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Studi Sistem Dispersi Padat Isoxsuprine Hcl Povidon K-30 Taslim, Tuty; Halim, Auzal; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on Solid Dispersion System of Isoxsuprine HCl by using syntetic polymer Povidon K-30 to increase solubility has been done has been done. The solid dispersion system were prepared by using solvent method with any comparison ( Taslim, 2007). Charactheristics of physical chemistry properties of solid dispersion such as dissolution test, X-ray diffraction analysis, Differential Scanning Calorimetry, and Fourier Transform Infra Red were assayed. The dissolution test from solid dispersion by using UV spectrophotometer. Statistical analysis of solid dispersionâs dissolution test was done by using Anova. The characteristic X-rayâs diffraction and FTIR showed that solid dispersion with drug to polimer ratio of 1:9 ; 2:8 ; 3:7 were amorf in comparison to other solid dispersions. Statistical analysis by one direction Anova concluded that the dissolution profile of the solid dispersion system of 2:8 was the highest.

Analisis Aspek Farmakokinetika Klinik Pasien Gagal Ginjal pada Irna Penyakit dalam RSUP Dr. M. Djamil Padang Lucida, Henny; Trisnawati, Riah; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the evaluation of clinical pharmacokinetic aspect to in-patient with renal failure at internal Ward Dr. M. Djamil hospital Padang has been conducted. The aspect studied was dosage individualization bades on patientâs patophysiological condition. The study aimed at comparing the dosage regimen given to the renal failure patient with that calculated using pharmacokinetic equations. This study was observasionaly prospective by using cross-sectional method. In the period of June â September 2010, 48 renal failure patients includes in inclusion criterion. Results showed that medications which mainly renal excreted or potentially nephrotoxic given to patients are ciprofloxacin, digoxin, ranitidin, metformin, captopril, furosemide and hydrochlortiazide. Patients treated with those medications were evaluated in terms of dosage regimens and clinical response. There were 4 cases of higher dose than recommended included 1 of 8 cases of captopril use, 2 of 9 cases of ciprofloxacin use and 1 of case of metformin use. It uses also found that hydrochlortiazide which should be avoided to patients with Clcr < 30 ml/min (4 cases)

Pemahaman dan Sikap Apoteker Rumah Sakit di Kota Padang Terhadap Asuhan Kefarmasian Almasdy, Dedy; Suardi, Muslim; Pitricia, Deby; Kurniasih, Nina
Jurnal Sains dan Teknologi Farmasi Vol 19 No 1 (2017)
Publisher : Fakultas Farmasi Universitas Andalas

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Penelitian terhadap pemahaman dan sikap apoteker rumah sakit di kota Padang terhadap asuhan kefarmasian (pharmaceutical care) telah dilakukan. Penelitian ini bertujuan untuk mengetahui pemahaman dan sikap apoteker terhadap asuhan kefarmasian. Penelitian dilakukan dengan menggunakan instrumen berupa daftar pertanyaan (kuisioner), berisi 6 pertanyaan tentang demografi responden, 13 pernyataan tentang pemahaman, 14 pernyataan tentang keterampilan, 14  pertanyaan tentang sikap dan 19 pernyataan tentang kendala yang membatasi penyediaan asuhan kefarmasian. Hasil penelitian menunjukkan bahwa apoteker rumah sakit di kota Padang mempunyai pemahaman yang baik dan menunjukkan sikap yang positif terhadap asuhan kefarmasian. Sedangkan kendala utama yang membatasi penyediaan asuhan kefarmasian adalah kemampuan pemecahan klinis berkaitan dengan obat yang tidak memadai.

