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All Journal Majalah Obat Tradisional Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) CERATA Jurnal Ilmu Farmasi HERBAPHARMA : Journal of Herb Farmacological Medical Sains : Jurnal Ilmiah Kefarmasian JURNAL BESEMAH CERATA Medical Sains : Jurnal Ilmiah Kefarmasian
Marini Marini
STIKES Muhammadiyah Kuningan
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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

 1 
PHYSICAL EVALUATION OF CURCUMA RHIZOME EXTRACT (Curcuma xanthorrhiza) FORMULATION IN ANTI ACNE LOOSE POWDER Marini Marini; Haty Latifah Priatni; Azmi Darotulmutmainnah; Dea Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.811

Abstract

When Staphylococcus aureus and Staphylococcus epidermis are isolated from acne-proneskin, the essential oil and curcuminoids in curcumin (Curcuma zanthorrhiza Roxb) exhibitantibacterial activity against blemished skin. The purpose of this study was to create an antiacne loose powder using Curcuma rhizome extract and to determine which formulationsmeet the best test requirements. Extraction was carried out using the maceration methodwith 96% ethanol solvent. The powder formulation consisted of alba bolus, magnesiumcarbonate, magnesium stearate, zinc oxide, oleum rosae, and talc, developed withtemulawak rhizome extract at concentrations of F0 (0%), F1 (8%), F2 (10%), and F3 (12%).The evaluation of the powder preparation was organoleptic, humidity, powder flow rate,specific gravity, and pH.. The results indicated that the F1 formulation's humidity test resultsof less than 10%, the speed of the powder flow evaluation test results was 15.6%, the angleof repose test result was 26.6°, and the measurement of pH showed that the result of 6fulfilled the requirements. Based on a physical test of the anti-acne loose powder, theCurcuma rhizome extract in the FI formulation with an 8% concentration produced optimalresults. Keywords: anti acne, physical evaluation, loose powder, curcuma
EFFECTIVENESS TEST OF WOUND PATCH PREPARATIONS OF GOTU KOLA LEAF EXTRACT (Centella asiatica (L.) Urb.) ON INCISION WOUND IN RABBITS Marini Marini; Nur Azizah; Devin Nur Rohman; Angga Anugra Diputra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.923

Abstract

A wound patch is a dosage form that delivers drugs through the skin to produce systemic effects, with the advantage of controlled drug release. Centella asiatica (L.) Urb.) is widely used to heal incision wounds on the skin. The most important component was asiaticoside, which plays a major role in accelerating wound healing. This  study  was  conducted  to  test  the  effectiveness  of  transdermal  patches  from Centella asiatica (L.) Urb.) against incision  wounds was performed on 5 rabbits divided into different treatment groups, namely group I without treatment, group II wound patch base (negative control), group III plaster (positive control), and groups IV and V, comprising a wound patch of gotu kola leaf extract at concentrations of 16% and 32%, respectively. The data obtained were statistically tested for normality using the Shapiro-Wilk test.  The results showed that the wound patch preparation of 16% gotu kola leaf extract showed  a significant difference (p < 0.05) in wound length reduction compared to the negative and normal controls.  The wound healing time observed at concentrations of 16% and 32% provided wound healing effects. The best effect was observed at a concentration of 16%, with an average wound closure time of 12 days. It can be concluded that gotu kola leaf extract in the form of a wound patch preparation was effective in wound healing. Keywords: Gotu kola leaf extract; incision wound; Wound patch; Effectiveness test
Co-Authors Aas Mugi Lestari Ai A’yunin Syam Amalia Sumiar Angga Anugra Diputra Astri Pratiwi Azis Sugarna Azmi Darotulmutmainnah Cici Sri Nurjanah Daniar Pratiwi Dea Safitri Devin Nur Rohman Diana Fitri Dama Yanti Egy Nurnabhilah Ersih - Saphira Fany Lesmana Haty Latifah Priatni Ii Carsita Maesaroh, Imas Mirna Mirna Moch. Saiful Bachri Nova Oktavia Nufa Abriana Nur Azizah Rina Nurhayatina Risqika Y.T. Paramidhita Rosyida, Anis Ryan Farhan Pebrian Sinta Partiwi Suwijiyo Pramono wilda yuniar