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All Journal Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia Abdimas Universal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Dyah Ratna Budiani
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Hubungan antara Kadar Feritin dengan Kreatinin Serum pada Pasien Thalassemia di RSUD Dr. Moewardi Utami, Eko Dewi Ratna; Salimo, Harsono; Budiani, Dyah Ratna
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background : Patients with thalassemia that underwent routine blood transfusion are developing iron overload. In the state of excess iron, ferritin levels increase. When iron storage capacity has been depleted, free iron will cause tissue damage. One of that damaged organ is kidney. One of parameter used to know the function of kidney is GFR (Glomerular Filtration Rate). A simple way to estimate GFR is serum creatinine. Increased 1-2 mg/dL of creatinine serum showed decrease ±50% of GFR. This research was aimed to determine the correlation between ferritin levels and serum creatinine of patients with thalassemia. Methods : A cross-sectional study which the subjects were 30 patients with thalassemia in the pediatric ward RSUD Dr. Moewardi who met the inclusion criteria. Ferritin levels and serum creatinine obtained from medical records or patient report book. Data normality was tested with Shapiro-Wilk normality test. Correlation between ferritin levels and serum creatinine were analyzed with non-parametric correlation test Spearman using Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : Ferritin levels ranged from 1004.2 to 9600 ng/mL. Creatinine serum were 0.2 mg/dL; 0.3 mg/dL; 0.4 mg/dL; 0.5 mg/dL with almost equal distribution. Results of the analysis with non-parametric correlation test Spearman obtained R = 0.044 and p = 0.816. Conclusion : There was no correlation between ferritin levels and serum creatinine of patients with thalassemia. Keywords : thalassemia, ferritin, creatinine
Kombinasi Ekstrak Etanolik Kunyit dan Temulawak Lebih Berpotensi sebagai Fitofarmaka Hepatoprotektif: Studi Efek Hepatoprotektif pada Mencit Balb/C yang Diinduksi Parasetamol Nirmala, Atika Zahro; Widjokongko, S. Bambang; Budiani, Dyah Ratna
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

The occurrence of liver damage especially caused by consuming non steroidal anti inflammatory medicine is high in some countries. In the other hand, turmeric and curcuma are frequently consumed as a herbal treatment. Those herbals contain antioxidant. The purposes of this experiment were to know the differences of hepatoprotective effect of ethanolic extract of turmeric, curcuma, and the combination of both in mice Balb/C induced by paracetamol. This research was a laboratory experimental study with the post test only control group design. The research used 25 male Balb/C mice that were devided into 5 groups: negative [KK (-)] and positive control group [KK (+)] were administered 0.2 ml of aquades, while group treatment 1 (KP1), 2 (KP2) and 3 (KP3) consecutively  were administered 2.8 mg of turmeric ethanolic extract, 14 mg of curcuma ethanolic extract and the combination of 1.4 mg of turmeric extract and 7 mg of curcuma ectract. The treatments were conducted in 14 days. The dose of paracetamol toxic was treated to KK (+), KP1, KP2, and KP3 on the 12th, 13th, and 14th days. Hepatoprotective effect was assessed by the number of disfunctional cells of liver. The data were analyzed by One Way ANOVA and LSD test. The result of one way ANOVA showed a significant difference in the five groups with p = 0.03. LSD test showed a significant difference among KK (-), KP1, and KP3 against KK (+) and KP2. There were some differences of the hepatoprotective effect of ethanolic extract of turmeric, curcuma, and the combination of both in mice Balb/C induced by paracetamol. Keywords: hepatoprotective, turmeric, curcuma, paracetamol consecutively
Pengaruh Ekstrak Air Buah Nanas terhadap Ekspresi Caspase-3 dan Fragmentasi DNA Sel Adenokarsinoma Kolorektal WiDr Pribadi, Sintin Khotijah; Budiani, Dyah Ratna; Pesik, Riza Novierta
