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All Journal Pharmacon Jurnal Litbang Provinsi Jawa Tengah Abdi Geomedisains Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Farmasi Klinik dan Sains Usadha Journal of Pharmacy
Maryati Maryati
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PEMANFAATAN UMBI ILES-ILES SEBAGAI BAHAN BAKU BIOETANOL UNTUK BAHAN BAKAR ALTERNATIF DI PEDESAAN Kusmiyati Kusmiyati; Maryati Maryati; Farida Nurcahyani; Ichsanudin Febrianto
JURNAL LITBANG PROVINSI JAWA TENGAH Vol 12 No 1 (2014): Jurnal Litbang Provinsi Jawa Tengah
Publisher : Badan Perencanaan Pembangunan, Penelitian dan Pengembangan Daerah Provinsi Jawa Tengah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36762/jurnaljateng.v12i1.314

Abstract

Bioethanol has attracted considerable attention as alternative fuel during the past decades. The main problem to the commercialization of bioethanol is the cost of raw material. Use an inexpensive raw material such as starchy material (Iles-Iles or Amorphophallus muelleri B.) is an attractive lower the cost of bioethanol. In this work, bioethanol was produced from iles-iles starch using four steps processes: hydrolysis by using enzym α–amylase and enzym glucoamylase, fermentation using yeast Saccharomyces cereviceae, distillation and adsorption using CaO. The initial iles-iles starch concentration used in this experiment was 25% and 40% w/v (g starch/l solution). For both of starch concentrations were hydrolyzed by sequence liquefaction and saccharification. For liquefaction, this carried out at 95-97°C, pH 6, 1% enzym α–amylase for 45 minutes. For saccharification, this treatment was carried out for 24 hours at 58-60°C by the used of enzym glucoamylase solution in various concentration (1%; 1.5%; 2%; 2.5% v/v) at a constant pH (5), and the used of constant glucoamylase solution (2% v/v) at various pH (4; 4.5; 5; 5.5). After hydrolysis, enzymatic fermentation was carried out for 76 hours at 30°C by the used of various concentration of yeast Saccharomyces cereviceae (0.6%; 0.8%; 1%; 1.2% w/v) at constant pH (4) and by the used of various pH (4; 4.5; 5; 5.5) at constant yeast Saccharomyces cereviceae concentration (1% w/v). After fermentation, bioethanol (95%) was obtained by two steps distillation. After distillation, adsorption process using CaO was carried out to obtain the highest bioethanol purity (99%). Enzymatic hydrolysis yielded glucose, based on the result the increasing of enzym glucoamylase increase the glucose yield. The result showed the decreasing pH increase the glucose yield. The highest amount of glucose (3.1% w/v) was obtained under conditions : 25% (w/v) iles-iles starch concentration, 2% (v/v) enzym glucoamylase, pH 4, 24 hours. A higher sugar concentration and, consequently, a higher final bioethanol concentration can be obtained by increasing the iles-iles starch concentration. Hydrolyzed starch was fermented by Saccharomyces cereviceae and yielded 7.8% (g ethanol/Kg iles-iles). The result of the research indicated that to produce 1 liter bioethanol 99% needs 9,4 kg Iles-iles tubers.
Pengaruh Penyuluhan Terhadap Pengetahuan Demam Berdarah Warga Desa Potronayan, Nogosari, Boyolali Hidayah Karuniawati; Maryati Maryati; Gunawan Setiyadi; Suprapto Suprapto; Andika Permana; Septi Fatmawati; Ashari Wahyu Budi Aji; Hevi Mifta Kumalasari; Yunika Isnanda Pratiwi; Sakinatul Hayati
Abdi Geomedisains Vol. 1, No. 1, July 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.488 KB) | DOI: 10.23917/abdigeomedisains.v1i1.96

Abstract

Secara Nasional, kasus Demam Berdarah Dengue terus meningkat dikalangan masyarakat. Kasus terbanyak ada di wilayah Jawa Timur, Jawa Tengah, Nusa Tenggara Timur, dan Kupang. Pengetahuan masyarakat mengenai demam berdarah terutama cara pencegahan dan pengobatan belum sepenuhnya mengerti sehingga diperlukan pengabdian untuk membantu masyarakat dalam mencegah dan memberantas kasus demam berdarah dengan memberikan sosialisasi penyuluhan. Kegiatan penyuluhan yang dilakukan adalah dengan memberikan materi kesehatan berupa upaya pencegahan, menjaga kebersihan lingkungan dan penanganan pertama yang dilakukan jika terkena Demam berdarah. Kegiatan pengabdian masyarakat diikuti 43 peserta. Sebelum dan sesudah pemberian materi tentang demam berdarah, peserta diberi soal sebagai pretest dan post-test. Hasil analisis statistik menunjukkan adanya pengaruh peningkatan pengetahuan yang signifikan sebelum dan setelah penyuluhan dengan nilai P 0,005.
Aktivitas Sitotoksik Ekstrak Heksan, Ekstrak Etil Asetat, Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L ) Terhadap Sel T47D Maryati Maryati; Ahmad Novian Nur Anas; Muhammad Nur Khairudin
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10761

