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Roedi Irawan
Child Health Department, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Paediatrica Indonesiana

 1 
Vitamin D, insulin-like growth factor-1, and stunting in children with transfusion-dependent thalassemia I Gusti Ayu Putu Eka Pratiwi; Roedi Irawan; I Dewa Gede Ugrasena; Muhammad Faizi
Paediatrica Indonesiana Vol 62 No 2 (2022): March 2022
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi62.2.2022.98-103

Abstract

Background Transfusion-dependent thalassemia (TDT) has a major impact on a child's growth and is associated with stunting, risk of vitamin D deficiency, and decreased insulin-like growth factor-1 (IGF-1). To date, the relationship between vitamin D levels and stunting in TDT remains unclear. Futhermore, the role of vitamin D and IGF-1 in mediating stunting in TDT patients is still unknown. Objective To investigate the relationship between stunting and vitamin D as well as IGF-1 levels in children with TDT. Methods This cross-sectional study involved 50 TDT children aged 5 to 18 years, included consecutively from the Pediatric Hemato-oncology Outpatient Clinic, Dr. Soetomo Hospital, Surabaya, East Java. Subjects were divided into two groups: stunted (S) and not stunted (NS). Vitamin D and IGF-1 were evaluated by antibody competitive immunoassay and sandwich-enzyme-linked immunosorbent assay (ELISA), respectively. Age, sex, and duration of repeated transfusion were analyzed as confounding factors. Results Median IGF-1 levels were 91.43 (13.67-192.86) ng/mL and 161.53 (17.99-363.01) ng/mL in the S and NS groups, respectively (P=0.011). Mean vitamin D levels were 20 (+ 5.71) ng/mL and 20.46 (5.25) ng/mL in the S and NS groups, respectively (P=0.765). The correlation coefficient (r) of vitamin D and IGF-I levels was not significant. Multivariate analysis showed that low IGF-1 levels, male, and longer duration of repeated transfusions were associated with stunting in children with TDT. Conclusion Low IGF-1 level is associated with stunting in children with TDT. Vitamin D is not significantly associated with either stunting or IGF-1 in children with TDT.
Co-Authors Alexander Leonard Caesar Josediputra Alifah Fajriyyatul Izzah Ana Qonitatillah Ayuning Tetirah Ramadhani Boerhan Hidajat Boerhan Hidayat Boerhan Hidayat Budi Prasety Chasan Ismail Christine Florens Christine Florens Darto Saharso Dina Angelika Dwi Lestari Avianti Eddy Bagus Wasito Esthy Poespitaningtyas Frieska Piesesha Hanindita, Meta Herdiana Hanindita, Meta Herdiana Hardiani, Kartika Hardiyani, Kartika Hartojo Hartojo Hidayatunnikmah, Nina I Dewa Gede Ugrasena I Gusti Ayu Putu Eka Pratiwi Indri Safitri Mukono Jusak Nugraha Kartika Hardiyani Khadijah Rizky Sumitro Khadijah Rizky Sumitro Mahrus A. Rahman Masayu Ramadhani Polanunu Meity Ardiana Melvanda Gisela Putri Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Miriawati Miriawati Muhammad Faizi Nanda Hudawarrahmah Ninik Asmaningsih Soemyarso Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja, Nur Aisiyah Nur Aisiyah Widjaya Nur Aisiyah Wijaya Nur Aisyah Widjaja Nur Aisyah Widjaja Piesesha, Frieska Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rina Elizabeth Risa Etika, Risa Rizky Arisanti Maharani Siti Nurul Hidayati Siti Nurul Hidayati Taufiq Hidayat Widati Fatmaningrum Widati Fatmaningrum Widjaja, Nur Aisyah Wigati, Kristanti Wanito Windhu Purnomo Windhu Purnomo