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Colorectal adenocarcinoma is the third most diagnosed neoplasm in the world. Many approaches have been taken for therapy, especially targeted therapy. However, the resistance event still occurs due to constitutive activation of intracellular signaling. In the other hand, pineapple fruit [Ananas comosus (L.) Merr.] has bromelain enzyme that can specifically influence intracellular signaling and not only lead to inhibit proliferation but also lead apoptosis induction in neoplasm cell. The purpose of this study was to elucidate the effect of pineapple fruit aqueous extract to caspase-3 expression and DNA fragmentation of apoptosis process in WiDr colorectal adenocarcinoma cells. Methods: This research was an experimental laboratory study with the post test only control group design. The samples of this research were WiDr colorectal adenocarcinoma cells divided into 6 groups: Negative control group, Positive control group with doxorubicin 5 μg/ml and four Treatment groups with 270 μg/ml, 202.5 μg/ml, 135 μg/ml and 67.5 μg/ml of extract concentration, each. The samples were incubated for 48 hours in 37oC and 5% CO2. The caspase-3 expression was determined by cytologic score of samples stained with caspase-3 antihuman antibody. The DNA fragmentation was determined by 1% agarose gel electrophoresis. The cytologic score was analyzed by one way ANOVA test and LSD test. Result: The result showed that there was significant difference between Positive control group and the other groups (p=0.000), but there wasn’t significant difference between the Negative control group and the Treatment groups (p>0.05). The result from electrophoresis showed that there wasn’t DNA fragmentation in WiDr colorectal adenocarcinoma cells. Conclusion: The pineapple fruit aqueous extract did not increase caspase-3 expression and did not lead DNA fragmentation to WiDr colorectal adenocarcinoma cells for 48 hours of treatment. Keywords: pineapple fruit aqueous extract, WiDr colorectal adenocarcinoma cell, caspase-3 expression, DNA fragmentation  
Hubungan antara Kejadian Abortus Spontan dengan Paritas dan Usia Ibu Hamil di RSUD Dr Moewardi Badri, Dwi Septiadi; Melinawati, Eriana; Budiani, Dyah Ratna
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Abortion is one of the health problems that causing high morbidity and mortality. there are various factors suspected to be associated with the cause of abortion including the factor of age and parity. A very young or a very old maternal age can increase the risk of abortion. So does the parity, the more parity of the mothers, the higher the risk of abortion. The purpose of this study was to determine the incidence of spontaneous abortion associated with maternal age and parity status during pregnancy. Methods: This study was an observational analytic study using cross-sectional. A total of 40 study subjects were selected by purposive random sampling was the pregnant women who become inpatients at the Department of Obstetrics and Gynecology at Dr. Moewardi State Hospital Surakarta who met the inclusion criteria . Data were collected by direct interview to the patient . The data were analyzed using logistic regression analysis test. Results: Based on the research status of pregnant women with parity ≥ 4 are 8.53 times likely to experience spontaneous abortion ( p = 0.000 , OR = 8.53 ). While pregnant women with age of < 20 years and > 35 years are 14.77 times likely to experience spontaneous abortion ( p = 0.000 , OR = 14.77 ). Conclusions: There is a significant relationship between the incidence of spontaneous abortion with parity and maternal age. Pregnant women with parity status ≥ 4 are 8.53 times likely to experience a spontaneous abortion while pregnant women with age < 20 years and > 35 years are 14.77 times likely to experience spontaneous abortion. Keywords: spontaneous abortion , parity , age  
Hubungan Antara Kejadian Abortus Spontan dengan Kadar Hemoglobin di RSUD Dr. Moewardi Sitorus, Andreas Peter; Melinawati, Eriana; Budiani, Dyah Ratna
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background : Many cases of abortions are caused by abnormal hemoglobin levels. World Health Organization (WHO) estimates that 35-75% of pregnant women in developing countries and 18% of pregnant women in developed countries undergo anemia while being pregnant. The purpose of this study is to determine the relationship between the incidence of spontaneous abortion with hemoglobin levels. Methods : This study is an analitic observational study with cross-sectional design. Its population are pregnant women who had been treated at the Obstetrics and Gynecology of Dr. Moewardi General Hospital. Subjects were taken with purposive random sampling technique. The data were collected using direct