Abstract

Noni fruit (Morinda citrifolia L) is one of the natural ingredients commonly used as traditional medicine to overcome various diseases, such as cancer. Noni fruit contains anthraquinone and coumarin which have anticancer effects. This study aims to determine the cytotoxic effects of n-hexane, ethyl acetate and ethanol extract of noni fruit and to determine the presence of anthraquinone and coumarin in the extract. Extraction was carried out by maceration method using n-hexane, followed by ethyl acetate and ethanol. The cytotoxic activity on T47D cells was carried out by the MTT method. The presence of anthraquinone and coumarin was identified using thin layer chromatography (TLC). Results showed that n-hexane extract had moderate cytotoxic effect on T47D cells with IC50 value of 582.13 ± 61.64 µg/mL, while the ethanol and ethyl acetate extract did not have cytotoxic effect on T47D cells. TLC results indicated that n-hexane extract of noni fruit contains anthraquinone and coumarin.
Aktivitas Sitotoksik dan Antiproliferasi Fraksi n-Heksan Biji Al-pukat (Percea americana Mill.) Terhadap sel T47D Juwita Rahmawati; Maryati Maryati
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.14271

Abstract

Avocado plants are widely used as traditional medicine in Indonesia. This research aimed to determine the cytotoxic and antiproliferation activity of avocado seed extract and fractions on the T47D breast cancer cell line. Extraction was done by maceration method using 96% ethanol, then fractionation was done by liquid-liquid partition using n-hexane, chloroform, and ethyl acetate. Cytotoxic and antiproliferation tests were done by the MTT method. Apoptosis activity was investigated by the double staining method, using acridine orange-propidium iodide as a staining reagent. Results showed that the n-hexane fraction of avocado seed had a cytotoxic activity with IC50 27.9 µg/mL. N-hexane fraction of avocado seed inhibited proliferation and induced apoptosis of T47D cell line.
Cytotoxic and Antiproliferation Activity of n-Hexane Fraction of Avocado seed (Persea americana Mill.) on MCF7 cell Juwita Rahwawati; Maryati Maryati; Ratna Yuliani
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18274

Abstract

Avocado seeds, which often end up as food waste, have many health benefits, including anticancer activity. This study aimed to determine the potential cytotoxic activity of avocado seeds against breast cancer cells, MCF7. Avocado seeds were macerated with 96% ethanol and fractionated with n-hexane, chloroform, and ethyl acetate as solvents. Cytotoxic activity of the extract and fractions was tested using the MTT method, while antiproliferation activity and apoptosis of the n-hexane fraction were tested using the doubling time and double staining methods, respectively. The selectivity of the n-hexane fraction was also determined. The results showed that the extract and n-hexane fraction of avocado seeds had cytotoxic activity on MCF7 with IC50 values of 211.2±25 and 47.87±1.5 µg/mL, respectively. The cytotoxic activity of the n-hexane fraction was selective (Selectivity Index = 4.73). The fraction can extend the doubling time to 76.54-77.41 hours. The double staining test results showed red fluorescence in the cells, indicating the apoptosis of MCF7 cells. The n-hexane fraction of avocado seed extract has the potential to be developed as an anticancer therapeutic agent. 
Anti-inflammatory Effect of Ethyl Acetate Fraction of Ethanol Extract of Guazuma ulmifolia Lamk E Emsutrisna; Sri Wahyuni; Tanti Azizah Sujono; M Maryati
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of this research is to investigate the anti-inflammatory effect of ethyl acetate fraction of ethanol extract of Guazuma ulmifolia Lamk. The research used pre and post test with control group design. A number 25 white rats wistar strain were devided into 5 groups. Group 1 was treated by Diclofenac sodium at dose of 50mg/kgbw; group 2 was treated by Aqueous 2 mL/rats; group 3, 4 and 5 were treated by ethyl acetate fraction of ethanol extract of Guazuma ulmifolia Lamk. (EAGU) at dosage of 250; 500 and 1000 mg/kgbw respectively. After treated, volume of rats’s right paw was measured by plethysmometer for 330minutes. The compound of ethyl acetate fraction of ethanol extract of Guazuma ulmifolia Lamk was analyzed by phytochemicals analysis. The EAGU at dosage of 1000 mg/kgbw can reduce edema volume at minutes 60 and minutes 90 significantly (by anova P. <0.05). The phytochemical compounds of EAGU are alkaloid, flavonoid, tannin, saponin and triterpen.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN PUCUK MERAH (Syzygium myrtifolium) DAN PENETAPAN KADAR FENOL TOTAL Alifiyah Sugihartini; Maryati Maryati
Usadha Journal of Pharmacy Vol. 1 No. 3 (2022): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v1i3.77

