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All Journal Folia Medica Indonesiana MNJ (Malang Neurology Journal) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology AKSONA
Turchan, Agus
Departemen Bedah Saraf, Fakultas Kedokteran, Universitas Airlangga; RSUD Dr. Soetomo, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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The Effect of Estrogen, Progesterone, and Its Combination on The Expression of Brain-Derived Neurotrophic Factor Medula Spinalis in Regeneration Process of Peripheral Nerve Mochamad Rizki Yulianto1 , Agus Turchan1 , Hari Basuki Notobroto2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.12094

Abstract

Background: The presence of modulation factors in the regeneration process of peripheral nerve cellsinfluenced by estrogen and progesterone. Peripheral nerve injury is a fairly common case of trauma. Brainderived neurotrophic factor (BDNF) is the most active group of neurotrophins in stimulating neurogenesis.Objectives: To proves the effect of estrogen and progesterone on the expression of BDNF on the spinal cordin peripheral nerve regeneration process. Methods: Laboratory experimental study with the completelyrandomized design. Total transitory nerve ischiadicus was performed on four groups of rats. Each groupreceived hormone therapy according to the group. Hormone therapy is administered every 3 days for28 days, and on the 29th day is termination, spinal cord sampling, and followed by BDNF expressionexamination by Immunohistochemistry method. Results: In the control group, BDNF expression of spinalcord neuron cells was 93.0±14.0. In the treatment group, BDNF expression was obtained after estrogentherapy was 77.25±19.19, progesterone was 84.5±20.61, and in a combination of estrogen and progesteronewas 77.75±16.54. After statistical tests, no significant differences were found between the treatment groups(p = 0.316). Conclusion: The administration of estrogen, progesterone, or a combination of both did notsignificantly increase BDNF expression when compared to the control group.
NUMERIC RATING SCALE ANALYSIS OF TRIGEMINAL NEURALGIA PATIENTS BEFORE AND AFTER MICROVASCULAR DECOMPRESSION Fitri Amelia, Elena Ghentilis; Turchan, Agus; Rehatta, Nancy Margarita; Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 7, No 1 (2021): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.4

Abstract

Background: Trigeminal Neuralgia is a common condition of facial pain and its significantly affect patients’ daily life. Microvascular decompression is one of the interventional pain management for trigeminal neuralgia. There is still a little data obtained on evaluation of facial pain after microvascular decompression in Indonesia.   Objective: This research aimed to evaluate facial pain after microvascular decompression of  trigeminal neuralgia patients in Dr. Soetomo General Hospital, PHC Hospital, and Bangil General Hospital, Indonesia.Methods: The research design was a pretest-posttest with total sampling. Data were obtained from medical records from January 2018 until June 2019. Researches used Numeric Rating Scale (NRS) as pain measurement. The data obtained were analyzed by descriptive statistical test, normality test, and paired t-test.Results: Trigeminal Neuralgia patients that has been treated with microvascular decompression have an average facial reduction from 7.33±2.29 to 1.89±3.41 with p = 0.001. This result showed that the microvascular decompression has significantly reduce facial pain in patients with trigeminal neuralgia.Conclusion: Microvascular decompression significantly reduce the facial pain of trigeminal neuralgia patients.
Case Report: Ventriculoperitoneal Shunt Catheter Migration and Transanal Extrusion in Persistent Vegetative State Adult Patient Asra Al Fauzi; Muhammad Arifin Parenrengi; Joni Wahyuhadi; Eko Agus Subagio; Agus Turchan
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.392 KB) | DOI: 10.20473/fmi.v55i4.24515

Abstract

The complications of ventriculoperitoneal (VP) shunts are many and are reported in literature extensively. The complication of transanal extrusion after bowel perforation is known although rare. This complication is very well described amongst the children. The authors describe the case of bowel perforation and transanal extrusion of a VP shunt occurring in a 51-year-old adult patient. The patient has a history of craniotomy for acute subdural hematoma after severe head injury one year ago continued with VP shunt for post-traumatic hydrocephalus. Home care with bedridden conditions is done at home until finally, the family gets the catheter extrude from the transanal. Bowel perforation and transanal extrusion of VP shunt catheter is a rare but serious problem. The exact pathogenesis of shunt-related organ perforation and extrusion through the anus is unclear, and various mechanisms have been suggested, Among many factors, age is the prominent factor for bowel perforation.1 Because of weak bowel musculature and stronger peristaltic activity, children are more susceptible to bowel perforation than adult patients. In adult shunted patient, one of the risk factors is related to PVS with chronic immobilization, as described in this case. Risk factors of bowel perforation in adult are quite distinct from children. Persistent vegetative state (PVS) with chronic immobilization is one of the risk factors to be aware of.
Adherence of NSAID Administration in Patients with Mild and Moderate Traumatic Brain Injury in Dr. Soetomo General Hospital, Surabaya Finna Permata Putri; Agus Turchan; Nurmawati Fatimah; Muhtarum Yusuf
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 2 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I22021.94-97

