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All Journal Jurnal Kedokteran Syiah Kuala Kesmas: Jurnal Kesehatan Masyarakat Nasional Folia Medica Indonesiana Health Notions JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) Jurnal Gizi Klinik Indonesia AL-ATHFAL : JURNAL PENDIDIKAN ANAK MATAPPA: Jurnal Pengabdian Kepada Masyarakat Journal of Maternal and Child Health Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Jurnal Karinov Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL KESANS : International Journal of Health and Science
Linda Dewanti
Departemen IKM-KP, Fakultas Kedokteran Universitas Airlangga, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Majalah Biomorfologi (Biomorphology Journal)

 1 
EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION Audi Salman Faza; Linda Dewanti; Ema Qurnianingsih
Majalah Biomorfologi Vol. 30 No. 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.038 KB) | DOI: 10.20473/mbiom.v30i1.2020.7-13

Abstract

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Materials and Methods: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p<0.050. Results: The results showed that body weight was significantly different on the 6th week between Control vs Group 1 (p=0.010) and Control vs Group 3 (p=0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p=0.019 and 0.011 respectively). Conclusion: Both of low dose (150 mg/kg BW) and high dose (300mg/kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.
Co-Authors Abu Rizal Dwikatmono Johan Ahmad Cholifa Fahruddin Ahmad Cholifa Fahruddin Alda Dini Wijayanti Alfi Syifa Darmastuti Anandia Nafisah Putri Anang Endaryanto Andriati Andriati Anisa Ayu Maharani Anjelina Kristina Mogi Ariikah Dyah Lamara Arya Ivan Mahendra Arya Ivan Mahendra Arya Wiradewa Asra Al Fauzi Atika Anggarsari Audi Salman Faza Auliai Khoirunnisa Ayu Liana Gunawan Azwin Mengindra Putera Bagus Setyo Boedi Barizatul Husniyah Benny Iswanto Pantoro Berli Arfani Rantam Birgitta Vania Rarasati Bisyamsi Nawaijaya Moediarso Bonfilio Neltio Ariobimo Branandito Putra Chabib Fachry Albab Cincin Hari Purwati Dessy Putri Pratiwi Dessy Putri Pratiwi Dharmadjati, Budi Baktijasa Dian Neni Naelasari Djohar Nuswantoro Djohar Nuswantoro Dominicus Husada Dominicus Husada Dwi Retno Wulandari Eddy Bagus Wasito Eko Budi Koendhori, Eko Budi Ema Qurnianingsih Emilia Eka Arrianti erma nurlita sari Ernawati Ernawati Estya Nadya Meitavany Farah Mujtaba Fardana, Nur Ainy Fitri Nurina Septiana Gusti Agung Ayu Ira Kencana Dewi H. M. S. Wiyadi Heru, Rayhan Alma Shafannisa Imran H Kamal K Kuntaman Kasiati Kasiati Koyuki Atifa Rahmi Laksmi Wulandari Lilik Djuari Lilik Djuari Lukman Hakim Lupita Ghilang Laraz Maria Marind Desrianti Hutauruk Masyithoh Wahyu Diani Mohammad Fata Fatihuddin Monica Tiara Arum Kinanthi Muhammad Ardian Cahya Laksana Nabila Ilma Nisa Rukmana Ni Ketut Maya Purvitagiri Nida&#039;an Khafiya Nining Febriana Niswah Silmi Fatimah Nur Anisah Rahmawati Pandu Satriya Adi Perthdyatama Syifaq Budiono Prafidina Qualisa Prasticha, Anggraini Dian Pratiwi, Dessy Putri Prima Ardiansah Surya Puguh Oktavian Putri Nudy Purwanto Qonita Hanifah Rayanti Sagala Reka Elvia Dirda Prasasta Rio Wironegoro Rize Budi Amalia Romdhoni, Achmad Chusnu Rosantia Sarassari Sacharissa Zerlina Tsarwah Thirafi Sampurna, Mahendra Tri Arif Shuviatul Chasanah Silvia Salsabilah Sitisalma Amirah Dzakiyyah Sri Utami Sulis Bayusentono Sulistiawati Sulistiawati Sulistiawati Sulistiawati Sulistiawati Sulistiawati Theophilus Tan Zhu En Triadi Putra Paladan Triana Novitasari Ulinnuha Qurrota A'yunin Wahyul Anis Wardhani, Indrayuni Lukitra Widati Fatmaningrum Wildan Anugrah Erlangga Wiwin Retnowati Yolanda Ayu Yashinta Zaufy Verlieza Oktaviano Subagyo