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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacology and Clinical Pharmacy Research CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Jurnal Sains dan Teknologi Farmasi Indonesia

Hesti Riasari

Program Studi S1 Farmasi, Sekolah Tinggi Farmasi Indonesia

Author-ID : 2857840

Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 8 Documents Claim Missing Document

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Articles

Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) from Garut West Java Diki Prayugo Wibowo; Yessi Febriana; Hesti Riasari; Diah Lia Auilifa
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

West Java is rich in essential oil-producing plants, essential oils known to be responsible for some pharmacological activities among its antioxidant and antimicrobial. This research aims to know antimicrobial, antioxidant activity and identify the components of a compound essential oil of nutmeg (Myristica fragrans Houtt.). Components chemistry identified with GC-MS (Gas Chromatography-Mass pectrometer). Antioxidant activity measured by using the DPPH method (2 2-diphenyl-1-picrylhydrazyl) at 516 λ wavelength absorbance. Antimicrobial activity determined Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) using microdilution method. The result of GC-MS showed the highest component on nutmeg containing 22.22% myristicin. The antioxidant test showed nutmeg had IC50 at 3,16%, essential oil showed antibacterial activity against Gram positive and Gram negative bacteria. Minimum inhibitory concentrations of essential oils range from 0.313% to 10%. The content of essential oils of nutmeg plants that grow in the area of West Java Garut can be used to overcome the problems of antioxidants and antimicrobial.Key words: Antioxidant, Antibacterial, Pala (Myristica fragrans Houtt), Chemical Composition.

Toxicity Assay of Fermented Artocarpus altilis Leaves Using Brine Shrimp Lethality Test Hesti Riasari; Yessi Febriani; Winda A. Nurfauziah
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Fermented Artocarpus altilis leaves contains phenolic compound that has pharmacological activity. Differences in fermentation method, i.e., aerobic and anaerobic fermentation might change its characteristics and biological activity. The purpose of this study was to compare toxicity properties between aerobically and anaerobically fermented Artocarpus altilis leaves using brine shrimp lethality (BSL) test. Both types of fermented leaves were cold extracted using ethanol solvent (1:6) for 3 x 24 hours. Phytochemical screening was then performed to examine the presence of secondary metabolite compounds. BSL test was performed in 7 treatment groups, i.e., negative control, 1000, 500, 100, 50, 25, 12.5 ppm of extract. Each vial contained 10 Artemia larvae, extract, and sea water up to 10 ml. Toxicity is measured by calculating LC50 after 24 hours observation. The experiment was repeated three times. The results of the study showed that LC50 of aerobic extract was 712 ppm, thus it can be categorized as toxic, while that of anaerobic extract is 1.927 ppm, or non-toxic to the Artemia salina larvae. In conclusion, aerobically fermented Artocarpus altilis leaves had toxicity potency, while anaerobically fermented Artocarpus altilis leaves had no toxicity potency against Artemia salina in BSL test. Key words: Artocarpus altilis, brine shrimp lethality test, toxicity.

Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats Hesti Riasari; Sani Nurlalela; Ginanjar C. Gumilang
Pharmacology and Clinical Pharmacy Research Vol 4, No 1
Publisher : Universitas Padjadjaran, Indonesia

Inflammation is a local reaction in vascular tissue characterized by several symptoms, e.g., swelling, redness, and pain. Indonesia is one of the countries with high biodiversity, including traditional medicinal plants. Artocarpus altilis is one the plants that is widely used to treat inflammation. There is limited information on biological activity of A. altilis.This study was performed to evaluate anti-inflammatory properties of A. altilis detached and attached leaves in Wistar male rats. A. altilis was extracted using soxhlet method at 67.4 0C with methanol solvent. Inflammation was induced by the administration of carrageenan to the rats paw. Subsequently, the extract of A. altilis were orally administered. The edema were measured using plethysmometer for 6 hours. We found that there were differences in anti-inflammatory activity between detached and attached leaves. The inhibition of edema in attached leaves were 50% and 53.33% for the concentration of 50 mg and 100 mg, respectively. The greater inhibiton was observed in the detached leaves, with 73.33% and 76.67% inhibition, for the concentration of 50 mg and 100 mg, respectively. Nevertheless, the inhibition percentage was still below diclofenac sodium as a positive control (83.33%). In conclusion, A. altilis leaves extracts showed good anti-inflammatory properties and has the potential for development of anti-inflammatory drug. Keywords: Artocarpus altilis, carageenan, inflammation, edema

