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All Journal Jurnal Kesehatan Andalas Majalah Kedokteran Andalas Majalah Patologi Indonesia
Noza Hilbertina
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Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Kedokteran Andalas

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ADENOKARSINOMA PROSTAT: PENILAIAN PROGNOSTIK DAN DERAJAT HISTOPATOLOGI Anandia Putriyuni; Noza Hilbertina
Majalah Kedokteran Andalas Vol 37, No 2 (2014): Published in September 2014
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.516 KB) | DOI: 10.22338/mka.v37.i2.p93-100.2014

Abstract

AbstrakKanker prostat merupakan kanker kedua terbanyak pada pria di seluruh dunia. Tujuan penelitian ini adalah untuk mengetahui faktor prognostik adenokarsinoma prostat seperti derajat histopatologi berdasarkan the 2005 ISUP modified Gleason system, invasi perineural dan kadar PSA serum sebelum operasi. Ini adalah suatu penelitian deskriptif kasus adenokarsinoma prostat yang didiagnosis di laboratorium patologi anatomi periode 2010-2012. Data usia dan kadar PSA diperoleh dari rekam medik. Review sediaan histopatologi dilakukan untuk konfirmasi skor Gleason, lalu dikelompokan berdasarkan derajat histopatologi. Kasus adenokarsinoma prostat yang memenuhi kriteria inklusi adalah 163. Hasil penelitian menunjukkan kasus adenokarsinoma prostat terbanyak pada kelompok usia 61-70 tahun sebanyak 38,65%, derajat histopatologi poorly differentiated yaitu 46,63%, invasi perineural 22,7% dan 83,33% kadar PSA serum >20 ng/ml. Pada kelompok usia 51-60 tahun adenokarsinoma prostat terbanyak ditemukan dengan derajat histopatologi well differentiated; sedangkan kelompok usia 61-70 tahun, 71-80 tahun dan 81-90 tahun terbanyak poorly differentiated. Invasi perineural positif terbanyak pada derajat histopatologi poorly differentiated. Semua derajat histopatologi adenokarsinoma prostat menunjukkan kadar PSA serum terbanyak >20 ng/ml. Penelitian ini menunjukkan kecenderungan peningkatan usia, invasi perineural dan kasus dengan kadar PSA serum >20 ng/ml bersamaan dengan peningkatan derajat histopatologi adenokarsinoma prostat.AbstractProstate cancer is the second most common cancer in men around the world. The objective of this study was to determine prognostic factors of prostate adenocarcinoma such as histopathological grading based on the 2005 ISUP modified Gleason system, perineural invasion, and PSA serum. This was a descriptive study of prostate adenocarcinoma diagnosed in Pathology Department from 2010 to 2012. The age and PSA serum level were taken from the medical records. The histological slides were reviewed to confirm Gleason score, and then classified into the histopathological grading. The number of prostate adenocarcinoma cases included in this study was 163. The result shows that the majority of cases were found at 61–70 years old (38.65%), histopathological grading was mostly poorly differentiated (46.63%), positive perineural invasion 22.7% and 83.33% PSA serum above 20 ng/ml. Prostate adenocarcinomas found at age 51-60 years old were mostly well differentiated. On the other hand, cases found at age above 60 years old were mostly poorly differentiated. Perineural invasion was mostly found on poorly differentiated cases. All of histopathological grading showed PSA serum above 20 ng/ml. This study suggested that higher age, perineural invasion and PSA serum level above 20 ng/ml were congruent with the histopathological grading.
PERANAN PATOLOGI DALAM DIAGNOSTIK TUMOR PAYUDARA Noza Hilbertina
Majalah Kedokteran Andalas Vol 38 (2015): Supplement 1 | Published in September 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.383 KB)

