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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology
Usman Hadi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Varicella Pneumonia in an Elderly Patient Isidro Lumanpauw; Usman Hadi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16918

Abstract

Varicella pneumonia is a common complication in adults, while it is a mild and self-limiting disease inchildren. Elderly patients may have severe manifestations compared to adults due to the weakening oftheir immune system in clearing the virus. Treatment with intravenous acyclovir and varicella-zosterimmunoglobulin (VZIG) offers a good prognosis, while the use of steroids is still debated. Despite standardmanagement, our case presents a fatality in an older woman with varicella pneumonia.
Physical Exercise in Clinical Stage IIhuman Immunodeficiency Virus Infection Patients’ Increasesskeletal Muscle MAss Through the Increasing of Myogenic Regulatory Factors Expression Sri Mardjiati Mei Wulan; Hening Laswati; Usman Hadi; Nasronudin Nasronudin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17091

Abstract

Background: Human Immunodeficiency Virus infection is a chronic diseasethat threatensthe health ofmillionsof people inthe worldand causing disability. One of the factors that causedisabilityis HIVmusclewasting,causing a decrease inthe quality of lifethat interferethe daily activitiesand evenincreased mortality. Properphysical exercise is needed to prevent and treat muscle wasting.Methods: This studyusinghuman subjectswithclinicalstageII HIVinfection. Subjectswere groupedinto two:Intervention (n =9) that subjects whogetmoderate-intensity physicalexercise (HIVA) for 8weeks andControl (n=9) as subjects wereobservedfor 8 weeks. Muscles samples were taken fromthe vastuslateralismusclebiopsiesthat performed24 hoursafterthe lastphysical exercise,immunohistochemicalexaminationwithmonoclonalantibodyanti-Pax7, anti-MyoD1 andanti-myogenin and measurement of thigh circumference.Results: Therewere significant increase in regeneration of skeletal muscle in the intervention group(increasing of Pax7, MyoD1 and myogenin) than the control groupand significant increase in quadricepsmuscles mass as measured by thigh circumference (p < 0.001).Conclusion: HIVA physical exerciseof moderate intensityincreasesskeletal muscleregenerationinclinicalstageII HIVinfectionthroughthe increasingPax7, MyoD1, myogeninexpression and followed by an increaseof quadriceps muscles mass.
Successful Treatment of Cerebral Tuberculoma and Tuberculous Lymphadenitis in an HIV/AIDS Patient: A Case Report Tenta Hartian Hendyatama; Usman Hadi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17654

Abstract

Tuberculosis is one opportunistic infection that may occur in HIV/AIDS patients. Its clinical presentation may depend on infected organs. A 37-years old man complained of left limb weakness followed by mild fever, weight loss of more than 10 kgs within two months, and swelling in his left submandibular region. Laboratory tests showed mild anemia, hypoalbuminemia, and positive serology HIV test. Histopathological examination of neck swelling showed inflammation of chronic granulomatous tuberculous with acid-fast bacilli positive in Ziehl Nielsen staining. Head CT scan with contrast, showed multiple isodense lesions with rim contrast enhancement accompanied by perifocal edema. Anti-Tuberculosis Drug and Anti-Retroviral Therapy were given as a combination treatment for this patient. Clinical and radiological improvement in the patient indicated good outcome and successful treatment.
A Patient with AIDS and Embolic Stroke: A Case Report Troy Fonda; Usman Hadi
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17656

Abstract

Human immunodeficiency virus (HIV) infection is a global concern. Globally, 36.7 million people are living with HIV and 1 million people died at the end of 2016. There is an association between human immunodeficiency virus (HIV) infection with neurological manifestations. Between 1% and 5% of patients with HIV develop stroke. The pathogenesis of AIDS with stroke is still controversial. A 37-year-old male patient with AIDS had an embolic stroke. The diagnosis of the patient was based on clinical condition and the CT scan results of the head with contrast. The stroke-causing mechanism in patients is HIV-associated vasculopathy that results from accelerated atherosclerosis. After administration of antiplatelet and statin, the patient’s condition improves.
Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia Usman Hadi; Bramanton; Tri Pudy Asmarawati; Musofa Rusli; Nasronudin; Brian Eka Rachman; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17659

