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Pengaruh Pemberian Klorofil Terhadap Kenaikan Kadar Hemoglobin pada Tikus Model Anemia Faisal Hafidh; Jarot Subandono; Sri Hartati Hadinoto
Nexus Biomedika Vol 3, No 2 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Chlorophyll has a chemical structure similar to hemoglobin, it's just different on the central ion. Anemia is a disease in which the blood contains less hemoglobin than normal. This study aims to prove that chlorophyll can increase levels of hemoglobin and to determine whether the increase in dose of chlorophyll may increase hemoglobin. Methods: This was an experimental laboratory study with pretest and posttest control group design. Samples were female white rats, 2 to 3 months old, weighing approximately 200 grams. Thirty five samples were taken by incidental sampling and divided randomly into 5 groups, each group consisted of 7 rats. The control group was administered distilled water, in contrast the treatment group I (KPI) and II (KPII), each was treated 0.6 mg and 1.2 mg of chlorophyll once a day, while treatment group III (KPIII) and IV (KPIV), each was treated 0.6 mg and 1.2 mg of chlorophyll twice a day, respectivelly. This treatment was done for 14 days. Before acclimatization, 3 ml of rats blood was drawn from retro orbital vein. One week later, the rats blood was taken again for pretest purposes. On the day 15th, rats blood was taken again in the same way for the purposes of the posttest. Data were analyzed by Friedman test and Post Hoc Multiple Comparison (Wilcoxon) (? = 0.05). Results: Hemoglobin levels ot rats significantly increased in the chlorophyll-treated groups than in the group of no treated one. Friedman test showed significant differences between the groups treated chlorophyll and the group no treated one with p = 0.000 (p <0.05). Wilcoxon test showed no significant difference between KPI-KPII, KPI-KPIII, KPI-KPIV, KPII-KPIII, KPII-KPIV, KPIII-KPIV the value of P> 0.05 (p <0.05). Conclusion: Chlorophyll increases hemoglobin levels significantly, but increasing the dose does not provide significantly increased hemoglobin. Keywords: chlorophyll, hemoglobin, anemia
Correlations between Emotional Intelligence with Achieved Cumulative Grade Point Average (GPA) of Undergraduate Students of Faculty of Medicine, Sebelas Maret University Risnu Ardian Witjaksana; Jarot Subandono; Bhisma Murti
Nexus Pendidikan Kedokteran dan Kesehatan Vol 5, No 1 (2016): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Introduction: Healthcare service could not be distinguished from medical education in Indonesia. Beside his academic capabilities, a doctor's behaviour towards his surroundings must also be taken into account. But in reality, there hasn't been a significant amount of emotional intelligence teaching included in the curriculum of Indonesian medical education. This study is conducted to define the Correlations between Emotional Intelligence with Achieved Cumulative Grade Point Average (GPA) of Undergraduate Students of Faculty of Medicine, Sebelas Maret University Surakarta. Method: This study was an analytic observational experiment with cross sectional approach. The sample had been taken from the population of undergraduate students of Faculty of Medicine, Sebelas Maret University, class of 2012. The sampling had been done using cluster random sampling technique. The obtained data had been statistically analyzed with simple linear regression technique, using Statistical Package for Social Sciences23 (SPSS 23) for Mac and p <0.05 was chosen as the minimal significance level. Result: The data analysis result with simple linear regression technique showed that there was no significant correlation between emotional intelligence and the achieved cumulative grade point average (GPA) in undergraduate students of Faculty of Medicine, Sebelas Maret University Surakarta. (p = 0.536 ; p>0.05). Conclusion: There was no significant correlation between emotional intelligence and the achieved cumulative grade point average (GPA) in undergraduate students of Faculty of Medicine, Sebelas Maret University Surakarta. Keywords: emotional intelligence, cumulative grade point average (GPA), undergraduate students of faculty of medicine.