observation and subjects’ medical records. Data were analyzed using Chi Square. Results : The results of this study found 40 subjects due to the case of this study. Subjects with anemia who did not experience abortion counted only 2 people (5.0%) and subjects who experienced abortion counted as many as 17 people (42.5%). While subjects with normal hemoglobin levels who did not experienced abortion aggregates to 18 people (45%) and subjects who experienced abortion counted as many as 3 people (7.5%). The calculation obtained p-value = 0.000 <0.05, and OR = 0.020, which means there is a relationship between the incidence of spontaneous abortion with hemoglobin levels. Conclusions : There is a significant relationship between the incidence of spontaneous abortion with hemoglobin levels. Low hemoglobin levels will increase the risk of abortion.Keywords: abortion, hemoglobin levels, anemia 
Perbandingan Sensitivitas dan Spesifisitas antara Pengukuran Lingkar Lengan Atas, Lingkar Pinggang dan Lingkar Leher untuk Identifikasi Anak dengan Obesitas Irawati, Cempaka; Nugroho, Hari Wahyu; Budiani, Dyah Ratna
Nexus Kedokteran Klinik Vol 3, No 2 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Childhood obesity is a global phenomenon. Oneoften childreninthe worldare over weight. Then in Indonesia, the prevalence of childhood obesityis relatively increasedyear to year. Screening forobese childrenneeds to be doneearly, given thatobesity inchildhoodis likely to leadtoadultobesitylater. Anthropometric measurements are easy and inexpensive way. Therefore, there was some studies using anthropometryas the tool for identify obesityin addition to body mass index(BMI), which is the gold standard. However, there is no studies have compared the validity of assorted anthropometricas a tool to identify obese children, so that there searcherintends to compare the sensitivity and specificity between mid-upper arm circumference (MUAC), waist circumference (WC), and neck circumference (NC) in identification obese children. Methods: This study is observational analytic cross sectional approach. A sample included 72 children who were aged 6 to 12 years from four elementary school in Surakarta. Sampling population was obesity and healthy children (controls) who selected by simple random sampling had been carried out previously by fixed disease samples. Then the child was measured height, weight, MUAC, WC, and NC. Height and weight will be converted into BMI to determine obesity or not. Data were analyzed with diagnostic tests are grouped in table 2x2. From diagnostic test, we can determine the sensitivity and specificity. Furthermore, data were analyzed by Chi Square test and analysis receiver operating characteristic curve (ROC) to determine accuracy. Results: Among 72 children, 51,4% are male. MUAC (≥ percentile 90th), WC (≥ percentile 90th) and NC (cut off point 27,0-31,5) are significantly correlated with BMI. The sensitivity of MUAC was 58,33% with specificity 100%. The sensitivity of waist circumference was 66,67% with specificity 97,22%. The sensitivity of the neck circumference was 80,56% with specificity 63,89%. Conclusions: MUA Cisthe best measuring tool to identification obesityin children because it hasthe highest specificity, that is 100%. Keywords: Mid-upper arm circumference, waist circumference, neck circumference, obesity, children 
The Difference Expressions of EBNA-1 in Epstein-Barr Virus Infection in Low and High Grade Colorectal Carcinoma Simatupang, Epistel Pangujian; Simadibrata, Marcellus; Gani, Rino Alvani; Budiani, Dyah Ratna
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/13120122-7

Abstract

Background: Colorectal carcinoma is a common malignancy with the highest mortality rate. Epstein- Barr virus (EBV) as the virus that most commonly infect humans, also can infect the body in a latent and induce the occurrence of malignancy. This study aimed to prove an association between EBV virus infection with degree of colorectal carcinoma by examining the main EBV oncogene expression, namely Epstein-Barr nuclear antigen-1 (EBNA-1), in low grade and high grade colorectal carcinoma. Method: Cross-sectional study was performed in 14 colorectal cancer patients in Moewardi Hospital, Surakarta between July 2011 and January 2012. The biopsy specimens were stained for EBNA-1 expression using immunohistochemical technique. Statistical analysis was performed using T-test and Mann-Whitney by SPSS software version 