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PERBANDINGAN UJI AKTIVITAS ANTI DIABETES EKSTRAK ETANOL BUAH PARE (Momordicacharantia L.) DANDAUN LIDAH BUAYA (Aloe vera L.) PADA MENCIT JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Samsia Yolanda Sari
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Diabetes is a non-communicable degenerative disease that will increase in number in the future. This is evidenced by the increasing incidence of diabetes every decade. Bitter gourd and aloe vera are an alternative in treating Diabetes Mellitus because these plants contain saponins, flavonoids, and polyphenols (strong antioxidants), as well as glycosides cucurbitacin, momordicin, and charantin that can lower blood sugar, saponins, flavonoids, and alkaloids. This study aims to determine secondary metabolite compounds, anti-diabetic activity, and the combination of aloe vera extract and bitter melon extract that has antidiabetic activity. The method used in this study is an experimental method, namely testing the antidiabetic effect of extracts obtained from ethanol of bitter melon and aloe vera leaves on alloxan-induced mice. The results obtained from the research are that the administration of aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group with the ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW showed a very good effect on reducing BGD. This means that aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group given ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW had good antidiabetic activity.

PERBANDINGAN UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN LIDAH BUAYA DAN LIDAH MERTUA PADA MENCIT PUTIH JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Rifka Gloria
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Diabetes mellitus (DM) is a disease whose prevalence is increasing from year to year. This increase was accompanied by an increase in the cost of treatment and the number of complications. The use of traditional medicine is an alternative for the community to control blood sugar levels (KGD). Considering that synthetic drugs have various side effects, one of the medicinal plants used as traditional medicine is aloe vera leaf and mother-in-law's tongue leaf which contain flavonoid compounds, alkaloids, tannins, saponins, and steroids/triterpenoids. The purpose of this study was to determine the antidiabetic activity of aloe vera leaf extract and mother-in-law's tongue and to compare the activities of the two. The results of the analysis of the glucose tolerance ANOVA test showed a significant difference in the percentage reduction at 60, 90, and 120 minutes for all treatment preparations. The alloxan induction test showed a significant difference in the percentage decrease from days 3, 5, 7, 9, 11, 13, and 15. Based on these results, it can be concluded that Aloe Vera Leaf Ethanol Extract (EEDLB) and LidahMertua Leaf Ethanol Extract (EEDLM) with each dose of 150 and 200 mg/kg BW and the combination of the two gave antidiabetic activity against mice as well as differences in effectiveness between samples of aloe vera leaf and LidahMertua leaf as well as a single dose with a combination.

PENETAPAN KADAR PROTEIN DALAM SUSU FORMULA BAYI DAN ASI DI MEDAN SECARA KJELDAHL Eka Margaret Sinaga; Siti Maimunah; Erly Sitompul
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Breast milk (ASI) is the best food for babies. Breast milk has advantages compared to other milk, including guaranteed cleanliness, the composition of breast milk is also very suitable for digestion, growth, and development of babies, one of the compositions contained in breast milk is protein. Currently, many mothers cannot breastfeed their own babies, so they choose infant formula as a substitute for breast milk. The purpose of this study was to determine differences in protein levels in infant formula and breast milk. Determination of protein content was carried out using the Kjeldahl method which is a simple method for determining total nitrogen in protein and other nitrogen-containing compounds. The Kjeldahl method is carried out through 3 processes, namely: the destruction process, the distillation process, and the titration process according to the procedures and tools used in the Chemistry Laboratory of the Sari Mutiara Indonesia University. The results of the determination of protein levels using the Kjeldahl method contained a protein with average levels in infant formula brand A (10.10 ± 0.96) %, infant formula brand B (10.95 ± 2.43) %, infant formula brand C (11.0666 ± 1.6932) %, and breast milk (20.5733 ± 3.1828) %.