Abstract

HUBUNGAN PERSENTASE DAN POLA STROMA REAKTIF DENGAN DERAJAT HISTOPATOLOGI LESI PROSTAT Noza Hilbertina; Henny Mulyani
Majalah Kedokteran Andalas Vol 35, No 2 (2011): Published in August 2011
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (647.695 KB) | DOI: 10.22338/mka.v35.i2.p106-116.2011

Abstract

AbstrakAktivasi dari lingkungan mikro stromal pada pejamu diperkirakan merupakan tahapan kritis dalam pertumbuhan dan progresi dari adenokarsinoma. Stroma reaktif ini sangat penting dalam merangsang invasi, progresi dan metastasis tumor. Kanker prostat adalah kanker yang tersering pada laki-laki.. Elemen pembeda pada prostat adalah fenotipe otot polos yang ada pada jaringan prostat normal sulit dibedakan dengan stroma reaktif pada pewarnaan rutin yaitu hematoksilin eosin. Dengan aplikasi pulasan Masson trichrome maka stroma normal dan stroma reaktif dapat dibedakan secara jelas. Penelitian ini bertujuan untuk mengetahui persentase dan pola distribusi stroma reaktif berdasarkan derajat histopatologi lesi prostat.Seratus sepuluh kasus lesi prostat yang telah didiagnosis di Laboratorium Patologi FK-Unand, Padang dilakukan review ulang terhadap derajat histopatologi lesi. Selanjutnya blok parafin dari kasus yang bersangkutan dipotong ulang untuk pewarnaan Masson trichrome dan dinilai secara mikroskopik persentase dan pola stroma reaktif tersebut.Analisis statistik menunjukkan hubungan yang kuat dan bermakna secara statistik antara persentase stroma reaktif dengan derajat histopatologi lesi prostat dengan nilai r = 0,679 dan p < 0,05 dan juga terdapat hubungan yang bermakna secara statistik antara pola distribusi stroma reaktif dengan derajat histopatologi lesi prostat dengan nilai p < 0,05Kata Kunci : Derajat histopatologi, persentase stroma reaktif, pola stroma reaktifAbstractActivation of the host stromal microenvironment is predicted to be a critical step in adenocarcinoma growth and progression. Reactive stroma in cancer would be predicted to enhance tumor progression, stimulating invasion and metastasis. Prostat cancer is the most cancer in men. Prostat cancer reactive stroma is composed of a myofibroblast/fibroblast mix. A simple trichrome stain makes the process of distinguishing normal stroma and reactive stroma more obvious. We examined the association of percentage and pattern of reactive stroma to histopatologic grading from the prostate lesions.A hundred and ten of prostate lesion were obtain from the Pathological Anatomic Laboratorium, Medical Faculty of Andalas University in Padang. The hematoxilinARTIKEL PENELITIAN107eosin slides were reviewed by two viewer for histopathologic grading and than whole mount thin section were stained with Masson trichrome. To evaluate the reactive stromal interpretation classified in to percentage (+, ++, +++) and pattern of reactive stroma (regular and irregular).There were significant association between percentage of reactive stroma with histopathologic grading statistically (p<0,05 and r=0,679) and significant association between pattern of reactive stroma with histopathologic grading statistically (p<0,05).Key word : histopathologic grading, percentage, pattern
PERANAN PATOLOGI DALAM DIAGNOSTIK TUMOR PAYUDARA Noza Hilbertina
Majalah Kedokteran Andalas Vol 38, No 2 (2015): Published in September 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (43.732 KB) | DOI: 10.22338/mka.v38.i2.p1-8.2015

Abstract

PERANAN PATOLOGI DALAM DIAGNOSTIKTUMOR PAYUDARA
Co-Authors Anandia Putriyuni Avit Suchitra Hedo Hidayat Henny Mulyani Husna Yetti Husna Yetti Loli Devianti Muhammad Ridho Azhari Nana Liana Prima Adelia Rachmita Rika Susanti Salmiah Agus Siqbal Karta Asmana Syahredi Syahredi Yan Edward Yenita .