Pengaruh Pemberian Ekstrak Daun Sambiloto Terhadap Kadar Kolesterol LDL Darah Tikus Putih (Rattus norvegicus) Yohana Trissya Anggraeni; Jarot Subandono; . Kustiwinarni
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Andrographis paniculata,Nes leaves contain flavonoids, beta-sitosterol, and andrographolide which can lower LDL cholesterol level of blood. The objective of this research was to determine the effect of Andrographis paniculata,Ness leaves extract against blood LDL cholesterol level of white rats (Rattus norvegicus). Methods: This study was a laboratory experimental research design, using posttest only controlled group design. Subjects of this research were white rats (Rattus norvegicus), strain Wistar, male, 3 months old, 200 grams weight. By incidental sampling technique, data were collected from 25 rats. Those rats were arranged into 5 groups, each group consisted of 5 rats. The normal control group (KKn) was administered distilled water, while the negative control group (KKn(-)) and the 1st (KP1), 2nd (KP2) and 3rd treatment group (KP3) were administered high cholesterol diet (6.25 g/kg BW/day of egg yolk). Besides that, the KP1, KP2 and KP3 were treated with 160 mg, 320 mg, and 640 mg per 200 g BW of Andrographis paniculata,Ness leaves extract, successively. This research was held for 28 days. Data of blood LDL cholesterol levels were collected 10-12 hours after the last treatment. Later, the data was analyzed by One-Way ANOVA test (? = 0.05) and Posthoc Multiple Comparisons (LSD) test (? = 0.05). Results: The one-way ANOVA test showed a significant difference among five groups p = 0.000 (p <0.05). Whereas, the LSD test showed significant differences between KKn-KKn(-), KKn-KP1, KKn-KP2, KKn-KP3, KKn(-)-KP1, KKn(-)-KP2, KKn(-)-KP3, (p < 0.05) and non-significant differences between KP1-KP2, KP1-KP3, and KP2-KP3 (p > 0.05). Conclusions Andrographis paniculata,Ness leaves extract significantly lowered blood LDL cholesterol levels of Rattus norvegicus but the increase of the dose did not enhance its function in lowering blood LDL cholesterol. Keywords: Andrographis paniculata Ness leaves extract, LDL cholesterol
Efek Hepatoprotektor Ekstrak Daun Dandang Gendis (Clinacanthus nutans) terhadap Kadar SGPT Tikus Putih (Rattus novergicus) yang Diinduksi Parasetamol Devi Purnamasari Sasongko; Jarot Subandono; Martini .
Nexus Kedokteran Translasional Vol 1, No 2 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Paracetamol was a safe drug, but would cause oxidative stress if taken too much.. Dandang gendis leaves contained a flavonoid antioxidant. This research intended to prove the antioxidant effect of dandang gendis leaves that could prevent liver cell damage of white rat induced by paracetamol. Methods: This research was an experimental laboratoric with post test only control group design. This research had taken place at Parasitology and Micology Faculty of Medicine Sebelas Maret University Surakarta. The sample was 32 Wistar white rats. The dependent variable was the SGPT level of white rats and the independent variable was the dandang gendis leaves extract. The white rats were divided into 4 groups: negative control group (KK0), positive control group (KK1), first threated group (KP1), and second threated group (KP2). KP1 had been given 30 mg/200 gr BB dose and KP2 had been given 60 mg/200 gr BB dose for 14 days. At 11th 13th days, the white rats from KK1, KP1, and KP2 had been given 291.6 mg/200 gr BB dose of paracetamol. At 14th day, rats blood had been taken from orbitalis sinus. The damage of the liver cell had been measured with SGPT laboratory test. The data had been analyzed with one way ANOVA test then with post hoc test (? = 0.05). Results: The highest rate of SGPT levels was KK1, following KP1, KP2, and the lowest was KK0. Oneway ANOVA test resuls showed a significant difference among the four groups with p = 0.000. Post hoc test results showed a significant difference between KK0 KK1 (p = 0.003) and KK0 KP2 (p = 0.019) whereas between KK0 KP1 (p = 0.204), KK1 KP1 (p = 0.885), KK1 KP2 (p = 0.077), and KP1 KP2 (p = 0.932) had no significant difference. Conclusion: Giving dandang gendis leaves extract was not significant to raise the SGPT level of white rat induced by paracetamol. Raising dandang gendis leaves extract doses was not significant to raise its hepatoprotector effect. Keywords: dandang gendis leaf, SGPT, white rat, hepatoprotector, paracetamol
Pembentukan dan Pelatihan Kader Kesehatan Anak Berkebutuhan Khusus tentang Protokol Kesehatan Masa Pandemi COVID-19 Risya Cilmiaty A. R.; Ida Nurwati; Selfi Handayani; Muthmainah Muthmainah; Dyah Ratna Budiani; Betty Saptiwi; Sarsono Sarsono; Martini Martini; Danus Hermawan; Jarot Subandono
Abdimas Universal Vol. 4 No. 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v4i1.141

Abstract

The incidence of COVID-19 in Indonesia is significantly increasing. In Indonesia, there were 965.283 confirmed cases and 27.453 people died of covid as of January 22, 2021. Meanwhile, the 7.505 confirmed cases and 352 death were from Surakarta. In this pandemic situation, the community must protect itself from being infected by the virus. Prevention is done by implementating the 5M health protocol, which are wearing mask, social distancing, and hand washing. Those health protocols are also part of clean and healthy lifestyle (PHBS). Special needs children (ABK) are those who have different characteristics than any other common children. Special health consideration should be given for those special needs child, including PHBS because of the special needs they are having and probable difficulties into implementing PHBS. The consideration can be given by their teacher, caretaker, parents, or trained social health workers in the hope of special needs children become independent into implementing the PHBS. The aim of this program is implementating social service program and helping special needs children to become independent in implementating PHBS and health protocol. The program was held by lecturing, demonstration, simulation, and supervised practice. This program hopefully will prevent either health issues or prevent the spreading of infective disease, specifically in this pandemic situation.
