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Rifda Naufalin
Fakultas Pertanian, Jenderal Soedirman University
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Journal : Mandala of Health : A Scientific Journal

 1 
EFFECT OF TORCH GINGER EXTRACT (Etlingera elatior) ON THE ERADICATION OF Aggregatibacter actinomycetemcomitans BIOFILM ANS CAUSES AGGRESSIVE PERIODONTITIS Meylida Ichsyani; Haris Budi Widodo; Rifda Naufalin; Aisha Tiara Dewi; Adninda Rimawati; Devi Anisya Putri; Novita Dwi Lokasari
Mandala Of Health Vol 13 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2021.13.2.8745

Abstract

Aggregatibacter actinomycetemcomitans is an oral microflora that forms biofilms and is the main cause of aggressive periodontitis. Long-term mouthwash therapy can cause mucositis and even oral cancer. The ethanol extract of torch ginger (Etlingera elatior) is reported to have analgesic, anti-inflammatory, and antibacterial activities, so it can be developed as an alternative to prevention or adjuvant therapy for aggressive periodontitis. The aim of this study was to determine the effect of the ethanol extract of the torch ginger plant on the biofilm degradation of A. actinomycetemcomitans. The study used ethanol extracts of torch ginger flowers, leaves, and stems at concentrations of 1.56 mg/mL, 3.125 mg/mL, 6.25 mg/mL, 12.5 mg/mL, 25 mg/mL, and 50 mg/mL. CHX 0.2% mouthwash was used as a positive control, while 1% DMSO was used as a negative control. The biofilm degradation test was carried out using a microtiter plate assay with 1% crystal violet staining at a wavelength of 450 nm. The results showed that there was significant activity against biofilm degradation of A. actinomycetemcomitans in the administration of an ethanol extract of torch ginger flowers, leaves, and stems compared to the negative control (p<0.05). The optimum concentrations of biofilm degradation by extracts of flowers, leaves, and stems were 25 mg/mL (85.54%), 25 mg/mL (84.43%), and 50 mg/mL (72.10%), respectively. MBEC50 values of flowers are 4.82 mg/mL, MBEC50 leaves are 5.96 mg/mL, and MBEC50 stems are 10.15 mg/mL. The conclusion of this study is that there is an effect of giving an ethanol extract of torch ginger flowers, leaves, and stems on the biofilm degradation of A. actinomycetemcomitans bacteria.
Co-Authors A Haris Budi Widodo A.A. Ketut Agung Cahyawan W Adninda Rimawati Aisha Tiara Dewi Anna Sulistyaningrum Budi Sustriawan Condro Wibowo Devi Anisya Putri Diah Setyorini Gunawan Dimas Arya Denta Dwi Nugroho Wibowo Edi Susilo Erminawati Erminawati Erminawati Erminawati Friska Citra Agustia Haris Budi Widodo Herastuti Herastuti Herastuti Sri Rukmini Herastuti Sri Rukmini Herastuti Sri Rukmini Herastuti Sri Rukmini Herastuti Sri Sukmini Hidayah Dwiyanti Hidayah Dwiyanti Icuk Rangga Bawono Icuk Rangga Bawono Icuk Rangga Bawono Indra Warman Islami, Laila Sausan El Jajang Jajang Kusmantoro Edy Sularso Meylida Ichsyani Novita Dwi Lokasari Nur Aini Nurul Latifasari Parwito Parwito Poppy Arsil Poppy Arsil Poppy Arsil Ritonga, Abdul Mukhlis Rumpoko Wicaksono Rumpoko Wicaksono Rumpoko Wicaksono Rumpoko Wicaksono Sakhidin Santi Dwi Astuti Siti Nuryanti SR Herastuti, SR Sri Maryani Sulasih Tri Yanto Tri Yanto Tri Yanto Tri Yanto triana setyawardani Weni Novandari Wicaksono, Rumpoko Wuryatmo, Erminawati