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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indian Journal of Forensic Medicine & Toxicology
Irmadita Citrashanty
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effect of Amniotic Membrane Stem Cell Metabolite Product (AMSP-MP) Combine with Vitamin E after Microneedling in Photoaging Progress Cita Rosita Sigit Prakoeswa; Agatha Anindhita Ayu Ardhaninggar; Riyana Noor Oktaviyanti; Irmadita Citrashanty; Maylita Sari; Menul Ayu Umborowati; Dwi Murtiastutik
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14695

Abstract

Introduction: The photoaging is a cumulative process. Amniotic Membrane Stem Cell Metabolite Products(AMSC-MP) that contain cytokines and growth factors that have a role in the skin’s rejuvenation process.Vitamin E is an antioxidant that has a photoprotective effect. Topical combination of AMSC-MP and VitaminE are expected to have an effect on clinical photoaging improvement.Objective: To evaluate the effect of topical combination of AMSC-MP with vitamin E after microneedlingcompared with AMSC metabolite products after microneedling.Methods: A total 60 photoaging women were included in this experimental analytic, controlled, matchingresearch. Each participant’s face was allocated to topical combination of AMSC-MP and vitamin E inintervention group and AMSC-MP only in control group. Microneedling modality was use to enhanceepidermal penetration. Three treatment sessions were repeated at two weeks’ interval.Results: From the comparison of the two groups showed there were significant different of mean value inwrinkle, skin tone and UV spots with p-value < 0,005 in the intervention grup. While pore and polarized spotdo not show significant differences between two groups.Conclusion: The administration of a topical combination of MP-AMSC and vitamin E after microneedlingprovides clinical improvement in photoaging.
Insufisiensi Adrenal Sekunder pada Eritema Nodosum Leprosum: Studi Profil TNF-α dan Kortisol Serum Irmadita Citrashanty; Sunarso Suyoso; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.361 KB) | DOI: 10.20473/bikk.V26.2.2014.1-6

Abstract

Latar belakang: Beberapa studi mengemukakan bahwa peningkatan tumor necrosis factor–alpha (TNF-α) sebanding dengan derajat keparahan Eritema Nodosum Leprosum (ENL), sehingga sitokin ini dianggap sebagai seromarker. Sekresi adrenocorticotropin hormone (ACTH) meningkat akibat pelepasan sitokin proinflamasi, kemudian ACTH akan merangsang pelepasan glukokortikoid adrenal sebagai umpan balik. Apabila rangsangan sitokin ini berlangsung kronis, korteks adrenal akan mengalami kelelahan yang berakibat menurunnya serum kortisol. Pemberian kortikosteroid eksogen jangka panjang diduga menyebabkan terjadinya penurunan kortisol. Tujuan: Mengevaluasi profil TNF-α dan kortisol serum pada pasien ENL yang diterapi kortikosteroid berdasarkan riwayat lamanya ENL. Metode: Dua puluh satu subjek dilakukan pemeriksaan fisik, anamnesis riwayat ENL, dan pengambilan sampel darah jam 08.00-09.00 untuk melihat kadar TNF-α dan kortisol serum. Hasil: Dari 21 sampel didapatkan rerata TNF-α serum sebesar 4,51 ± 1,7 ρg/mL. Rerata kortisol serum pada pasien dengan riwayat ENL 1-12 bulan sebesar 15,23 ± 2,3 μg/dL, riwayat ENL > 12-24 bulan sebesar 8,75 ± 4,8 μg/dL, dan riwayat ENL > 24-36 bulan sebesar 1,17 ± 0,7 μg/dL. Simpulan: Rerata penurunan kortisol serum tampak seiring dengan semakin lamanya pasien menderita ENL dan mendapatkan terapi kortikosteroid. Insufisiensi adrenal sekunder pada penelitian ini dapat disebabkan oleh pemberian kortikosteroid jangka panjang maupun adanya paparan sitokin proinflamasi kronis. Kata kunci: eritema nodosum leprosum, insufisiensi adrenal sekunder, kortikosteroid, TNF-α, kortisol.
Wide excision of Basal Cell Carcinoma on the upper extremity: A case report Maylita Sari; Putri Halla Shavira; Bagus Haryo Kusumaputra; Irmadita Citrashanty; M Yulianto Listiawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 2 (2023): Journal Qanun Medika Vol 07 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i2.15495

