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Roedi Irawan
Child Health Department, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Indian Journal of Forensic Medicine

 1 
Comparison of the Serum Concentrations of Micronutrients Zinc and Iron in Epileptic Children before and after Administration of Valproic ACID Ratih Dwi Andini1 , Darto Saharso2 , Roedi Irawan2 , Prastiya Indra Gunawan2
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13421

Abstract

Introduction: The mortality rate of epileptic patients has increased despite advances in the treatment ofepilepsy. Several studies have indicated that changes of micronutrient homeostasis led to seizures. Theanticonvulsant valproic acid affects the intracellular concentration of micronutrients.Objective: To compare the serum concentrations of micronutrients zinc and iron in paediatric patients withepilepsy before and after administration of valproic acid.Method: A prospective cohort design study was conducted in children with epilepsy from July to December2019 in the outpatient department of paediatric neurology, Dr. Soetomo Regional Public Hospital, Surabaya,Indonesia. Serum concentrations of micronutrients zinc and iron were measured using the colorimetricmethod. Statistical analysis used paired t-test with p<0.05 being considered significant.Results: The study sample comprised 20 children with epilepsy. There were 13 (65%) males. Eight (40%)children were in the 1-5 year age group. Seizure type was generalised in 18 (90%) patients. The mean serumiron concentrations before and after valproic acid treatment were 23.9±16.8 µmol/L and 25.8±16.4 µmol/Lrespectively (p=0.700). The mean serum zinc concentrations before and after valproic acid treatment were13±16.8 µmol/L and 26.8±15.4 µmol/L respectively (p=0.004).Conclusions: There was a statistically significant increase in the mean serum zinc concentration aftervalproic acid treatment in children with epilepsy. There was however no statistically significant increase inthe mean serum iron concentration after valproic acid treatment in children with epilepsy.
The Association of Adiponectin Serum Level and Body Mass Index among Javanese Obese Adolescents Christine Florens; Nur Aisiyah Widjaja; Roedi Irawan; Meta Herdiana Hanindita
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16831

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Association of Adipoq +45 T>G Gene Polymorphism with Insulin Resistance and Icam-1 Value in Obese Adolescents Alexander Leonard Caesar Josediputra; Nur Aisiyah Widjaja; Roedi Irawan
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17444

Abstract

Alteration of Iron, Zinc, Vitamin A Breast Milk Levels During Lactation Period Among Mothers of Low Birth Weight Infant Born at Preterm and Term Rizky Arisanti Maharani; Roedi Irawan; Risa Etika
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17625

Abstract

Background: Duration of lactation and preterm delivery were noticed as dominant factors affecting breast milk composition, including its micronutrient particularly iron, zinc and vitamin A. This study was to analyze the alteration of iron, zinc, vitamin A levels within colostrum and mature breast milk among mothers of low birth weight (LBW) preterm and term infants.Methods: This cross-sectional study was conducted between July 2019 and April 2020 among mothers of LBW infant delivered at preterm and term at Dr. Soetomo hospital. Seventeen samples of breast milk were enrolled on each group. Respectively, colostrum and mature milk were collected between day 2 and 4, between day 15 and 20 after delivery.Results: The iron levels on both groups did not change significantly during lactation period (respectively p=0,266 and p=0,845). Zinc levels were found significantly higher in colostrum of both groups, as well as vitamin A levels within colostrum in LBW preterm group (p<0,05).Conclusions: Higher levels were found in zinc within colostrum of both groups, similar to vitamin A in LBW preterm group. In contrast, iron did not differ significantly during lactation period.
Co-Authors Alexander Leonard Caesar Josediputra Alifah Fajriyyatul Izzah Ana Qonitatillah Ayuning Tetirah Ramadhani Boerhan Hidajat Boerhan Hidayat Boerhan Hidayat Budi Prasety Chasan Ismail Christine Florens Christine Florens Darto Saharso Dina Angelika Dwi Lestari Avianti Eddy Bagus Wasito Esthy Poespitaningtyas Frieska Piesesha Hanindita, Meta Herdiana Hanindita, Meta Herdiana Hardiani, Kartika Hardiyani, Kartika Hartojo Hartojo Hidayatunnikmah, Nina I Dewa Gede Ugrasena I Gusti Ayu Putu Eka Pratiwi Indri Safitri Mukono Jusak Nugraha Kartika Hardiyani Khadijah Rizky Sumitro Khadijah Rizky Sumitro Mahrus A. Rahman Masayu Ramadhani Polanunu Meity Ardiana Melvanda Gisela Putri Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Meta Herdiana Hanindita Miriawati Miriawati Muhammad Faizi Nanda Hudawarrahmah Ninik Asmaningsih Soemyarso Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja Nur Aisiyah Widjaja, Nur Aisiyah Nur Aisiyah Widjaya Nur Aisiyah Wijaya Nur Aisyah Widjaja Nur Aisyah Widjaja Piesesha, Frieska Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Rina Elizabeth Risa Etika, Risa Rizky Arisanti Maharani Siti Nurul Hidayati Siti Nurul Hidayati Taufiq Hidayat Widati Fatmaningrum Widati Fatmaningrum Widjaja, Nur Aisyah Wigati, Kristanti Wanito Windhu Purnomo Windhu Purnomo