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Kesaktian Manurung
Program Studi S1 Farmasi, Universitas Sari Mutiara Indonesia
Medicine & Pharmacology

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthussonchifolius) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Ahmad Ghazali; Ulfayani Mayasari
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Insulin leaves are known as one of the ingredients of traditional medicine. Insulin leaves contain potential substances such as tannins, alkaloids, flavonoids, saponins, and terpenoids which have antibacterial abilities. This study aims to determine the effectiveness of insulin leaf ethanol extract as an antibacterial. This research is an experimental study that includes the collection and processing of insulin leaf samples, examination of the characteristics of Simplisia, phytochemical screening, testing of the antibacterial diffusion method using a disk paper brace, and using the One Way ANOVA analysis method. The test results showed that the ethanol extract could inhibit bacterial growth at a concentration of 50 - 60% with an average resistor potential of 14.8 - 17.83 mm while Ampicillin as a comparison control averaged 33.62 mm. So that the ethanol extract of insulin leaves was effective in inhibiting the growth of Bacillus cereus bacteria with a minimum resistance concentration of 60 mg/ml. Keywords: Antibacterial, Bacillus cereus, insulin leaf extract
PENGARUH INFUSA KULIT BUAH MANGGIS (Garcinia mangostana) TERHADAP PROFIL FARMAKOKINETIKA PARASETAMOL PADA TIKUS PUTIH JANTAN (Rattus norvegicus L.) Kesaktian Manurung; Siti Nurbaya; Rezkita Raysyah
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.94 KB) | DOI: 10.51544/jf.v4i2.2706

Abstract

Mangosteen rind is traditionally used by residents of Southeast Asia, especially Indonesia, to treat various diseases. Drug interactions can reduce or eliminate efficacy and cause serious health problems or problems. This study aims to determine the effect of mangosteen rind infusion on the pharmacokinetic profile of paracetamol administered orally to male white rats. Infusion of mangosteen rind was made in doses of 10% and 20%. The study was conducted by giving the solution successively for 7 days and on the 7th day after 4 hours, paracetamol solution was given orally. Furthermore, the blood of each male rat was taken with a time of 0 minutes, 10 minutes, 20 minutes, 30 minutes, 40 minutes, 60 minutes, 90 minutes, 120 minutes, 180 minutes, 240 minutes, 300 minutes, and 360 minutes and measured by UV spectrophotometry. a wavelength of 257 nm. The results showed that there was an effect of mangosteen rind infusion on paracetamol in test animals.
UJI AKTIVITAS EKSTRAK ETANOL BAWANG PUTIH (Alliumsativum L.)YANG DIHITAMKAN SEBAGAI ANTI INFLAMASI YANG DIINDUKSI OLEH KARAGENAN TERHADAP Mus musculus Dicky Yuswardi Wiratma; Kesaktian Manurung; Supartiningsih Supartiningsih; May Fransisca Telaumbanua
Jurnal Farmanesia Vol 4 No 2 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.897 KB) | DOI: 10.51544/jf.v4i2.2712

