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All Journal Universa Medicina The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Kuntjoro Harimurti
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Universa Medicina

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Serum lactate as predictor and diagnostic biomarker of plasma leakage in adult dengue patients Bur, Rika; Suwarto, Suhendro; Santoso, Widayat Djoko; Harimurti, Kuntjoro
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.213-221

Abstract

Background Dengue fever (DF) and dengue hemorrhagic fever (DHF) are differentiated by the occurrence in DHF of plasma leakage into the interstitial space as shown by pleural and peritoneal effusion, hemoconcentration, and intravascular hypovolemia. Perfusion dysfunction causes anaerobic metabolism, which leads to increased serum lactate. This study was to determine serum lactate as prognostic predictor and diagnostic biomarker of plasma leakage in adult dengue patients.Methods A cross-sectional retrospective cohort study was conducted on 57 adult dengue patients hospitalized in the internal medicine ward of Cipto Mangunkusumo Hospital and Persahabatan Hospital in Jakarta. Serum lactate was examined to determine its mean difference between DF and DHF. The data was analyzed by independent t-test and the cut-off points were identified for presence as well as absence of plasma leakage, then the receiver operating characteristics (ROC) curve was used to determine sensitivity and specificity.Results Mean serum lactate was significantly higher in DHF than in DF. From the ROC curve, the cut-off point for serum lactate as prognostic predictor on day 3 of fever was ³2.65 mmol/L with AUC of 0.626 (95% CI 0.480-0.772; p=0.108). The cut-off point for diagnostic biomarker of plasma leakage on day 5 of fever was 2.55 mmol/L with sensitivity 66.6%, specificity 54.2%, and AUC 0.668 (95% CI 0.550-0.826; p=0.016).Conclusion There was a significant difference in serum lactate between DF and DHF. In the critical phase, serum lactate of 2.55 mmol/L could be used as plasma leakage diagnostic marker of low accuracy.
Co-Authors Adityo Susilo, Adityo Agus Joko Susanto, Agus Joko Andhika Rachman Andra Aswar, Andra Andri Sanityoso Sulaiman Anis Karuniawati Anna Mira Lubis Ario Perbowo Putra Ario Perbowo Putra, Ario Perbowo Aru W Sudoyo Aulia Rizka, Aulia Birry Karim C Martin Rumende C. Martin Rumende, C. Martin Ceva W Pitoyo Chyntia Olivia Maurine Cleopas M Rumende, Cleopas M Cleopas Martin Rumende Czeresna Heriawan Soejono Dedy G Sudrajat, Dedy G Dharmeizar Dharmeizar Djumhana Atmakusuma, Djumhana Edy Rizal Wahyudi Elza Febria Sari Em Yunir, Em Ening Krisnuhoni Eric Daniel Tenda Esthika Dewiasty, Esthika Ginova Nainggolan Gunawan Gunawan Gurmeet Singh Harini Oktadiana, Harini Harryanto, A. HILMAN TADJOEDIN, HILMAN Idrus Alwi Ika P Wijaya, Ika P Indra G Mansur, Indra G Iris Rengganis Jeo, Wifanto Saditya Juferdy Kurniawan Koesno, Soekamto M Sadikin Martini, Rose D Mira Yulianti, Mira Muhadi Muhadi, Muhadi Murdani Abdullah Murdani Abdullah Ni Made Hustrini, Ni Made Noto Dwimartutie Parlindungan Siregar Rachmat Hamonangan, Rachmat Rika Bur Rino Alvani Gani Rino Alvani Gani Roza Mulyana Rudi Putranto Sally A Nasution, Sally A Setiati, Slti Shufrie Effendy Siti Setiati Sudrajat, Dedy G. Suhardjono Suhardjono Suhendro Suwarto, Suhendro Sukamto Koesnoe TB Djumhana, TB Triyani Kresnawan, Triyani Wawan Kurniawan Widayat Djoko Santoso, Widayat Djoko Wulyo Rajabto