PERBANDINGAN UJI AKTIVITAS ANTI DIABETES EKSTRAK ETANOL BUAH PARE (Momordicacharantia L.) DAN DAUN LIDAH BUAYA (Aloe vera L.) PADA MENCIT JANTAN Erly Sitompul; Supartiningsih Supartiningsih; Karnerius Harefa; Samsia Yolanda Sari
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes is a non-communicable degenerative disease that will increase in number in the future. This is evidenced by the increasing incidence of diabetes every decade. Bitter gourd and aloe vera are an alternative in treating Diabetes Mellitus because these plants contain saponins, flavonoids, and polyphenols (strong antioxidants), as well as glycosides cucurbitacin, momordicin, and charantin that can lower blood sugar, saponins, flavonoids, and alkaloids. This study aims to determine secondary metabolite compounds, anti-diabetic activity, and the combination of aloe vera extract and bitter melon extract that has antidiabetic activity. The method used in this study is an experimental method, namely testing the antidiabetic effect of extracts obtained from ethanol of bitter melon and aloe vera leaves on alloxan-induced mice. The results obtained from the research are that the administration of aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group with the ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW showed a very good effect on reducing BGD. This means that aloe vera extract 150 mg/kg BW and 200 mg/Kg BW, the group given ethanol extract of bitter melon 150 mg/kg BW and 200 mg/Kg BW had good antidiabetic activity.

PENETAPAN KADAR PROTEIN DALAM SUSU FORMULA BAYI DAN ASI DI MEDAN SECARA KJELDAHL Eka Margaret Sinaga; Siti Maimunah; Erly Sitompul
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Breast milk (ASI) is the best food for babies. Breast milk has advantages compared to other milk, including guaranteed cleanliness, the composition of breast milk is also very suitable for digestion, growth, and development of babies, one of the compositions contained in breast milk is protein. Currently, many mothers cannot breastfeed their own babies, so they choose infant formula as a substitute for breast milk. The purpose of this study was to determine differences in protein levels in infant formula and breast milk. Determination of protein content was carried out using the Kjeldahl method which is a simple method for determining total nitrogen in protein and other nitrogen-containing compounds. The Kjeldahl method is carried out through 3 processes, namely: the destruction process, the distillation process, and the titration process according to the procedures and tools used in the Chemistry Laboratory of the Sari Mutiara Indonesia University. The results of the determination of protein levels using the Kjeldahl method contained a protein with average levels in infant formula brand A (10.10 -+ 0.96) %, infant formula brand B (10.95 -+ 2.43) %, infant formula brand C (11.0666 -+ 1.6932) %, and breast milk (20.5733 -+ 3.1828) %.

ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR TAWAR DAN UDANG AIR TAWAR SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Zuhairiah Zuhairiah; Erly Sitompul; Elly Sitorus; Yosy Cinthya Eriwaty Silalahi
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Fish containing mercury will have a bad impact on the health of the human body. The maximum limit of mercury levels in fish that has been determined by SNI (2009) on fish is 0.5 mg/kg. This study aims to determine the presence or absence of mercury (Hg) metal contamination in several types of freshwater fish, namely catfish (Clariasgariepinus), catfish (Pangsiushypophthalmus), tilapia (Oreochromis mossambicus), tilapia (Oreochromis niloticus), pomfret (Colossomamacropomum) and giant prawn (Macrobrachiumrosenbergii), by Atomic Absorption Spectrophotometry (AAS). Quantitative analysis of mercury used atomic absorption spectrophotometry (Shimadzu AA-6200). Measured at a wavelength of 253.7 nm. The results of this study were white pomfret containing mercury with levels of 0.2043 -+ 0.0079 mg/kg, catfish containing mercury with levels of 0.4116 -+ 0.1105 mg/kg, catfish containing mercury with levels of 0.4088 -+ 0.1076 mg/kg, tilapia fish contains mercury with levels of 0.4034 -+ 0.1443 mg/kg, tilapia fish contains mercury with levels of 0.4191 -+ 0.0750 mg/kg, and giant prawns contain mercury with levels of 0, 3928 -+ 0.0521 mg/kg. The calculation results show that all types of fresh water fish contain mercury <0.5 in accordance with the requirements set by SNI No.7387 (2009) on fish, namely 0.5 mg/kg.

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