19.0 for windows. Results: Of the 14 patients, there were 7 patients with low grade colorectal carcinoma and 7 patients with high grade colorectal carcinoma. EBNA-1 expression was found in epithelium of low grade and high grade colorectal carcinoma with p = 0.01; CI = -5.24-0.88. We also assessed the expression of EBNA-1 on lymphocytes B of low grade colorectal carcinoma and high grade colorectal carcinoma with p = 0.043. Conclusion: Significant differences in the expression of EBNA-1 was found in association with EBV infection either in low grade and high grade colorectal carcinoma. The role of EBNA-1 as tumor initiator needs to be elucidated further. Keywords: carcinoma colorectal, Epstein-Barr virus, EBNA-1
Ekspresi Faktor Antiangiogenesis Thrombospondin-1 (TSP-1) dan Angiostatin Kanker Payudara Invasif Ambar Mudigdo; Dyah Ratna Budiani
Majalah Patologi Indonesia Vol 24 No 3 (2015): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Angiogenesis is one of the characteristics of malignant cancer cells. Angiogenesis activity considered as one of many determinants of prognosis of invasive breast cancer. The body has endogenous factors that act as antiangiogenesis, such as thrombospondin-1 (TSP1) and angiostatin. TSP1 is an antiangiogenesis factor that is dependent on wild-type p53. TSP-1 expression is induced by the transcription factor p53 WT. In some breast malignancies occurs mutations in the p53 gene, so TSP1 can not be expressed. The absence of TSP1 expected to bring a worse prognosis. Study of antiangiogenesis protein expression is expected to be used as an indicator of prognosis in breast cancer invasive ductal mammary carcinoma which divided into four sub-types: luminal A; luminal B; Her2 (over-expression) and triple negative/basal-like. This study is to analyzed TSP-1 and angiostatin of invasive breast cancer. Methods A total of 20 paraffin blocks of breast cancer tissue invasive ductal carcinoma from Pathology Anatomy RS Dr. Moewardi in 2013 were divided into four groups based on the expression status of estrogen receptors, progesterone receptors and Her2/neu as follows: luminal A subtype (ER+/PR+/Her2 negative); sub-type luminal B (ER-/PR and Her2 positive); Her2 over expression subtype (ER-/PR-/Her2 over-expression); and triple negative subtypes (basal-like tumors). Technique immunohistochemical ABC (avidin-biotin complex) used in special stains to measure the expression of TSP-1 and angiostatin, using monoclonal antibodies anti-human TSP-1 and anti-human angiostatin. Expression values are expressed in scale IDS, with a value range 0 to IDS 300. Analysis of the data used is difference test paired between groups (p
Pembentukan dan Pelatihan Kader Kesehatan Anak Berkebutuhan Khusus tentang Protokol Kesehatan Masa Pandemi COVID-19 Risya Cilmiaty A. R.; Ida Nurwati; Selfi Handayani; Muthmainah Muthmainah; Dyah Ratna Budiani; Betty Saptiwi; Sarsono Sarsono; Martini Martini; Danus Hermawan; Jarot Subandono
Abdimas Universal Vol. 4 No. 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v4i1.141

Abstract

The incidence of COVID-19 in Indonesia is significantly increasing. In Indonesia, there were 965.283 confirmed cases and 27.453 people died of covid as of January 22, 2021. Meanwhile, the 7.505 confirmed cases and 352 death were from Surakarta. In this pandemic situation, the community must protect itself from being infected by the virus. Prevention is done by implementating the 5M health protocol, which are wearing mask, social distancing, and hand washing. Those health protocols are also part of clean and healthy lifestyle (PHBS). Special needs children (ABK) are those who have different characteristics than any other common children. Special health consideration should be given for those special needs child, including PHBS because of the special needs they are having and probable difficulties into implementing PHBS. The consideration can be given by their teacher, caretaker, parents, or trained social health workers in the hope of special needs children become independent into implementing the PHBS. The aim of this program is implementating social service program and helping special needs children to become independent in implementating PHBS and health protocol. The program was held by lecturing, demonstration, simulation, and supervised practice. This program hopefully will prevent either health issues or prevent the spreading of infective disease, specifically in this pandemic situation.