Abstract

Basal cell carcinoma (BCC) is the most common skin cancer, usually occurring in the sun-exposed area, such as the head and neck, but also seen in less common areas like the upper or lower extremities. The initial treatment of BCC lesions is completing tumor removal. One of the standard therapy for BCC is wide surgical excision, as it is highly efficacious. A 76-year-old female patient complained of a wounded blackish lump on the left upper extremity for about 2 years. It started small, then grew bigger. Complained of itchiness, but no pain. The lump easily bled when accidentally touched. Dermatology examination identified a hyperpigmented nodule about 1.5 cm, with a clear border, irregular raised edges, slightly rough surface, and erosion. A dermoscopy examination showed short-fine telangiectasia, blue-grey ovoid nests, and ulceration. The patient was diagnosed with suspected BCC and underwent biopsy, also wide excision surgery. Histopathology showed pigmented BCC. One month later, surgery proved a good result. Selecting appropriate therapy in BCC should be given to reduce the recurrence rate. The common treatment for BCC is wide surgical excision, because of its association with a low recurrence rate and the ability to confirm residual tumor pathologically. In conclusion, wide excision surgery is one of the effective therapy options for BCC.
Excellent Response of Infantile Hemangioma with Oral Propranolol: A Case Report Denissafitri, Armyta; Pramitha, Riezky Januar; Yuri Widia; Zulkarnain, Iskandar; Irmadita Citrashanty; Sawitri, Sawitri
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.217-222

Abstract

Background: Infantile hemangioma (IH) is the most common benign tumor in infancy. Most IHs resolve spontaneously and do not require treatment. Therapeutic intervention is necessary for life-threatening IH, tumors posing functional risks, ulceration, and severe anatomic distortion, especially on the face. Beta-blockers, most specifically propranolol, have been shown to induce involution of IH, which should be administered as early as possible to avoid potential complications. Purpose: To report a case of IH with visual impairment treated successfully using oral propranolol. Case: A 4-month-old girl weighing, 6.3 kg, with redness plaques on the right face since 3 weeks after birth. The lesions rapidly increased in size within 2 months, and the lesions on her right eyelid made it difficult to open her right eye. Dermatological examination showed erythematous plaques, compressible and varying in size and ptosis. The patient was diagnosed with periocular infantile hemangioma and was given oral propranolol therapy with an initiated dose 3x1 mg. The dose was increased gradually. The lesions were significantly decreased and she could open her right eye normally after 5 months of propranolol therapy. Discussion: Some cases of IH require early treatment. Early treatment is indicated for IH causing functional impairment. The use of propranolol in the management of IH is very effective in the reduction of the lesions and Has minimal side effects. Conclusion: Early diagnosis and intervention with propranolol for IH play an important role in determining the optimal outcomes.
A Retrospective Study of Demographic, Clinical, and Histopathological Profiles of Cutaneous Tumors Bintanjoyo, Lunardi; Hidayati, Afif Nurul; Cita Rosita Sigit Prakoeswa; Murtiastutik, Dwi; Bagus Haryo Kusumaputra; Listiawan, Muhammad Yulianto; Irmadita Citrashanty; Maylita Sari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.149-155

Abstract

Background: In 2007, skin cancers were third most common malignancies in Indonesia. However, profile of cutaneous tumors in our institution has not been studied. Purpose: To evaluate profile of cutaneous tumors in Dermatology and Venerology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya, Indonesia. Methods: This is a descriptive retrospective study. Inclusion criteria was new cutaneous tumor patients. Exclusion criteria was incomplete data. Medical record and  photograph database from 2019-2020 were assessed for demography, clinical features, histopathological examination and final diagnosis. Results: There were 379 (5,5%) cutaneous tumors among 6896 new patients at Dermatology and Venereology Outpatient Clinic. Overall, there were more female patients (53.7%) and age group of 0-45 years old (70.4%). Cutaneous tumors more commonly presented as papular (50.4%), multiple (56.5%), nonpigmented (58.3%), asymptomatic lesions (62.5%), with time from onset 0-24 months (66.2%) and location on head and face (61.2%). Benign cutaneous tumors showed similar findings. Malignant cutaneous tumors showed differences including predominantly male sex, age above 45 years old, nodular, solitary, pigmented and easily bleeding lesions. Malignant tumors were less common (6.9%). Most common malignant tumor was BCC. Most common benign and overall cutaneous tumor was seborrheic keratosis. Conclusion: Cutaneous  tumors presented across gender and ages, showing heterogenous clinical manifestations. Malignant and benign cutaneous tumors showed similarity on time from onset and location of lesions. However, differences were seen in demographic profiles and majority of clinical features. BCC was the most common malignant cutaneous tumors, while seborrheic keratosis was the most common benign and overall cutaneous tumors.
Co-Authors Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ayu Ardhaninggar Bagus Haryo Kusumaputra Bintanjoyo, Lunardi Cita Rosita Sigit Prakoeswa Denissafitri, Armyta Dwi Murtiastutik M. Yulianto Listiawan Maylita Sari Maylita Sari Menul Ayu Umborowati Pramitha, Riezky Januar Putri Halla Shavira Rahmadewi Rahmadewi Riyana Noor Oktaviyanti Sawitri Sawitri Sunarso Suyoso T. Riza Zarzani N Yuri Widia, Yuri