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All Journal Gravity : Jurnal Ilmiah Penelitian dan Pembelajaran Fisika Indonesian Journal of Physics and Nuclear Applications ORBITA: Jurnal Pendidikan dan Ilmu Fisika SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Amal Ilmiah : Jurnal Pengabdian Kepada Masyarakat Jurnal Pendidikan Fisika dan Sains (JPFS) Jurnal Pengabdian Masyarakat (ABDIRA) Educate: Journal of Community Service in Education PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL)
Rosenti Pasaribu
Department Of Physics Education, Universitas Katolik Widya Mandiri
Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Physics and Nuclear Applications

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Clinical trial design of Boron Neutron Capture Therapy on breast cancer using D-D coaxial compact neutron generator as neutron source and Monte Carlo N-Particle simulation method Rosenti Pasaribu; Kusminarto Kusminarto; Yohannes Sardjono
Indonesian Journal of Physics and Nuclear Applications Vol 1 No 1 (2016)
Publisher : Fakultas Sains dan Matematika Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (578.821 KB) | DOI: 10.24246/ijpna.v1i1.34-43

Abstract

A clinical trial simulation of Boron Neutron Capture Therapy (BNCT) for breast cancer was conducted at National Nuclear Energy Agency Yogyakarta, Indonesia. This was motivated by high rate of breast cancer in the world, especially in Indonesia. BNCT is a type of therapy by nuclear reaction 10B(n,α)7Li that produces kinetic energy totaling 2.79 MeV. High Linear Energy Transfer (LET) radiation of α-particle and recoil 7Li would locally deposit their energy in a range of 5-9 μm, which corresponds to the human cell diameter. Fast neutron coming out of Compact Neutron Generator (CNG) was moderated using Fe and MgF2 material. A collimator, along with breast cancer and the corresponding organ at risk were designed compatible to Monte Carlo N-Particle X (MCNPX). The radiation were simulated by the MCNPX software and the physical quantities were counted by tally MCNPX codes. The highest neutron thermal flux was found at a depth of 1.4 cm on fat tissue. En face and upward intersection radiation techniques were adopted for the breast cancer radiation. The average dose rate of radiation used on breast cancer was 1.72×10-5 Gy/s for the en face method and 8.98×10-6 Gy/s for the upward intersection method. Dose 50±3 Gy was given into cancer cell, (4.18±0.06) ×10-2 Gy into heart and (8.16±0.06) ×10-2Gy into lung for 806.34 hours irradiation.
Co-Authors Alfons Bunga Naen Claudia Mariska Claudia Mariska M. Maing Egidius Dewa Godelfridus H. Lamanepa Godelfridus H. Lamanepa Godelfridus Hadung Lamanepa Godelfridus Hadung Lamanepa Kusminarto Kusminarto Maria Irma Ina Lipat Maria Ursula Jawa Mukin Oktavianus Ama Ki’i Petrus Ola Begu Petrus Ola Begu Tapin Yohanes Yohannes Sardjono