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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK ETANOL DAGING BUAH ALPUKAT (Persea americana Mill.) Yettrie Simarmata; Kesaktian Manurung; Karnerius Harefa; Mei Sri Rezeki Hasibuan
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.698 KB)

Diabetes mellitus is a set of symptoms that arise in a person characterized by blood glucose levels exceeding normal (hyperglycemia) due to a lack of insulin in the body. One of the medicinal plants that can be used is avocado flesh. This study aims to determine the antidiabetic activity of avocado pulp extract (Persea americana Mill) against male white rats. This study used 25 male white rats divided into 5 groups, namely the negative control group CMC-Na 1%, the positive control group glibenclamide 0.45 mg/kg BW, the EEBA test group at doses of 50, 100, 200 mg/kg BW. The results of the one-way ANOVA analysis of the Tukey HSD test showed that the administration of EEBA at a dose of 100 mg/kg BW and EEBA at a dose of 200 mg/kg BW had a significant difference with a significance value of 0.024 and 0.026 and EEBA at a dose of 50 mg/kg BW had no significant difference with the significance 0.275. Based on the results of the study, it can be concluded that EEBA doses of 50, 100, 200 mg/kg BW have antidiabetic activity.

IDENTIFIKASI CEMARAN LOGAM Sn (TIMAH) DALAM SUSU KENTAL MANIS KEMASAN KALENG Siti Maimunah; Yettrie Simarmata; Dina Riani Purba
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Condensed milk or more commonly sweetened condensed milk is cow's milk in which the water is removed and sugar is added, resulting in milk that is very sweet in taste and can last for up to a year if not opened. In general, the term sweetened condensed milk means sweetened milk, namely milk in the form of a thick liquid, yellowish-white or other colors depending on the aroma added, with a distinctive smell and taste. This research was conducted to determine the presence or absence of metallic Sn (tin) in canned sweetened condensed milk in whole and dented cans. The samples examined were whole and dented canned sweetened condensed milk sold around Jalan Kapten Muslim Medan, the samples were taken randomly from three different brands. This study used a qualitative test method, the sample was ashed first using 0.1N HCl solvent, this research was carried out using 0.1N sodium hydroxide reagent there was no white or negative precipitate, using 0.1N sodium carbonate reagent there was no white precipitate or negative. Sweetened condensed milk sold around Jalan Kapten Muslim Medan does not contain Sn (tin) in the qualitative test, this shows that the sweetened condensed milk is safe for consumption.

UJI AKTIVITAS ANTIOKSIDAN DALAM BEBERAPA MINUMAN YOGHURT DENGAN METODE DPPH (1,1-Diphenyl-2-Picryhydrazil) Yettrie Simarmata; Eka Margaret Sinaga; Maringan Silitonga
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Antioksidan merupakan senyawa kimia yang dapat menyumbangkan satu atau lebih electron(electrondonor) kepada radikal bebas untuk menghambat reaksi oksidatif. Salah satu contoh yang berpotensi sebagai antioksidan adalah yoghurt. Yoghurt merupakan pangan yang mengandung sejumlah bakteri hidup yang member efek yang menguntungkan bagi kesehatan karena memiliki aktivitas antioksidan, antimikroba, antidiare serta dapat meningkatkan system kekebalan tubuh. Ada beberapa factor yang dapat mempengaruhi aktivitas antioksidan yoghurt diantaranya suhu, kondisi penyimpanan, dan bahan tambahan yang digunakan seperti penambahan cita rasa buah-buahan. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan probiotik dari minuman yoghurt dengan berbagai merk. Sampel diambil dari Pasar Swalayan yang terdapat di Kota Medan dengan 3 merk yang berbeda yang diberikode A, B, dan C. Aktivitas antioksidannya ditentukan dengan metode DPPH (1,1-diphenyl-2-picryhidrazyl) menggunakan spektrofotometervisible yang diukur pada panjang gelombang 516 nm. Hasil penelitian menunjukkan bahwa ada dua sampel minuman yoghurt yang diberi kode A dan B termasuk dalam kategori kuat dan sampel kode C termasuk dalam kategori lemah. Minuman Yoghurt dengan merek kode A memiliki aktivitas antioksidan yang paling kuat dibandingkan dengan minuman yoghurt merek lain (B dan C) dengan nilai IC50 dari sampel kode A(80,52ml), B(90,14ml), dan C(194,81ml).