Abstract

One of the plants used as an alternative to traditional medicine is Garlic (Allium sativum L.). Garlic which is rich in organic organo sulfur compounds (amino acids and essential oils) in the form of allin has many benefits in treating various types of diseases. One of the processed forms of garlic is black garlic. Black garlic is a heating product from garlic that is heated at a temperature of 70oC with a relative humidity of 70-80%. This study aims to determine the use of black garlic as an anti-inflammatory, how to make black garlic and at what concentration black garlic has an anti-inflammatory effect. The method used in this research is a pure experimental method. The results of the %R measurement, the negative control group had the highest level of inflammation and the lowest was the black garlic extract group with a concentration of 60%. Meanwhile, in the %IR measurement, the black garlic extract group with a concentration of 60% had the greatest ability to block inflammation. From the tests that have been carried out, black garlic is obtained from heating results and the results of measuring the effectiveness of its anti-inflammatory activity, namely black garlic extract with a concentration of 60% have a better anti-inflammatory effect compared to other concentrations and diclofenac sodium.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIDIABETES DARI EKSTRAK ETANOL DAGING BUAH ALPUKAT (Persea americana Mill.) Yettrie Simarmata; Kesaktian Manurung; Karnerius Harefa; Mei Sri Rezeki Hasibuan
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Diabetes mellitus is a set of symptoms that arise in a person characterized by blood glucose levels exceeding normal (hyperglycemia) due to a lack of insulin in the body. One of the medicinal plants that can be used is avocado flesh. This study aims to determine the antidiabetic activity of avocado pulp extract (Persea americana Mill) against male white rats. This study used 25 male white rats divided into 5 groups, namely the negative control group CMC-Na 1%, the positive control group glibenclamide 0.45 mg/kg BW, the EEBA test group at doses of 50, 100, 200 mg/kg BW. The results of the one-way ANOVA analysis of the Tukey HSD test showed that the administration of EEBA at a dose of 100 mg/kg BW and EEBA at a dose of 200 mg/kg BW had a significant difference with a significance value of 0.024 and 0.026 and EEBA at a dose of 50 mg/kg BW had no significant difference with the significance 0.275. Based on the results of the study, it can be concluded that EEBA doses of 50, 100, 200 mg/kg BW have antidiabetic activity.
UJI AKTIVITAS EKSTRAK ETANOL DAUN SAWO MANILA (Manikara zapota L.) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Adiansyah Adiansyah; Yosy Cinthya Eriwaty Silalahi; Sry Hayati
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Sawo manila (Manikara zapota L.) merupakan salah satu bahan alam sebagai obat alternatif yang telah banyak dimanfaatkan oleh masyarakatnya juga untuk mengobati berbagai penyakit dan sawo merupakan tanaman dari family Sapotaceae yang digunakan dalam pengobatan tradisional. Ekstrak daun sawo manila mengandung alkaloid, tanin, flavonoid, dan saponin yang diketahui memiliki aktivitas antibakteri. Tujuan penulisan surat ini adalah untuk mengetahui aktivitas antibakteri sawo manila (Manikara zapota L.) terhadap bakteri Bacillus cereus. Penelitian ini menggunakan metode eksperimen, dengan metode ekstraksi maserasi dan metode chakra difusi untuk aktivitas antibakteri. Hasil penelitian menunjukkan bahwa simplisia memiliki kadar air 9,30%, larut dalam air 23,72%, kadar larut air ekstrak 31,15%, kadar abu total 1,11%, dan kadar ask tidak larut asam. 0,30%. Percobaan aktivitas anti bakteri ekstrak etanol daun sawo terhadap daya hambat bakteri bacillus cereus pada konsentrasi 20%, 40%, 60%, 80% dan 100% yaitu 12,62 mm, 15,0 mm, 15,74 mm, 16,9 mm , dan 18,78 mm, control positif menggunakan kotrimoksazol dan luas zona hambat 21,5 mm daun sawo manila dapat menghambat Bacillus cereus.
PEMERIKSAAN KADAR ASAM MERKAPTOASETAT DALAM SEDIAAN PENGERITING RAMBUT YANG BEREDAR DI SALON SEKITAR UNIVERSITAS SARI MUTIARA INDONESIA Siti Nurbaya; Siti Maimunah; Kesaktian Manurung; Risda Hernidawati Nainggolan
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.137 KB) | DOI: 10.51544/jf.v5i2.2731

Abstract

Cosmetics used for this purpose, such as curling hair, use hair curling preparations containing mercaptoacetic acid. Curling hair aims to change the structure of straight hair into wavy. The purpose of this study was to determine the levels of mercaptoacetic acid in hair curling preparations circulating in salons around Sari Mutiara University, Indonesia. The research was conducted on 3 types of samples determined by iodometric titration method using potassium iodide titer solution and starch indicator. The results of this study examined the levels of mercaptoacetic acid in hair curling preparations in samples A: 5,676%, B: 6,053%, C: 6,478%. These results indicate that the 3 types of samples meet the requirements in accordance with the decision of the POM RI No. HK.00.05.42.1018 the Year 2008 with a maximum level of 8.0%.
AKTIVITAS PENGHAMBAT ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA DARI SPONGE(Filum Porifera) SECARA IN SILICO Kesaktian Manurung; Siti Maimunah; Fitri Yulia Sari
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