Abstract

Introduction: Traumatic brain injury (TBI) has a concerning incidence rate. One of the therapies for patients with TBI is non-steroidal anti-inflammatory drugs (NSAID) administration as an analgesic with proper adherence to achieve optimal therapy results. This research aimed to evaluate physicians’ NSAID administration adherence in patients with mild and moderate TBI in Dr. Soetomo General Hospital, Surabaya.Methods: This was an observational descriptive study with a retrospective design. NSAID administration adherence was graded by evaluating the dose, route, frequency, and interval of NSAID administration. The variables were evaluated by observing the medical records of inpatients with mild and moderate TBI from 1 January to 31 December 2018.Results: NSAIDs used for TBI management were metamizole, paracetamol, mefenamic acid, and ketorolac. Metamizole was administered in 10 patients (34.5%), paracetamol in 1 patient (3.4%), metamizole and  paracetamol in 15 patients (51.7%), metamizole and mefenamic acid in 1 patient (3.4%), metamizole and paracetamol with mefenamic acid in 1 patient (3.4%), and metamizole and ketorolac in 1 patient (3.4%). Adherence of paracetamol, mefenamic acid, and ketorolac administration in patients with mild and moderate TBI were well-administered in every evaluated variable. Metamizole administration’s adherence was already well-administered in drug dosage and drug administration route, but it was not well-administered in drug administration interval and frequency.Conclusion: Physicians’ adherence to NSAID administration in patients with mild and moderate TBI in Dr. Soetomo General Hospital, Surabaya was well-administered, except for metamizole.
SERUM GLIAL FIBRILLARY ACIDIC PROTEIN LEVELS PROFILE IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY Arief S. Hariyanto; Endang Retnowati; Agus Turchan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1151

Abstract

Glial Fibrillary Acidic Protein (GFAP) sangat khas untuk otak (highly brain specific protein), sebagai petunjuk kerusakan sel,merupakan protein yang berhubungan dengan peningkatan tekanan intrakranial dan sebagai petanda perjalanan penyakit di pasiencedera otak. Penelitian ini menganalisis profil kadar GFAP serum pasien cedera otak berat sebagai petanda perjalanan penyakit dankeluarannya. Desain penelitian deskriptif observasional. Kadar GFAP serum dari sampel darah vena, diperiksa dengan metode ELISApada hari pertama datang ke Instalasi Gawat Darurat dan hari ke-2,3,4 perawatan. Jumlah sampel 25 orang, laki-laki 20 orang (80%),perempuan 5 orang (20%). Umur terbanyak ≤ 25 tahun, 8 orang (32%), rerata umur 35,92 ± 13,80 tahun. Jejas berdasarkan hasilCT Scan kepala terbanyak Diffuse Axonal Injury (DAI) 7 (28%), tindakan operasi sebanyak 18 (72 %), non-operasi 7 (28%), penyebabcedera, kecelakaan lalu lintas 23 (92%), jatuh 2 (8%). Rerata kadar GFAP serum hari ke-1,2,3,4 berturut-turut 2,72±1,44 ng/mL,1,85±0,85 ng/mL, 1,67±1,26 ng/mL, 0,79±0,35 ng/mL. Keluaran pasien, hidup 19 (76%), meninggal 6 (24%). GFAP sangat khaspada otak berguna sebagai petanda di pasien cedera otak berat, yaitu peningkatan kadarnya dapat digunakan sebagai faktor perjalananpenyakit untuk kematian dan keluarannya. Peningkatan kadar GFAP serum dapat digunakan sebagai faktor perjalanan penyakit.Penelitian lanjutan diperlukan dengan sampel yang lebih besar
Pengaruh Usia dan Jenis Kelamin pada Skala Nyeri Pasien Trigeminal Neuralgia Hanik Badriyah Hidayati; Elena Ghentilis Fitri Amelia; Agus Turchan; Nancy Margarita Rehatta; Atika; Muhammad Hamdan
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.957 KB) | DOI: 10.20473/aksona.v1i2.149