Hubungan Antara Hiperglikemi dengan Kejadian Infark Serebri pada Pemeriksaan Multi Slice CT-scan Kepala Tanpa Kontras di RSUD Dr. Moewardi Siska Dewi Agustina; . Widiastuti; Jarot Subandono
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: In recent year, numerous studies reported that stress hyperglycemia has been shown to be a risk factor for neurocardiovascular disease, with high risk of dying from coronary disease such as stroke. Stroke is the third leading cause of death in the world, with a high prevalence of death in low-and middle-income countries. Hyperglycemia has been associated with increased cerebral lactate resulting in local brain tissue acidosis. It worsens mitochondrial function in the penumbra, the moderately ischemic tissue of the brain. CT-scans are considered sufficiently sensitive for detecting mass lesions, such as a brain mass or abscess, as well as detecting acute hemorrhage. The aim of this study is to determine the relationship between hyperglycemia with cerebral infarction in non contrast multi slice head CT-scan. Methods: This was an observational cross sectional study. A total of 70 subjects were selected by fixed disease sampling, they were patients who have been perfomed non contrast multi slice head CT-scan in Dr. Moewardi Hospital. Data were collected from the report result of non contrast multi slice head CT-scan and the result of glucose blood level on patiensmedical record.Data analysis used chi square models and were processed with Statistical Product and Service Solutions (SPSS) 17.00 for Windows. Results: This study showed a positive association and statistically significant between hyperglycemia with cerebral infarction (?2 = 8,123; p<0.05) with moderate correlation strength. The result of OR (Odds Ratio) for cerebral infarction is 4,667 (CI 95% = 1,557 13.983). Confounding factor, e.g blood pressure and age have been controlled. Conclusions: There is a significance association between hyperglycemia with cerebral infarction in multi slice head CT-scan noncontrast at Dr Moewardi Hospital . Keywords: Hyperglycemia, cerebral infarction, head CT-scan without contrast
Efek Perlindungan Susu Kedelai (Glycine max) Ultra High Temperature (UHT) Terhadap Lambung Mencit Ginong Pratidina Wijnaputri; Endang Listyaningsih; Jarot Subandono
Nexus Biomedika Vol 1, No 2 (2012): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: White Soybean (Glycine max) Milk Ultra High Temperature (UHT) is potential to protect gaster because it contains flavonoid. This study aimed to investigate the protective effect of white soybean milk UHT on mices gaster due to aspirin. Higher dose of the milk reduces the damaged on gastric mucous induced by aspirin Methods: This was a labroratory experimental research with posttest only controlled group design conducted in in Histology Laboratory of Sebelas Maret University. The samples were thirty five mice divided into 5 groups. Negative control group (KN) was given normal food and aquadest, positive control group (KP) was given aspirin dose 2,275 mg/20g Body weight (W), dan first treatment group (P1) was given cimetidine dose 0,78 mg/20g W second treatment group (P2) and third treatment group (P3) was given soybean milk UHT dose 0,7ml/20 g W and 1,4 ml/20 g W. All treatments for KN, KP, P1 , P2, P3 was given in 10 days. Aspirin was given to KP, P1 , P2, P3 with dose 2,275 mg/20g weight of mice on day 8, 9 and 10. to evaluate the level of damage based on histologic appearance, gastric staining was performed using Haem eos. Results: Kruskal-Wallis test result showed significant result among four groups. Mann-Whitney showed significant result for KN compared to KP,P1,P2 , P3 and KP compared to P1, P2 and P3 ; while P1 compared to P2, P3 and P2 compared to P3 had no significant result. Conclusion: White Soybean (Glycine max) Milk Ultra High Temperature(UHT) protect mices gastric from gastritis. However, higher dose of White Soybean (Glycine max) Milk Ultra High Temperature(UHT) does not increase the protective effect of white soybean milk UHT on mices gaster due to aspirin. Keywords: White Soybean (Glycine max) Milk Ultra High Temperature(UHT), gastric protection, gastritis, aspirin.