The metabolite content in sponge has a unique chemical structure and very interesting pharmacological activity, such as anticancer, antimicrobial, anti-inflammatory, antifouling, antifouling, and inhibiting enzyme activity. The purpose of this study is to find out the value of RMSD in protein validation 6LU7 in silico, to know the ability of Sponge compounds in inhibiting protease enzyme 6LU7 from SARS-CoV-2 Virus in silico, and to know the comparison of the results of docking score of Sponge compounds in the inhibition of protease enzyme 6LU7SARS-CoV-2 virus to visualize docking results to know the amino acids that bond with each other. This research is a descriptive study that is to test the activity of Sponge compounds against inhibition of protease enzyme 6LU7 SARS-CoV-2. The phases in this study include downloading and installation applications needed. And validation of in silico tethering method to protease enzyme 6LU7 SARS-CoV-2 virus, as well as the docking of Sponge compound molecules against protease enzyme 6LU7 SARS-CoV-2 virus in silicon. The results of the study obtained that the process of tethering protease enzyme 6LU7 sars-cov-2 virus is declared valid so that it can be used for molecular tethering of Sponge test compounds in silico. Sponge test compounds can inhibit the protease enzyme 6LU7 Sars-CoV-2 virus. The docking score of Sponge test compounds on protease enzyme 6LU7 SARS-CoV-2 virus is lower than the comparison. As the result of docking visualization, several amino acid residues interact with each other including hydrogen bonds.
PENETAPAN ANGKA KAPANG KHAMIR (AKK) PADA REMPAH-REMPAH YANG DIJUAL DI PASAR SRI GUNTING MEDAN Yosy Cinthya Eriwaty Silalahi; Kesaktian Manurung; Putri Niat Salma Halawa
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Spices containing fungal contamination exceed the stipulated limit of 1x104 colonies/g which will affect the stability of the preparation and aflatoxins that are harmful to health such as liver cancer. This study aims to determine the value of the yeast mold number (AKK) in spices at the Sri Gunting market, Medan. The population in this study were spices in the form of wet powder, namely turmeric (Curcuma longa Linn.), ginger (Zingiber officinale Rosc.), and temulawak (Curcuma xanthorhiza Roxb.), and 250 grams of each ingredient was taken from four spice traders. with location criteria such as on the edge of a highway, near a ditch/gully, inside a kiosk, and near a meat seller as a sample. Subjects of research and observations are presented in the form of tables and figures which are then analyzed descriptively. The results of the study found that the AKK of spices sold at the Sri Gunting market in Medan was equal to trader A (turmeric 16.1x10^4, Ginger 7.9x10^4, Temulawak 11.1x10^4cfu/g), trader B (turmeric > 150, Ginger 11.5x10^4Temulawak 18x10^4cfu/g), merchant C (turmeric 12.2x10^4, Ginger 6.1x10^4, Temulawak 4.5x10^4cfu/g), and merchant D (turmeric >150, Ginger 10.9x10^4, Temulawak >150cfu/g) which means that the AKK contained from spices sold at the Sri Gunting market in Medan does not meet the requirements according to the Food and Drug Supervisory Agency (BPOM).
UJI AKTIVITAS BUAH OKRA(Abelmoschus esculentus L) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS Dicky Yuswardi Wiratma; Kesaktian Manurung; Soraya Syaviera
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Diabetes mellitus is a metabolic disorder disease characterized by hyperglycemia. Abelmuschus esculentus or known as the okra plant, is often used as a treatment for DM because it has hypoglycemic and antioxidant effects. Okra (Abelmuschus esculentus) is believed by the public as one of the plants that can prevent and treat diabetes. This study aims to test whether the administration of okra fruit extract can reduce blood glucose levels in rats. The research subjects were 25 rats which were divided into 5 groups, which consisted of a negative control group with 1% NaCMC, a positive control group using glibenclamide and ethanol extract of okra fruit at a dose of 200 mg/kgBW, a dose of 250 mg/kgBW, a dose of 300 mg. /kgBB. Glucose levels were measured at T0, T1, T2, T3, T4 AND T5 using a test strip glucometer. This study was experimental.
UJI EFEK EKSTRAK ETANOL DAUN SALAM (Syzygiumpolyanthum) SEBAGAI DIURETIKA PADA TIKUS PUTIH JANTAN Kesaktian Manurung; Novarianti Marbun; Salomo Joseph Empindonta
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Bay leaf is a plant that one of its benefits is as a diuretic. Diuretics are drugs that act directly on the kidneys and increase the excretion of urine and sodium salts. The aim of the study was to determine the diuretic effect of ethanol extract of bay leaf (EEDS) on male white rats. The study used 25 male white rats, divided into 5 treatment groups: negative control group (CMC suspension 0.5%), positive control (furosemide suspension at a dose of 3.6 mg/kg BW), and a test group EEDS suspension at a dose of 100 mg/kg. BW, 200 mg/kg BW and 300 mg/kg BW. The test preparation was given orally to rats and then observed in a modified metabolic cage for 6 hours. The results of simplicia phytochemical screening showed positive for flavonoids, saponins and tannins. The results of EEDS characterization included a total ash content of 3.66%, water-soluble extract content of 3.69%, and ethanol-soluble extract content of 3.65%. The results showed that EEDS at a dose of 300 mg/kg BW showed the best diuretic effect compared to 200 mg/kg BW and 100 mg/kg BW, but the effect was lower than S. Furosemide 3.6 mg/kg BW. The results of the ANOVA EEDS test at doses of 100, 200 and 300 mg/kg BW had significant differences.
Co-Authors Adiansyah Adiansyah Ahmad Ghazali Ahmad Hafizullah Ritonga Cut Masyithah Thaib Dicky Yuswardi Wiratma Fitri Yulia Sari Jon Kenedy Marpaung Karnerius Harefa Mardianis Mardianis May Fransisca Telaumbanua Mei Sri Rezeki Hasibuan Novarianti Marbun Putri Niat Salma Halawa Rezkita Raysyah Risda Hernidawati Nainggolan Salomo Joseph Empindonta Siti Maimunah Siti Nurbaya Soraya Syaviera Sry Hayati Supartiningsih Supartiningsih Taruli Rohana Sinaga Ulfayani Mayasari Yettrie Simarmata Yohana Monica Yosy Cinthya Eriwaty Silalahi