflamation effect of the hexane fraction was then determined at various doses (10 ; 20 and 30 mg/20 g BW with positive control acetosal 1,3 mg/20 g BW, by induction of rat back edema. The edema was induced by administration of 1 % carrageen in sessame oil at day 0 (0,1 ml) and day 1 st (0,5 ml) respectively. Parameters such as edema volume, haemoglobin and haematocrit were observed. Results indicated that percent inhibition of inflammation diameter after administration of the fraction at doses  10, 20, 30 mg/20 g BW and acetosal 1,3 mg/20 g BW on day 5th was 11 ; 15 ; 17 ; and 20 % respectively. While percent inhibition of inflammation volume of those groups were 19, 38, 62 and 63 % respectively the haemoglobine (Hb) of dose group 10, 20, 30 mg/20 g BW and negative control was 14.808 ; 15.117 and 12.944 g/dL respectively and 45,25 that of control positive 44,2 respectively. The mean value of necrosis hepatocyte at 3 sites of dose group 30 mg/20 g BW, positive and negative control groups was 6,38 ; 13,82 and 3,55 respectively.
Co-Authors Almahdy A Armi Djamain Bita Revira Deddi Prima Putra Fithriani Armin Harfia Mudahar Marlina . Muhammad Taher P Pachaly Rahma Yulia Suci Rahmawati Yulianis Yulianis