FORMULASI SEDIAAN ANTISEPTIK DARI BUAH RIMBANG (Solanum torvum) SEBAGAI HAND SANITIZER Siti Maimunah; Yettrie Simarmata; Eka Margaret Sinaga; Kristini Siboro
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Rimbang fruit (Solanum torvum) has properties as a skin antiseptic. Rimbang fruit extract (Solanum torvum) which has been isolated has antibacterial activity against Staphylococcus aureus bacteria. This is because the Rimbang fruit extract (Solanum torvum) contains compounds such as solasonins, glucosides, saponins, and sterolins. Formulation and testing of antibacterial activity of hand sanitizer gel preparations of Rimbang fruit extract and evaluation of the physical quality of hand sanitizer preparations. Rimbang fruit extract was made by the maceration method using 70% ethanol. Then it was evaporated using a rotary evaporator and the remaining solvent was evaporated until a thick extract was formed. Testing of antibacterial activity by agar diffusion method using disc paper against Staphylococcus aureus by measuring the diameter of the zone of inhibition of bacterial growth. The concentration of Rimbang fruit extract and hand sanitizer gel formula used (F1) 0.5% and (F2) 1%; Evaluation of the physical quality of the hand sanitizer preparation includes organoleptic test, homogeneity test, and pH test. The results of the antibacterial activity test of Rimbang fruit extract against Staphylococcus aureus at a concentration of 0.5% with an inhibitory diameter of 5.2 mm. Meanwhile, the results of the gel hand sanitizer activity test of Rimbang fruit extract obtained the inhibition of Staphylococcus aureus bacteria at a concentration of 1% with a diameter of 9.0 mm.

PENETAPAN KADAR NITRAT PADA IKAN KALENG SARDEN SECARA SPEKTROFOTOMETRI VISIBLE Yettrie Simarmata; Siti Nurbaya; Nina Paramita; Vivi Purwandari
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Canned fish is a food that is synonymous with preservatives and food coloring. In the manufacturing process, manufacturers often use natural preservatives to lower production costs. This research is descriptive research. The research location is at PT. Mutifa. Aims to determine how much nitrate levels in branded canned sardines are sold at supermarkets in the city of Stabat whether they meet the requirements of SNI or not. From the results of the study, the levels of nitrate with Brand A were 0.00694% and sardines with Brand B were 0.0453% with a maximum wavelength of 435 nm. According to regulations set by the government according to SNI Number 01-35481994 nitrate levels should not be more than 0.2%. From all samples of canned sardines studied, it was found that nitrate levels were low and did not exceed SNI requirements.

IDENTIFIKASI CEMARAN LOGAM Sn (TIMAH) DALAM SUSU KENTAL MANIS KEMASAN KALENG Siti Maimunah; Ahmad Hafizullah; Yettrie Simarmata
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2729

Condensed milk or more commonly sweetened condensed milk is cow's milk in which the water is removed and sugar is added, resulting in milk that is very sweet in taste and can last for up to a year if not opened. In general, the term sweetened condensed milk means sweetened milk, namely milk in the form of a thick liquid, yellowish-white or other colors depending on the aroma added, with a distinctive smell and taste. This research was conducted to determine the presence or absence of metallic Sn (tin) in canned sweetened condensed milk in whole and dented cans. The samples examined were whole and dented canned sweetened condensed milk sold around Jalan Kapten Muslim Medan, the samples were taken randomly from three different brands. This study used a qualitative test method, the sample was ashed first using 0.1N HCl solvent, this research was carried out using 0.1N sodium hydroxide reagent there was no white or negative precipitate, using 0.1N sodium carbonate reagent there was no white precipitate or negative. Sweetened condensed milk sold around Jalan Kapten Muslim Medan does not contain Sn (tin) in the qualitative test, this shows that the sweetened condensed milk is safe for consumption.