Kreasi Olahan Pangan Berbahan Buah Pepaya Dan Buah Naga dalam Kegiatan Pengabdian kepada Masyarakat Siti Uswatun Hasanah; Hesti Riasari; Sani Nurlaela Fitriansyah
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 2 No. 5 (2022): September 2022 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25008/altifani.v2i5.284

Kegiatan pengabdian kepada masyarakat merupakan salah satu dari tridarma seorang dosen. Kegiatan pengabdian kali ini dilaksanakan di Desa Sukaluyu, yang berada di kabupaten Tasikmalaya. Potensi alam desa tersebut diantaranya adalah buah naga dan buah pepaya. Desa tersebut memanfaatkan buah naga dan pepaya sebagai konsumsi harian dan dijual dalam bentuk buah segar tanpa diolah. Atas dasar kondisi tersebut, dilakukanlah pengabdian masyarakat dengan tema utama pengolahan potensi alam Desa Sukaluyu menjadi produk pangan dengan nilai jual tinggi. Sasaran dalam kegiatan ini adalah seluruh warga Desa Sukaluyu, melalui para ibi-ibu Pemberdayaan Kesejahteraan Keuarga. Pelaksanaan pengabdian terbagi atas dua sesi, yaitu sesi penyuluhan, dan sesi kedua adalah pelatihan pembuatan produk. Produk pangan yang diangkat dalam pengabdian ini adalah baso, chips/keripik, mie nature, serta dan satu produk kosmetik, berupa lulur tradisonal dengan memanfaatkan limbah kulit buah naga. Warga sekitar sangat antusias dengan diadakannya pelatihan tersebut, karena dapat memberikan tambahan pengetahuan, dan memberikan peluang usaha baru.

KARAKTERISASI SENYAWA FENOL DARI FRAKSI TERPILIH DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) KUNING NEMPEL SEBAGAI ANTIOKSIDAN Hesti - Riasari; Achmad - Zainuddin; Dini Yulia Handayani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 2 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakTumbuhan sukun (Artocarpus altilis) banyak dijumpai di Indonesia. Penelitian terdahulu menyatakan bahwa ekstrak metanol daun sukun kuning nempel memiliki aktivitas antioksidan. Tujuan penelitian ini adalah untuk mengetahui fraksi daun sukun kuning nempel yang memberikan aktivitas antioksidan paling baik, serta mengisolasi senyawa tersebut. Daun sukun kuning nempel diekstraksi menggunakan metode maserasi dan difraksinasi menggunakan metode ekstraksi cair-cair, sehingga diperoleh fraksi n-heksan, fraksi etil asetat dan fraksi air untuk dilakukan pengujian aktivitas antioksidan dengan metode DPPH. Fraksi etil asetat menunjukkan hasil paling baik dengan IC50 sebesar 17,11 dibandingkan dengan IC50 fraksi n-heksan sebesar 26,16 dan IC50 fraksi air sebesar 20,68 sehingga dilakukan pemisahan lebih lanjut pada fraksi etil asetat. Hasil identifikasi isolat 1 menggunakan spektrofotometri UV-Vis menunjukkan panjang gelombang 291 nm yang diduga merupakan senyawa fenol. Dan isolat 2 menunjukkan panjang gelombang 320 nm pada pita I dan pita II 276 nm yang merupakan ciri khas senyawa flavanon. Hasil diperkuat dengan penambahan pereaksi geser dan FTIR yang menunjukkan adanya gugus OH, gugus CH alifatik, ikatan rangkap C=O, gugus C=C aromatik dan gugus C-O pada isolat 2. Hal tersebut membuktikan bahwa isolat 2 merupakan senyawa fenol golongan flavonoid yaitu flavanon yang memiliki aktivitas antioksidan. Kata kunci : Daun sukun, antioksidan, DPPH, isolasi, flavanon AbstractPlant breadfruit (Artocarpus altilis) found in Indonesia. According to the previous research the methanol extract of leaves of breadfruit yellow has antioxidant activity. The purpose of this research is to know the fraction of breadfruit attached yellow leaves was given the most excellent antioxidant activity, and isolating the compound. Leaves of breadfruit attached yellow extracted using maceration method and fractination method using liquid-liquid extraction, obtained the n-hexan fraction, ethyl acetate fraction and the water fraction for tested antioxidant activity with DPPH method. Ethyl acetate fraction shows the best results with IC50 17.11 compared with IC50 n-hexan fraction 26.16 and IC50 water fraction 20.68 so that further separation carried out on ethyl acetate fraction. The results of isolates 1 identification used spectrophotometry UV-Vis a wavelength 291 nm was suspected phenol compound. And isolates 2 shows wavelength 320 nm the band I and band II 276 nm which is characteristic of the flavanon compound. The results reinforced with the addition of shift reagent and FTIR that indicate the presence of hydroxyl OH, aliphatic CH, double bond C = O , C = C aromatic and group of C-O of isolates 2. It proves that isolates 2 is phenol compound, flavonoid group, namely flavanon which has antioxidant activity. Keywords: Breadfruit leaves, antioxidant, DPPH, isolation, flavanon