The Relation between Level of Knowledge and Attitude towards Practice of Rabies Disease in Residents in the Area of Puskesmas Kuta II Ni Kadek Ayu Septiani Sarjana; Arsita Eka Prasetyawati; Dyah Ratna Budiani
Nexus Kedokteran Komunitas Vol 4, No 2 (2015): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Rabies is a disease of animals (usually vertebrate) which is zoonotic (transmissible to humans). Rabies occurs in 24 out of the 34 provinces of Indonesia. Rabies is caused by a virus in the Family: Rhabdivoridae, Genus: Lyssavirus. Control and vaccination strategies in dogs is deemed to be the most effective and economical method in preventing the incidences of rabies in humans. This study aims to determine whether there is a significant relationship between level of knowledge of and attitude practise employed for rabies in residents of the area covered by Puskesmas Kuta II. Methods: This is a cross-sectional study analysing observations in a sample of people. Sampling was carried out by simple random sampling of 96 residents in the area of Puskesmas Kuta II. In this study, the independent variables are knowledge of and attitudes towards rabies disease while the dependent variable is the practice for rabies. Data for these variables were collected via a questionnaire-based interview. Analyses were then carried out using the chi-square (x2) followed by multivariate analysis using multiple logistic regression, Results: This study showed that knowledge has a significant relationship with practice for rabies disease (p = 0.013; OR 4.240; 95% CI 1.352 up to 13.296). Attitude has a significant positive relationship with the value of practice for rabies disease (p = 0.015; OR 3.073; 95% CI 1.233 up to 7.627). The combined effect of knowledge and attitudes to practice for rabies were approximately 20.90% (Negerkerke R square = 0.209). Conclusions: There was a significant relationship between knowledge and attitudes to practice for rabies disease in residents in the area of Puskesmas Kuta II, the higher level of knowledge and improved attitudes will improve practice for rabies disease amongst residents in the area of Puskesmas Kuta II. Keywords: Rabies, Rabies Prevention, Knowledge, Attitude, Practice
Co-Authors Alindina Izzani Ambar Mudigdo Andreas Peter Sitorus Andreas Peter Sitorus Ari Natalia Probandari Aris Sudiyanto Arsita Eka Prasetyawati Atika Zahro Nirmala Betty Saptiwi Cempaka Irawati Cempaka Irawati Danus Hermawan Dwi Septiadi Badri Eko Dewi Ratna Utami Epistel Pangujian Simatupang Eriana Melinawati Farida Nurhayati Fikar Arsyad Hakim Hari Wahyu Nugroho Harsono Salimo Ida Ayu Sinthia Pradnya Swari Ida Nurwati Imam Prabowo Jarot Subandono Krisnawati Intan Suwignyo Made Setiamika Marcellus Simadibrata Marcellus Simadibrata Martini Martini Melani Ratih Mahanani Muhardjo M Muthmainah Muthmainah Ni Kadek Ayu Septiani Sarjana Rifai Hartanto Rino Alvani Gani Rino Alvani Gani Risya Cilmiaty A. R. Riza Novierta Pesik Riza Novierta Pesik S. Bambang Widjokongko Sarsono Sarsono Selfi Handayani Sintin Khotijah Pribadi Sunardo Budi Santoso