Abstract

Introduction: World Health Organization had identified COVID-19 in January 2019. This disease is caused by SARS-CoV-2, which spread throughout the world and became a pandemic on March 20, 2020. COVID-19 is still a health problem because it has not clear whether the patients will be cured and survive from the disease or not. This study aims to determine the predictors of mortality from COVID-19 at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia.Method: This study was conducted in Dr. Soetomo General Academic Hospital (referral hospital for COVID-19, 1500 beds) and Universitas Airlangga Hospital (Referal Hospital for COVID-19, 600 beds). The study used data on patients with confirmed COVID-19 who were hospitalized at these two referral hospitals. Predictors of mortality were analyzed using logistic regressions.Result: There were 247 COVID-19 patients enrolled in this study, all patients were tested positive PCR SARS-CoV-2. The main complaints were cough, nasal congestion, dyspnea, and fever. Significant predictor mortality in this study were age >60 years old (OR: 3.24, 95% CI, 1.36 - 7.70), chronic kidney disease (OR: 5.71, 95% CI, 2.05 - 15.89), obesity (OR: 8.22, 95% CI,1.5 - 54.17), malignancy (OR: 6.025, 95% CI, 1.1- 33.00), coronary heart disease (OR: 5.31, 95% CI, 1.28 - 21.98) , and C-reactive protein >10 mg/L (OR 4.603, 95% CI, 2.03 - 10.44).Conclusions: Obesity and the presence of malignancy, chronic kidney disease, heart disease and age >60 yearsold are the strongest predictors of mortality in people with COVID-19, despite high CRP results.
Analysis of Risk Management Cycle on Capitation Mechanism at First Level Healthcare Facilities in East Java Rachmad Suhanda; Usman Hadi; Widodo J. Pudjirahardjo; Djazuly Chalidyanto
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14381

Abstract

The implementation of risk management is an essential function in an organization to control risk. Basedon the preliminary research that has been carried out, only 4.2% of FLHF in East Java implemented thecomplete risk management process, starting from establishing context to evaluating risks. Modificationsof risk management cycle implementation are made by reviewing the opinion of Carroll (2001) and ISO31000:2009. This research aims to analyze the influence between the stages of implementing modified riskmanagement based at 95 FLHF in East Java. The results show that each stage of the capitation mechanismrisk management has a strong significant influence on each other. The results provide recommendation thatFLHF should improve the understanding and awareness of the risks and expected to be able to apply riskmanagement cycle as a whole.
Influence of Employee Relationship Unit on Team Intention:A Case Study in Implementation of Patient Safety Program Heru Suswojo; Usman Hadi; Widodo Jatim Pudjirahardjo; Fendy Suhariadi; Agung Dwi Laksono
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15792

Abstract

Incidencesregarding patient safety still occur,and not all are reported to the Hospital Patient SafetyCommittee. The aim studyto analyze the employee relationship influences the work unit staff’s intention inimplementingthe patient safety program—the study was conducted bythe quantitative design of observationalanalytics and through a cross-sectional staff approach. The research sites includedSidoarjo Regional Hospital,Anwar Medika Sidoarjo Hospital, and Ahmad Yani Surabaya Islamic Hospital. The research collects dataduring May–July 2019. The variables consist of employee relationship as the independent variable andintention as the dependent variable. The results show that the development stage’s employee relationshipwas broadly establishing (46.51%), whereas, for the relationship stage, it was a majority of trusts (72.09%).The source intention stage was mostly personal intention(62.79%), and at the intention level, most of thedistal intention was 84.88%. The leadership type affects theworking unit staff’s discretionto implementpatient safety programs in hospitals, with employee relationships as a variable mediator.The study concludedthat the employee relationships had a significant influence on the working unit staff’s intention in hospitalsto carry out patient safety programs. However,employee relationships affect the work unit staff’s intentionto carry out the patient safety program.
A Patient with AIDS and Embolic Stroke: A Case Report Troy Fonda; Usman Hadi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15828

Abstract

Human immunodeficiency virus (HIV) infection is a global concern. Globally, 36.7 million people areliving with HIV and 1 million people died at the end of 2016. There is an association between humanimmunodeficiency virus (HIV) infection with neurological manifestations. Between 1% and 5% of patientswith HIV develop stroke. The pathogenesis of AIDS with stroke is still controversial. A 37-year-old malepatient with AIDS had an embolic stroke. The diagnosis of the patient was based on clinical condition andthe CT scan results of the head with contrast. The stroke-causing mechanism in patients is HIV-associatedvasculopathy that results from accelerated atherosclerosis. After administration of antiplatelet and statin, thepatient’s condition improves.
ANALYSIS OF DENGUE SPECIFIC IMMUNE RESPONSE BASED ON SEROTYPE, TYPE AND SEVERITY OF DENGUE INFECTION Ade Rochaeni; Aryati Aryati; Puspa Wardhani; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1199