AKTIVITAS ANTIHIPERGLIKEMIA DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) KUNING JATUH DAN JATUH KERING PADA MENCIT PUTIH JANTAN GALUR SWISS WEBSTER DENGAN METODE INDUKSI ALOKSAN Hesti - Riasari; Maria - Ulfah; Linda - Audina
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 7, No 1 (2018)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakDiabetes melitus atau yang lebih dikenal dengan penyakit gula diakibatkan oleh kekurangan hormon insulin. Sukun merupakan salah satu tanaman yang dimanfaatkan masyarakat sebagai obat untuk penyakit diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol dari daun sukun jatuh kering dan kuning jatuh sebagai antihiperglikemia pada mencit putih jantan galur Swiss Webster yang diinduksi aloksan. Uji aktivitas antihiperglikemia dilakukan dengan menggunakan 27 ekor mencit yang dibagi menjadi 9 kelompok perlakuan. Masing-masing kelompok terdiri dari 3 ekor mencit. Kelompok perlakuan terbagi menjadi kelompok kontrol normal, kontrol negatif, kontrol positif dan kelompok uji, kelompok uji terdiri dari Kuning Jatuh 200, 400 dan 600 mg/KgBB, Jatuh Kering 200, 400 dan 600 mg/KgBB. Semua kadar gula darah awal diukur sebelum di induksi aloksan. Semua kelompok diinduksi aloksan sebesar 70mg/KgBB kecuali kelompok normal dan kontrol negatif. Setelah 7 hari diinduksi, hewan dipuasakan lalu diukur kadar gula darah. Kadar gula darah dicek pada hari ke-7, ke-14 dan ke-21. Data diuji secara statistik menggunakan one way ANOVA dengan tahap kepercayaan p<0,05. Hasil pengujian menunjukkan Ekstrak etanol daun sukun kuning jatuh dan jatuh kering memiliki aktivitas antihiperglikemia, daun sukun jatuh kering dosis 600mg/KgBB menunjukkan aktivitas antihiperglikemia yang paling baik diantara semua kelompok uji secara bermakna jika dibandingkan dengan kelompok kontrol. Kata kunci : Antihiperglikemia, Daun Sukun, Aloksan, Swiss Webster AbstractDiabetes mellitus or more commonly known as diabetes caused by insulin deficiency. Breadfruit (Artocapus altilis (Park.) Fosberg) is one of the plant that used by native people as diabetics medicin. This study aimed to determine the effect of ethanol extract of dried breadfruit leaf fall and yellow fall as antihyperglycemia in mice white male Swiss Webster strain induced alloxan. Antihyperglycemia activity test was performed using 27 mice were divided into 9 groups. Each group consisted of three mice. The treatment group was divided into normal control group, negative control, positive control and test group, test group consisted of Fallen dry 200, 400 and 600 mg/KgBW, Falen Yellowl 200, 400 and 600 mg / KgBW. All initial blood sugar levels were measured before induction of alloxan. All groups alloxan induced by 70mg/KgBW except the normal group and negative control. After 7 days induced, the animals were fasted and then measured blood sugar levels. Blood sugar levels are calculated on the 7th, 14th and 21st. Data were statistically tested using one-way ANOVA with the stage of confidence p<0.05. The test results showed the ethanol extract of leaves of breadfruit has antihyperglycemia activity, breadfruit leaves tumble drier dose of 600mg/KgBW showed activity antihyperglycemia the best among all of the test groups were significantly when compared with the control group. Keywords: Antihyperglycemia, Breadfruit Leaves, Alloxan, Swiss Webster