Abstract

Tanaman pucuk merah (Syzygium myrtifolium Walp.) merupakan familia Myrtaceae yang banyak dimanfaatkan masyarakat sebagai tanaman hias. Uji fitokimia daun berwarna merah Syzygium myrtifolium pada penelitian Haryati et al. (2015) menunjukkan adanya kandungan fenolik, flavonoid, alkaloid, triterpenoid, steroid, dan saponin. Beberapa senyawa tersebut mengindikasikan adanya aktivitas antioksidan, sehingga perlu dilakukan uji antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan kadar fenol total ekstrak etanol daun merah pucuk merah. Uji aktivitas antioksidan dilakukan dengan metode DPPH (2,2-difenil-1-pikrilhidrazil), sedangkan penetapan kadar fenol total dilakukan dengan metode folin-ciocalteu. Hasil penelitian menunjukkan bahwa ekstrak etanol daun merah pucuk merah memiliki aktivitas antioksidan sangat kuat dengan nilai IC50 sebesar 2,195 ppm. Aktivitas antioksidan ekstrak tersebut sangat kuat karena adanya beberapa kandungan senyawa, salah satunya fenol yang dapat meredam radikal DPPH. Hasil penetapan kadar fenol total ekstrak etanol daun merah pucuk merah adalah 371,833 ± 1,818 mg GAE/g ekstrak. Kadar fenol total tersebut menunjukkan bahwa tiap gram ekstrak setara dengan 371,833 mg asam galat.  
AKTIVITAS ANTIBAKTERI EKSTRAK DAUN LABU SIAM (Sechium edule (Jacq.) Swartz) TERHADAP BAKTERI Staphyloccocus epidermidis dan Pseudomonas aeruginosa dan BIOAUTOGRAFINYA Dolita Khurfia Janna; Maryati Maryati
Usadha Journal of Pharmacy Vol. 2 No. 3 (2023): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i3.106

Abstract

Penyakit infeksi kulit merupakan salah satu penyakit menular, baik melalui kontak langsung maupun tidak. Infeksi kulit dapat disebabkan oleh bakteri antara lain seperti Staphylococcus epidermidis dan Pseudomonas aeruginosa. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak daun labu siam (Sechium edule (Jacq.) Swartz) terhadap bakteri Staphylococcus epidermidis dan Pseudomonas aeruginosa, serta mengidentifikasi senyawa aktif yang berperan terhadap aktivitas tersebut. Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70%. Uji aktivitas antibakteri dilakukan dengan metode sumuran. Konsentrasi ekstrak untuk pengujian yakni 1, 2, 4, 8, 16 mg/sumuran. Senyawa dalam ekstrak diidentifikasi dengan kromatografi lapis tipis (KLT). Hasil uji menunjukkan adanya aktivitas antibakteri ekstrak etanol daun labu siam terhadap bakteri Staphylococcus epidermidis dan Pseudomonas aeruginosa. Pada konsentrasi 16 mg/sumuran ekstrak daun labu siam menghasilkan rerata diameter zona hambat sebesar 12,5±0,0 mm dan 10,66±0,28 mm terhadap bakteri Staphylococcus epidermidis dan Pseudomonas aeruginosa. Hasil uji KLT menunjukkan adanya kandungan senyawa flavonoid, tanin, alkaloid, saponin. Hasil uji bioautografi tidak menunjukkan adanya zona hambat pertumbuhan bakteri.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SALAM (Syzygium polyanthum) DAN DAUN MATOA (Pometia pinnata J.R.Forst & G.Forst) TERHADAP BAKTERI Shigella sonnei DAN Bacillus cereus Ismi Dwi Widyanti; Maryati Maryati
Usadha Journal of Pharmacy Vol. 2 No. 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i1.115