Abstract

Pendahuluan: Trigeminal neuralgia (TN) merupakan kondisi yang digambarkan sebagai nyeri hebat seperti tersilet pada satu sisi wajah  pada distribusi area saraf ke lima. Nyeri ini dapat mengganggu aktivitas sehari-hari pasien. Rasa nyeri merupakan fenomena subjektif yang dapat dipengaruhi oleh banyak faktor, seperti usia dan jenis kelamin. Tujuan: Mengetahui pengaruh usia dan jenis kelamin terhadap skala nyeri pasien Trigeminal Neuralgia. Metode: Data diambil dari rekam medik pasien pada periode Januari 2017 hingga Juni 2019 di RSUD Dr. Soetomo Surabaya, RS PHC Surabaya, dan RSUD Bangil Pasuruan berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: TN banyak ditemukan pada kelompok usia  36-64 tahun (55,55%) dan jenis kelamin perempuan (66,67%). Tidak didapatkan hubungan pengaruh usia dan jenis kelamin terhadap skala nyeri pasien (p > 0.05). Kesimpulan: Usia dan jenis kelamin merupakan faktor yang tidak dapat diubah dalam mempengaruhi nyeri. Usia dan jenis kelamin mempengaruhi nyeri melalui perubahan anatomi, hormonal, dan psikologis. Tidak ada hubungan antara usia dan jenis kelamin pada skala nyeri pasien dengan TN.  
Penyakit Parkinson: Tinjauan Tentang Salah Satu Penyakit Neurodegeneratif yang Paling Umum Safia Alia; Hanik Badriyah Hidayati; Muhammad Hamdan; Priya Nugraha; Achmad Fahmi; Agus Turchan; Yudha Haryono
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.044 KB) | DOI: 10.20473/aksona.v1i2.145

Abstract

Penyakit Parkinson (PP) adalah penyakit neurodegeneratif paling umum ke dua yang melibatkan hilangnya neuron dopaminergik di otak tengah yang menyebabkan gejala motorik dan nonmotorik pada pasien yang mengalaminya. Gejala motorik ini dapat dikelola dan dikendalikan dalam  jangka waktu tertentu dengan menggunakan obat-obatan seperti levodopa. PP mempengaruhi jutaan orang di seluruh dunia, oleh karena itu tinjauan pustaka tinjauan pustaka tentang PP menjadi penting dan kami akan menyampaikan berbagai hal penting dari PP mulai dari patofisiologi hingga tindakan pengobatan baik medikamentosa maupun tindakan intervensi.
An Overview of the Quality of Life of Post Severe Brain Injury Patients within 2018-2020 Period of Time in Dr. Soetomo General Academic Hospital based on Short Form-36 Agus Turchan; Alivery Raihanada Armando; Meisy Andriana; Martha Kurnia Kusumawardani
AKSONA Vol. 2 No. 2 (2022): JULY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1300.511 KB) | DOI: 10.20473/aksona.v2i2.35816

Abstract

Highlight: Until today, Traumatic Brain Injury is still a major cause of death, disability, and a serious health issue Traumatic Brain Injury patients have a good quality of life if they get adequate therapy and on time interventions   ABSTRACT Introduction: Approximately 90 million traumatic brain injury (TBI) cases worldwide exist yearly. TBI pathophysiology varies, which may cause diverse complications. These complications may decrease the patients’ quality of life. Objective: Describing the quality of life of traumatic brain-injured patients after being treated at Dr. Soetomo General Academic Hospital Period 2018-2020. Methods: This research is a descriptive cross-sectional study using SF-36 questionnaire data from patients with post-severe brain injury at Dr. Soetomo General Academic Hospital in 2018-2020. Results: The value of the physical component (59.9) and mental component (68.6) in patients with severe brain injury at Dr. Soetomo General Academic Hospital showed a good quality of life, with values ​​in the SF-36 domains, namely physical function (58.2), physical limitations (46.7), body pain (73.6), general health (61.3), vitality (65.3), social functioning (72.5), emotional limitations (60), and mental health (76.5) is above the threshold value (50) except for physical limitations (46.7).Conclusion: Patients with severe brain injury had a good quality of life after receiving treatment in Dr. Soetomo General Academic Hospital.
Co-Authors Achmad Fahmi Alia, Safia Alivery Raihanada Armando Amelia, Elena Ghentilis Fitri Arief S. Hariyanto Asra Al Fauzi Atika atika Elena Ghentilis Fitri Amelia Endang Retnowati Fahmi, Achmad Fauzi, Asra Al Finna Permata Putri Fitri Amelia, Elena Ghentilis Hanik Badriyah Hidayati, Hanik Badriyah Joni Wahyuhadi, Joni Martha Kurnia Kusumawardani Meisy Andriana, Meisy Muhammad Arifin Parenrengi Muhammad Hamdan Muhammad Hamdan Muhammad Hamdan1, Riani Wisnujono1, Yudha Haryono1, Abdulloh Machin1, Dian Puspitarini1 Nugraha, Priya Nurmawati Fatimah Parenrengi, Muhammad Arifin Priya Nugraha Rehatta, Nancy Margarita Safia Alia Subagio, Eko Agus Yusuf, Muhtarum