PERBANDINGAN METODE FERMENTASI, EKSTRAKSI, DAN KEPOLARAN PELARUT TERHADAP KADAR TOTAL FLAVONOID DAN STEROID PADA DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) Hesti Riasari; Sani Nurlaela Fitriansyah; Irna Siti Hoeriah
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 11, No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Indonesia

Daun sukun mengandung metabolit sekunder antara lain flavonoid, polifenol, kuinon, dan steroid1. Proses biosintetik dapat menyebabkan perubahan warna, kandungan, dan jenis kandungan yang ada pada daun sukun. penelitian menggambarkan konsentrasi total metabolit sekunder yang dipisahkan berdasarkan polaritas pelarut dan metode ekstraksi. Proses biosintetik adalah fermentasi daun hijau segar menjadi daun hijau fermentasi (HF) melalui metode fermentasi aerob dan anaerob. Ekstraksi dilakukan dengan dua metode yaitu metode panas (sokletasi) dan metode dingin (maserasi) untuk membandingkan metode ekstraksi yang lebih baik. Ekstraksi dilakukan dengan kepolaran bergradasi menggunakan pelarut N-heksana, etil asetat, dan etanol. Ekstraksi kepolaran bertingkat akan menghasilkan senyawa-senyawa tertentu yang terpisah secara spesifik pada setiap pelarut yang digunakan, oleh karena itu tujuan dari penelitian ini adalah untuk memperoleh data ilmiah mengenai pengaruh metode fermentasi, metode ekstraksi, dan gradien polaritas pelarut terhadap kandungan flavonoid dan steroid total ekstrak daun. . sukun (Artocarpus altilis (Parkinson) Fosberg). Hasil kandungan flavonoid total tertinggi adalah ekstrak etil asetat dari daun sukun fermentasi aerobik dengan metode maserasi 0,3054 g QE/100g dan kandungan steroid total tertinggi pada ekstrak N-heksana dari daun sukun fermentasi aerobik maserasi 0 , 1169g/100g. Berdasarkan penelitian yang telah dilakukan, dapat disimpulkan bahwa metode ekstraksi terbaik untuk menentukan kadar total flavonoid dan steroid adalah metode maserasi. Sedangkan polaritas pelarut yang baik untuk penentuan kadar flavonoid total adalah etil asetat aerobik, dan N-heksana aerobik untuk penentuan kadar steroid total, metode fermentasi yang efektif dalam meningkatkan kadar metabolit sekunder pada daun sukun adalah metode fermentasi aerobik.

Pelatihan Pembuatan Parem dan Minuman Herbal Sebagai Peningkat Imunitas dan Peluang Usaha Mandiri Siti Uswatun Hasanah; Diki Prayugo Wibowo; Hesti Riasari; Sani Nurlaela
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2023): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v5i3.1767

Conditions after the COVD-19 pandemic still require residents to maintain their immunity, one of which is by using family medicinal plants. Ginger plant is a traditional spice that is found in many areas. This community service activity aims to provide knowledge about the benefits of herbal plants as immune boosters and processing ginger spices to become herbal drink products and parem, as daily consumption. The method of activity is to provide counseling to residents and make products directly, along with packaging and brochures as product companions. As a result of community service activities, people get additional knowledge about herbal plants that can increase body immunity as well as get knowledge about simple ways to process herbal plants.

Co-Authors Achmad - Zainuddin Diah Lia Auilifa Diki Prayugo Wibowo Dini Yulia Handayani Ginanjar C. Gumilang Irna Siti Hoeriah Linda - Audina Maria Ulfah Sani Nurlaela Sani Nurlaela Fitriansyah Sani nurlaela fitriansyah Sani Nurlalela Siti Uswatun Hasanah Siti Uswatun Hasanah Winda A. Nurfauziah Yessi Febriana Yessi Febriani

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