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All Journal Dentika Dental Journal Journal of Mathematical and Fundamental Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kesehatan Gigi UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science AloHA International Journal of Health Advancement (AIJHA)
I Dewa Ayu Ratna Dewanti
Department Of Biomedical Science, Faculty Of Dentistry, Jember University, Jl. Kalimantan 37, Jember 68121
Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Journal : AloHA International Journal of Health Advancement (AIJHA)

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TNFα and IL-10 Expression in Dental Pulp after Administration of Gouramy Bone Paste (Osphronemus gouramy) and Calcium Hidroxide Sunana Ageng Hikmawati; Dheamira Rosida; I Dewa Ayu Ratna Dewanti; Erawati Wulandari
Aloha International Journal of Health Advancement (AIJHA) Vol 3, No 6 (2020): June
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha30602

Abstract

Mechanical trauma causes pulp exposure and make the invasion of pathogenic microorganisms into the dental tissue. This condition causes pulp inflammation characterized by the release of pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) and anti-inflammatory cytokine interleukin-10 (IL-10). Gouramy bone paste (Osphronemus gouramy) contains amino acids, omega-3, omega-6, and flavonoids which is thought to accelerate healing of inflamed pulp tissue that triggers decreased TNF-α expression and increased IL-10 expression. This study aims to analyze the expression of TNF-α and IL-10 in dental pulp after administration of Gouramy bone paste (Osphronemus gouramy) and calcium hydroxide. The sample size consisted of 24 Rattus novergicus which were divided into 3 groups i.e (K1) without the application of direct pulp capping material, (K2) with the application of calcium hydroxide, and (K3) with the application of gouramy bone paste. Data measured are the number of inflammatory cells (neutrophils, macrophages, and lymphocytes) that express TNF-α and IL-10 on the 4th and 7th days histologically by immunohistochemical methods. Statistical test results showed that administration of gouramy bone paste in dental pulp decreased TNF-α expression and increased IL-10 expression more than those without gouramy bone paste with a significant difference (p
Co-Authors Depi Praharani Dheamira Rosida Dyah Setyorini Erawati Wulandari Farah Rachmah Aulia Wardani Fiona Budi Amarta Domini Hestieyonini Hadnyanawati I Dewa Ayu Susilawat I Dewa Ayu Susilawati Melok Aris Wahyukundari Nadie Fatimatuzzahro Narita Ajeng Loviana Nuzulul Hikmah P. Purwanto Pudji Astuti Pujiana Endah Pujiana Endah Lestari Purwanto Purwanto , Ristya Widi Endah Lestari Ristya Widi Endah Yani Roedy Budirahardjo Sri Lestari Sunana Ageng Hikmawati Sunlip Wibisono