Gambaran Surveilans Campak di Puskesmas Tawangmangu Kabupaten Karanganyar Aiman Hilmi Asaduddin; Azhar Citra Lukito; Benedictus .; Bima Wahyu Wijaya; Shafira Yasmine Anshari; Supardi .; Jarot Subandono; Ita Kusumawati
Nexus Kedokteran Komunitas Vol 7, No 2 (2018): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Pendahuluan: Campak merupakan salah satu penyakit yang dapat dicegah dengan imunisasi (PD3I). Angka insiden campak yang tinggi hingga dikategorikan Kejadian Luar Biasa (KLB) menjadi masalah kesehatan di Kecamatan Tawangmangu karena warga yang menolak pemberian vaksin. Artikel ilmiah ini dibuat untuk mengetahui seberapa besar pengaruh pemberian vaksin di Kecamatan Tawangmangu terhadap munculnya penyakit dari golongan PD3I terutama campak.Metode: Artikel ilmiah ini dilakukan menggunakan metode kuantitatif deskriptif berupa survey dengan surveilans aktif mewawancarai petugas puskesmas dan surveilans pasif berupa pengumpulan data. Analisis data dilakukan dengan metode one way ANOVA mengggunakan aplikasi SPSS. Hasil: Hasil kegiatan surveilans didapatkan data mengenai kasus campak, cakupan imunisasi, ketersediaan logistik dan status gizi di Kecamatan Tawangmangu. Kasus campak yang terdeteksi pada studi surveilans adalah 8 kasus dari 15 suspek. Pada cakupan imunisasi, terdapat 3 desa yang dikategorikan dalam daerah Non Universal Child Immunization (NON UCI). Ketersidaan logistic vaksin masih dalam kategori cukup. Berdasarkan hasil analisis data tes one way ANOVA, dapat diketahui bahwa pengaruh kurang gizi terhadap campak dan hasil uji statistik tersebut, didapatkan hasil bahwa antara gizi kurang dan imunisasi MR tidak memiliki hubungan yang signifikan dengan munculnya campak (P>0.5).Kesimpulan: Surveilans campak di Kecamatan Tawangmangu memiliki angka insidensi yang tinggi pada tahun 2013 dan tidak berlanjut pada tahun 2014 hingga 2019. Cakupan imunisasi dan ketersediaan logistik berpengaruh terhadap risiko penyakit campak sehingga perlu dilakukan kontrol berkelanjutan, sedangkan status gizi tidak memiliki pengaruh terhadap angka kejadian penyakit campak.Kata Kunci: Surveillance, Measles, Tawangmangu
Hubungan Hiperglikemia Dengan Kejadian Stroke Hemoragik Pada Pemeriksaan Multislice CT-Scan Kepala Tanpa Kontras Di RSUD DR. Moewardi Surakarta Fernando Feliz Christyan; . Widiastuti; Jarot Subandono
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Stroke is the third most common cause of death in the world, with a high prevalence of death in low-and middle-income countries. Hyperglycemia has been associated with atherosclerotic lession resulting in cerebral aneurysm which can lead to hemorrhagic stroke. CT-Scan is considered sufficiently sensitive for detecting acute hemorrhage, as well as detecting mass lessions. The aim of this study was to determine the correlation between hyperglycemia and hemorrhagic stroke incident on noncontrast multislice CT-Scan of the head examination. Methods: This study was an observational study with the analytical approach to the subject of cross-sectional study. 70 subjects were selected by fixed- disease sampling methods. These subjects have been performed a noncontrast multislice CT-Scan of the head examination. Data was collected by reading the result of blood glucose level and CT-Scan of the head examination on patients medical record. Data were processed with Statistical Product and Service Solution (SPSS) 17.00 for Windows Results: Chi-Square models showed that X2 = 7,19 with 5% significancy. OR (Odds Ratio) in hemorrhagic stroke was 4,26 (CI 95% = 1,43-12,74). Patient with hyperglycemia increases the risk of getting hemorrhagic stroke 4,26 (4) times than patient without hyperglycemia. Conclusion: There is a correlation between hyperglycemia and hemorrhagic stroke incident. Keywords: hyperglycemia, hemorrhagic stroke, noncontrast head CT-Scan