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All Journal Buletin Penelitian Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Nurse and Health: Jurnal Keperawatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Anesthesiology and Reanimation (IJAR) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology
betty Agustina Tambunan, betty Agustina
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Airlangga – RSUD Dr.Soetomo Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Indian Journal of Forensic Medicine

 1 
Evaluation of Storage Length to Blood Component Platelet Concentrate Quality in the Blood Bank, Dr. Soetomo General Hospital, Surabaya, Indonesia Dhinasty Armenia1 , Betty Agustina Tambunan2,3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.11609

Abstract

Storage of Platelet Concentrate (PC) can cause changes in thrombocyte quality that affect thrombocyteviability and decrease hemostatic function. All biochemical, structural and functional changes to plateletsduring storage in the Blood Bank are known as platelet storage lesions. To analyze the effect of storagelength on changes in thrombocyte morphology and function as well as the metabolic parameters of plateletconcentrate bag components. This was an analytical study with time series design. Sampling was doneconsecutively. Samples were new PC bags which were processed and stored at room temperature withagitation during June-July 2019 in the Blood Bank of the Dr. Soetomo General Hospital, Surabaya.Examination of platelet count and MPV were performed to determine morphological changes and metabolicparameters like pH, pCO2, and pO2 on day 1, day 3, and day 5th. Data were analyzed by using Shapiro-Wilktest, Paired t test and Wilcoxon Signed Rank Test. There were significant changes in MPV, pH, and pCO2values during storage (p <0.05). However, there were no significant changes in platelet count and pO2value. Metabolic changes in PC bag were obtained but there was no decrease in platelet count so that the PCcomponent was still feasible to be given to the patient. Further research is needed for other parameters thatcan be affected by the storage process.
The Effect of Long Storage of Whole Blood Components on the Level of 2,3 Diphosphoglycerate and Lactic Acid in the Blood Bank, Dr. Soetomo General Hospital, Surabaya, Indonesia Dwi Ajeng Roosanti; Betty Agustina Tambunan; Arifoel Hajat
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17485

Abstract

The purpose of this study was to analyze changes in levels of 2,3 DPG and lactic acid on WB storagetime. This research is an observational analytical with time series design was conducted at the ClinicalPathology Installation and Blood Bank Dr. Soetomo General Hospital Surabaya in the period July- September 2020. Levels of 2,3 DPG and lactic acid were measured in 16 bags of Whole Bloodcomponents on the day 1, day 5, day 10, day 20 and day 30. Statistical analysis was performed usingthe Friedman test. The results were statistically significant if p <0.05. The Friedman statistical testshowed that there were significant differences in levels of 2.3 DPG (p <0.001) and levels of lacticacid (p <0.001) during storage. The results showed that the level of 2,3 DPG in WB which was storeddecreased according to the duration of storage. The yield of lactic acid on stored WB increased withthe duration of storage. Therefore, saving WB is recommended to be given within <6 days to reducethe risk of acidosis. Further research is needed for other parameters that can affect the storage process.
Soluble Cluster of Differentiation 25 (sCD25) as a Predictor of Mortality of COVID-19 Patients in Surabaya, Indonesia Harida Zahraini; Betty Agustina Tambunan; Bambang Pujo Semedi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17553

Abstract

The purpose of this study was to analyze and determine the cut-off level of sCD25 as a predictor ofmortality in COVID-19 patients. In an observational analytic study with a prospective cohort design, thestudy population was COVID-19 patients who were hospitalized at RIK RSUD Dr. Soetomo Surabayafor the period July 2020-December 2020. Sampling was taken by consecutive sampling, divided intotwo groups, mild-moderate and severe-critical groups. The examination of sCD25 levels in both groupswas carried out on day-0 and day-6 of hospitalization using the sandwich ELISA method. The pairedgroup statistical analysis used the Wilcoxon range test, the unpaired group used the Mann WithneyU test. ROC curve analysis to determine the cut off level of sCD25 as a predictor of mortality. Therewere a total of 83 study patients consisting of 36 patients in the mild-moderate group, 47 patients inthe severe-critical group. There was a difference in sCD25 levels between mild-moderate COVID-19patients who were treated on day-6 compared to day-0, whereas in the severe-critical group there wasno difference in sCD25 levels. There was a difference in sCD25 levels in COVID-19 patients betweenthe mild-moderate group by severe-critical. The level of sCD25 with a cut off of 3.14 ng/mL (AUC0.719, p = 0.001) can be used as a predictor of mortality in COVID-19 patients with a sensitivity of96.2%, a specificity of 47.4%. Levels of sCD25 >3.14 ng/mL can be used as a predictor of mortality inCOVID-19 patients
Co-Authors Almira Saskia Sabila Anindya Widyasari Arifoel Hajat Aryati Aryati Awalia Awalia Citra Novita Desak Nyoman Surya Suameitria Dewi Devi Rahmadhona Dwi Ajeng Roosanti Edward Kusuma Endang Retnowati Ersa Bayung Maulidan Faizatuz Azzahrah Syamsudi Francisca Srioetami Tanoerahardjo Fransiska Sri Oetami Hardiono Hardiono Hardiono Hardiono Harida Zahraini I. Komang Parwata IGAA. Putri Sri Rejeki Istiana Hairiah Abas John Wiwin Jusak Nugraha Jusak Nugraha Jusak Nugraha Kintan Putri Mario Mario Maulydia Miftahul Ilmiah Mirna Rahmafindari Ni Made Rindra Hermawathi Oetami, Fransisca Sri Paulus Budiono Notopuro Rahma Indah Pratiwi Semedi, Bambang Pujo Siti Nurul Hapsari Soedarsono Soedarsono Soeprapto Maat Sri Rejeki Wulandari Tanzilia, May Fanny Tedja, I G.A. Wiradari Tigor Pandapotan Sianturi Vicky S. Budipramana Willy Sandhika Windu Nafika Yulia Nadar Indrasari