Abstract

Penyakit diare dan infeksi merupakan salah satu dari berbagai masalah kesehatan utama di daerah tropis seperti di Indonesia. Penyakit diare dapat ditimbulkan karena beberapa faktor antara lain bakteri dan lingkungan hidup yang kurang sehat. Daun salam dan daun matoa mengandung senyawa metabolit sekunder yang memiliki aktivitas antibakteri sehingga dapat mencegah terjadinya infeksi atau diare. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri pada ekstrak etanol 96% daun salam dan daun matoa terhadap bakteri Shigella sonnei dan bakteri Bacillus cereus penyebab diare. Daun salam dan daun matoa masing-masing dimaserasi menggunakan etanol 96% kemudian dibuat seri konsentrasi 25%, 50%, 75% dan 100% dengan masing-masing loading ekstrak 2,5 ; 5 ; 7,5 ; 10 (mg/disk). Seri konsentrasi daun salam dan daun matoa yang memiliki aktivitas antibakteri paling kuat yaitu pada konsentrasi ekstrak 100%. Hasil KLT-bioautografi menunjukkan senyawa dalam ekstrak daun salam dan ekstrak daun matoa yang memiliki aktivitas antibakteri terhadap bakteri Shigella sonnei yaitu senyawa tanin. Senyawa dalam ekstrak daun salam yang menghambat bakteri Bacillus cereus yaitu senyawa flavonoid sedangkan senyawa dalam ekstrak daun matoa yang memiliki aktivitas antibakteri yaitu senyawa tanin.
AKTIVITAS ANTIBAKTERI EKSTRAK DAUN SALAM (Syzygium polyanthum) DAN DAUN MATOA (Pometia pinnata J.R.Forst & G.Forst) TERHADAP BAKTERI Shigella sonnei DAN Bacillus cereus Ismi Dwi Widayanti; Maryati Maryati
Usadha Journal of Pharmacy Vol. 2 No. 2 (2023): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i2.145

Abstract

Penyakit diare dan infeksi merupakan salah satu dari berbagai masalah kesehatan utama di daerah tropis seperti di Indonesia. Penyakit diare dapat ditimbulkan karena beberapa faktor antara lain bakteri dan lingkungan hidup yang kurang sehat. Daun salam dan daun matoa mengandung senyawa metabolit sekunder yang memiliki aktivitas antibakteri sehingga dapat mencegah terjadinya infeksi atau diare. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antibakteri pada ekstrak etanol 96% daun salam dan daun matoa terhadap bakteri Shigella sonnei dan bakteri Bacillus cereus penyebab diare. Daun salam dan daun matoa masing-masing dimaserasi menggunakan etanol 96% kemudian dibuat seri konsentrasi 25%, 50%, 75% dan 100% dengan masing-masing loading ekstrak 2,5 ; 5 ; 7,5 ; 10 (mg/disk). Seri konsentrasi daun salam dan daun matoa yang memiliki aktivitas antibakteri paling kuat yaitu pada konsentrasi ekstrak 100%. Hasil KLT-bioautografi menunjukkan senyawa dalam ekstrak daun salam dan ekstrak daun matoa yang memiliki aktivitas antibakteri terhadap bakteri Shigella sonnei yaitu senyawa tanin. Senyawa dalam ekstrak daun salam yang menghambat bakteri Bacillus cereus yaitu senyawa flavonoid sedangkan senyawa dalam ekstrak daun matoa yang memiliki aktivitas antibakteri yaitu senyawa tanin.   
Co-Authors Ahmad Novian Nur Anas Alifiyah Sugihartini Andika Permana Ashari Wahyu Budi Aji Dolita Khurfia Janna Em Sutrisna Farida Nurcahyani Gunawan Setiyadi Hevi Mifta Kumalasari Hidayah Karuniawati Ichsanudin Febrianto Ismi Dwi Widayanti Ismi Dwi Widyanti Juwita Rahmawati Juwita Rahwawati Kusmiyati Kusmiyati Manira Zahratunisa Muhammad Nur Khairudin Namira Zahratunisa Ratna Yuliani Sakinatul Hayati Septi Fatmawati Setyo Nurwaini Sri Wahyuni Suprapto Suprapto Tanti Azizah Sujono Yunika Isnanda Pratiwi