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All Journal International Journal of Public Health Science (IJPHS) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Surya Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Surya Masyarakat Community Empowerment Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat
Muhammad Thesa Ghozali
Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Journal of Fundamental and Applied Pharmaceutical Science

 1 
Determining Caffeine in Fat-Burning Supplements Using Thin Layer Chromatography-Densitometry and UV-Vis Spectrophotometer Muhammad Luthfi Maulana; Muhammad Theza Ghozali
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 1 (2020): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.010105

Abstract

There are so many ways to lose weight, such as consuming fat burner supplements to burn fat faster. A fat burner supplement consists of various ingredients, such as caffeine. Fat burner supplements are usually not registered in BPOM RI. This study aims to evaluate caffeine in fat burner supplements qualitatively and quantitatively. These supplements were analyzed in the pharmaceutical laboratory in Universitas Muhammadiyah Yogyakarta using Thin Layer Chromatography (TLC)–Densitometry and UV–Vis Spectrophotometer. Sample preparation was conducted by separating caffeine from supplements by a separatory funnel with chloroform as an organic solvent. Qualitative analysis was carried out by TLC and analyzing standard spectrum, and sampling technique was carried out with UV–Vis Spectrophotometer. The first quantitative analysis used densitometry by measuring the spot on the TLC plate. Meanwhile, the second quantitative analysis used UV–Vis Spectrophotometer by observing absorbency value on samples with λ 273.5 nm. The result of the qualitative test using TLC was analyzed by comparing the Rf value of the standard and the sample. The Rf value of caffeine standard was 0.63, and every sample showed similar value with caffeine standard, indicating that all samples contain caffeine. The result of quantitative test with TLC - Densitometry method revealed 1st sample 5.68 mg/ml, 2nd sample 5.74 mg/ml, 3rd sample 3.43 mg/ml, 4th sample 8.90 mg/ml, and 5th sample 1.88 mg/ml. The qualitative test result was analyzed using the UV–Vis Spectrophotometer method, and all of the caffeine standard spectra can be read at wavelength 273.5 nm, which means all samples contain caffeine. The second quantitative test result analyzed by using UV–Vis Spectrophotometer method  showed 1st sample 3.22 mg/g, 2nd sample 4.56 mg/g, 3rd sample 2.23 mg/g, 4th sample 11.22 mg/g, and 5th sample 0.26 mg/g. It can be concluded that all samples (fat burners) contained caffeine.
The Formulation of Lotion Preparations of Betel Leaf Extract (Piper betle) Ingenida Hadning; Putri Kurnyaningtyas; Muhammad Thesa Ghozali
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 1 (2020): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.010104

Abstract

Betel leaf (Piper betle) contains an essential oil that has extreme antiseptic power (bactericidal and fungicidal). Betel leaf (Piper betle) can be used in the treatment of Tinea versicolor or known in the community as panu. However, its use in the form of leaves is considered impractical by the public and also difficult to obtain. This research formulated betel leaf (Piper betle) into lotion preparations, so its use in the community can be more practical. This study aims to determine the type and concentration of the suspending agent used to produce lotion preparations from betel leaf extract (Piper betle), which has optimal physical quality. This research was an experimental study. The distillation of betel leaf (Piper betle) was carried out to get essential oils. The essential oils of betel leaf (Piper betle), which was used as an active substance in formulations, was 5%. Suspending agents that were used in this study were Arabic gum with concentrations of 10%, 15%, 20%, and CMC Na, with concentrations of 0.25%, 0.5%, and 1%. The formulation of lotion preparations included organoleptic observation, pH test, homogeneity test, and adhesion test. Based on the physical quality test of the lotion preparations that had been conducted, it can be concluded that the lotion preparations of betel leaf extract with 20% concentration of Arabic Gum suspending agent had physical qualities in accordance with lotion dosage criteria.
Co-Authors Abdul Samad Aji Winanta Aji Winanta Aji Winanta Amallia Puspitasari Andy Eko Wibowo Bagus Hidayaturrohim Dyani Primasari Sukamdi Fadhilah Anwar Hidayat Fanny Rohimatul Azizah Putri Indardi Indardi Ingenida Hadning Ingenida Hadning Izdihar Dinah Amalia Islamy Maulana Yusuf Rahadian Muhammad Fariez Kurniawan Muhammad Luthfi Maulana Nurul Maziyyah Octavia, Mega Pinasti Utami Pinasti Utami Pinasti Utami, Pinasti Pramitha Esha Nirmala Dewi Putri Kurnyaningtyas Rahajeng, Bangunawati Rima Erviana Rosemaladewi Septiyanna Sabtanti Harimurti Salmah Orbayinah Salmah Orbayinah Siti Halimatussa’diyah Surria Dwiwahyu Tiyas Putri Nugraheni Vella Laili Damarwati Vella Lailli Damarwati