UJI AKTIVITAS ANTIOKSIDAN DALAM BEBERAPA MINUMAN YOGHURT DENGAN METODE DPPH (1,1-Diphenyl-2-Picryhydrazil) Yettrie Simarmata; Eka Margaret Sinaga; Maringan Silitonga
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2736

Antioxidants are chemical compounds that can donate one or more electrons (electron donors) to free radicals to inhibit oxidative reactions. One example that has the potential as an antioxidant is yogurt. Yogurt is a food that contains a number of live bacteria that have a beneficial effect on health because it has antioxidant, antimicrobial, antidiarrheal activity and can boost the immune system. There are several factors that can affect the antioxidant activity of yogurt including temperature, storage conditions, and additional ingredients used such as adding fruit flavors. The purpose of this study was to determine the antioxidant activity of probiotics from yogurt drinks with various brands. Samples were taken from supermarkets in Medan City with 3 different brands coded A, B, and C. The antioxidant activity was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method using a visible spectrophotometer measured at wavelengths. 516 nm. The results showed that there were two samples of yogurt drink coded A and B which were included in the strong category and code C samples were included in the weak category. Yogurt drink with brand code A has the strongest antioxidant activity compared to other brand yogurt drinks (B and C) with IC50 values from samples code A (80.52 ml), B (90.14 ml), and C (194, 81 ml).

FORMULASI SEDIAAN ANTISEPTIK DARI BUAH RIMBANG (Solanum torvum) SEBAGAI HAND SANITIZER Siti Maimunah; Yettrie Simarmata; Eka Margaret Sinaga
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2738

Rimbang fruit (Solanum torvum) has properties as a skin antiseptic. Rimbang fruit extract (Solanum torvum) which has been isolated has antibacterial activity against Staphylococcus aureus bacteria. This is because the Rimbang fruit extract (Solanum torvum) contains compounds such as solasonins, glucosides, saponins, and sterolins. Formulation and testing of antibacterial activity of hand sanitizer gel preparations of Rimbang fruit extract and evaluation of the physical quality of hand sanitizer preparations. Rimbang fruit extract was made by the maceration method using 70% ethanol. Then it was evaporated using a rotary evaporator and the remaining solvent was evaporated until a thick extract was formed. Testing of antibacterial activity by agar diffusion method using disc paper against Staphylococcus aureus by measuring the diameter of the zone of inhibition of bacterial growth. The concentration of Rimbang fruit extract and hand sanitizer gel formula used (F1) 0.5% and (F2) 1%; Evaluation of the physical quality of the hand sanitizer preparation includes organoleptic test, homogeneity test, and pH test. The results of the antibacterial activity test of Rimbang fruit extract against Staphylococcus aureus at a concentration of 0.5% with an inhibitory diameter of 5.2 mm. Meanwhile, the results of the gel hand sanitizer activity test of Rimbang fruit extract obtained the inhibition of Staphylococcus aureus bacteria at a concentration of 1% with a diameter of 9.0 mm.

PENETAPAN KADAR NITRAT PADA IKAN KALENG SARDEN SECARA SPEKTROFOTOMETRI VISIBLE Yettrie Simarmata; Siti Nurbaya; Vivi Purwandari
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v6i1.2747

Canned fish is a food that is synonymous with preservatives and food coloring. In the manufacturing process, manufacturers often use natural preservatives to lower production costs. This research is descriptive research. The research location is at PT. Mutifa. Aims to determine how much nitrate levels in branded canned sardines are sold at supermarkets in the city of Stabat whether they meet the requirements of SNI or not. From the results of the study, the levels of nitrate with Brand A were 0.00694% and sardines with Brand B were 0.0453% with a maximum wavelength of 435 nm. According to regulations set by the government according to SNI Number 01-35481994 nitrate levels should not be more than 0.2%. From all samples of canned sardines studied, it was found that nitrate levels were low and did not exceed SNI requirements.

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