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All Journal Dental Journal (Majalah Kedokteran Gigi) Journal of Dentomaxillofacial Science Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Journal of Dental Medicine Berkala Penelitian Hayati
Rini Devijanti Ridwan
Department Of Oral Biology Faculty Of Dentistry Airlangga University Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Journal : Journal of Dentomaxillofacial Science

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A.actinomycetemcomitans adhesi protein increasing IL-8 titre in heart of wistar rat with aggressive periodontitis (Protein adhesin dari A.actinomycetemcomitans meningkatkantiter IL -8 di dalamjantungtikuswistar denganperiodontitis agresif) Rini Devijanti Ridwan; Retno Indrawati
Journal of Dentomaxillofacial Science Vol. 13 No. 2 (2014): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v13i2.392

Abstract

Cardiovascular and periodontal diseases are common inflammatory conditions in the human population. Tlymphocytesparticipateinthepathogenesis and inflammatory events of atherosclerosis. These immune cells enter theinflamed artery wall and join macrophages via a number of interferon-c-inducible chemokines. Chemokines (IL-8),cytokines, and growth factors also participate in this process. The interaction between interleukin- 8 and its receptor,CXCR2, can also contribute to lesion formation in mice. The main causes of aggressive periodontitis isActinobacillusactinomycetemcomitans. Previous studies have proven that adhesin protein with 24 kDa molecular weight from A.actinomycetemcomitans is a specific adhesin, this adhesin proteins play a role in the adhesion process on host. thiskind adhesion in the epithelial attachment would lead to colonization and invasion ofA.actinomycetemcomitans thatwill stimulate the host immune response. This study aimed to analyze the influence of induction 24 kDaA.actinomycetemcomitans adhesin protein to the titre of IL-8 in heart of Wistar rat with aggressive periodontitis usingElisa method to measure and analyze the titre of IL-8. After analyzed with analysis of variance, showed significantdifferences of IL-8 titre in the control group and the group with the induction byA.actinomycetemcomitans,A.actinomycetemcomitans plus 24 kDa A.actinomycetemcomitans adhesin protein, and only with 24 kDaA.actinomycetemcomitans adhesin protein. It can be concluded that A.actinomycetemcomitans adhesin protein with 24kDa molecular weight has a role in increasing of IL-8 titre in heart wistar rat with aggressive periodontitis.
Co-Authors Devi Rianti Diah Savitri Ernawati Dimas Rudianto Fardha Eha Renwi Astuti Hendrik Setia Budi Hesham Mohammed Al-Sharani Ika Rhisty Cendana Sari Indeswati Diyatri Ira Widjiastuti Jihan Hijriya Nabilla K. Kuntaman Kinanti Nasywa Prajnasari Mahela Sefrian Luthfimaidah Markus Budi Rahardjo Moh. Malik Alhakim Mohammed Aljunaid Nova Andriani Hepitaria Nur Dianawati Oktaviani Suci Lestari Putra, Ramadhan Hardani R. Darmawan Setijanto Reinaya Tifa Pratiwi Retno Indrawati Roestamadji Riski Rahayu Putri Rahmasari Sidarningsih Sidarningsih, Sidarningsih Soetjipto Soetjipto Subijanto Marto Sudarmo Tantiana Tantiana Tuti Kusumaningsih Tuti Kusumaningsih Wahyu Setyarini Willy Wijaya Wisnu Setyari Juliastuti Yeka Ramadhani Yuliati