TINJAUAN AKUMULASI SEFTRIAKSON DARI DATA URIN MENGGUNAKAN ELEKTROFORESIS KAPILER PADA PASIEN GANGGUAN FUNGSI GINJAL STADIUM TIGA Suardi, Muslim; Raveinal, Raveinal; Sari, Lisa Oktia; Lailaturrahmi, Lailaturrahmi
Jurnal Ipteks Terapan Vol 11, No 2 (2017): JIT
Publisher : LLDIKTI Wilayah X

Ceftriaxone is a third-generation cephalosporin which are excreted mostly via the kidneys. Drugs which are eliminated primarily by the kidneys may accumulate in the patients with impaired renal function. Ceftriaxone is widely used in DR.M.Djamil Hospital Padang. The dosage adjustment for this drug has not yet performed in the hospital so far. This study was conducted in patients who suffered from stage 3 renal failure, received ceftriaxone therapy, and were 20-65 years of age. Urine samples were collected from patients at 4, 4.5, 5.75, 6.5, 7.75, and 8.25 hours after drug administration. Samples were analyzed using capillary electrophoresis. The buffer used was sodium tetraborate with pH of 9, concentration of 50 mM and pKa 9,24. The absorbance of solutions were measured at wavelength of 241.2 nm. From the standard calibration curve of ceftriaxone, the equation of Y = 4.455x - 2.297 (R2 = 0.995), (SD =1.40) was obtained. The migration time of ceftriaxone was 9 minutes. The LOD and LOQ were 0.94 and 3.14 Âµg/mL, respectively. The elimination rate and elimination half life were 0.046/h and 15,06 h, respectively. Du cumulative and acumulation fraction of drugs were 365.10 mg and 0.33 (33%), respectively. Dmax and Dmin were 2.985 and 985 mg, respectively. Cmax and Cmin were 224,43 and 74,06 mg/L, respectively. The accumulation index of the drug was 1.49. Cl. AUC0Ë and the CpO were 0.612 L/h, 3.268 mg h/L and 150.37 mg/L, respectively. Impaired renal function may affect pharmacokinetic parameters such as elimination rate, elimination half-time, and drug clearance.Â Â

KERASIONALAN PENGGUNAAN ASIKLOVIR PADA SALAH SATU POLIKLINIK KULIT DAN KELAMIN DI SUMATERA SELATAN Suardi, Muslim; Erjon, .; Khodijah, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 4 (2007)
Publisher : Indonesian Research Gateway

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The aim of this study was to observe the rationality of acyclovir use and to provide information in order to improve quality of medical services at a hospital in Sumatera Selatan. A descriptive survey studies was conducted on 77 patients Herpes simplex Virus (HSV), and Varicella zoster Virus (VZV) infections at Ambulatory Clinic of Dermato-Venereology. Data were collected from status cards in medical record installation using systematic sampling method. Data were analyzed quantitatively and qualitatively as well. Results showed that the score of rationalities in drug therapy regarding the appropriateness of indication, drug, and patients, were 100, 89.6, and 100% respectively. While rationalities regarding the appropriateness of: dose, route, time, duration, frequency, and interval of administrations were 49.4, 88.3, 0, 0, 72.7, and 72.7% respectively. As a conclusion, the usage of acyclovir at Ambulatory Clinic of Dermato-Venereology at a hospital in Sumatera Selatan Province hospital were irrational. ABSTRAK Penelitian ini bertujuan untuk mengetahui kerasionalan penggunaan ACV dan diharapkan sebagai bahan masukan untuk meningkatkan mutu pelayanan kesehatan di salah satu Rumah Sakit di Provinsi Sumatera Selatan. Satu rancangan penelitian survei deskriptif dilakukan terhadap 77 pasien infeksi Virus Herpes simpleks (VHS), dan Virus Varisela zoster (VVZ) yang berobat di Poliklinik Kulit dan Kelamin. Data diperoleh dari kartu status pasien pada instalasi rekam medik selama tahun 2005. Selanjutnya data ditabulasikan dalam tabel, dianalisis secara kuantitatif maupun kualitiatif dan dipaparkan dalam bentuk grafik. Hasil penelitian menunjukkan bahwa penilaian kerasionalan yang mencakup tepat indikasi, tepat obat, dan tepat penderita, masing-masing adalah, 100; 89,6; dan 100%. Sedangkan penilaian kerasionalan yang mencakup tepat dosis, tepat rute, tepat saat, tepat lama, tepat frekuensi, dan tepat interval pemberian masing-masing adalah: 49,4 ; 88,3; 0; 0; 72,7; dan 72,7%. Sebagai kesimpulan, penggunaan ACV pada Poliklinik Kulit dan Kelamin salah satu Rumah Sakit di Provinsi Sumatera Selatan adalah tidak rasional.

