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All Journal Indonesian Journal of Tropical and Infectious Disease Care : Jurnal Ilmiah Ilmu Kesehatan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology
Muhammad Vitanata Arfijanto
1. Division Of Tropical Infectious Disease, Departemen Ilmu Penyakit Dalam FK - Unair RSUD Dr. Soetomo Surabaya 2. Institute Of Tropical Disease Airlangga University
Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga

 1 
Sepsis: Antibiotic Resistances of Gram-Positive and Gram-Negative Bacterial in a Tertiary Care Hospital Siti Nurul Jannah; Muhammad Vitanata Arfijanto; Musofa Rusli; Agung Dwi Wahyu Widodo
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 12 No. 1 (2021): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V12I12021.29-37

Abstract

Introduction: Sepsis is a systemic infection that causes multiorgan failure and death. The death rate that is caused by sepsis is increasing. This high value of death has a correlation with the resistance of antibiotics. However, increased antibiotic resistance is not balanced with new research about antibiotics. As a consequence, it causes difficulties in handling sepsis patients who need antibiotic 1-2 hours after diagnosis is enforced. Methods: This was a descriptive study with case study design to analyze medical records of the patients, evaluating the pattern of bacterial resistance to antibiotic in 221 patients with sepsis with 240 blood isolates to identify. Results: From 221 patients identified as sepsis, there were 97 male patients (43.9%) and 124 female patients (56.1%), mostly between 18-59 years old (63.8%), with the highest level in female (54.8 %) and elderly (66.3%). The bacteria that caused the most sepsis were gram-positive. The most species in gram-positive are Staphylococcus haemolyticus (16.3%) and Staphylococcus aureus (12.5%), and the most species in gram-negative is Escheriichia coli (13.3%). The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam (100%), Daptomycin (99.2%), and Clindamycin (99.2%). The sensitive antibiotics in gram-negative bacteria were Amikacin (85.9%), Cefoperazone (84.6%), and Piperacillin-Tazobactam (84.1%). Conclusion: The most sensitive antibiotics in gram-positive bacteria were Piperacillin-Tazobactam, Daptomycin, and Clindamycin. The sensitive antibitics in gram-negative bacteria were Amikacin, Cefoperazone, and Piperacillin-Tazobactam. 
Co-Authors Agung Dwi Wahyu Widodo Aryati Aryati Asmarawati, Tri Pudy Bramanton Bramantono - Brian Eka Rachman Dominicus Husada Heri Krisnata Ginting Ilham Munandar Jihan Kalishah Lydia Juanita M Thohirin Ramadhani Maria Lucia Inge Lusida Meiwinda Rizky Nurhidayah Moh. Hamzah Raka Pratama Musofa Rusli Nasronudin Nenci Siagian Prihartini Widiyanti S. Ugroseno Yudho Bintoro Siti Irma Mashitah Siti Nurul Jannah Ulfa Kholili Usman Hadi Usman Hadi