Abstract

Infeksi Virus Dengue (IVD) menimbulkan derajat klinis beragam dari DD hingga DBD/SSD. Respons imun spesifik dengue berupaIgM dan IgG anti dengue masih merupakan perdebatan untuk patogenesis DBD di samping faktor virulensi virus dan jenis infeksi.Penelitian ini bertujuan untuk menganalisis respons imun spesifik dengue terhadap serotipe, jenis dan derajat IVD di Surabaya. Subjekadalah pasien IVD yang dirawat di Ruang Tropik Infeksi Penyakit Dalam RSUD Dr. Soetomo dengan hasil penyaringan uji cepat NS1 (SDBioline Dengue Duo) dan/atau PCR (Simplexa Dengue) positif. Pemeriksaan IgM dan IgG anti dengue kuantitatif dengan metode ELISA(Panbio Dengue Duo IgM and IgG Capture). Penelitian dilakukan Maret–Agustus 2016 dan didapatkan 61 pasien dengan hasil NSI dan/atau PCR dengue positif. Identifikasi serotipe didominasi DEN-3, namun serotipe yang lebih virulen ditunjukkan DEN-1 yaitu semuapasien bermanifestasi sebagai infeksi sekunder dan DBD. Jenis infeksi primer sebanyak 19 (31,1%) dan infeksi sekunder 42 (68,9%).Derajat IVD meliputi DD 10 (16,4%), DBD 47 (77%) dan SSD 4 (6,56%). Nilai indeks rerata IgM dan IgG anti dengue di kelompokinfeksi serotipe DEN-1 (5,140 dan 5,774), DEN-2 (2,971 dan 2,222), DEN-3 (1,863 dan 2,792); kelompok jenis infeksi primer (1,478 dan0,746), sekunder (4,028 dan 4,864) dan kelompok derajat DD (1,170 dan 1,492), DBD I (3,370 dan 3,651), DBD II (3,924 dan 4,439)dan DBD III (4,164 dan 4,243). Sebagai simpulan respons imun spesifik dengue didapatkan lebih tinggi bermakna di kelompok infeksiserotipe DEN-1, kelompok jenis infeksi sekunder dan kelompok DBD/SSD.
IDENTIFICATION OF DENGUE VIRUS SEROTYPES AT THE DR. SOETOMO HOSPITAL SURABAYA IN 2016 AND ITS CORRELATION WITH NS1 ANTIGEN DETECTION Jeine Stela Akualing; Aryati Aryati; Puspa Wardhani; Usman Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1138

Abstract

Serotipe virus dengue yang beredar terus mengalami perubahan dan berbeda di setiap daerah. Pergeseran serotipe maupun genotipedi dalamnya, mempengaruhi terjadinya wabah dengue di berbagai negara. Perbedaan serotipe diduga bernasab dengan deteksi antigen(Ag) non-structural 1 (NS1), namun belum banyak penelitian yang mendukung hal tersebut. Penelitian potong lintang dikerjakan sejakFebruari-Agustus 2016 dan didapatkan 60 subjek infeksi virus dengue (IVD) dan 25 non-IVD. Ribonucleic acid (RNA) virus denguediperiksa di semua subjek menggunakan Simplexa Dengue Real-Time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR)termasuk identifikasi serotipe virus dengue dan pemeriksaan NS1 menggunakan uji cepat NS1 Panbio. Perbedaan perbandingan variabelkategorikal dianalisis dengan uji Fisher Exact. Kenasaban antara serotipe dengan deteksi Ag NS1 dianalisis dengan Chi-Kuadrat. RNAvirus dengue terdeteksi di 43 dari 60 subjek IVD (71,7%). Serotipe terbanyak adalah DENV-3 (62,8%). Pergeseran dominasi serotipetelah terjadi di Surabaya, sebelumnya dari DENV-2 ke DENV-1 dan sekarang DENV-3, kemungkinan akibat mobilitas pejamu, transporvirus dan faktor geografis. Kepekaan uji cepat NS1 75% dan kekhasan 100%. Persentase deteksi NS1 antar serotipe berbeda bermakna(p=0,002). Deteksi NS1 lebih rendah pada DENV-1 dibandingkan DENV-2 (p=0,007) ataupun DENV-3 (p=0,003). Serotipe virusdengue bernasab dengan deteksi NS1 (p=0,005). Ciri serotipe maupun genotipe virus dengue kemungkinan mempengaruhi sekresiNS1. Telah terjadi pergeseran serotipe virus dengue di pasien IVD di Surabaya sehingga diperlukan surveillance berkesinambunganuntuk memperkirakan terjadinya wabah. Serotipe bernasab dengan deteksi NS1. Salah satu penyebab hasil negatif palsu NS1 adalahperbedaan serotipe.
Co-Authors Ade Rochaeni Agung Dwi Laksono Aryati Aryati Asmarawati, Tri Pudy Bramanton Bramantono - Brian Eka Rachman Brian Eka Rahman Dicky Febrianto Djazuly Chalidyanto Erika Marfiani Erwin Astha Triyono Fendy Suhariadi Hening Laswati Heru Suswojo Isidro Lumanpauw Jeine Stela Akualing M Vitanata Muhammad Vitanata Arfijanto Musofa Rusli Nasronudin Nasronudin Nasronudin Puspa Wardhani Puspa Wardhani Rachmad Suhanda Sri Mardjiati Mei Wulan Tenta Hartian Hendyatama Tripudi Asmarawati Troy Fonda Widodo J. Pudjirahardjo Widodo Jatim Pudjirahardjo