KERASIONALAN PENGGUNAAN ASIKLOVIR PADA SALAH SATU POLIKLINIK KULIT DAN KELAMIN DI SUMATERA SELATAN Suardi, Muslim; Erjon, .; Khodijah, .
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.91

The aim of this study was to observe the rationality of acyclovir use and to provide information in order to improve quality of medical services at a hospital in Sumatera Selatan. A descriptive survey studies was conducted on 77 patients Herpes simplex Virus (HSV), and Varicella zoster Virus (VZV) infections at Ambulatory Clinic of Dermato-Venereology. Data were collected from status cards in medical record installation using systematic sampling method. Data were analyzed quantitatively and qualitatively as well. Results showed that the score of rationalities in drug therapy regarding the appropriateness of indication, drug, and patients, were 100, 89.6, and 100% respectively. While rationalities regarding the appropriateness of: dose, route, time, duration, frequency, and interval of administrations were 49.4, 88.3, 0, 0, 72.7, and 72.7% respectively. As a conclusion, the usage of acyclovir at Ambulatory Clinic of Dermato-Venereology at a hospital in Sumatera Selatan Province hospital were irrational. ABSTRAK Penelitian ini bertujuan untuk mengetahui kerasionalan penggunaan ACV dan diharapkan sebagai bahan masukan untuk meningkatkan mutu pelayanan kesehatan di salah satu Rumah Sakit di Provinsi Sumatera Selatan. Satu rancangan penelitian survei deskriptif dilakukan terhadap 77 pasien infeksi Virus Herpes simpleks (VHS), dan Virus Varisela zoster (VVZ) yang berobat di Poliklinik Kulit dan Kelamin. Data diperoleh dari kartu status pasien pada instalasi rekam medik selama tahun 2005. Selanjutnya data ditabulasikan dalam tabel, dianalisis secara kuantitatif maupun kualitiatif dan dipaparkan dalam bentuk grafik. Hasil penelitian menunjukkan bahwa penilaian kerasionalan yang mencakup tepat indikasi, tepat obat, dan tepat penderita, masing-masing adalah, 100; 89,6; dan 100%. Sedangkan penilaian kerasionalan yang mencakup tepat dosis, tepat rute, tepat saat, tepat lama, tepat frekuensi, dan tepat interval pemberian masing-masing adalah: 49,4 ; 88,3; 0; 0; 72,7; dan 72,7%. Sebagai kesimpulan, penggunaan ACV pada Poliklinik Kulit dan Kelamin salah satu Rumah Sakit di Provinsi Sumatera Selatan adalah tidak rasional.

TINJAUAN AKUMULASI SEFTRIAKSON DARI DATA URIN MENGGUNAKAN ELEKTROFORESIS KAPILER PADA PASIEN GANGGUAN FUNGSI GINJAL STADIUM TIGA Muslim Suardi; Raveinal Raveinal; Lisa Oktia Sari; Lailaturrahmi Lailaturrahmi
Jurnal Ipteks Terapan Vol 11, No 2 (2017): JIT
Publisher : LLDIKTI Wilayah X

Ceftriaxone is a third-generation cephalosporin which are excreted mostly via the kidneys. Drugs which are eliminated primarily by the kidneys may accumulate in the patients with impaired renal function. Ceftriaxone is widely used in DR.M.Djamil Hospital Padang. The dosage adjustment for this drug has not yet performed in the hospital so far. This study was conducted in patients who suffered from stage 3 renal failure, received ceftriaxone therapy, and were 20-65 years of age. Urine samples were collected from patients at 4, 4.5, 5.75, 6.5, 7.75, and 8.25 hours after drug administration. Samples were analyzed using capillary electrophoresis. The buffer used was sodium tetraborate with pH of 9, concentration of 50 mM and pKa 9,24. The absorbance of solutions were measured at wavelength of 241.2 nm. From the standard calibration curve of ceftriaxone, the equation of Y = 4.455x - 2.297 (R2 = 0.995), (SD =1.40) was obtained. The migration time of ceftriaxone was 9 minutes. The LOD and LOQ were 0.94 and 3.14 µg/mL, respectively. The elimination rate and elimination half life were 0.046/h and 15,06 h, respectively. Du cumulative and acumulation fraction of drugs were 365.10 mg and 0.33 (33%), respectively. Dmax and Dmin were 2.985 and 985 mg, respectively. Cmax and Cmin were 224,43 and 74,06 mg/L, respectively. The accumulation index of the drug was 1.49. Cl. AUC0˜ and the CpO were 0.612 L/h, 3.268 mg h/L and 150.37 mg/L, respectively. Impaired renal function may affect pharmacokinetic parameters such as elimination rate, elimination half-time, and drug clearance.

Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat Rieke Azhar; Muslim Suardi; Salman Umar
Jurnal Farmasi Higea Vol 1, No 1 (2009)
Publisher : STIFARM Padang

Effects of polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersion systems have been studied. Solid dispersions were prepared by solvent method using several ratios of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9, 3:7, 5:5, 7:3, 9:1. Physical mixtures of ketoprofen-polyvinylpyrrolidone K-30 were used as a comparison. The solid dispersion systems and physical mixtures were evaluated for physicochemical properties and dissolution characteristics. Dissolution tests were measure with modified basket method using pH 7.2 phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15, 20, 30, 45, and 60 minutes. Results generally showed that solid dispersion system of ketoprofenpolyvinylpyrrolidone K-30 have a different physicochemical properties compared to physical mixtures and pure ketoprofen and exhibited better dissolution rate and dissolution efficiency of ketoprofen. Dissolution efficiency and dissolution rate constant of the solid dispersion system were 59.41%, and 1.66 mg/s, respectively.

Kesesuaian Dosis Vankomisin pada Pasien Penyakit Ginjal Kronik Stadium 3 dan 4 di Bangsal Penyakit Dalam RSUP Dr. M. Djamil Padang Muslim Suardi; Marissa Sofjan; Raveinal Raveinal
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Vancomycin is a glycopeptide antibiotic which almost completely eliminated by renal unchanged in the urine (> 90%). Elimination of vancomycin is delayed in patients with renal insufficiency. The purposes of the research were to examine dosing adjustment and quantity individualized dose of vancomycin in patients with chronic kidney disease in Internal Ward of Dr. M. Djamil Padang Hospital based on pharmacokinetics dosing method. The study was designed by observational retrospective method conducted on patient’s medical record during January 2015 – March 2016. A number of 21 patients were treated using vancomycin with chronic kidney disease stage 3 and 4. Results showed that 19.05% patients received exceed dose based on pharmacokinetic dosing method calculation. Clearance of vancomycin in patients with chronic kidney disease on stage of 3 and 4 were 1.88 ± 0.28 and 0.88 ± 0.21L/h, respectively. The elimination half-life prolonged to patients with chronic kidney disease stage 3 and 4 were 14.11 ± 2.89 and 24.48 ± 5.44, respectively. While accumulation factor in patients with chronic kidney disease on stage of 3 and 4 were 0.50 ± 0.1 and 0.67 ± 0.09, respectively.

Pengaruh Kualitas Pelayanan dan Kepuasan Pasien Peserta BPJS Kesehatan sebagai Mediasi terhadap Loyalitas Pasien Rosiana Rizal; Muslim Suardi; Yulihasri Yulihasri
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The formation of a positive perception of the patient is expected to bring satisfaction in pharmaceutical services, especially drug information services to improve patients’ loyalty to health care services they have used. The design of this research is probability sampling, with a population of patients in public hospitals in Padang city: Dr. M. Djamil Hospital; Dr. Rasidin Hospital; and Dr. Reksodiwiryo Hospital Padang who have used the service of National Health Insurance (BPJS) from January to June 2014. The sampling technique was simple random sampling (105 patients) by using a questionnaire. Data analysis was performed using Cronbach’s alpha analysis, Multiple Regression, R Square, t-test and path analysis. The results of this study indicated that the service quality affected patients’ satisfaction in the dimensions of responsiveness, assurance and direct evidence (p <0.05); toward the loyalty of patients in the direct evidence dimension (p<0.05); and towards patients’ loyalty mediated by patients’ satisfaction in the dimension of direct evidence (p <0.05).

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